1,2-Dimethylhydrazine: A DNA alkylating agent that has been shown to be a potent carcinogen and is widely used to induce colon tumors in experimental animals.Dimethylhydrazines: Hydrazines substituted with two methyl groups in any position.Methylhydrazines: Hydrazines substituted by one or more methyl groups in any position.Monomethylhydrazine: Hydrazine substituted by one methyl group.Colonic Neoplasms: Tumors or cancer of the COLON.Carcinogens: Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.HydrazinesColon: The segment of LARGE INTESTINE between the CECUM and the RECTUM. It includes the ASCENDING COLON; the TRANSVERSE COLON; the DESCENDING COLON; and the SIGMOID COLON.Aberrant Crypt Foci: Clusters of colonic crypts that appear different from the surrounding mucosa when visualized after staining. They are of interest as putative precursors to colorectal adenomas and potential biomarkers for colorectal carcinoma.Precancerous Conditions: Pathological processes that tend eventually to become malignant. (From Dorland, 27th ed)Chlorophyllides: Products of the hydrolysis of chlorophylls in which the phytic acid side chain has been removed and the carboxylic acids saponified.Methylazoxymethanol Acetate: The aglycone of CYCASIN. It acts as a potent carcinogen and neurotoxin and inhibits hepatic DNA, RNA, and protein synthesis.Neoplasms, Experimental: Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms.Cocarcinogenesis: The combination of two or more different factors in the production of cancer.Rats, Inbred F344Intestinal Neoplasms: Tumors or cancer of the INTESTINES.Intestinal Mucosa: Lining of the INTESTINES, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. In the SMALL INTESTINE, the mucosa is characterized by a series of folds and abundance of absorptive cells (ENTEROCYTES) with MICROVILLI.Anticarcinogenic Agents: Agents that reduce the frequency or rate of spontaneous or induced tumors independently of the mechanism involved.Amorphophallus: A plant genus of the family ARACEAE. Members contain konjac glucomannan (MANNANS) and SEROTONIN.Adenosarcoma: A malignant neoplasm arising simultaneously or consecutively in mesodermal tissue and glandular epithelium of the same part. (Stedman, 25th ed)Adenocarcinoma: A malignant epithelial tumor with a glandular organization.Azo CompoundsCecal Neoplasms: Tumors or cancer of the CECUM.Intestine, Large: A segment of the LOWER GASTROINTESTINAL TRACT that includes the CECUM; the COLON; and the RECTUM.Dietary Fiber: The remnants of plant cell walls that are resistant to digestion by the alimentary enzymes of man. It comprises various polysaccharides and lignins.Rats, Inbred Strains: Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.Adenoma: A benign epithelial tumor with a glandular organization.Colonic Diseases: Pathological processes in the COLON region of the large intestine (INTESTINE, LARGE).Alkylation: The covalent bonding of an alkyl group to an organic compound. It can occur by a simple addition reaction or by substitution of another functional group.Pectins: High molecular weight polysaccharides present in the cell walls of all plants. Pectins cement cell walls together. They are used as emulsifiers and stabilizers in the food industry. They have been tried for a variety of therapeutic uses including as antidiarrheals, where they are now generally considered ineffective, and in the treatment of hypercholesterolemia.GuanineCellulose: A polysaccharide with glucose units linked as in CELLOBIOSE. It is the chief constituent of plant fibers, cotton being the purest natural form of the substance. As a raw material, it forms the basis for many derivatives used in chromatography, ion exchange materials, explosives manufacturing, and pharmaceutical preparations.Rats, Wistar: A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.Rectum: The distal segment of the LARGE INTESTINE, between the SIGMOID COLON and the ANAL CANAL.Injections, Subcutaneous: Forceful administration under the skin of liquid medication, nutrient, or other fluid through a hollow needle piercing the skin.Azoxymethane: A potent carcinogen and neurotoxic compound. It is particularly effective in inducing colon carcinomas.Cecum: The blind sac or outpouching area of the LARGE INTESTINE that is below the entrance of the SMALL INTESTINE. It has a worm-like extension, the vermiform APPENDIX.Intestine, Small: The portion of the GASTROINTESTINAL TRACT between the PYLORUS of the STOMACH and the ILEOCECAL VALVE of the LARGE INTESTINE. It is divisible into three portions: the DUODENUM, the JEJUNUM, and the ILEUM.Cell Division: The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.
*  1,2-Dimethylhydrazine
... or symmetrical dimethylhydrazine, is one of the two isomers of dimethylhydrazine. It is a potent carcinogen that acts as a DNA ... Unsymmetrical dimethylhydrazine 74-79-3 1,2-Dimethylhydrazine 1,2-Dimethylhydrazine from PubChem Record of 1,2-Dimethylhydrazin ...
*  ENPP7
3.0.CO;2-E. PMID 9028353. Di Marzio L, Di Leo A, Cinque B, Fanini D, Agnifili A, Berloco P, Linsalata M, Lorusso D, Barone M, ... 43 (2): 316-24. PMID 11861674. Duan RD, Cheng Y, Hansen G, Hertervig E, Liu JJ, Syk I, Sjostrom H, Nilsson A (June 2003). " ... 235 (1): 141-6. doi:10.1016/j.canlet.2005.04.016. PMID 16290921. Soo I, Madsen KL, Tejpar Q, Sydora BC, Sherbaniuk R, Cinque B ... J. 394 (Pt 1): 299-308. doi:10.1042/BJ20051121. PMC 1386028 . PMID 16255717. Andersson D, Kotarsky K, Wu J, Agace W, Duan RD ( ...
*  Bread
24 (2): 115-119. doi:10.1016/j.fm.2006.07.004. McGee, Harold (2004). On Food and Cooking: The Science and Lore of the Kitchen. ... Retrieved 1 October 2016. Wheat, in the form of bread, provides more nutrients to the world population than any other single ... Retrieved 1 January 2017. Kaplan, Steven Laurence: Good Bread is Back: A Contemporary History of French Bread, the Way It Is ... Retrieved 1 October 2016. Aside from bread wheat and durum, other types of wheat include spelt, emmer, einkorn and kamut. These ...
*  Crustless bread
2-dimethylhydrazine". European Journal of Cancer Prevention. 18 (4): 291-302. doi:10.1097/CEJ.0b013e32832945a6. PMID 19417676. ... 2-dimethylhydrazine". Eur J Cancer Prev. 18 (4): 291-302. Aug 2009. doi:10.1097/CEJ.0b013e32832945a6. PMID 19417676. ... 2-dimethylhydrazine". European Journal of Cancer Prevention. 18 (4): 291-302. doi:10.1097/CEJ.0b013e32832945a6. PMID 19417676. ... effect of bread crust antioxidant pronyl-lysine on two different categories of colonic premalignant lesions induced by 1, ...
*  Propionibacterium freudenreichii
9 (2): 179-188. doi:10.1038/sj/cdd/4400935. ISSN 1350-9047. PMID 11840168. Lan, A.; et al. (2008). "Increased induction of ... 2 C2H5CO2 + C2H3O2 + CO2). The products of this fermentation contribute to the nutty and sweet flavors of the cheese, and the ... 2-dimethylhydrazine". British Journal of Nutrition. 100 (6): 1251-1259. doi:10.1017/S0007114508978284. ISSN 0007-1145. PMID ... by Propionibacterium freudenreichii TL133 in colonic mucosal crypts of human microbiota-associated rats treated with 1, ...
*  Azane
UDMH is easier to manufacture than symmetrical dimethylhydrazine is, and UDMH is a fairly common rocket fuel. gyromitrin and ... symmetrical dimethylhydrazine) are hydrazines where two hydrogen atoms are replaced by methyl groups. ... 2,4-dinitrophenylhydrazine (2,4-DNPH) is commonly used to test for ketones and aldehydes in organic and clinical chemistry. ... Saturated hydronitrogens can be: linear (general formula N nH n + 2) wherein the nitrogen atoms are joined in a snakelike ...
*  Orlistat
240 (2): 221-4. doi:10.1016/j.canlet.2005.09.011. PMID 16377080. Takayama T, Katsuki S, Takahashi Y, Ohi M, Nojiri S, Sakamaki ... 132 (2): 656-66. doi:10.1021/ja907716f. PMID 20028024. Peng-Yu, Yang; Min, Wang; Kai, Liu; Mun Hong, Ngai; Omar, Sheriff; J. ... 70 (1): 196-202. doi:10.1002/hlca.19870700124. Pommier A, Pons M, Kocienski P (1995). "The first total synthesis of (−)- ... ISBN 1-56363-527-5. "myalli.com - frequently asked questions". GlaxoSmithKline. 2007. Archived from the original on 12 July ...
*  List of IARC Group 2A carcinogens
Volumes 1-115". IARC Monographs on the Evaluation of Risk to Humans. IARC. February 22, 2016. Retrieved March 5, 2016. "IARC ... 3-cyclohexyl-1-nitrosourea) 4-Chloro-o-toluidine Chlorozotocin Cisplatin Cyclopenta[c,d]pyrene Diazinon Dibenz[a,j]acridine ... 2,3-Trichloropropane Tris(2,3-dibromopropyl) phosphate Vinyl bromide Vinyl fluoride Bitumens, occasional exposure to oxidized ... 2-Dimethylhydrazine Dimethyl sulfate Epichlorohydrin Ethylene dibromide Ethyl carbamate (urethane) N-Ethyl-N-nitrosourea ...
*  Dimethylhydrazine
... is the name of two compounds with the molecular formula C2H8N2. These are: unsymmetrical dimethylhydrazine (1 ... with both methyl groups bonded to the same nitrogen atom symmetrical dimethylhydrazine (1,2-dimethylhydrazine), with one methyl ...
*  Methylhydrazines
Members of this class include: Monomethylhydrazine Dimethylhydrazines Symmetrical dimethylhydrazine (1,2-dimethylhydrazine) ... Trimethylhydrazine 1,1,2-trimethylhydrazine 1,1,1-trimethylhydrazinium (cationic and exists as a variety of salts e.g. 1,1,1- ... 1,1,2-tetramethylhydrazinium (cationic and exists as a variety of salts) Pentamethylhydrazinium (cationic and exists as a ...
*  List of MeSH codes (D02)
... dimethylhydrazines MeSH D02.442.600.400.200 --- 1,2-dimethylhydrazine MeSH D02.442.600.601 --- monomethylhydrazine MeSH D02.442 ... vitamin k 1 MeSH D02.455.849.291.523.500.844 --- vitamin k 2 MeSH D02.455.849.291.523.500.922 --- vitamin k 3 MeSH D02.455. ... 3-oxo-1,5-pentanediyl)bis(n,n-dimethyl-n-2-propenyl-), dibromide MeSH D02.092.146.325 --- p-dimethylaminoazobenzene MeSH ... 5-nitro-2-furyl)vinyl)-1,2,4-oxadiazole MeSH D02.640.600.290 --- fanft MeSH D02.640.600.308 --- furagin MeSH D02.640.600.313 ...
*  Yuanzheng-1
It uses the storable hypergolic propellants unsymmetrical dimethylhydrazine (UDMH) and dinitrogen tetroxide (N2O4), and can ... "YZ-1 space tug". B14643.DE. Retrieved 2015-07-25. [permanent dead link] "长征七号首飞成功 空间实验室任务大幕拉开" [Successful maiden flight of the ... Yuanzheng-2 (AKA YZ-2) (Chinese: 远征二号; pinyin: Yuǎn Zhēng Èr Hào; literally: "Expedition Two"): New version used with the 5.2 m ... The YZ-1 was designed for restart capability, and to remain operational for more than 6 hours required to
*  Jupiter-C
... unsymmetrical dimethylhydrazine and 40% diethylenetriamine), as fuel propellant feed, turbopump type turbopump drive, 90% ... lifted a 1/3-scale Jupiter nose cone to an altitude of 285 mi (460 km) and a range of 1,330 mi (2,140 km); Juno I (four-stage ... U for 2, ..., E for 9 and X for 0. For example, the Jupiter-C modified to launch Explorer 1 had "UE" painted on the side, ... Stage 1 62,700 lb (28,400 kg)/9,600 lb (4,400 kg) Stage 2 1,020 lb (460 kg)/490 lb (220 kg) Stage 3 280 lb (130 kg)/140 lb (64 ...
