1,2-Dimethylhydrazine: A DNA alkylating agent that has been shown to be a potent carcinogen and is widely used to induce colon tumors in experimental animals.Dimethylhydrazines: Hydrazines substituted with two methyl groups in any position.Methylhydrazines: Hydrazines substituted by one or more methyl groups in any position.Monomethylhydrazine: Hydrazine substituted by one methyl group.Colonic Neoplasms: Tumors or cancer of the COLON.Carcinogens: Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.HydrazinesColon: The segment of LARGE INTESTINE between the CECUM and the RECTUM. It includes the ASCENDING COLON; the TRANSVERSE COLON; the DESCENDING COLON; and the SIGMOID COLON.Aberrant Crypt Foci: Clusters of colonic crypts that appear different from the surrounding mucosa when visualized after staining. They are of interest as putative precursors to colorectal adenomas and potential biomarkers for colorectal carcinoma.Precancerous Conditions: Pathological processes that tend eventually to become malignant. (From Dorland, 27th ed)Chlorophyllides: Products of the hydrolysis of chlorophylls in which the phytic acid side chain has been removed and the carboxylic acids saponified.Methylazoxymethanol Acetate: The aglycone of CYCASIN. It acts as a potent carcinogen and neurotoxin and inhibits hepatic DNA, RNA, and protein synthesis.Neoplasms, Experimental: Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms.Cocarcinogenesis: The combination of two or more different factors in the production of cancer.Rats, Inbred F344Intestinal Neoplasms: Tumors or cancer of the INTESTINES.Intestinal Mucosa: Lining of the INTESTINES, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. In the SMALL INTESTINE, the mucosa is characterized by a series of folds and abundance of absorptive cells (ENTEROCYTES) with MICROVILLI.Anticarcinogenic Agents: Agents that reduce the frequency or rate of spontaneous or induced tumors independently of the mechanism involved.Amorphophallus: A plant genus of the family ARACEAE. Members contain konjac glucomannan (MANNANS) and SEROTONIN.Adenosarcoma: A malignant neoplasm arising simultaneously or consecutively in mesodermal tissue and glandular epithelium of the same part. (Stedman, 25th ed)Adenocarcinoma: A malignant epithelial tumor with a glandular organization.Azo CompoundsCecal Neoplasms: Tumors or cancer of the CECUM.Intestine, Large: A segment of the LOWER GASTROINTESTINAL TRACT that includes the CECUM; the COLON; and the RECTUM.Dietary Fiber: The remnants of plant cell walls that are resistant to digestion by the alimentary enzymes of man. It comprises various polysaccharides and lignins.Rats, Inbred Strains: Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.Adenoma: A benign epithelial tumor with a glandular organization.Colonic Diseases: Pathological processes in the COLON region of the large intestine (INTESTINE, LARGE).Alkylation: The covalent bonding of an alkyl group to an organic compound. It can occur by a simple addition reaction or by substitution of another functional group.Pectins: High molecular weight polysaccharides present in the cell walls of all plants. Pectins cement cell walls together. They are used as emulsifiers and stabilizers in the food industry. They have been tried for a variety of therapeutic uses including as antidiarrheals, where they are now generally considered ineffective, and in the treatment of hypercholesterolemia.GuanineCellulose: A polysaccharide with glucose units linked as in CELLOBIOSE. It is the chief constituent of plant fibers, cotton being the purest natural form of the substance. As a raw material, it forms the basis for many derivatives used in chromatography, ion exchange materials, explosives manufacturing, and pharmaceutical preparations.Rats, Wistar: A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.Rectum: The distal segment of the LARGE INTESTINE, between the SIGMOID COLON and the ANAL CANAL.Injections, Subcutaneous: Forceful administration under the skin of liquid medication, nutrient, or other fluid through a hollow needle piercing the skin.Azoxymethane: A potent carcinogen and neurotoxic compound. It is particularly effective in inducing colon carcinomas.Cecum: The blind sac or outpouching area of the LARGE INTESTINE that is below the entrance of the SMALL INTESTINE. It has a worm-like extension, the vermiform APPENDIX.Intestine, Small: The portion of the GASTROINTESTINAL TRACT between the PYLORUS of the STOMACH and the ILEOCECAL VALVE of the LARGE INTESTINE. It is divisible into three portions: the DUODENUM, the JEJUNUM, and the ILEUM.Cell Division: The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.Caloric Restriction: Reduction in caloric intake without reduction in adequate nutrition. In experimental animals, caloric restriction has been shown to extend lifespan and enhance other physiological variables.Sirtuins: A homologous family of regulatory enzymes that are structurally related to the protein silent mating type information regulator 2 (Sir2) found in Saccharomyces cerevisiae. Sirtuins contain a central catalytic core region which binds NAD. Several of the sirtuins utilize NAD to deacetylate proteins such as HISTONES and are categorized as GROUP III HISTONE DEACETYLASES. Several other sirtuin members utilize NAD to transfer ADP-RIBOSE to proteins and are categorized as MONO ADP-RIBOSE TRANSFERASES, while a third group of sirtuins appears to have both deacetylase and ADP ribose transferase activities.Sirtuin 3: A sirtuin family member found primarily in MITOCHONDRIA. It is a multifunctional enzyme that contains a NAD-dependent deacetylase activity that is specific for HISTONES and a mono-ADP-ribosyltransferase activity.United States Indian Health Service: A division of the