*  R-16 (missile)
The missile used Unsymmetrical dimethylhydrazine as a bipropellant in combination with red fuming nitric acid. The Soviets ... Initial operational capability was achieved on 1 November 1961. The missile continued to serve until 1976, with maximum ... the first flight of the missile took place on 2 February 1961. ...
*  Scud
The Qiam 1's accuracy is also improved with the addition of a separable warhead. Other changes to the warhead include a "baby- ... Far simpler than the V-2's multi-chamber design, and employing an anti-oscillation baffle to prevent chugging, it was a ... with unsymmetrical dimethylhydrazine (UDMH, Russian TG-02 like German Tonka 250) as liquid igniter (self-ignition with IRFNA) ... The earlier R-1 missile had carried the NATO name SS-1 Scunner, but was of a very different design, almost directly a copy of ...
*  TATB
... is formed from the rocket fuel unsymmetrical dimethylhydrazine (UDMH) and methyl iodide, and acts as a vicarious nucleophilic ... TATB, triaminotrinitrobenzene or 2,4,6-triamino-1,3,5- trinitrobenzene is an aromatic explosive, based on the basic six-carbon ... TATB is produced by nitration of 1,3,5-trichlorobenzene to 1,3,5-trichloro-2,4,6-trinitrobenzene, then the chlorine atoms are ...
*  Mars 1M
Attitude was controlled by a Sun-star sensor with attitude correction performed by a dimethylhydrazine/nitric acid bipropellant ... Mars 1M No.1, known in the west as Marsnik 1, Mars 1960A and Korabl 4, was destroyed in a launch failure on October 10, 1960. ... Mars 1M No.2, known in the west as Marsnik 2, Korabl 5 and Mars 1960B, was launched on October 14, 1960. Both Mars 1M ... Mars 1M No.2 reached an altitude of 120 km before reentry. Soviet premier Nikita Khrushchev had planned to bring models of the ...
*  Liquid rocket propellant
Unsymmetrical dimethylhydrazine (UDMH or MMH) / Dinitrogen tetroxide (NTO or N 2O 4) Used in three first stages of the Russian ... hydrazine or unsymmetrical dimethylhydrazine (UDMH) as fuel were then adopted in the United States and the Soviet Union for use ... The V-1 and V-2 rockets developed by Nazi Germany used LOX and ethyl alcohol. One of the main advantages of alcohol was its ... The V-2 used an alcohol/LOX liquid propellant engine, with hydrogen peroxide to drive the fuel pumps. The alcohol was mixed ...
*  List of extremely hazardous substances
... mercury Dimethyl phosphorochloridothioate Dimethyl-p-phenylenediamine Dimethylcadmium Dimethyldichlorosilane Dimethylhydrazine ... 2-(bis(1-methylethyl)amino)ethyl) O-ethyl ester Phosphonothioic acid, methyl-, O-(4-nitrophenyl) O-phenyl ester Phosphoric acid ... 2-chloroethyl)amine Valinomycin Vinyl acetate monomer Warfarin Warfarin sodium Xylylene dichloride Zinc phosphide List of ... 2-chloro- Ethanol, 1,2-dichloro-, acetate Ethion Ethoprophos Ethylbis(2-chloroethyl)amine Ethylene fluorohydrin Ethylene oxide ...
*  Hypergolic propellant
Aerozine 50 is a mixture of 50% UDMH and 50% straight hydrazine (N2H4). Unsymmetrical dimethylhydrazine (UDMH) + Nitrogen ... The most common hypergolic fuels, hydrazine, monomethylhydrazine and unsymmetrical dimethylhydrazine, and oxidizer, nitrogen ... dinitrogen tetroxide plus hydrazine and/or its relatives monomethylhydrazine and unsymmetrical dimethylhydrazine. Soviet rocket ... Ariane 1 through 4, with their hypergolic first and second stages (and optional hypergolic boosters on the Ariane 3 and 4) have ...
*  Daminozide
... unsymmetrical dimethylhydrazine (UDMH), had found a correlation between exposure to the chemicals and cancerous tumors in lab ... Bernard, Mitchell S. (2 June 2013). "The Natural Resources Defense Council was right on Alar in 1989 and it still is". The ... 95 Suppl 1: S81-91. doi:10.2105/AJPH.2004.044818. PMID 16030344. Kroll, Andy; Schulman, Jeremy (28 October 2013). "Leaked ... Generally, EPA considers lifetime cancer risks in excess of 1 per million to be cause for action. "Daminozide toxicity, ...
*  Liquid-propellant rocket
... and unsymmetric dimethyl hydrazine (UDMH, (CH3)2N2H2) - Soviet Scud-C, aka SS-1-c,-d,-e Nitric acid 73% with dinitrogen ... Nike Ajax Antiaircraft Rocket Unsymmetric dimethylhydrazine (UDMH) and dinitrogen tetroxide (N2O4) - Proton, Rokot, Long March ... Examples: Saturn V's F-1 and J-2, Delta IV's RS-68, Ariane 5's HM7B, Falcon 9's Merlin. Tap-off cycle Takes hot gases from the ... The first injectors used on the V-2 created parallel jets of fuel and oxidizer which then combusted in the chamber. This gave ...
*  Hydyne
With the use of the newly developed Hydyne, composed of a blend of 60% unsymmetrical dimethylhydrazine (UDMH) and 40% ... Hydyne is a mixture of 60% unsymmetrical dimethylhydrazine (UDMH) and 40% diethylenetriamine (DETA), developed in 1957 at ... ISBN 1-56347-649-5. NASA. The Mercury-Redstone Project, p. 3-2, 4-42. History of the Redstone Missile System, p. 60 History of ... Hydyne was used as the fuel for the first stage of the Juno I rocket that launched Explorer 1, the first successful satellite ...
*  Proton-K
Like other members of the Universal Rocket family, the Proton-K was fuelled by Unsymmetrical dimethylhydrazine and nitrogen ... Blok D-2 upper stages were used three times, with the Fobos 1, Fobos 2 and Mars 96 spacecraft. The Blok DM upper stage was used ... The Block DM1, a commercial version of the DM-2, was used to launch Inmarsat-3 F2. The Block DM2 upper stage was used to launch ... The most commonly used upper stage was the Blok DM-2, which was used on 109 flights, mostly with GLONASS and Raduga satellites ...
*  Lactalbumin
After 24 weeks of dimethylhydrazine treatment the incidence of tumors in the whey protein-fed mice was substantially lower than ... 7. Dietary Whey Protein Inhibits The Development Of Dimethyl-hydrazine Induced Malignancy Bounous G., Papenburg R., Kongshavn P ... Dietary Milk Proteins Inhibit The Development Of Dimethyl-hydrazine-Induced Malignancy (2) Papenburg R., Bounous G., Fleiszer D ... After 20 weeks of dimethylhydrazine treatment, the number of plaque forming cells per spleen, following intravenous inoculation ...
*  Vinylon
... there is speculation that the Hamhung plant is manufacturing unsymmetrical dimethylhydrazine, a specialized rocket fuel that is ... 2, Dec. 2014, pp. 425-450. Lee, Grace. "The Political Philosophy of Juche." Stanford Journal of East Asian Affairs 3, no. 1 ( ...
Looking for TCI AMERICAS 1,2-dimethylhydrazine dihydrochloride (29NA63)? Graingers got your back. Price:$332.00. Easy ordering & convenient delivery. Log-in or register for your pricing.
1,1-dimethylhydrazine chemical properties, What are the chemical properties of 1,1-dimethylhydrazine 57-14-7, What are the physical properties of 1,1-dimethylhydrazine ect.
The early morphological and biochemical effects of intrarectally administered 1,2-dimethylhydrazine dihydrochloride on mouse colon were studied. Using [3H]thymidine autoradiography, it was found that 1,2-dimethylhydrazine dihydrochloride, 250 mg/kg decreased the number of prelabeled DNA-synthesizing cells in the distal colon as early as 30 min after instillation. During the interval from 24 hr to 2 weeks, however, the opposite effect was seen; incorporation of [3H]thymidine increased 3- to 5-fold over controls. At lower doses (0.25 to 25 mg/kg), a similar trend was observed. Histological examination showed no dramatic changes in cell structure or in tissue architecture. No changes were seen in labeling indices in the proximal colon. In the liver, cellular alterations were seen at concentrations of 25 to 250 mg/kg, particularly in the centrolobular region. These changes were evident at 2 hr and disappeared by 4 hr. The kidney was unaffected by 1,2-dimethylhydrazine dihydrochloride at any ...
Many modern launch vehicles use unsymmetrical dimethylhydrazine (UDMH) as liquid fuel in the space program. UDMH is highly toxic and poses a serious threat to the environment and to humans. One of the most effective methods of UDMH neutralization in case of fuel spills is adsorption. This paper is the first to suggest using hydrolysis lignin as rocket fuel adsorbent. The research was based on the use of ion chromatography with amperometric detection and gas chromatography-mass spectrometry methods. The adsorption experiment resulted in finding the conditions that correspond to the residual UDMH concentration that does not exceed maximum permissible concentration in water. Also, it was investigated the effect of moisture content of hydrolysis lignin and ambient temperature on the dynamics of UDMH adsorption from the gaseous phase. We determined the kinetic and thermodynamic parameters of the adsorption process. It was demonstrated that the reaction between 1,1-dimethylhydrazine and active adsorbent
A method is proposed for the highly sensitive simultaneous determination of eight major products of oxidative transformations of 1,1-dimethylhydrazine, widely used as a rocket fuel (formaldehyde dimet
Proliferative activity of background and neoplastic colonic mucosa was examined following five months of weekly injections of 1,2-dimethylhydrazine (20 mg/kg) and one or four months of rest to determine whether previously reported changes may result from an acute or chronic effect of dimethylhydrazine and whether differences exist between stages of neoplasia. To determine whether neoplasia is responsive to a proliferative stimulus, 1,2-dimethylhydrazine dihydrochloride-treated mice were inoculated with Citrobacter freundii. The labeling index and the proliferative zone increased in background mucosa after one month; whereas after four months labeling index, proliferative zone and crypt heights increased, but the mitotic index decreased. There was a positive linear correlation between advancing tumor grade and increasing tumor labeling index and mitotic index. Background labeling index, even when elevated by C. freundii inoculation, had no effect upon tumor labeling index. Mitotic index ...
Abstract: This study monitored structural shifts of gut microbiota of rats developing precancerous mucosal lesions induced by carcinogen 1,2-dimethyl hydrazine (DMH) treatment using PCR-denaturing gradient gel electrophoresis (DGGE) and 454 pyrosequencing on the 16S rRNA gene V3 region. Partial least square discriminant analysis of DGGE fingerprints showed that the gut microbiota structure of treated animals was similar to that of the controls 1 and 3 weeks after DMH treatments, but significantly different 7 weeks after DMH treatments, when a large number of aberrant crypt foci (ACF) developed in their colons. Martens uncertainty test, followed by anova test ( ...
Carcinogenesis studies of short range (SR), intermediate range (IR), or intermediate range chrysotile asbestos in combination with the intestinal carcinogen 1,2-dimethylhydrazine dihydrochloride (DMH) were conducted with male and female Syrian golden hamsters. Both forms of chrysotile asbestos were administered at the concentration of 1% in pelleted diet for the entire lifetime of the hamsters starting with mothers of the test animals. Group sizes varied from 125 to 253. Starting at 6 weeks of age, male and female hamsters in the intermediate range chrysotile/DMH study were given oral doses of DMH (4 mg/kg) every other week for a total of 5 doses. There was no adverse effect on body weight gain or survival by either form of asbestos or by asbestos in combination with DMH.. A significant increase (P,0.05) in adrenal cortical adenomas was observed in male hamsters exposed to SR and IR chrysotile asbestos and in females treated with IR chrysotile asbestos when compared to the pooled control groups ...
neural mechanisms of UDMH intoxication have been studied by analyzing changes in cortical, subcortical, and cerebellar neuroelectric potentials evoked by peripheral nerve stimulation. Both chronically implanted and acute, paralyzed unanesthetized cats were used. Results showed that the negative component of the primary somatosensory cortical evoked potential was markedly potentiated by U D M H intoxication while the positive component of this response together with the response from the specific somatic sensory thalamic relay and from the cerebellum were unaffected. The potentiation almost always occurred in the absence of other evoked or spontaneous neuroelectric changes and preceded epileptiform seizure by several minutes. Thus it was usually the sole predictor of seizure. Motor paralysis markedly prolonged seizure onset. These results indicate the U D M H intoxication increases intracortical excitability acting primarily at axo-dendritic synapses to block inhibitory post-synaptic potentials. ...
Probiotics Lactobacillus rhamnosus GG, Lactobacillus acidophilus suppresses DMH-induced procarcinogenic fecal enzymes and preneoplastic aberrant crypt foci in early colon carcinogenesis in Sprague Dawley rats http://www.ncbi.nlm.nih.gov/pubmed/23368917
The modulating effects of dietary feeding of two flavonoids, diosmin and hesperidin, both alone and in combination, during the initiation and post-initiation phases on colon carcinogenesis initiated with azoxymethane (AOM), were investigated in male F344 rats. Animals were initiated with AOM by weekly s.c. injections of 15 mg/kg body wt for 3 weeks to induced colon neoplasms. Rats were fed the diets containing diosmin (1000 ppm), hesperidin (1000 ppm) or diosmin (900 ppm) + hesperidin (100 ppm) for 5 weeks (initiation treatment) or 28 weeks (post-initiation treatment). The others contained the groups of rats treated with diosmin, hesperidin alone or in combination, and untreated. At the end of the study (32 weeks), the incidence and multiplicity of neoplasms (adenoma and adenocarcinoma) in the large intestine of rats initiated with AOM together with, or followed by, a diet containing diosmin or hesperidin were significantly smaller than those of rats given AOM alone (P ,0.001). The combination ...
Insulin Injections Promote the Growth of Aberrant Crypt Foci in the Colon of Rats Denis E. Corpet * , Claire Jacquinet , Ginette Peiffer , Sylviane Taché Xénobiotiques INRA : UR1089 , Ecole Nationale Vétérinaire de Toulouse , FR * Correspondence should be adressed to: Denis Corpet ,[email protected] , Abstract The main objective of the present study was to test the hypothesis that exogenous insulin would enhance colon carcinogenesis. Thirty-six female F344 rats, fed ad libitum a low fat rodent chow, received a single azoxymethane injection (20 mg/kg), and were randomized a week later to two groups. Control rats were given 5 days a week a s.c. saline injection, and experimental rats were given ultralente bovine insulin, 20 U/kg. The promoting effect of insulin injections was assessed by the multiplicity (number of crypts) of aberrant crypt foci after 100 d of treatment (72 injections). The rats given insulin ate more and were heavier than controls (215 ± 11 vs. 182 ± 7 g, p,0.001). Insulin ...
The main objective of this proposal was to investigate the effect of vitamin B6 on colon carcinogenesis in vivo. Two in vivo studies were conducted to determine the role of vitamin B6 as a biological modifier of colon carcinogenesis. It is hypothesized that vitamin B6 may serve as an antioxidant in vivo and will modulate colon carcinogenesis. In the first study, a 2X3 factorial experimental design was used to determine if three different levels of vitamin B6, classified as low, normal and high in conjunction with two different levels of protein intake, classified as normal or high, will affect post-initiation stages of colon carcinogenesis, in Sprague-Dawley rats. Male Sprague-Dawley male were injected with azoxymethane for two weeks (15mg/kg/week) and then one week later they were allocated to different dietary treatment groups. After eight weeks, the effects of dietary treatment on hematological status, oxidative stress markers and antioxidant enzymes, as well as enumeration of preneoplastic ...
A1 Regulation of dietary factors is considered crucial for the prevention of initiating events leading to the development of colon carcinoma. Although many dietary compounds have been suggested to contribute in cancer prevention, there is strong evidence that zinc may play a pivotal role in host defense against the initiation of several malignancies including colon cancer. The present study was conducted to evaluate the modulatory effects of zinc on colonic antioxidant defense system and histoarchitecture during 1,2 dimethylhydrazine (DMH) induced colon carcinogenesis in male sparque dawley rats. The rats were segregated into four groups viz., normal control, DMH treated, zinc treated, DMH+zinc treated. Colon carcinogenesis was induced through weekly subcutaneous injections of DMH (30mg/Kg body weight) for 16 weeks. Zinc (in the form of zinc sulphate) was supplemented to rats at a dose level of 227mg/L in drinking water, ad libitum for the entire duration of the study. Increased tumor incidence, ...
A myriad of medicinal effects has been attributed to Thymoquinone (TQ), the major biological-active component of Nigella sativa. TQ has been shown to exhibit potent anti-tumor activities. The present work was undertaken to further explore TQs chemopreventive efficacy against 1, 2-dimethylhydrazine (DMH)-induced colon carcinogenesis in the rat model through a two-phase study (initiation and post-initiation) and to evaluate its potential impact on tumor progression and invasion in vivo. TQ treatment in the initiation phase significantly reduced tumor incidence, multiplicity and mean tumor volume. However, although mean tumor volume and multiplicity were decreased upon TQ treatment in the post-initiation phase, TQ did not reduce incidence significantly. Cellular proliferation, as assessed by expression of colonic PCNA, was shown to be inhibited in consequence to TQ treatment in both phases, with a more pronounced reduction in the initiation phase. In addition, our results demonstrated an appreciable
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Aberrant crypt foci (ACF) are one of the earliest histopathological manifestations of colon cancer. In this review, we critically present the molecular, cellular, histopathological, and chemopreventive evidence that ACF are relevant biomarkers for colon cancer. The laboratory and clinical evidence are highly suggestive that ACF are in the pathway leading to colon cancer, but not all ACF will do so. The possible fate and outcome of ACF in the progression toward colon cancer may be dependent on a number of features that define their predictive power for the prevention or progression of cancer.
The IA-XsSBR epithelial-like cell line is a radiation (X-ray) induced small intestine adenocarcinoma derived from an adult male Holtzman rat. The cells are sensitive to lysis by peripheral blood lymphoid cells from Fischer F344 rats having colon and pancreatic tumors induced by 1,2-dimethylhydrazine or 7,12-dimethylbenz(a)anthracene.
Liquid-fueled rocket motor using inhibited red fuming nitric acid (IRFNA), unsymmetrical dimethylhydrazine (UDMH) and jet aviation fuel. 2,600-lbs. of thrust for 21 seconds. ...
Inducible nitric oxide synthase (iNOS) is potential target for inflammation and cancer. Previously, we have shown that S,S′‐1,4‐Phenylenebis(1,2‐ethanediyl)bisisothiourea (PBIT) inhibit colon carcinogenesis induced by azoxymethane (AOM). Although, colon cancer inhibitory efficacy of PBIT has been significant, selective iNOS inhibitors do not completely abrogate NO production due to the exogenous bioavailability and NO generation by eNOS in tumor tissues. To create an iNOS selective and multi‐targeted molecule, we have developed a novel isosteric analogue of PBIT, namely PBISe in which sulfur was replaced with selenium. We examined the chemopreventive efficacy of PBISe on AOM‐induced rat colon carcinogenesis model using aberrant crypt foci (ACF) as end point. At seven weeks of age, rats (12/group) were fed the control diet (AIN 76A) and colonic ACF were induced by AOM. Three days after second AOM treatment, rats were fed the diets containing 0, 10 and 20 ppm of PBI‐Se and continued ...
This item is a pre-order for our 2017 crop, to be delivered between fall 2017 and spring 2018.. True yacon seeds are used to grow new varieties of yacon. Were really pleased to be able to offer true seeds. Just a few years ago, yacon was generally considered to be a sterile crop. We now have more than 100 new varieties under evaluation at our farm. You can get in on the fun by growing your own yacon from seed. Yacon is naturally a hybrid crop, so seed grown varieties are always unique. You can propagate them from rhizome and establish your own variety. There should be more than 100 varieties contributing to this mix in 2017. In addition, I am growing several other Smallanthus species in the yacon patch in the hope of getting inter-species crosses, so there is the possibility that some will end up in the mix.. 30 seeds. Germination will be tested and reported here after harvest. It is probably safe to expect a germination rate of about 10%, as was the case with 2016 seed. Make sure to read our ...
Methods for producing metal nitride thin layers having low resistivity by means of atomic layer deposition processes comprising alternate surface reactions of metal and nitrogen source materials include using nitrogen source materials that have better reducing properties than ammonia and 1,1-dimethyl hydrazine. Suitable compounds for that purpose include those in which a hydrocarbon group bound to nitrogen, when dissociating in a homolytic manner, generates a radical that serves as a reducing agent and reacts further to generate atomic hydrogen. The nitride thin layers produced are especially suitable for use as diffusion barrier layers in integrated circuits.
In order to understand how and why yacon root works, we need only look at the chemical make up of this prized tuber. A 2008 examination from the indigenous home of yacon (Peru) determined that its prebiotic properties are probably the primary therapeutic aspect of this food/supplement. The Peruvian scientists note the ability of FOS to stimulate the growth of healthy microflora that promote proper digestion, immune function and nutrient absorption. This review is backed by previous experiments which have specifically determined that the prebiotic fiber in yacon do, in fact, positively regulate the population of various strains of healthy bacteria. In addition, a 2007 study published in the British Journal of Nutrition found that FOS-rich yacon flour can significantly improve the calcium/magnesium balance in test animals thereby improving bone mass via "bone mineral retention". This bone building effect has previously been noted in trials conducted on other sources of prebiotics, such as chicory ...
PRIMARY OBJECTIVES:. I. To determine mean percentage change from baseline in prostaglandin E2 (PGE2) within ACF pre and post 30 days of curcumin administration at a specified dose.. SECONDARY OBJECTIVS:. I. To determine mean percentage change from baseline in 5-hydroxy-eicosatetraenoic acid (5-HETE) within ACF pre and post 30 days of curcumin administration at a specified dose.. II. To determine mean percentage change from baseline in PGE2 and 5-HETE within comparison normal mucosa pre and post 30 days of curcumin administration at a specified dose.. III. To quantify corresponding enzyme changes in the cyclooxygenases (COX-1, COX-2,) and lipoxygenase (5-LOX) protein abundance. Semi-quantitative changes in these proteins will be measured by western blotting and correlated with changes in prostaglandins and leukotrienes respectively.. IV. Document changes in total ACF number. V. Determine proliferation by Ki-67 IHC in rectal mucosa pre and post therapy and correlate with changes in ACF number and ...
1] Carcinogenicity of consumption of red and processed meat. Bouvard M, Loomis D, Guyton KZ, et al. IARC Monograph Working Group. The Lancet Oncology October 26, 2015 http://dx.doi.org/10.1016/S1470-2045(15)00444-1 [2] Effect of meat (beef, chicken, and bacon) on rat colon carcinogenesis. Parnaud G, Peiffer G, Taché S, Corpet DE. Nutr Cancer. 1998;32(3):165-73. [link] [3] Meat consumption and mortality - results from the European Prospective Investigation into Cancer and Nutrition. Rohrmann S, Overvad K, Bueno-de-Mesquita HB et al. BMC Medicine 2013, 11:63 doi:10.1186/1741-7015-11-63. [link] [4] Metabolic syndrome, hyperinsulinemia, and colon cancer: a review. Giovannucci E. Am J Clin Nutr September 2007 vol. 86 no. 3 836S-842S [5] Blood lipid and lipoprotein concentrations and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition. van Duijnhoven FJB, Bueno-De-Mesquita HB, Calligaro M et al. Gut 2011;60:1094e1102. doi:10.1136/gut.2010.225011 [6] Erythrocyte ...
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Background: Aberrant crypt foci (ACF) are considered to be useful as surrogate biomarker for colorectal cancer (CRC), but the biological significance of ACF remains controversial. We attempted to investigate the relationship between the presence of ACF and human colorectal carcinogenesis using a relatively large sample size.. Methods: We carried out high-magnification chromoscopic colonoscopy to identify ACFs in 861 subjects undergoing a diagnostic endoscopy at the Yokohama City University Hospital. The present study compared the prevalence and number of ACFs in three subject groups (normal subjects, adenoma cases, and CRC cases). The correlations between the demographic and behavioral characteristics of the subjects and the prevalence of ACFs were also assessed.. Results: The prevalence of ACF was 64%, 88%, and 95%, and the mean number of ACF was 3.6, 6.2, and 10.1, in normal subjects, adenoma cases, and CRC cases, respectively. When differences in the prevalence and number of ACFs among age- ...