UNITED STATES PUBLIC HEALTH SERVICE that is responsible for the public health and the provision of medical services to NATIVE AMERICANS in the United States, primarily those residing on reservation lands.AlaskaIndians, North American: Individual members of North American ethnic groups with ancient historic ancestral origins in Asia.Inuits: Inuktitut-speakers generally associated with the northern polar region.Federal Government: The level of governmental organization and function at the national or country-wide level.Health Services, Indigenous: Health care provided to specific cultural or tribal peoples which incorporates local customs, beliefs, and taboos.United StatesThreshold Limit Values: Standards for limiting worker exposure to airborne contaminants. They are the maximum concentration in air at which it is believed that a particular substance will not produce adverse health effects with repeated daily exposure. It can be a time-weighted average (TLV-TWA), a short-term value (TLV-STEL), or an instantaneous value (TLV-Ceiling). They are expressed either as parts per million (ppm) or milligram per cubic meter (mg/m3).Air Pollutants, Occupational: Air pollutants found in the work area. They are usually produced by the specific nature of the occupation.Occupational Exposure: The exposure to potentially harmful chemical, physical, or biological agents that occurs as a result of one's occupation.Maximum Allowable Concentration: The maximum exposure to a biologically active physical or chemical agent that is allowed during an 8-hour period (a workday) in a population of workers, or during a 24-hour period in the general population, which does not appear to cause appreciable harm, whether immediate or delayed for any period, in the target population. (From Lewis Dictionary of Toxicology, 1st ed)Ventilation: Supplying a building or house, their rooms and corridors, with fresh air. The controlling of the environment thus may be in public or domestic sites and in medical or non-medical locales. (From Dorland, 28th ed)Air Movements: The motion of air currents.Air Microbiology: The presence of bacteria, viruses, and fungi in the air. This term is not restricted to pathogenic organisms.
3.0.CO;2-E. PMID 9028353. Di Marzio L, Di Leo A, Cinque B, Fanini D, Agnifili A, Berloco P, Linsalata M, Lorusso D, Barone M, ... 43 (2): 316-24. PMID 11861674. Duan RD, Cheng Y, Hansen G, Hertervig E, Liu JJ, Syk I, Sjostrom H, Nilsson A (June 2003). " ... 235 (1): 141-6. doi:10.1016/j.canlet.2005.04.016. PMID 16290921. Soo I, Madsen KL, Tejpar Q, Sydora BC, Sherbaniuk R, Cinque B ... J. 394 (Pt 1): 299-308. doi:10.1042/BJ20051121. PMC 1386028 . PMID 16255717. Andersson D, Kotarsky K, Wu J, Agace W, Duan RD ( ...
24 (2): 115-119. doi:10.1016/j.fm.2006.07.004. McGee, Harold (2004). On Food and Cooking: The Science and Lore of the Kitchen. ... Retrieved 1 October 2016. Wheat, in the form of bread, provides more nutrients to the world population than any other single ... Retrieved 1 January 2017. Kaplan, Steven Laurence: Good Bread is Back: A Contemporary History of French Bread, the Way It Is ... Retrieved 1 October 2016. Aside from bread wheat and durum, other types of wheat include spelt, emmer, einkorn and kamut. These ...
2-dimethylhydrazine". European Journal of Cancer Prevention. 18 (4): 291-302. doi:10.1097/CEJ.0b013e32832945a6. PMID 19417676. ... 2-dimethylhydrazine". Eur J Cancer Prev. 18 (4): 291-302. Aug 2009. doi:10.1097/CEJ.0b013e32832945a6. PMID 19417676. ... 2-dimethylhydrazine". European Journal of Cancer Prevention. 18 (4): 291-302. doi:10.1097/CEJ.0b013e32832945a6. PMID 19417676. ... effect of bread crust antioxidant pronyl-lysine on two different categories of colonic premalignant lesions induced by 1, ...
9 (2): 179-188. doi:10.1038/sj/cdd/4400935. ISSN 1350-9047. PMID 11840168. Lan, A.; et al. (2008). "Increased induction of ... 2 C2H5CO2 + C2H3O2 + CO2). The products of this fermentation contribute to the nutty and sweet flavors of the cheese, and the ... 2-dimethylhydrazine". British Journal of Nutrition. 100 (6): 1251-1259. doi:10.1017/S0007114508978284. ISSN 0007-1145. PMID ... by Propionibacterium freudenreichii TL133 in colonic mucosal crypts of human microbiota-associated rats treated with 1, ...
UDMH is easier to manufacture than symmetrical dimethylhydrazine is, and UDMH is a fairly common rocket fuel. gyromitrin and ... symmetrical dimethylhydrazine) are hydrazines where two hydrogen atoms are replaced by methyl groups. ... 2,4-dinitrophenylhydrazine (2,4-DNPH) is commonly used to test for ketones and aldehydes in organic and clinical chemistry. ... Saturated hydronitrogens can be: linear (general formula N nH n + 2) wherein the nitrogen atoms are joined in a snakelike ...
It uses the storable hypergolic propellants unsymmetrical dimethylhydrazine (UDMH) and dinitrogen tetroxide (N2O4), and can ... "YZ-1 space tug". B14643.DE. Retrieved 2015-07-25. [permanent dead link] "长征七号首飞成功 空间实验室任务大幕拉开" [Successful maiden flight of the ... Yuanzheng-2 (AKA YZ-2) (Chinese: 远征二号; pinyin: Yuǎn Zhēng Èr Hào; literally: "Expedition Two"): New version used with the 5.2 m ... The YZ-1 was designed for restart capability, and to remain operational for more than 6 hours required to
240 (2): 221-4. doi:10.1016/j.canlet.2005.09.011. PMID 16377080. Takayama T, Katsuki S, Takahashi Y, Ohi M, Nojiri S, Sakamaki ... 132 (2): 656-66. doi:10.1021/ja907716f. PMID 20028024. Peng-Yu, Yang; Min, Wang; Kai, Liu; Mun Hong, Ngai; Omar, Sheriff; J. ... 70 (1): 196-202. doi:10.1002/hlca.19870700124. Pommier A, Pons M, Kocienski P (1995). "The first total synthesis of (−)- ... ISBN 1-56363-527-5. "myalli.com - frequently asked questions". GlaxoSmithKline. 2007. Archived from the original on 12 July ...