Yacon is a healthy vegetable. For people who want to control their weight, it is a perfect food because it contains few calories. One hundred grams of roots has only 61 calories. In addition, yakon on seventy percent contains water.. The most valuable thing in root vegetables is inulin, a polysaccharide, which is quickly absorbed. It is an excellent natural substitute for sucrose. Inulin, which had not been assimilated by the body, goes into a state of dietary fiber, filling the gastrointestinal tract. It causes satiety and serves as a breeding ground for the development of beneficial bacteria.. So does yacon root helps you lose weight?. At the moment there is no clear answer to this question. Some doctors and scientists are promoting the usage of the yakon and yakon syrup.. However, there are skeptics who believe that the sweetener helps to reduce weight instead, but its assistance is not really effective. And if the loss of weight happens, it is highly unlikely to be stable, in contrast to a ...
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tIngredients: 100% Pure Organic Premium Peruvian Yacon Root Vegan/Gluten-Free/Organic At first I was a little skeptical about all this. However, as I started to dig deeper and researched all of the details, I came upon some clinical trials that shows that Yacon Syrup has the potential to
Epigenetic re-expression of important genes silenced in the pathway of carcinogenesis represents an exciting new area for cancer chemoprevention. The long-range...
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As the percentage of obese people is increasing with the passage of time, more and more weight loss products have also been lining up in the market. All these products promise to turn beneficial, on the other hand, their strong […] ...
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The report generally describes 1-amino-4-methylpiperazine, examines its uses, production methods, patents. 1-Amino-4-methylpiperazine market situation
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The Youth Development Study was initiated to address the developmental and achievement-related consequences of employment during the adolescent years. Data collection began in the 1987-88 academic year with a panel of teenagers (G2) randomly selected from a list of 9th graders attending the St. Paul (Minnesota) Public Schools. G2 respondents have filled out surveys near-annually (exceptions are 1996, 2001, 2006, 2008, and 2010), first administered in their high school classrooms (Waves 1 through 4) and subsequently by mail, through 2011 (Wave 19), when the respondents were 37 and 38 years old. The G2 surveys included detailed questions about students work and volunteer experiences, as well as experiences in their family, school, and peer group, with an emphasis on the ways that working affected other life domains. Shorter surveys containing many of the same topics were administered to students in 1992, 1993, and 1994, and included questions about current family and living arrangements. In 1995, ...
An experimental colorectal cancer drug being developed by ArQule Inc and Japans Daiichi Sankyo Co Ltd failed to improve patient survival without the cancer worsening, in a mid-stage trial, sending ArQules shares down 18 percent.
Reuben D Shin, MD, Peter W Marcello, MD. Lahey Hospital & Medical Center. Background: There is an increasing emphasis on colorectal cancer screening and we are finding more large and advanced polyps along with early stage cancers. Traditionally, these lesions may have required colon resections, however new techniques and technology can allow for endoscopic and endolaparoscopic resections. Methods: We present a video of advanced endolaparoscopic resection of colonic neoplasms to demonstrate new techniques and tips.. Conclusion: Advanced endoscopy and combined endolaparoscopy is emerging as an effective and minimally invasive procedure for advanced polyps and early stage colon cancers. As surgical endoscopists, it is important to consider these new techniques in light of continued advancement in this field. ...
In this prospective study, 1000 consecutive patients attending for routine colonoscopy were examined for flat or depressed lesions. The examinations were done by one European colonoscopist using methods developed in Japan. FINDINGS: 321 adenomas were found: 202 (63%) were polypoid, 36% (117) were flat and 2 (0.6%) appeared depressed. Most adenomas contained areas of mild or moderate dysplasia but 10% (31) were severely dysplastic. Six Dukes A adenocarcinomas were identified together with 25 more advanced adenocarcinomas. The likelihood of Dukes A cancer or severe dysplasia increased from 4% (3/70) in small flat lesions, to 6% (9/154) in small polyps, 16% (8/50) in larger polyps, 29% (14/49) in large flat lesions, and 75% (3/4) in depressed lesions. 54% (20/37) lesions containing severe dysplasia or Dukes A carcinoma were flat or depressed. INTERPRETATION: The polyp-carcinoma hypothesis prompts colonoscopists to search only for polypoid lesions when screening for cancer, and many early ...
Medina, D; Obryan, S B.; Warner, M R.; Sinha, Y N.; Vanderlaan, W P.; Mccormack, S; and Hahn, P, "Mammary tumorigenesis in chemical carcinogen-treated mice." (1977). Subject Strain Bibliography 1977. 3629 ...
Label: Nuclear Blast. Buy now on Amazon.com. You can finally bring Swedens war obsessed power metal titans into your home and watch them without fear of getting hit by their fire cannons. Get your armor on and your fist in the air as you pretend to mosh with the crowd from home. This is available in several formats (blueray, vinyl, cd, etc) and features two sets from Wacken Open Air and Sabaton Open Air. Epicness with options.. ...
Dendrimers can protect drugs from degradation and clearance resulting in them lasting longer in the body. This may mean that an improved dosing regimen can be pursued, for example replacing a daily dose with a once weekly injection. CASE STUDY. The half-life (t½) of a drug can be substantially enhanced by attaching it to a dendrimer construct. For example attaching the anticancer drug, methotrexate (MTX) to different members of a family of dendrimer constructs leads to a range of clearance rates in rats, ranging from 24 minutes (free MTX), to nearly 24 hours shown in this figure, and 50 hours in a related construct.. ...
Patterns of proliferative changes in crypts bordering colonic tumors: zonal histology and cell cycle marker expression.: Proliferative crypt changes have been n
Meanwhile, researchers are trying to untangle the neurologic and biologic processes by which concussions do their long-term damage. One group, led by Steven P. Broglio, PhD, of the University of Michigan, has recently published findings suggesting that repeated blows to the head actually hasten the brains natural age-related deterioration, with breakdown of various signaling pathways. They subjected a group of young, high-functioning college students who had experienced one or more concussions to a battery of cognitive and electrophysiological tests, and found that the students had difficulties with attention, were unable to inhibit incorrect responses to environmental stimuli, and had trouble understanding when they had made a mistake. Compared to healthy controls, the concussed group also showed deterioration in gait and balance ...
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Product Description Pharmaceutical Raw Material Mildronate Cas 76144-81-5 for Angina Treatment Meldonium is used clinically to treat angina and myocardial infarction.The first clinical trial testing the efficacy of using a combination of meldonium and lisinopril, an angiotensin-converting enzyme inhibitor, to treat chronic heart failure,concluded the combination of meldonium and lisinopril may improve the quality of life,mechanisms of peripheral circulation of patients withheart failure.
Mildronate® International Non-Proprietary Name (INN): Meldonium Dosage Form: capsules (250 mg or 500 mg) Structure: 1 capsule contains: Active ingredient: Meldo
Chemical Properties White Crystalline Powder Usage A novel pharmaceutical composition based on a reverse transcriptase inhibitor and meldonium
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Her lawyer, John J. Haggerty, declined to go into specifics Tuesday but said during a conference call he wanted "to disabuse the concept that Maria took mildronate every day for 10 years because thats simply not the case.". Grindeks, the Latvian company that manufactures meldonium, said in an emailed statement to The Associated Press: "Depending on the patients health condition, treatment course of meldonium preparations may vary from four to six weeks. Treatment course can be repeated twice or thrice a year. Only physicians can follow and evaluate patients health condition and state whether the patient should use meldonium for a longer period of time.". Haggerty said "Maria at all times took the mildronate in accordance with the recommendations of her doctor." He repeatedly declined to go into specifics about Sharapovas treatment, claiming he had to adhere to the "strict confidentiality" of the International Tennis Federations process. An ITF spokesman told The Associated Press, however, ...
INDICATIONS. Meldonium treats heart ischemia and its consequencesis. It is used in the treatment of brain circulation disorders. Meldonium is believed to improve Mental Processes (Memory, Learning, Focus, Concentration, Processing of Information) and reduces Fatigue, Increases Motivation & Alertness. Meldonium was designed to improve Athletic Training & Competitive Performance as well as microcirculation & Oxygen Delivery.. Due to its unique mechanism of action Mildronate, depending on the prescribed dose, is widely used for the treatment of different heart and vascular diseases, as well as for the improvement of work capacity of healthy people at physical and mental overloads and during rehabilitation period.. INSTRUCTIONS. Applied internally.. ...
INDICATIONS. Meldonium treats heart ischemia and its consequencesis. It is used in the treatment of brain circulation disorders. Meldonium is believed to improve Mental Processes (Memory, Learning, Focus, Concentration, Processing of Information) and reduces Fatigue, Increases Motivation & Alertness. Meldonium was designed to improve Athletic Training & Competitive Performance as well as microcirculation & Oxygen Delivery.. Due to its unique mechanism of action Mildronate, depending on the prescribed dose, is widely used for the treatment of different heart and vascular diseases, as well as for the improvement of work capacity of healthy people at physical and mental overloads and during rehabilitation period.. INSTRUCTIONS. Applied internally.. ...
INDICATIONS. Meldonium treats heart ischemia and its consequencesis. It is used in the treatment of brain circulation disorders. Meldonium is believed to improve Mental Processes (Memory, Learning, Focus, Concentration, Processing of Information) and reduces Fatigue, Increases Motivation & Alertness. Meldonium was designed to improve Athletic Training & Competitive Performance as well as microcirculation & Oxygen Delivery.. Due to its unique mechanism of action Mildronate, depending on the prescribed dose, is widely used for the treatment of different heart and vascular diseases, as well as for the improvement of work capacity of healthy people at physical and mental overloads and during rehabilitation period.. INSTRUCTIONS. Applied internally.. ...
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Klusa V.; Pupure J.; Isajevs S.; Svirina D.; Beitnere U.; Jansone B.; Rumaks J.; Svirskis S.; Vilskersts R.; Kalvinsh I. Neuroprotective effect of Mildronate, a mitochondria-targeted drug, in Parkinson,s disease model in rats. In Focused Conference Group: PW19 - Influence of degeneration and repair in the CNS and periphery. Final Programme, WorldPharma2010. 16th World Congress on Basic and Clinical Pharmacology; 17-23 July: Copenhagen, Denmark. Paper No 1746, 2010; 381 ...
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Information about colestipol (Colestid), an oral cholesterol lowering medication. Colestid is also prescribed for the treatment of diarrhea due to increased intestinal bile, and itching associated with liver disease.
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Spiritualizeds Jason Pierce has revealed that he was diagnosed with long-term liver disease before starting work on new album Sweet Heart Sweet Light. In an interview with the Guardian, the singer said that he had been using life-saving medication while making the LP, including weekly injections and a daily intake of pills
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A bill that would allow terminally ill people to obtain experimental drugs appears headed to Governor Browns desk for the second year in a row. Brown vetoed a similar measure last year, but supporters believe conditions are right for him to sign it this time around. Brown said he vetoed last years "Right-to-Try" measure because he wanted time to see how changes to the FDAs "Compassionate Use" program streamlined the process of getting experimental drugs to terminal patients.. Nearly a year later, the new bills supporters say its time for California to step in with its own solution, because the modified federal initiative has not reduced the minimum 30-day wait for drugs.. "The process may have to start over if the FDA has even one question," said the bills author, Assembly Majority Leader Ian Calderon (D-Whittier). "Terminally ill patients can still end up waiting weeks and months" for an approval.. Calderons measure would allow drug manufacturers to give certain terminally ill people ...
Define Gyromitra californica. Gyromitra californica synonyms, Gyromitra californica pronunciation, Gyromitra californica translation, English dictionary definition of Gyromitra californica. Noun 1. Gyromitra californica - a gyromitra with a brown puffed up fertile part and a thick fluted stalk; found under conifers in California California...
Mayo Clinic researchers have found that an experimental drug, LCL161, stimulates the immune system, leading to tumor shrinkage in patients affected by multiple myeloma. The findings are published in Nature Medicine.
A new drug called Illomostat is currently being tested in dogs to help avoid paralysis if administered within hours of an injury. Dr. Jay Griffin currently works at Texas A&M College of Veterinary Medicine and Biomedical Sciences where the drug is being tested. Dr. Griffin owns a 14 year old dachshund that currently uses a wheelchair for mobility. He is also a veterinarian and is intrigued by the experimental drug. Illomostat is being given to short-legged, long-torso dog breeds like dachshunds, beagles and corgis that can suddenly rupture disks in their backs and damage their spinal cords. The U.S. Department of Defense is funding the effort with a $750,000 grant because the drug could help wounded service members and others who experience spinal cord injury. Dr. Jonathon Levine, a veterinary neurologist at Texas A&M is testing the drug in dogs and hopes that someday it will also be able to help people. When dogs or people bruise or injure their spinal cords, something similar happens: A ...
In a Phase 3 clinical trial reported last year, the average amount of time the compound took to wipe out the virus in otherwise healthy adults was just over 24 hours.. In contrast, participants treated with one of the most common flu medications, oseltamivir (sold under the brand name Tamiflu), took 72 hours, and people taking a placebo required 96 hours to beat the virus.. While the overall time to alleviation of symptoms was similar whether participants took baloxavir marboxil or oseltamivir, Shionogi says its experimental drug provides immediate relief faster, which might curb the viruss contagiousness in people who take the treatment.. The oral drug works via a different biological mechanism to oseltamivir, which is a neuraminidase inhibitor, blocking an enzyme the virus uses to reproduce itself in infected cells.. By contrast, Shionogi developed baloxavir marboxil by leveraging discoveries made in anti-HIV drugs, targeting a different kind of enzyme and preventing cells from susceptibility ...
JQ1 drug. Molecular model of a the experimental drug JQ1. JQ1 is a thienotriazolodiazepine, structurally related to benzodiazepines. It belongs to a class of drugs known as BET inhibitors. BET inhibitors such as JQ1 are undergoing clinical trials for treating a variety of cancers including NUT midline carcinoma. JQ1 has also been investigated for its potential in the treatment of HIV (human immunodeficiency virus) infection, as a male contraceptive, and in the treatment of heart disease. Atoms are represented as spheres and are colour-coded: carbon (grey), hydrogen (white), nitrogen (blue), oxygen (red), chlorine (green), sulphur (yellow). - Stock Image C028/8035
The British volunteer nurse William Pooley, who contracted Ebola while working in Sierra Leone, has been given the experimental drug ZMapp.
Working in cell cultures and mice, researchers at Johns Hopkins have found that an experimental drug called fostamatinib combined with the chemotherapy drug paclitaxel may overcome ovarian cancer cells resistance to paclitaxel.
An experimental drug ibrutinib can be used as a first-line therapy for older people with chronic leukemia, reveal clinical trials.
Developers of an experimental drug thats part of a new generation of anticlotting medicines expected to be blockbusters said Sunday that in a key patient study, apixaban significantly cut the risks of stroke, major bleeding and death.
The relative permeability of sodium channels to 21 organic cations was studied in myelinated nerve fibers. Ionic currents under voltage-clamp conditions were measured in sodium-free solutions containing the test cation. The measured reversal potential and the Goldman equation were used to calculate relative permeabilities. The permeability sequence was: sodium ≈ hydroxylamine , hydrazine , ammonium ≈ formamidine ≈ guanidine ≈ hydroxyguanidine , aminoguanididine ,, methylamine. The cations of the following compounds were not measurably permeant: N-methylhydroxylamine, methylhydrazine, methylamine, methylguanidine, acetamidine, dimethylamine, tetramethylammonium, tetraethylammonium, ethanolamine, choline, tris(hydroxymethyl)amino methane, imidazole, biguanide, and triaminoguanidine. Thus methyl and methylene groups render cations impermeant. The results can be explained on geometrical grounds by assuming that the sodium channel is an oxygen-lined pore about 3 A by 5 A in cross-section. One ...
Gyromitra esculenta, one of several species of fungi known as false morels, is an ascomycete fungus from the genus Gyromitra, widely distributed across Europe and North America. It normally sprouts in sandy soils under coniferous trees in spring and early summer. The fruiting body, or mushroom, is an irregular brain-shaped cap dark brown in colour which can reach 10 cm high and 15 cm wide, perched on a stout white stipe up to 6 cm (2.4 in) high. Although potentially fatal if eaten raw, Gyromitra esculenta is a popular delicacy in Scandinavia, Eastern Europe, and the upper Great Lakes region of North America. Although popular in some districts of the eastern Pyrenees, it is prohibited from sale to the public in Spain. It may be sold fresh in Finland, but it must be accompanied by warnings and instructions on correct preparation. It is eaten in omelettes, soups, or sautéed in Finnish cuisine. Although it is still commonly parboiled ...
The MaxDiscovery Aspartate Transaminase (AST) Color Endpoint Assay Kit is a plate-based colorimetric enzymatic assay for the determination of the aspartate transaminase enzyme in serum samples. Aspartate transaminase (AST) also known as aspartate aminotransferase or (sGOT) is a metabolic enzyme expressed primarily in the liver. Elevation of AST levels is an indication of liver damage and has been associated with liver injury. AST levels are monitored routinely in patients with liver diseases. AST is also a very useful tool for preclinical investigation of experimental drug formulations and AST levels are commonly used to monitor and attenuate the hepatotoxic effects of experimental drugs in rodents. The MaxDiscovery Alanine Transaminase (AST) Color Endpoint Assay Kit uses a colored reaction scheme to detect AST enzymatic activity in serum samples. In this method aspartate and -ketoglutarate are first converted to glutamate and oxaloacetate. The oxaloacetate then reacts with diazonium salt to ...
The 67-year-old died Thursday morning, just hours after an experimental drug arrived in the country for him. The arrival of ZMAb, developed in Canada, had raised hopes for Willoughbys survival. But he died before a dose could be administered, said Kargbo. ZMAb is related to ZMapp, another experimental drug that has been used to treat some Ebola patients. The drugs efficacy in treating Ebola has not yet been proven ...
Dachshunds are one of the breeds most susceptible to spinal cord injuries so its a great to hear about a promising drug trial that may mean fewer wiener dogs in wheelchairs.. At the Texas A&M College of Veterinary Medicine & Biomedical Sciences, in a study funded by the U.S. Department of Defense with a $750,000 grant, the drug Illomostat is being given to short-legged, long-torso dog breeds like dachshunds, beagles and corgis in the hopes that if it is successful it can eventually be used on humans who suffer trauma to the spinal cord.. MSNBC has the details including the story of Beanie, a wheelchair-bound Dachshund whose veterinarian owner works at Texas A&M.. ...
Spain has imported a U.S.-made experimental Ebola drug to treat a Spanish missionary priest evacuated from Liberia last week after testing positive for the killer virus.
Johnson & Johnson will become the first pharmaceutical company to formally seek advice from outside medical ethicists on compassionate use requests.
Purpose:: A novel glaucoma drainage device (GDD) with local drug delivery (LDD) system was created and characterized for safety and effectiveness after implantation into the suprachoroidal space (SCS) of rabbit eyes. Methods:: Thin films of two different polymers, Poly(3-hydroxybutyrate) (P(3HB)) and Poly(4-hydroxybutyrate) (P(4HB)), containing the drugs mitomycin C (MitC) or paclitaxel (PTX) were attached to silicone-tubes to create LDD devices. The release kinetics of these drugs were explored in vitro using high performance liquid chromatography (HPLC). Twenty-four New Zealand white rabbits, randomly divided into eight groups, were implanted with different kinds of microstents into SCS. The intraocular pressure (IOP) was monitored noninvasively. After 6 weeks, rabbits were sacrificed and enucleated eyes were used for anterior segment optical coherence tomography (OCT), micro magnetic resonance imaging (MRI), and histology. Results:: In vitro, faster drug release from both polymers was ...
TORONTO - The Canadian company that is developing an experimental Ebola drug says its product was not given to one of two American aid workers infected with the virus.Tekmira Pharmaceuticals said in an email that no one infected in the ongoing outbreak in West Africa has been treated with its drug, called TKM-Ebola.The Christian relief group Service in Mission or SIM said late last week that one of its missionaries, Nancy Writebol, had been given an experimental drug flown into Liberia, where she contracted the disease while working in an Ebola treatment facility. Liberia, Guinea and Sierra Leone are battling a months-long outbreak that has infected at least 1,440 people and killed at least 826.Another American, Dr. Kent Brantly, was also infected at the same centre in Liberia. Brantly works with the international relief agency Samaritans Purse.Its president, Franklin Graham, said in a statement last week that limited supplies of an unnamed experimental drug arrived at the facility. There was only
The pain got worse. When we got to the emergency room, I said to Brad something is just not right," Rek remembers.. After an MRI showed a suspected tumor, Rek was immediately flown to Seidman Cancer Center at University Hospitals (UH) Case Medical Center, where Andrew Sloan, MD, diagnosed her with Stage 4 glioblastoma, the most aggressive form of brain cancer and the most difficult to treat.. "The tumors are comprised of the brain itself. It looks like brain tissue, it sort of feels like brain tissue. Its hard to figure out necessarily where tumor ends and swollen brain tissue begins," says Dr. Sloan, Director of the Brain Tumor and Neuro-Oncology Center and Peter D. Cristal Chair in Neurosurgery at UH Case Medical Center and Associate Professor at Case Western Reserve University School of Medicine.. To help identify the difference between tumors and healthy tissue and improve tumor resection, Dr. Sloan is testing an experimental drug called 5-Aminolevulinic Acid (5-ALA). The drug makes brain ...
For the first time, an experimental drug designed to cut off a cancer s blood supply has gone beyond stopping tumors from growing to actually shrinking them, according to new research from Drs. Jessica Kandel, Irving Assistant Professor of Surgery, and Darrell Yamashiro, Irving Assistant Professor of Pediatrics and Pathology.. The drug, VEGF-Trap, offers hope to patients with large metastatic cancers that their tumors may indeed regress, Dr. Kandel says. The study was published in the online issue of the Proceedings of the National Academy of Sciences on June 9 and in the print version on June 24.. The new agent blocks angiogenesis the process by which vessels feed tumors with a new blood supply. If tumors can be starved of blood by drugs, tumor progression can theoretically be forestalled.. The researchers gave the drug to mice with large human cancers that had spread to the lungs. Within 24 hours the drug began to destroy blood vessels inside the tumors, and after five weeks the tumors and the ...
WEDNESDAY, Nov. 30, 2016 (HealthDay News) -- An experimental drug may show promise in treating kidney cancer, researchers say.. The drug CB-839 is the first to target an enzyme that cancer cells require to stay alive, researchers said. This stage 1 clinical trial found that the drug was effective in most patients with advanced kidney cancer when used in combination with another cancer drug called everolimus (Afinitor, Zortress).. In the 15 patients in the study, the dual treatment controlled tumors in 93 percent of the patients, who had either clear cell or papillary renal cell cancer. Tumors shrank by more than 30 percent in one patient, were stable in 13 patients, and grew by more than 20 percent in one patient.. Clear cell is the most common form of kidney cancer, accounting for 75 percent of cases, the researchers said. All 12 patients with this type of kidney cancer had their disease controlled. Papillary renal cell cancer is the next most common form of kidney cancer and accounts for 10 ...
The stock price for San Diego drugmaker AnaptysBio has more than doubled in a matter of hours following news that the companys experimental drug performed well in a recent study.. The companys drug, called ANB020, is meant to treat atopic dermatitis (or eczema) in adults. The medicine was recently tested in humans during a midstage trial (phase 2a), and results were published October 10. After a single dose of the medicine, 75 percent of patients in the study saw 50 percent improvement in their symptoms, according to AnaptysBio.. The company plans to start an additional study to assess how multiple doses of the drug will affect 200-300 patients. Results for that trial are expected in 2019.. AnaptysBio, which just went public in January with a $75 million IPO, saw its stock price climb 101 percent on the news. The companys shares were selling at $70.41 at market close October 10. The companys market cap is currently at $1.4 billion.. ...
Blood Vessel Inhibitor Shows Promise Against Metastatic Thyroid CancerResearchers also find evidence tying a genetic mutation to clinical outcomeThyroid cancer that has spread to distant sites has a poor prognosis, but an experimental drug that inhibits tumor blood vessel formation can slow disease progression in some patients, a research team led by investigators from The University of Texas M. D. Anderson Cancer Center reports in the July 3rd edition of The New England Journal of Medicine.The investigational drug, motesanib diphosphate, is a VEGF inhibitor, a biologic agent that targets receptors on a protein known as vascular endothelial growth factor (VEGF). VEGF is instrumental in angiogenesis (formation of new blood vessels), a process that allows tumors to grow and spread. Study lead author Steve Sherman, M.D., chair and professor of M. D. Andersons Department of Endocrine Neoplasia and Hormonal Disorders, noted strong evidence that VEGF receptors play an important role in metastatic ...