Volumes 1-115". IARC Monographs on the Evaluation of Risk to Humans. IARC. February 22, 2016. Retrieved March 5, 2016. "IARC ... 3-cyclohexyl-1-nitrosourea) 4-Chloro-o-toluidine Chlorozotocin Cisplatin Cyclopenta[c,d]pyrene Diazinon Dibenz[a,j]acridine ... 2,3-Trichloropropane Tris(2,3-dibromopropyl) phosphate Vinyl bromide Vinyl fluoride Bitumens, occasional exposure to oxidized ... 2-Dimethylhydrazine Dimethyl sulfate Epichlorohydrin Ethylene dibromide Ethyl carbamate (urethane) N-Ethyl-N-nitrosourea ...
Members of this class include: Monomethylhydrazine Dimethylhydrazines Symmetrical dimethylhydrazine (1,2-dimethylhydrazine) ... Trimethylhydrazine 1,1,2-trimethylhydrazine 1,1,1-trimethylhydrazinium (cationic and exists as a variety of salts e.g. 1,1,1- ... 1,1,2-tetramethylhydrazinium (cationic and exists as a variety of salts) Pentamethylhydrazinium (cationic and exists as a ...
... unsymmetrical dimethylhydrazine and 40% diethylenetriamine), as fuel propellant feed, turbopump type turbopump drive, 90% ... lifted a 1/3-scale Jupiter nose cone to an altitude of 285 mi (460 km) and a range of 1,330 mi (2,140 km); Juno I (four-stage ... U for 2, ..., E for 9 and X for 0. For example, the Jupiter-C modified to launch Explorer 1 had "UE" painted on the side, ... Stage 1 62,700 lb (28,400 kg)/9,600 lb (4,400 kg) Stage 2 1,020 lb (460 kg)/490 lb (220 kg) Stage 3 280 lb (130 kg)/140 lb (64 ...
... dimethylhydrazines MeSH D02.442.600.400.200 --- 1,2-dimethylhydrazine MeSH D02.442.600.601 --- monomethylhydrazine MeSH D02.442 ... vitamin k 1 MeSH D02.455.849.291.523.500.844 --- vitamin k 2 MeSH D02.455.849.291.523.500.922 --- vitamin k 3 MeSH D02.455. ... 3-oxo-1,5-pentanediyl)bis(n,n-dimethyl-n-2-propenyl-), dibromide MeSH D02.092.146.325 --- p-dimethylaminoazobenzene MeSH ... 5-nitro-2-furyl)vinyl)-1,2,4-oxadiazole MeSH D02.640.600.290 --- fanft MeSH D02.640.600.308 --- furagin MeSH D02.640.600.313 ...
... is the name of two compounds with the molecular formula C2H8N2. These are: unsymmetrical dimethylhydrazine (1 ... with both methyl groups bonded to the same nitrogen atom symmetrical dimethylhydrazine (1,2-dimethylhydrazine), with one methyl ...
... or symmetrical dimethylhydrazine, is one of the two isomers of dimethylhydrazine. It is a potent carcinogen that acts as a DNA ... Unsymmetrical dimethylhydrazine 74-79-3 1,2-Dimethylhydrazine 1,2-Dimethylhydrazine from PubChem Record of 1,2-Dimethylhydrazin ...
The missile used Unsymmetrical dimethylhydrazine as a bipropellant in combination with red fuming nitric acid. The Soviets ... Initial operational capability was achieved on 1 November 1961. The missile continued to serve until 1976, with maximum ... the first flight of the missile took place on 2 February 1961. ...
The Qiam 1's accuracy is also improved with the addition of a separable warhead. Other changes to the warhead include a "baby- ... Far simpler than the V-2's multi-chamber design, and employing an anti-oscillation baffle to prevent chugging, it was a ... with unsymmetrical dimethylhydrazine (UDMH, Russian TG-02 like German Tonka 250) as liquid igniter (self-ignition with IRFNA) ... The earlier R-1 missile had carried the NATO name SS-1 Scunner, but was of a very different design, almost directly a copy of ...
24 (2): 115-119. doi:10.1016/j.fm.2006.07.004.. *^ McGee, Harold (2004). On Food and Cooking: The Science and Lore of the ... Retrieved 2 October 2016.. *^ "Preferments". King Arthur Flour.. Missing or empty ,url=. (help); ,access-date=. requires ,url= ... Retrieved 2 October 2016.. *^ Finley, John H.; Phillips, R. O. (1989). Protein quality and the effects of processing. New York ... Retrieved 1 October 2016.. *^ Hamelman, Jeffrey (2004). Bread: a baker's book of techniques and recipes. New York: John Wiley. ...
... is formed from the rocket fuel unsymmetrical dimethylhydrazine (UDMH) and methyl iodide, and acts as a vicarious nucleophilic ... TATB, triaminotrinitrobenzene or 2,4,6-triamino-1,3,5- trinitrobenzene is an aromatic explosive, based on the basic six-carbon ... TATB is produced by nitration of 1,3,5-trichlorobenzene to 1,3,5-trichloro-2,4,6-trinitrobenzene, then the chlorine atoms are ...