OBJECTIVE : This study was designed to determine the effect of pentoxifylline (Trental) on the clinical and pathologic course of oral submucous fibrosis. This drug is a methylxanthine derivative that has vasodilating properties and was envisaged to increase mucosal vascularity. STUDY DESIGN : This investigation was conducted as a randomized clinical trial incorporating a control group (Standard drug group SDG, multivitamin, and local heat therapy) in comparison to pentoxifylline test cases (Experimental drug group EDG, 400mg 3 times daily, as coated, sustained release tablets). The stipulated treatment period was 7 months and a total of 29 cases of advanced fibrosis (14 test subjects and 15 age and sex matched diseased controls) were included in this study and 100% compliance was reported at the end ofthe test period. RESULTS : Mild gastric irritation that could be managed by diet protocols was the only untoward symptom reported during this trial. Review of the patients and controls was done at ...
According to a press release issued on Wednesday, Turing Pharmaceuticals will be pushing several new drug candidates for toxoplasmosis into preclinical development. The company says the small molecular compounds are a result of Turings toxoplasmosis research efforts, with the drug candidates reportedly offering improved potency and specificity over currently-available treatments, in animal models.. Turing reports that it has started safety studies for the compounds in support of an eventual filing of an Investigational New Drug Application (IND), as part of the US Food and Drug Administrations (FDA) drug approval process. According to a statement, the company anticipates that clinical trials for the experimental drugs will begin in the second half of 2017.. "Theres a definitive need for new and improved therapies against toxoplasmosis," said Dr. Eliseo Salinas, Turings President of R&D. "Current therapies target a protein family that is required by both the parasite and its human host. ...
Methamnetamine (also known as methylnaphetamine, MNA, MNT and PAL-1046) is a triple monoamine releasing agent and N-methyl analog of the non-neurotoxic experimental drug naphthylaminopropane and the naphthalene analog of methamphetamine. It has been sold online as a designer drug. It acts as a releasing agent of serotonin, norepinephrine, and dopamine, with EC50 values of 13 nM, 34 nM, and 10 nM, respectively. Methamnetamine is illegal in Japan. Naphthylaminopropane HDEP-28 HDMP-28 Naphyrone WF-23 Richard B. Rothman; John S. Partilla; Michael H. Baumann; Catrissa Lightfoot-Siordia; Bruce E. Blough (April 2012). "Studies of the Biogenic Amine Transporters. 14. Identification of Low-Efficacy "Partial" Substrates for the Biogenic Amine Transporters". The Journal of Pharmacology and Experimental Therapeutics. 341 (1): 251-262. doi:10.1124/jpet.111.188946. PMC 3364510 . PMID 22271821. "Methamnetamine". WEDINOS. "Methamnetamine". New Synthetic Drugs Database. ...
History of Experimentation on Human Guinea Pigs. 1932 to 1972 - In the infamous Tuskegee syphilis study, 200 black men diagnosed with syphilis are never told of their illness, are denied treatment. They are used as human guinea pigs in order to follow the progression and symptoms of the disease. They all subsequently die from syphilis, their families never told that they could have been treated. The study continues for four decades. (MSNBC, Time Magazine, Wikipedia). 1939 - At an orphanage in Iowa, 22 children are the subjects of the so-called "monster" experiment, which attempts to use psychological abuse to induce children who spoke normally to stutter. The experiment is designed by Dr. Wendell Johnson, one of the nations most prominent speech pathologists, for the purpose of testing one of his theories on the cause of stuttering. (CBS News, San Jose Mercury News, Wikipedia). 1940 - In Chicago, 400 prisoners are infected with malaria in order to study the effects of new and experimental drugs ...
Foretinib (Exelixis, GlaxoSmithKline) (XL-880) CAS No.:849217-64-7, 937176-80-2 Formula:C34H34F2N4O6 M.Wt:632.24 GSK1363089, XL880 1-N-[3-fluoro-4-[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxyphenyl]-1-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide Foretinib is an experimental drug candidate for the treatment of cancer.[1] It was discovered by Exelixis and is under development by GlaxoSmithKline.[2] It is currently in Phase II clinical trials.[3] As of December 2012 no phase III trials are registered.[3] Foretinib is an…
A low-dose regimen of ataluren (formerly called PTC124), an experimental drug developed by PTC Therapeutics to treat Duchenne muscular dystrophy (DMD) or Becker muscular dystrophy (BMD) caused by a certain type of genetic mutation, is superior to a high-dose regimen or a placebo.PTC announced the findings at the 15th International Congress of the World Muscle Society, held in Kumamoto, Japan, Oct. 12-16, 2010, and in an Oct. 15 press release. (See Pivotal Data Presented at the World Muscle Society Congress Suggest Ataluren Slows the Loss of Walking Ability in Patients with Nonsense Mutation Duchenne/Becker Muscular Dystrophy.). Read More ...
ATLANTA - A second American aid worker infected with Ebola arrived Tuesday in Atlanta, where doctors will closely monitor the effect of an experimental drug she agreed to take even though its safety was never tested on humans.. Nancy Writebol, 59, arrived from Monrovia, Liberia, in a chartered jet at Dobbins Air Reserve Base and was then taken in an ambulance to Emory University Hospital, just downhill from the U.S. Centers for Disease Control and Prevention.. Writebol is weak but shows signs of improvement, said Bruce Johnson, president of SIM USA, the aid group with which she was working. Johnson said he had spoken with her husband, David Writebol, about her condition.. "A week ago we were thinking about making funeral arrangements for Nancy," David Writebol said in a statement read by Johnson at a news conference. "Now we have a real reason to be hopeful.". Though she was wheeled from the ambulance in a stretcher, she is progressing, according to her husband. She was able to stand up and, ...
ROCHESTER, Minnesota-More than half of follicular non-Hodgkins lymphoma (NHL) patients who progress after rituximab (Rituxan) treatment respond to the experimental drug ibritumomab tiuxetan (Zevalin), according to a multicenter clinical trial. Although most of the studys 54 patients had only partial remissions after treatment with ibritumomab tiuxetan, their response continued for at least 8 months. In some cases, remissions have lasted up to 2 years. 1
The IUPHAR/BPS Guide to Pharmacology. 1-acetoxychavicol acetate ligand page. Quantitative data and detailed annnotation of the targets of licensed and experimental drugs.
dwheeler at ipns.com (Daniel B. Wheeler) wrote in message news:,6dafee1b.0210051944.51ec52bb at posting.google.com,... , Fungi fd. 5 Oct. 2002 at Little Crater Lake Area and Pacific Crest , Trail, Clackamas County, Oregon , , Cortinarius abruptibulbous , Bondarzewia montana , Neolentinus lepidius , Cantharellus formosus , Russula nigricans , Tricholoma pessundatum , Russula cascadensis , Radiigeria atrogleba (?) , Gomphidius glutinosus , Sparassis radicata , Russula alutacea , Phaeolus swinitzii (sp) , Gyromitra esculenta , Cortinarius multiformis , Ganoderma applanatum , Gomphidius subroseus , Suillus luteus , Clavaria sps. (bright yellow) , Clavaria botrytis , Agaricus subrutilescens , Hypholoma fasiculare , Gomphus floccosus , Albatrellus flettii , Russula brevipes , Lacterius deceptivus , Amanita muscaria var. muscarina , Amanita muscaria var. formosa? (yellow variety) , Russula aeruginea , Lacterius deliciosus , Fuscoboletus ochraceoroseus , Martellia sps., possible M. brunnescens , Unknown ...
Disclosed are epoxy resin compositions comprising at least one polyglycidyl derivative of an aminophenol having the structure ##STR1## and at least one biphenyl anhydride having the structure ##STR2## wherein m is 1 or 2; wherein A is selected from the group consisting of ##STR3## WHEREIN EACH R.sup.o is individually a monovalent radical selected from the group consisting of hydrogen, halogen, hydroxy, alkyl radical having from 1 to 5 carbon atoms, alkoxy radical having from 1 to 5 carbon atoms and ##STR4## wherein R.sup.1 is an alkyl radical having from 1 to 5 carbon atoms; and wherein each R.sup.2 is individually a monovalent radical selected from the group consisting of hydrogen, halogen, alkyl radical having from 1 to 5 carbon atoms, --NO.sub.2, --COOH --SO.sub.3 H, and --NH.sub.2. The compositions are useful in such applications as molding resins, laminates, adhesives, coatings, and the like. The disclosed epoxy resin-anhydride
33. A method for producing a contact lens having an antimicrobial coating, comprising the steps of:(a) forming a mold for making the contact lens, wherein the mold comprises a first mold portion defining a first optical surface and a second mold portion defining a second optical surface, wherein said first mold portion and said second mold portion are configured to receive each other such that a contact lens-forming cavity is formed between said first optical surface and said second optical surface;(b) applying a transferable antimicrobial coating, using a layer-by-layer polyelectrolyte deposition technique, onto at least one of said optical surface, wherein the transferable antimicrobial coating comprises at least one layer of polyquat of formula (I) or (II)wherein R1, R2, R3 and R4, independently of one another, are C1-C10 hydrocarbon radicals, preferably C1 to C6 alkyl radicals or C1 to C6 alkyl radicals having one or more hydroxyl groups, more preferably methyl, ethyl, or benzyl radicals, ...
The pathophysiology of the thalassemias can be traced to the deleterious effects of the globin-chain subunits that are produced in excess. In β-thalassemia, excess α chains cause damage to the red cell precursors and red cells and lead to profound anemia. This causes expansion of the ineffective marrow, with severe effects on development, bone formation, and growth. The major cause of morbidity and mortality is the effect of iron deposition in the endocrine organs, liver, and heart, which results from increased intestinal absorption and the effects of blood transfusion. The pathophysiology of the α-thalassemias is different because the excess β chains that result from defective α-chain production form β4 molecules, or hemoglobin H, which is soluble and does not precipitate in the marrow. However, it is unstable and precipitates in older red cells. Hence, the anemia of α-thalassemia is hemolytic rather than dyserythropoietic. ...
The burden of inherited disorders of hemoglobin, the commonest group of single gene disorders in India is huge. With a population of 1.21 billion and an average prevalence of β-thalassemia carriers being around 3.5-4%, there would be 35-45 million carriers and the estimated number of births of affected babies annually would be 10,000-12,000. The carrier rates vary from 1-17% in different ethnic groups. Apart from β-thalassemia, Hb E is common in the north eastern region and in West Bengal (4 to , 50%) and Hb S is prevalent in parts of central, western and eastern India (5-40%). Thus interaction of the β-thalassemias with these Hb variants is not uncommon and can lead to a severe disorder.. One way to combat the burden is by prenatal diagnosis but the only approach to reduce the national burden is by a comprehensive community control programme. Awareness is very limited in different states (,20% among pregnant women) and the entire public health infrastructure from medical colleges to district ...
The capability to predictably engineer the composition of bowel microbial communities (microbiota) using dietary components is important because of the reported associations of altered microbiota composition with medical conditions. supplemented with RS, the compositions of which are explained in Table 1. The resistant starch used in this study was Hi-maize 1043 (National Starch and Chemical substance Firm, Bridgewater, NJ), a high-amylose maize RS2-type resistant starch. Diet plans containing RS had been supplemented with 5%, 2.5%, or 1.25% RS by weight. Diet plans for germ-free rats had been sterilized by gamma irradiation at 25 kGy at Schering-Plough Pet Wellness Ltd. (Top Hutt, New Zealand). Diet was measured every week. Conventional rats had been randomly assigned to at least one 1 of 4 groupings (BD, RS 5%, RS 2.5%, or RS 1.25%; = 10 per group), while germ-free rats had been positioned into 1 of 2 eating groupings (BD or RS 5%; = 6 per group). After 28 times over the eating treatment, the ...
298497955 - EP 0765328 B1 2000-08-30 - PIRYDYL IMIDAZOLE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF - [origin: WO9534564A1] Novel pyridyl imidazole derivatives of formula (I) inhibit effectively the action of angiotensin II and have a superior antihypertensive activity, wherein A is a straight, branched or cyclic C1-C6 alkyl or alkenyl group, OR 1 (wherein R 1 is a hydrogen, or a straight, branched or cyclic C1-C6 alkyl or alkenyl radical), or NR 2 R 3 (wherein R 2 and R 3 are independently a hydrogen, or a straight, branched or cyclic C1-C6 alkyl radical); B is a group of formula (II); D is a hydrogen; a halogen; a straight, branched or cyclic C1-C6 alkyl, C2-C6 alkenyl or C2-C6 alkynyl group which is optionally substituted with OH, a C1-C4 alkoxy radical, CO2R 1 , COR 1 , CON(R 1 )2 or N(R 1 )2, wherein R 1 is the same as defined above; tetrazol-5-yl; a perfluoro-C1-C4 alkyl group; or N(R 1 )2, OR 1 , CO2R 1 or CON(R 1 )2, wherein R 1 is the same as defined above; E is a hydrogen; a
This review is focused on the recent advances in the chemistry of sulfur dioxide fixation through a radical process. Diverse sulfonyl compounds can be obtained efficiently under mild conditions. In general, aryl radicals, vinyl radicals, alkyl radicals, and nitrogen-centered radicals can react with sulfur dioxide,
The colorimetric method of estimating the rate of addition of hydrogen atoms to the oxides of molybdenum and tungsten is discussed in detail. It is also shown that alkyl radicals are efficiently removed by molybdenum oxide, and allowance is made for the effect of their presence on the blueing rate of the oxide surface. The method of evaluating collision efficiencies from the data obtained is indicated in full, and the construction and operation of a calculator to assist in the computation is described. ...
The progress of medicine can be viewed in steps determined by methodologic advances, as well as in the development of new ideas. Landmarks in methodology include early morphologic descriptions, and osmotic fragility tests used in diagnosing and screening for beta thalassemia, so effectively used by Silvestroni and Bianco in Italy from the 1940s onward. The discovery in 1957 by Kunkel and coworkers that hemoglobin A2 is elevated in most beta-thalassemia heterozygotes started a further phase of investigation, based on both clinical and population studies. Then came rapid developments in the analysis of the hemoglobin molecule, and the concept of alpha ...
Disrupting the microbial colonization sequence by use of broad-spectrum antibiotics in pediatric care has been shown to modulate the expression of important GI developmental-related genes (28). In addition, there appears to be a correlation between antibiotic treatment after birth and development of allergy (24), but the influence of antibiotic therapy during the neonatal period on development of the digestive and immune function of the gut has not been investigated thoroughly.. The findings of the present study, using the neonatal rat model, show that an increased level of Enterobacteriaceae during the suckling period has an impact on the GI growth and development. The stomach weight was decreased in the antibiotic group of pups, and both the E. coli and the antibiotic groups had a decreased HCl secretion, reflecting a decreased growth and functional maturation of the stomach. This may weaken the animals defense against ingested pathogenic bacteria. Germ-free rats have been found to have ...
Press Release issued Feb 14, 2017: Market Research Report on Hydrazine Monohydrobromide Market 2016 is a professional and in-depth study on the current state of the Hydrazine Monohydrobromide worldwide. First of all, Global Hydrazine Monohydrobromide Market 2016 report provides a basic overview of the Hydrazine Monohydrobromide industry including definitions, classifications, applications and Hydrazine Monohydrobromide industry chain structure.
This involved and moving download analytical profiles of drug substances, excipients, and does the technique could coordinate with a news First --! necessary, stopped the engagement with the city. He asserted a microtubule-based, was Evans.
Find elemental trace level articles on Environmental XPRT, the worlds largest environmental industry marketplace and information resource.
The thalassemias are inherited disorders of hemoglobin (Hb) synthesis. Their clinical severity widely varies, ranging from asymptomatic forms to severe (see the image below) or even fatal entities.
Most of the α-thalassemias are caused by deletions that remove one or more of the α-globin gene loci. The severity of the disease that results from these lesions is directly proportional to the number of α-globin genes that are missing ...
Engineers dressed in Self-Contained Atmospheric Protective Ensemble, or SCAPE suits, prepare to fuel Planck with liquid hydrazine on 15 April 2009.Planck will use its thrusters, propelled by liquid hydrazine, for manoeuvres in orbit. This is a volatile and toxic substance, commonly used a…
Watch Mark Harvey on former reporter Noreen Brays show - Week in Week out (27 min in) BBC Wales.Listen for yourself to the weasel words of Mark Harvey, partner at Hugh James exactly as recorded by the BBC here - http://web.archive.org/web/20061018054241/www.bbc.co.uk/wales/weekinweekout ...
(2-Ethoxyphenyl)hydrazine | C8H12N2O | CID 706126 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
Additional challenges to the new cleanroom paradigm from concurrent multiproduct manufacturing of bulk drug substances in a controlled non-classified (CNC) ballroom environment.
Model development and archiving support at physiome.org provided by the following grants: NIH/NIBIB BE08407 Software Integration, JSim and SBW 6/1/09-5/31/13; NIH/NHLBI T15 HL88516-01 Modeling for Heart, Lung and Blood: From Cell to Organ, 4/1/07-3/31/11; NSF BES-0506477 Adaptive Multi-Scale Model Simulation, 8/15/05-7/31/08; NIH/NHLBI R01 HL073598 Core 3: 3D Imaging and Computer Modeling of the Respiratory Tract, 9/1/04-8/31/09; as well as prior support from NIH/NCRR P41 RR01243 Simulation Resource in Circulatory Mass Transport and Exchange, 12/1/1980-11/30/01 and NIH/NIBIB R01 EB001973 JSim: A Simulation Analysis Platform, 3/1/02-2/28/07.. ...
Ioan Andricioaei - University of Michigan, Ann Arbor. 10:35am - 11:10am - Break. 11:10am - 11:45am - Hinge-Bending Motion in S-adenosyl-L-homocysteine Hydrolase: Mutagenesis, Fluorescence and Modeling Studies [PDF ...
1,2-Dimethylhydrazine - Wikipedia  1,2-Dimethylhydrazine - Wikipedia
... or symmetrical dimethylhydrazine, is one of the two isomers of dimethylhydrazine. It is a potent carcinogen that acts as a DNA ... Unsymmetrical dimethylhydrazine 74-79-3 1,2-Dimethylhydrazine 1,2-Dimethylhydrazine from PubChem Record of 1,2-Dimethylhydrazin ...
more infohttps://en.wikipedia.org/wiki/1,2-Dimethylhydrazine
1,2-dimethylhydrazine - Substance Information - ECHA  1,2-dimethylhydrazine - Substance Information - ECHA
Ss - Skin sensitiser (i.e. classified in skin sensitisation categories 1, 1A or 1B). More information about skin sensitiser ... 215-540-4, is covered by three harmonisations: 005-011-00-4; 005-011-01-1 and 005-011-02-9), CLH information cannot be ... Sr - Respiratory sensitiser (i.e. classified in respiratory sensitisation categories 1, 1A or 1B). More information about ...
more infohttps://echa.europa.eu/substance-information/-/substanceinfo/100.149.162
1,2-Dimethylhydrazine (IARC Summary & Evaluation, Volume 71, 1999)  1,2-Dimethylhydrazine (IARC Summary & Evaluation, Volume 71, 1999)
1,2-DIMETHYLHYDRAZINE. (Group 2A). For definition of Groups, see Preamble Evaluation. VOL.: 71 (1999) (p. 947). CAS No.: 540-73 ... 1,2-Dimethylhydrazine is probably carcinogenic to humans (Group 2A).. In making the overall evaluation, the Working Group took ... Name: 1,2-Dimethylhydrazine. 5. Summary of Data Reported and Evaluation. 5.1 Exposure data. 1,2-Dimethylhydrazine is believed ... 1,2-Dimethylhydrazine formed DNA adducts and induced gene mutations, DNA breaks and micronuclei in vitro and in vivo in rodents ...
more infohttp://www.inchem.org/documents/iarc/vol71/036-dimhydr.html
TCI AMERICAS 1,2-dimethylhydrazine dihydrochloride - 29NA63|D0741-25G - Grainger  TCI AMERICAS 1,2-dimethylhydrazine dihydrochloride - 29NA63|D0741-25G - Grainger
Looking for TCI AMERICAS 1,2-dimethylhydrazine dihydrochloride (29NA63)? Graingers got your back. Price:$332.00. Easy ordering ...
more infohttps://www.grainger.com/product/TCI-AMERICAS-TCI-306-37-6-29NA63
Aged garlic extract inhibits 1,2-dimethylhydrazine-induced colon  Aged garlic extract inhibits 1,2-dimethylhydrazine-induced colon
DLD-1 human colon cancer cells were utilized to investigate the effect of AGE on anti-cell proliferation. AGE decreased the ... We investigated the antitumor effects of AGE in rats with 1,2-dimethylhydrazine (DMH)-induced carcinogenesis, and the mechanism ... Aged garlic extract inhibits 1,2-dimethylhydrazine-induced colon tumor development by suppressing cell proliferation. ...
more infohttp://www.greenmedinfo.com/article/aged-garlic-extract-suppressed-proliferative-activity-adenoma-and-adenocarcino
Protective role of luteolin in 1,2-dimethylhydrazine induced experimental colon carcinogenesis  Protective role of luteolin in 1,2-dimethylhydrazine induced experimental colon carcinogenesis
... ... 2-dimethyl hydrazine (DMH). Twenty mg/kg body weight of DMH were administered subcutaneously once a week for the first 15 weeks ... effect of luteolin on bacterial enzymes such as β-glucuronidase and mucinase in a colon carcinogenesis model induced by 1, ...
more infohttps://insights.ovid.com/cbaf/200703000/01445390-200703000-00010
Thymoquinone, the Nigella sativa Bioactive Compound, Prevents Circulatory Oxidative Stress Caused by 1,2-Dimethylhydrazine in...  Thymoquinone, the Nigella sativa Bioactive Compound, Prevents Circulatory Oxidative Stress Caused by 1,2-Dimethylhydrazine in...
1) Catalase Activity. Catalase activity was measured in the hemolysate at 240 nm and 25°C according to [20]. Briefly, 20 μL of ... Hanene Jrah Harzallah,1 Rahma Grayaa,1 Wafa Kharoubi,2 Aya Maaloul,1 Mohamed Hammami,2 and Touhami Mahjoub1 ... 2, pp. 184-192, 1985. View at Google Scholar. *H. Gali-Muhtasib, M. Ocker, D. Kuester et al., "Thymoquinone reduces mouse colon ... 2. Material and Methods. 2.1. Animal Experimental Design. Adult male Wistar rats were bred in the animal care facility at the ...
more infohttps://www.hindawi.com/journals/omcl/2012/854065/
Glycine- and proline-rich glycoprotein regulates the balance between cell proliferation and apoptosis for ACF formation in 1,2...  Glycine- and proline-rich glycoprotein regulates the balance between cell proliferation and apoptosis for ACF formation in 1,2...
doi: 10.1002/(SICI)1099-0844(199912)17:4,253::AID-CBF837,3.0.CO;2-R PubMedCrossRefGoogle Scholar ... doi: 10.1002/1099-1387(200010)6:10,497::AID-PSC277,3.0.CO;2-W PubMedCrossRefGoogle Scholar ... Hinz B, Brune K (2002) Cyclooxygenase-2-10 years later. J Pharmacol Exp Ther 300:367-375. doi: 10.1124/jpet.300.2.367 PubMed ... 2.Center for the Control of Animal Hazards Using Biotechnology (BK 21)Chonnam National UniversityKwang-juSouth Korea ...
more infohttps://link.springer.com/article/10.1007%2Fs11010-009-0033-5
Abstract 3784: Caloric restriction inhibits 1, 2-dimethylhydrazine-induced aberrant crypt foci formation and induces...  Abstract 3784: Caloric restriction inhibits 1, 2-dimethylhydrazine-induced aberrant crypt foci formation and induces...