Attitude was controlled by a Sun-star sensor with attitude correction performed by a dimethylhydrazine/nitric acid bipropellant ... Mars 1M No.1, known in the west as Marsnik 1, Mars 1960A and Korabl 4, was destroyed in a launch failure on October 10, 1960. ... Mars 1M No.2, known in the west as Marsnik 2, Korabl 5 and Mars 1960B, was launched on October 14, 1960. Both Mars 1M ... Mars 1M No.2 reached an altitude of 120 km before reentry. Soviet premier Nikita Khrushchev had planned to bring models of the ...
Unsymmetrical dimethylhydrazine (UDMH or MMH) / Dinitrogen tetroxide (NTO or N 2O 4) Used in three first stages of the Russian ... hydrazine or unsymmetrical dimethylhydrazine (UDMH) as fuel were then adopted in the United States and the Soviet Union for use ... The V-1 and V-2 rockets developed by Nazi Germany used LOX and ethyl alcohol. One of the main advantages of alcohol was its ... The V-2 used an alcohol/LOX liquid propellant engine, with hydrogen peroxide to drive the fuel pumps. The alcohol was mixed ...
... mercury Dimethyl phosphorochloridothioate Dimethyl-p-phenylenediamine Dimethylcadmium Dimethyldichlorosilane Dimethylhydrazine ... 2-(bis(1-methylethyl)amino)ethyl) O-ethyl ester Phosphonothioic acid, methyl-, O-(4-nitrophenyl) O-phenyl ester Phosphoric acid ... 2-chloroethyl)amine Valinomycin Vinyl acetate monomer Warfarin Warfarin sodium Xylylene dichloride Zinc phosphide List of ... 2-chloro- Ethanol, 1,2-dichloro-, acetate Ethion Ethoprophos Ethylbis(2-chloroethyl)amine Ethylene fluorohydrin Ethylene oxide ...
Aerozine 50 is a mixture of 50% UDMH and 50% straight hydrazine (N2H4). Unsymmetrical dimethylhydrazine (UDMH) + Nitrogen ... The most common hypergolic fuels, hydrazine, monomethylhydrazine and unsymmetrical dimethylhydrazine, and oxidizer, nitrogen ... dinitrogen tetroxide plus hydrazine and/or its relatives monomethylhydrazine and unsymmetrical dimethylhydrazine. Soviet rocket ... Ariane 1 through 4, with their hypergolic first and second stages (and optional hypergolic boosters on the Ariane 3 and 4) have ...
... unsymmetrical dimethylhydrazine (UDMH), had found a correlation between exposure to the chemicals and cancerous tumors in lab ... Bernard, Mitchell S. (2 June 2013). "The Natural Resources Defense Council was right on Alar in 1989 and it still is". The ... 95 Suppl 1: S81-91. doi:10.2105/AJPH.2004.044818. PMID 16030344. Kroll, Andy; Schulman, Jeremy (28 October 2013). "Leaked ... Generally, EPA considers lifetime cancer risks in excess of 1 per million to be cause for action. "Daminozide toxicity, ...
... and unsymmetric dimethyl hydrazine (UDMH, (CH3)2N2H2) - Soviet Scud-C, aka SS-1-c,-d,-e Nitric acid 73% with dinitrogen ... Nike Ajax Antiaircraft Rocket Unsymmetric dimethylhydrazine (UDMH) and dinitrogen tetroxide (N2O4) - Proton, Rokot, Long March ... Examples: Saturn V's F-1 and J-2, Delta IV's RS-68, Ariane 5's HM7B, Falcon 9's Merlin. Tap-off cycle Takes hot gases from the ... The first injectors used on the V-2 created parallel jets of fuel and oxidizer which then combusted in the chamber. This gave ...
With the use of the newly developed Hydyne, composed of a blend of 60% unsymmetrical dimethylhydrazine (UDMH) and 40% ... Hydyne is a mixture of 60% unsymmetrical dimethylhydrazine (UDMH) and 40% diethylenetriamine (DETA), developed in 1957 at ... ISBN 1-56347-649-5. NASA. The Mercury-Redstone Project, p. 3-2, 4-42. History of the Redstone Missile System, p. 60 History of ... Hydyne was used as the fuel for the first stage of the Juno I rocket that launched Explorer 1, the first successful satellite ...
Like other members of the Universal Rocket family, the Proton-K was fuelled by Unsymmetrical dimethylhydrazine and nitrogen ... Blok D-2 upper stages were used three times, with the Fobos 1, Fobos 2 and Mars 96 spacecraft. The Blok DM upper stage was used ... The Block DM1, a commercial version of the DM-2, was used to launch Inmarsat-3 F2. The Block DM2 upper stage was used to launch ... The most commonly used upper stage was the Blok DM-2, which was used on 109 flights, mostly with GLONASS and Raduga satellites ...
Mixed with unsymmetrical dimethylhydrazine it was used as Hydyne, a propellent for liquid-fuel rockets. ... Diethylenetriamine (abbreviated DETA and also known as 2,2'-Iminodi(ethylamine)[2]) is an organic compound with the formula HN( ... In coordination chemistry, it serves as a tridentate ligand forming complexes such as Co(dien)(NO2)3.[5] ... 2,2'-Iminodi(ethylamine); Health-based Reassessment of Administrative Occupational Exposure Limits" (PDF). 2005.. ...
... or symmetrical dimethylhydrazine, is one of the two isomers of dimethylhydrazine. It is a potent carcinogen that acts as a DNA ... Unsymmetrical dimethylhydrazine 74-79-3 1,2-Dimethylhydrazine 1,2-Dimethylhydrazine from PubChem Record of 1,2-Dimethylhydrazin ...
Looking for TCI AMERICAS 1,2-dimethylhydrazine dihydrochloride (29NA63)? Graingers got your back. Price:$332.00. Easy ordering ...
Ss - Skin sensitiser (i.e. classified in skin sensitisation categories 1, 1A or 1B). More information about skin sensitiser ... 215-540-4, is covered by three harmonisations: 005-011-00-4; 005-011-01-1 and 005-011-02-9), CLH information cannot be ... Sr - Respiratory sensitiser (i.e. classified in respiratory sensitisation categories 1, 1A or 1B). More information about ...
1,2-DIMETHYLHYDRAZINE. (Group 2A). For definition of Groups, see Preamble Evaluation. VOL.: 71 (1999) (p. 947). CAS No.: 540-73 ... 1,2-Dimethylhydrazine is probably carcinogenic to humans (Group 2A).. In making the overall evaluation, the Working Group took ... Name: 1,2-Dimethylhydrazine. 5. Summary of Data Reported and Evaluation. 5.1 Exposure data. 1,2-Dimethylhydrazine is believed ... 1,2-Dimethylhydrazine formed DNA adducts and induced gene mutations, DNA breaks and micronuclei in vitro and in vivo in rodents ...
DLD-1 human colon cancer cells were utilized to investigate the effect of AGE on anti-cell proliferation. AGE decreased the ... We investigated the antitumor effects of AGE in rats with 1,2-dimethylhydrazine (DMH)-induced carcinogenesis, and the mechanism ... Aged garlic extract inhibits 1,2-dimethylhydrazine-induced colon tumor development by suppressing cell proliferation. ...
1) Catalase Activity. Catalase activity was measured in the hemolysate at 240 nm and 25°C according to [20]. Briefly, 20 μL of ... Hanene Jrah Harzallah,1 Rahma Grayaa,1 Wafa Kharoubi,2 Aya Maaloul,1 Mohamed Hammami,2 and Touhami Mahjoub1 ... 2, pp. 184-192, 1985. View at Google Scholar. *H. Gali-Muhtasib, M. Ocker, D. Kuester et al., "Thymoquinone reduces mouse colon ... 2. Material and Methods. 2.1. Animal Experimental Design. Adult male Wistar rats were bred in the animal care facility at the ...
doi: 10.1002/(SICI)1099-0844(199912)17:4,253::AID-CBF837,3.0.CO;2-R PubMedCrossRefGoogle Scholar ... doi: 10.1002/1099-1387(200010)6:10,497::AID-PSC277,3.0.CO;2-W PubMedCrossRefGoogle Scholar ... Hinz B, Brune K (2002) Cyclooxygenase-2-10 years later. J Pharmacol Exp Ther 300:367-375. doi: 10.1124/jpet.300.2.367 PubMed ... 2.Center for the Control of Animal Hazards Using Biotechnology (BK 21)Chonnam National UniversityKwang-juSouth Korea ...
Rats in groups 2 and 4 were fed a CR diet (60% of the ad libitum intake), and those in groups 1 and 3 were fed CE-2 diet (CLEA ... Groups 1 and 2 were given subcutaneous injection of 1, 2-dimethylhydrazine (DMH, 40 mg/Kg body weight), once a week for 2 weeks ... group 2 and group 3 vs. group 4). Interestingly, DMH treatment also increased the expression of sirt1 and sirt4 (group 1 vs. ... The number of ACF in colonic mucosa was significantly decreased in DMH-treated rats with CR (group 2) as compared to in DMH- ...
... ... 2-dimethyl hydrazine (DMH). Twenty mg/kg body weight of DMH were administered subcutaneously once a week for the first 15 weeks ... effect of luteolin on bacterial enzymes such as β-glucuronidase and mucinase in a colon carcinogenesis model induced by 1, ...
2,6-Diamino-2-butyloxy-3,5-azopyridine. Zeranol. Titanium Tetrabromide. Tetraglyme. ...
Array-comparative genomic hybridization (a-CGH) was performed on 10 paired TUM-NM samples hybridized on Rat genome arrays 2 × ... or 1,2-dimethylhydrazine (DMH)-induced colon carcinogenesis in rats shares many phenotypical similarities with human sporadic ... Open Peer Review Reports for: Gene expression profile and genomic alterations in colonic tumours induced by 1,2- ... dimethylhydrazine (DMH) in rats Back to article Pre-publication versions of this article are available by contacting [email protected] ...
... down-regulated the expression of anti-apoptotic Bcl-2, proto-oncogene K-ras and up-regulated pro-apoptotic Bax as well as tumor ... 2-dimethylhydrazine (DMH) and the treatment continued for 18 weeks. Prophylactic potentials of probiotics and celecoxib were ... probiotics L.rhamnosus GG or/and L.acidophilus in combination with celecoxib one week prior to the inducement of tumor by 1, ... and celecoxib modulate Bax-mediated apoptosis in 1,2-dimethylhydrazine-induced experimental colon carcinogenesis ...