Rats in groups 2 and 4 were fed a CR diet (60% of the ad libitum intake), and those in groups 1 and 3 were fed CE-2 diet (CLEA ... Groups 1 and 2 were given subcutaneous injection of 1, 2-dimethylhydrazine (DMH, 40 mg/Kg body weight), once a week for 2 weeks ... group 2 and group 3 vs. group 4). Interestingly, DMH treatment also increased the expression of sirt1 and sirt4 (group 1 vs. ... The number of ACF in colonic mucosa was significantly decreased in DMH-treated rats with CR (group 2) as compared to in DMH- ...
more infohttp://cancerres.aacrjournals.org/content/70/8_Supplement/3784
Gene expression profile and genomic alterations in colonic tumours induced by 1,2-dimethylhydrazine (DMH) in rats | BMC Cancer ...  Gene expression profile and genomic alterations in colonic tumours induced by 1,2-dimethylhydrazine (DMH) in rats | BMC Cancer ...
Array-comparative genomic hybridization (a-CGH) was performed on 10 paired TUM-NM samples hybridized on Rat genome arrays 2 × ... or 1,2-dimethylhydrazine (DMH)-induced colon carcinogenesis in rats shares many phenotypical similarities with human sporadic ... Open Peer Review Reports for: Gene expression profile and genomic alterations in colonic tumours induced by 1,2- ... dimethylhydrazine (DMH) in rats Back to article Pre-publication versions of this article are available by contacting [email protected] ...
more infohttps://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-10-194/open-peer-review
Anti-proliferative and Apoptotic Effects of Basella rubra (L.) Against 1, 2-Dimethyl Hydrazine-induced Colon Carcinogenesis in...  Anti-proliferative and Apoptotic Effects of Basella rubra (L.) Against 1, 2-Dimethyl Hydrazine-induced Colon Carcinogenesis in...
Against 1, 2-Dimethyl Hydrazine-induced Colon Carcinogenesis in Rats - Basella rubra;1, 2-dimethylhydrazine (DMH);colon cancer; ... Xu G, Ren G, Xu X, et al (2010). Combination of curcumin and green tea catechins prevents dimethylhydrazine- induced colon ... term bioassay for colon carcinogenesis using dimethylhydrazine in Wistar rats. Braz J Med Bio Res, 35, 351-5. ... 2.. Adhikari R, Naveen Kumar HN, Shruthi SD (2012). A review on medicinal importance of Basella alba L. Int J Pharm Sci Drug ...
more infohttp://www.koreascience.or.kr/article/ArticleFullRecord.jsp?cn=POCPA9_2016_v17n1_73
The Protective Effect of Cell Wall and Cytoplasmic Fraction of Selenium Enriched Yeast on 1 2-Dimethylhydrazine-induced Damage...  The Protective Effect of Cell Wall and Cytoplasmic Fraction of Selenium Enriched Yeast on 1 2-Dimethylhydrazine-induced Damage...
1, 2-Dimethylhydrazine (DMH) enhances lipid peroxidation rate by tumor mitochondria than normal tissue counterpart and causes ... Keywords: Dimethyl hydrazine, Liver enzymes, AST, ALT, ALP, Saccharomyces cerevisiae, Selenium, Colon cancer. ... dimethyl hydrazine chloride (40 mg/kg body weight) twice a week for 4 weeks except healthy control. At first colon carcinoma ( ... Volume 2, Issue 1 (Feb 2014) Res Mol Med (RMM) 2014, 2(1): 39-45 , Back to browse issues page ...
more infohttp://rmm.mazums.ac.ir/article-1-63-en.html
Potential Prophylactic Effect of Berberine against Rat Colon Carcinoma Induce by 1,2-Dimethyl Hydrazine  Potential Prophylactic Effect of Berberine against Rat Colon Carcinoma Induce by 1,2-Dimethyl Hydrazine
Methods: The rats were segregated into four groups: group 1, control rats; group2, rats were orally received berberine (75 mg/ ... Result: DMH injection decreasedthe antioxidants levels (GSH and SOD) and increased inflammatory markers (MPO, MAPK and COX-2). ... This study shows the ameliorating roles of berberine on 1,2 Di methyl hydrazine (DMH) induced coloncancer in male Swiss albino ... Ahmed E Ghareeb1; Fatma S M Moawed2; Doaa A Ghareeb 3, 4, 5; Eman I Kandil1 ...
more infohttp://journal.waocp.org/article_63485.html
Distribution of intestine-associated lymphoid tissue, aberrant crypt foci, and tumors in the large bowel of 1,2...  Distribution of intestine-associated lymphoid tissue, aberrant crypt foci, and tumors in the large bowel of 1,2...
In 1,2-dimethylhydrazine-treated mice the majority of ACF were present in the middle third of the colon, between the two peaks ... Six-week-old male CF-1 mice were fed the AIN-76 diet, given eight weekly s.c. injections of either the colon carcinogen 1,2- ... dimethylhydrazine or saline, and killed 24 weeks after the last injection. Parameters measured in the large bowel included the ... Distribution of intestine-associated lymphoid tissue, aberrant crypt foci, and tumors in the large bowel of 1,2- ...
more infohttps://soar.wichita.edu/handle/10057/4781
NAVER Academic | Chemopreventive effect of myrtenal on bacterial enzyme activity and the development of 1,2-dimethyl hydrazine...  NAVER Academic | Chemopreventive effect of myrtenal on bacterial enzyme activity and the development of 1,2-dimethyl hydrazine...
Methylene blue staining was carried out to visualize the impact of 1,2-dimethylhydrazine and myrtenal. Myrtenal-treated animals ... 2-dimethylhydrazine is histologically, morphologically, and anatomically similar to human colonic epithelial neoplasm. Discrete ... Methylene blue staining was carried out to visualize the impact of 1,2-dimethylhydrazine and myrtenal. Myrtenal-treated animals ... Chemopreventive effect of myrtenal on bacterial enzyme activity and the development of 1,2-dimethyl hydrazine-induced aberrant ...
more infohttps://academic.naver.com/article.naver?doc_id=177635796
Phytic acid improves intestinal mucosal barrier damage and reduces serum levels of proinflammatory cytokines in a 1, 2...  Phytic acid improves intestinal mucosal barrier damage and reduces serum levels of proinflammatory cytokines in a 1, 2...
Phytic acid improves intestinal mucosal barrier damage and reduces serum levels of proinflammatory cytokines in a 1, 2- ... dimethylhydrazine-induced rat colorectal cancer model[J]. British Journal of Nutrition, 2018, 120(2): 121-130. ... Phytic acid improves intestinal mucosal barrier damage and reduces serum levels of proinflammatory cytokines in a 1, 2- ... dimethylhydrazine-induced rat colorectal cancer model.. 2018-12-18Author:adminpraise:0 ...
more infohttps://www.elabscience.com/List-detail-5722.html
Phytic acid improves intestinal mucosal barrier damage and reduces serum levels of proinflammatory cytokines in a 1,2...  Phytic acid improves intestinal mucosal barrier damage and reduces serum levels of proinflammatory cytokines in a 1,2...
Phytic acid improves intestinal mucosal barrier damage and reduces serum levels of proinflammatory cytokines in a 1,2- ... dimethylhydrazine-induced rat colorectal cancer model - Volume 120 Issue 2 - Cuiping Liu, Chen Chen, Fuguo Yang, Xin Li, Lixue ... 2. Chen, W, Zheng, R, Baade, PD, et al. (2016) Cancer statistics in China, 2015. CA Cancer J Clin 66, 115-132. ... Eur J Pharm Sci 80, 1-8.. 23. Reeves, PG, Nielsen, FH & Fahey, GC Jr (1993) AIN-93 purified diets for laboratory rodents: final ...
more infohttp://core-cms.prod.aop.cambridge.org/core/journals/british-journal-of-nutrition/article/phytic-acid-improves-intestinal-mucosal-barrier-damage-and-reduces-serum-levels-of-proinflammatory-cytokines-in-a-12dimethylhydrazineinduced-rat-colorectal-cancer-model/2B06E7C99CC6396C7EF37D8DD1FC7EC1
Gastric Content of the Liquid Test Meals in Rats with Gastrointestinal Neoplasias Induced by N-methyl-N-nitrosoguanidineand 1,2...  Gastric Content of the Liquid Test Meals in Rats with Gastrointestinal Neoplasias Induced by N-methyl-N-nitrosoguanidineand 1,2...
Gastric Content of the Liquid Test Meals in Rats with Gastrointestinal Neoplasias Induced by N-methyl-N-nitrosoguanidineand 1,2 ... dimethylhydrazine ... 1:. Body weight gains of rats in the different MNNG-treated ... Gastrointest Liver Physiol 2), 239: G71-G76.. Direct Link , Kent, T.H., B. Cannon, J. Reynolds and J.W. Osborne, 1975. Gastric ... Gastroenterol., 51: 1-7.. Grills, I.S., L.L. Kestin, N. Goldstein, C. Mitchell, A. Martinez, J. Ingold and F.A. Vicini, 2003. ...
more infohttps://scialert.net/fulltext/?doi=ijcr.2006.19.30&org=10
Chemical Priority Lists for Acute Exposure Guideline Levels (AEGLs) | Acute Exposure Guideline Levels for Airborne Chemicals |...  Chemical Priority Lists for Acute Exposure Guideline Levels (AEGLs) | Acute Exposure Guideline Levels for Airborne Chemicals |...
The Acute Exposure Guideline Levels (AEGLs) Program develops AEGL values for chemicals that can potentially cause dangerous inhalation exposures to persons through accidental releases to air or by means of a terrorist action.. AEGL values are developed for chemicals from a priority list that is generated from nominations by stakeholder organizations. While AEGL development focuses primarily on the priority-listed chemicals, occasionally other chemicals become of interest and are nominated for priority consideration.. The First AEGL Chemical Priority List of 85 chemicals appeared in the Federal Register on May 21, 1997. Fifteen chemicals were subsequently added and are included in this Web site listing. See the May 21, 1997 Federal Register notice. The Second AEGL Chemical Priority List was published in the Federal Register on May 31, 2002, and contained 371 priority chemicals, 137 of which were considered a higher priority than the other 234 chemicals. See the May 31, 2002 Federal Register ...
more infohttps://www.epa.gov/aegl/chemical-priority-lists-acute-exposure-guideline-levels-aegls
  • Based on symmetry: I think that looking for symmetry phenol has a higher boiling point than 1,2-dihydroxybenzene because the two -OH groups projecting out from the benzene ring of 1,2-dihydroxybenzene will not allow close packing of them which results in a lower boiling point. (stackexchange.com)
  • The mechanism of action is probably associated with the ability of DHA to regulate COX-2 production, which decreases the expression of the antiapoptotic proteins Bcl-2, accelerating apoptosis. (scielo.br)
  • Oxidative stress produced by free radicals has been associated with the development of several diseases such as cardiovascular, cancer, and neurodegenerative diseases [ 2 ]. (hindawi.com)
  • In making the overall evaluation, the Working Group took into account that 1,2-dimethylhydrazine is consistently mutagenic in a wide range of test systems and gives rise to a similar pattern of DNA damage in human and animal tissues in vitro . (inchem.org)
  • Interestingly, the results in this study revealed that SNL glycoprotein has suppressive effects on activity of nuclear factor-kappa B (NF-κB), whereas it has stimulatory effect on the expression of p53, accompanying inhibitory effects on expression of NF-κBp50, inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), interleukin (IL)-6, and tumor necrosis factor (TNF)-α in DMH-stimulated ACF formation. (springer.com)
  • In addition to the already known free radical scavenging effect, flavonoids exert beneficial effects through the interaction with nuclear transcription factor kappa-B, activator protein 1, Janus kinases and phosphatidylinositol-3 kinase signaling pathways. (springer.com)
  • Result: DMH injection decreased the antioxidants levels (GSH and SOD) and increased inflammatory markers (MPO, MAPK and COX-2). (waocp.org)
  • This fatty acid is currently known to play a role in the prevention and treatment of cardiovascular diseases, hypertension, arthritis, autoimmune diseases, cancer and inflammatory diseases 1-4 . (scielo.br)
  • PA elevated the mRNA and protein expression of MUC2, TFF3 and E-cadherin, and diminished the mRNA and protein expression of claudin-1. (cambridge.org)
  • Although the activating pathway has not been clarified in detail, there is good evidence that human tissues, cells and subcellular preparations can activate 1,2-dimethylhydrazine in a similar manner to the corresponding rodent models. (inchem.org)
  • Structures and anti-HSV-2 activities of neutral polysaccharides from an edible plant, Basella rubra L. Intl J Biol Macromol, 50, 245-9. (koreascience.or.kr)