Against 1, 2-Dimethyl Hydrazine-induced Colon Carcinogenesis in Rats - Basella rubra;1, 2-dimethylhydrazine (DMH);colon cancer; ... Xu G, Ren G, Xu X, et al (2010). Combination of curcumin and green tea catechins prevents dimethylhydrazine- induced colon ... term bioassay for colon carcinogenesis using dimethylhydrazine in Wistar rats. Braz J Med Bio Res, 35, 351-5. ... 2.. Adhikari R, Naveen Kumar HN, Shruthi SD (2012). A review on medicinal importance of Basella alba L. Int J Pharm Sci Drug ...
Ca C 0.06 ppm (0.15 mg/m3) [2-hr] See Appendix A OSHA PEL. TWA 0.5 ppm (1 mg/m3) [skin] ...
For more information, you may call the ATSDR Information Center at 1-800-232-4636. This fact sheet is one in a series of ... 1600 Clifton Road NE, Mailstop S102-1. Atlanta, GA 30333 Phone: 1-800-CDC-INFO · 888-232-6348 (TTY). Email: Contact CDC-INFO ... Working in greenhouses where the chemical Alar is used may result in your being exposed to small amounts of 1,2- ... dimethylhydrazine.. top. How can hydrazines affect my health?. Breathing hydrazines for short periods may cause coughing and ...
O,O-Dimethyl 2-ethylmercaptoethyl thiophosphate. 8022-00-2. TG1760000. O,O-Dimethyl O-(2,4,5-trichlorophenyl) phosphorothioate ... 2,3-p-Dioxanethiol-S,S-bis(O,O-diethyl phosphoro-dithioate). 78-34-2. TE3350000. ... Decachlorooctahydro-1,3,4-metheno-2H-cyclobuta(cd)-pentalen-2-one. 143-50-0. PC8575000. ... O,O-Dimethyl-S-4-oxo-1,2,3-benzotriazin-3(4H)-ylmethyl phosphorodithioate. 86-50-0. TE1925000. ...
The Acute Exposure Guideline Levels (AEGLs) Program develops AEGL values for chemicals that can potentially cause dangerous inhalation exposures to persons through accidental releases to air or by means of a terrorist action.. AEGL values are developed for chemicals from a priority list that is generated from nominations by stakeholder organizations. While AEGL development focuses primarily on the priority-listed chemicals, occasionally other chemicals become of interest and are nominated for priority consideration.. The First AEGL Chemical Priority List of 85 chemicals appeared in the Federal Register on May 21, 1997. Fifteen chemicals were subsequently added and are included in this Web site listing. See the May 21, 1997 Federal Register notice. The Second AEGL Chemical Priority List was published in the Federal Register on May 31, 2002, and contained 371 priority chemicals, 137 of which were considered a higher priority than the other 234 chemicals. See the May 31, 2002 Federal Register ...
Methods: The rats were segregated into four groups: group 1, control rats; group2, rats were orally received berberine (75 mg/ ... Result: DMH injection decreasedthe antioxidants levels (GSH and SOD) and increased inflammatory markers (MPO, MAPK and COX-2). ... This study shows the ameliorating roles of berberine on 1,2 Di methyl hydrazine (DMH) induced coloncancer in male Swiss albino ... Ahmed E Ghareeb1; Fatma S M Moawed2; Doaa A Ghareeb 3, 4, 5; Eman I Kandil1 ...
2,5-bis(aziridin-1-yl)-1,4-benzoquinone Mass :190.19868 Formula : C10H10N2O2 ... 2,5-bis(2-hydroxyethylamino)-3,6-diaziridinylbenzoquinone Mass :308.334 Formula : C14H20N4O4 ...
Shaulian E, Karin M (2001) AP-1 in cell proliferation and survival. Oncogene 20(19):2390-2400PubMedCrossRefPubMedCentralGoogle ... Wagner EF (2001) AP-1 - introductory remarks. Oncogene 20(19):2334-2335PubMedCrossRefPubMedCentralGoogle Scholar ... Am J Physiol Renal Physiol 313(2):F414-F422PubMedCrossRefPubMedCentralGoogle Scholar ... Cold Spring Harb Perspect Biol 1(6):a001651PubMedCrossRefPubMedCentralGoogle Scholar ...
DIMETHYLHYDRAZINE ETHYL SILICATE. 1,2-DIMETHYLHYDRAZINE ETHYLAMINE. DIMETHYLPHTHALATE ETHYLENE. DINITOLMIDE ETHYLENE ... 1,2 - DIBROMOETHANE (ETHYLENE DIBROMIDE) DIMETHYL-1,2 - DIBROMO-2-PHOSPHATE DIBUTYL PHOSPHATE 2-6-DIMETHYL-4-HEPTANONE ... PHENAZOPYRIDINE (2,6-DIAMINO-3-PHENYLAZOPYRIDINE). NITROGEN MUSTARD N-OXIDE AND ITS HYDROCHLORIDE PHENAZOPYRIDINE HYDROCHLORIDE ... 2,4 - DIAMINOANISOLE & ITS SULFATE DIETHYLSTILBOESTROL. 4,4-DIAMIODIPHENYL ETHER 1,2-DIAMINOETHANE DIETHYLSTILBOESTROL ...
Figure 1. Chemical structures of (a) α-carotene; (b) β-carotene; (c) lycopene; (d) β-cryptoxanthin; (e) lutein; (f) zeaxantin ... Figure 1. Chemical structures of (a) α-carotene; (b) β-carotene; (c) lycopene; (d) β-cryptoxanthin; (e) lutein; (f) zeaxantin ... Cancer 1992, 18, 1-29. [Google Scholar] [CrossRef]. *Blot, W.J.; Li, J.Y.; Taylor, P.R.; Guo, W.; Dawsey, S.; Wang, G.Q.; Yang ... A recent study of ours indicated that db/db-ApcMin/+ with increased expression of IGF-1, IGF-1R and IGF-2 in the intestine was ...
3.0.CO;2-E. PMID 9028353. Di Marzio L, Di Leo A, Cinque B, Fanini D, Agnifili A, Berloco P, Linsalata M, Lorusso D, Barone M, ... 43 (2): 316-24. PMID 11861674. Duan RD, Cheng Y, Hansen G, Hertervig E, Liu JJ, Syk I, Sjostrom H, Nilsson A (June 2003). " ... 235 (1): 141-6. doi:10.1016/j.canlet.2005.04.016. PMID 16290921. Soo I, Madsen KL, Tejpar Q, Sydora BC, Sherbaniuk R, Cinque B ... J. 394 (Pt 1): 299-308. doi:10.1042/BJ20051121. PMC 1386028 . PMID 16255717. Andersson D, Kotarsky K, Wu J, Agace W, Duan RD ( ...
Phytic acid improves intestinal mucosal barrier damage and reduces serum levels of proinflammatory cytokines in a 1, 2- ... dimethylhydrazine-induced rat colorectal cancer model[J]. British Journal of Nutrition, 2018, 120(2): 121-130. ... Phytic acid improves intestinal mucosal barrier damage and reduces serum levels of proinflammatory cytokines in a 1, 2- ... dimethylhydrazine-induced rat colorectal cancer model.. 2018-12-18Author:adminpraise:0 ...
  • The etiology of CRC is known to be multifactorial, responding to family, environmental and dietary agents 2 , 3 , 4 putative preneoplastic lesions, are early morphological changes induced by the colon carcinogen azoxymethane (AOM. (isciii.es)
  • A fifth rat received a single oral dose of 5.8 mg of 2-ethylhexanol in 40% ethanol. (inchem.org)
  • High alcohol (ethanol) preference ratio (1/5) ( McClearn, 1965 ). (jax.org)
  • Low severity of ethanol withdrawal symptoms compared with DBA/2, possibly associated with differences in neuroactive steriod sensitivity ( Finn et al, 1997 ). (jax.org)
  • Several hepatotoxins contribute to liver damage, including ethanol, paracetamol, and carbon tetrachloride (CCl 4 ) [ 1 , 2 ]. (hindawi.com)
  • Although the activating pathway has not been clarified in detail, there is good evidence that human tissues, cells and subcellular preparations can activate 1,2-dimethylhydrazine in a similar manner to the corresponding rodent models. (inchem.org)
  • The required information included: (1) the effects on newborn animals, particularly those exposed to DSS through lactation: (2) an adequate long-term study in a rodent species: and (3) a study of the effects of DSS on the pulmonary vascular system. (inchem.org)
  • DLD-1 human colon cancer cells were utilized to investigate the effect of AGE on anti-cell proliferation. (greenmedinfo.com)
  • Oxidative stress produced by free radicals has been associated with the development of several diseases such as cardiovascular, cancer, and neurodegenerative diseases [ 2 ]. (hindawi.com)
  • Indonesian J Cancer Chemoprevent, 2, 227-32. (koreascience.or.kr)
  • Cancer Lett, 2, 147-51. (koreascience.or.kr)
  • 1,2-Dimethylhydrazine has caused colon cancer in laboratory animals following a single exposure. (cdc.gov)
  • The International Agency for Research on Cancer (IARC) has determined that hydrazine, 1,1-dimethylhydrazine, and 1,2-dimethylhydrazine are possible human carcinogens. (cdc.gov)
  • The American Conference of Governmental Industrial Hygienists (ACGIH) currently lists hydrazine and 1,1-dimethylhydrazine as suspected carcinogens, but has recently recommended that the listing of hydrazine be changed to that of animal carcinogen, not likely to cause cancer to people under normal exposure conditions. (cdc.gov)
  • To date, the cancer problem and the failure of conventional chemotherapy to achieve a reduction in the mortality rates for common epithelial malignancies such as carcinomas of the lung, colon, breast, prostate and pancreas, indicates a critical need for new approaches to control cancer development [ 1 , 2 ]. (mdpi.com)
  • The present study reveals the effect of galantamine (GAL) against 1, 2-dimethylhydrazine (DMH) induced colon cancer. (ovid.com)
  • It is also taken by mouth for type 2 diabetes, liver problems, Alzheimer's disease, to control snoring, lung disorders including emphysema and pneumonia, chronic fatigue syndrome, autoimmune disorders (systemic lupus erythematous), HIV infection and AIDS, and cancer (breast cancer and colon cancer). (webmd.com)
  • Fig. 1: DNA repair pathways and cancer. (nature.com)
  • Fig. 2: Mechanisms of BAP1 activity in cancer development. (nature.com)
  • This fatty acid is currently known to play a role in the prevention and treatment of cardiovascular diseases, hypertension, arthritis, autoimmune diseases, cancer and inflammatory diseases 1-4 . (scielo.br)
  • International Journal of Cancer Research, 2: 19-30. (scialert.net)
  • We have previously proposed a partnership between local radiation and immunotherapy in the treatment of cancer ( 1 ). (aacrjournals.org)
  • 1,2 Dietary fat has received considerable attention as a possible risk factor in the etiology of colon cancer. (springer.com)
  • For the most current information, contact the National Cancer Institute via the Internet web site at http://cancer.gov or call 1-800-4-CANCER. (healthlinkbc.ca)
  • It is the second neoplastic cause of death in developed countries (10% of cancer deaths in males and 11% in females) (1). (isciii.es)
  • It is estimated that in 2012 577,190 Americans (US) will die from cancer, corresponding to more than 1,500 deaths per day [ 1 ]. (mdpi.com)
  • Journal Article] Bitter gourd seed fatty acid rich in 9c, 11t, 13t-conjugated linolenic acid induces apoptosis and up-regulates the GADD45, p53 and PPARγ in human colon cancer Caco-2 cells. (nii.ac.jp)
  • Glucagon-like peptide-1 (GLP-1) and glucagon-like peptide-2 (GLP-2) are secreted in parallel from the intestinal endocrine cells after nutrient intake. (nih.gov)
  • GLP-2 is an intestinal growth hormone and is shown to promote growth of colonic adenomas in carcinogen treated mice. (nih.gov)
  • It is possible that DPP-4 inhibition by enhancing the exposure of endogenous GLP-2 to the intestinal epithelia also might mediate growth and promote neoplasia. (nih.gov)
  • We investigated the intestinal growth effect of the GLP-1 receptor agonists (GLP-1 RAs) (liraglutide and exenatide) and DPP-4 inhibition (sitagliptin) in healthy mice. (nih.gov)
  • Recent evidence that radiation induces an immunogenic tumor cell death and alters the tumor microenvironment to enhance recruitment of antitumor T cells supports the hypothesis that radiation can enhance both the priming and the effector phase of the antitumor immune response ( 2 - 5 ). (aacrjournals.org)
  • Group 1 served as normal control (normal saline, 3 ml/kg/day, p.o. (ovid.com)
  • A/J (highly susceptible), SWR/J (relatively susceptible) and AKR/J (resistant) mice were treated with 10 mg/kg AOM or saline i.p. once a week for 6 weeks and were killed at 1, 2, 4, 6, 9 and 24 weeks after the last injection. (oup.com)
  • Indeed, many reports have observed notably altered immune cell densities and cytokine profiles during CRC development ( 13 - 21 ), in which significantly increased CD4 and CD8-positive T lymphocyte populations are observed ( 22 - 24 ), along with decreased expression levels of T H 1 cytokines and increased expression levels of T H 2 cytokines in patients with CRC ( 7 , 8 , 25 , 26 ). (frontiersin.org)
  • 1,2-Dimethylhydrazine (DMH), a potent colon carcinogen, undergoes oxidative metabolism resulting in the production of electrophilic diazonium ion, which is known to elicit oxidative stress in the RBCs [ 4 ]. (hindawi.com)
  • Both GLP-1 analogues were potent growth stimulators of the healthy mouse intestine. (nih.gov)
  • Billed on The Dr. Oz Show as the "#1 supplement you've never heard of that you should be taking," astaxanthin is a super-potent dietary antioxidant with strong immunomodulatory and anti-inflammatory properties. (prohealth.com)
  • Luteolin has been reported to display a wide range of bioactive properties, such as anti-virus ( 1 , 2 ), hepatoprotective ( 3 ), anti-inflammatory ( 4 ) and anti-diabetic effects ( 5 ). (spandidos-publications.com)
  • 1984). Dietary or topically-applied BHA caused an inhibition in epidermal ornithine decarboxylase activity induced by 12-1-tetradec-anoylphorbol-13-acetate in mice (Kozumbo et al . (inchem.org)
  • The mechanism of action is probably associated with the ability of DHA to regulate COX-2 production, which decreases the expression of the antiapoptotic proteins Bcl-2, accelerating apoptosis. (scielo.br)
  • GLP-1 is an incretin hormone and analogues are available for the treatment of type 2 diabetes mellitus (T2DM). (nih.gov)
  • In making the overall evaluation, the Working Group took into account that 1,2-dimethylhydrazine is consistently mutagenic in a wide range of test systems and gives rise to a similar pattern of DNA damage in human and animal tissues in vitro . (inchem.org)
  • Since humans have no enzyme capable of hydrolyzing the β(21) bond, these fructans also serve as dietary fiber (Ojansivu et al. (academicjournals.org)
  • Human clinical trials have shown a protective effect of calcium supplementation on colorectal neoplasia ( 1 , 2 ), and epidemiologic data are broadly in agreement ( 3 - 6 ). (aacrjournals.org)
  • 1,2-Dimethylhydrazine formed DNA adducts and induced gene mutations, DNA breaks and micronuclei in vitro and in vivo in rodents. (inchem.org)
  • The analysis of gene expression showed that M2000 could effectively reduce the expression levels of COX-1 and COX-2 in comparison with untreated patients. (springermedizin.de)
  • Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter. (cancerindex.org)
  • 1,20 This results from reduced appetite and food intake, impaired nutrient absorption, and age-related medical and social changes. (lifeextension.com)
  • and third, to assess the activity of COX-1 and COX-2 enzymes in the presence/absence of M2000 at the different doses in the murine macrophage, J774 cell line. (springermedizin.de)
  • Low-power light micrograph of a transverse section of the distal colon from a normal mouse (A) and a mouse with transmissible murine colonic hyperplasia (B). Bar, 1 mm. (asmscience.org)
  • Interestingly, the results in this study revealed that SNL glycoprotein has suppressive effects on activity of nuclear factor-kappa B (NF-κB), whereas it has stimulatory effect on the expression of p53, accompanying inhibitory effects on expression of NF-κBp50, inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), interleukin (IL)-6, and tumor necrosis factor (TNF)-α in DMH-stimulated ACF formation. (springer.com)