InflammationVivoAcuteLipopolysaccharideMurineSecretionNeutrophilMonocyteMiceCytokinesInhibitionMacrophageImmunoglobulinOxidativeMSCsEfficacyBacterialSignificantlyMouseInfectionPatientsCellsPhagocytosisOxidative stressLiver injuryIntestinalPeritonealInflammatory264.7 cellsInhibitorAmelioratesInjuryModelsProductionEffect
Inflammation9
- Studies in Alzheimer's disease animal models, in stroke patients and in human retina pigment epithelial cells (RPE) have shown that PD1 can potentially reduce inflammation induced by oxidative stress and inhibit the pro-apoptotic signal, thereby preventing cellular degeneration. (wikipedia.org)
- These mediators are essential to induce correct healing and prevent from fibrosis and chronic inflammation. (ambiotis.com)
- Using co-culture models and mouse peritonitis model, we showed that exosomes from Raw264.7 cells overexpressing PPARγ inhibited LPS-induced inflammation in co-cultured human PMCs and in mice through downregulating CD14 and TLR4, two key regulators of the salmonella infection pathway. (bvsalud.org)
- Signals in the cervical vagus nerve controlled hepatic inflammation and markers of HSC activation in zymosan-induced peritonitis. (biomedcentral.com)
- We confirm that the protein has biological activity in acute inflammation, causing a significant reduction in monocyte recruitment during zymosan induced peritonitis. (ox.ac.uk)
- Using the zymosan induced peritonitis model of sterile inflammation we demonstrated that acute (1 h prior to zymosan) inhibition of BTK using a wide range of FDA (Ibrutinib and Acalabrutinib) and non-FDA approved inhibitors (ONO-4059, CNX-774, Olumatinib and LFM-A13) reduced neutrophil and monocyte recruitment. (ox.ac.uk)
- An important goal in pharmaceutics is to break the inflammatory cascade by blockage or suppression of specific cytokines and chemokines known to induce and amplify lung inflammation. (meliordiscovery.com)
- This LPS-induced inflammation model recapitulates aspects of the inflammatory cascades that are associated with pulmonary inflammation associated with lung disease in humans, and so is useful as a screen for compounds that may disrupt these cascades and attenuate or abort the disease process. (meliordiscovery.com)
- If you are interested in learning more about the LPS-induced Pulmonary Inflammation model, please contact us to start the conversation today! (meliordiscovery.com)
Vivo4
- CONCLUSIONS: These results suggested that overexpression of PPARγ largely altered the proteomic profile of macrophage exosomes and that exosomal PPARγ from macrophages acted as a regulator of intercellular communication to suppress LPS-induced inflammatory responses in vitro and in vivo via negatively regulating the CD14/TLR4 axis. (bvsalud.org)
- When challenged in vivo in zymosan-induced peritonitis and experimental asthma in mice, compound 73 showed remarkable anti-inflammatory efficacy. (inrae.fr)
- Finally, in zymosan-induced murine peritonitis, CBD increased SPM and 12/15-LOX products and suppressed pro-inflammatory eicosanoid levels in vivo. (therichardrosereport.com)
- We demonstrated superior LT biosynthesis in human neutrophils and monocytes, and in mouse macrophages from females, and we confirmed these sex differences in vivo where female mice produced more LTs during zymosan-induced peritonitis versus males. (unisa.it)
Acute2
- As a result of this defective neutrophil function, stim1-/- chimeras are protected from tissue injury in the zymosan model of acute peritonitis and show significantly reduced tissue injury in a hepatic ischemia reperfusion model. (ucsf.edu)
- These conditions are induced and exacerbated by pro-inflammatory molecules keyed to respond to acute infection, but often result in chronic immunological responses that induce acute crises and damage lung tissue over time. (meliordiscovery.com)
Lipopolysaccharide2
- Co-culture models of supernatants or exosomes with PMCs, as well as a mouse peritonitis model induced by lipopolysaccharide (LPS), were employed. (bvsalud.org)
- MSX (at 15, 30 and 60 mg kg-1) alleviated lipopolysaccharide-induced peritonitis by reducing the levels of pro-inflammatory cytokines including interleukin-1 beta (IL-1ß), IL-6, and tumor necrosis factor alpha (TNF-α) in the serum and major organs of the mice. (bvsalud.org)
Murine1
- We approached this issue with a small natural product derived oligosaccharide with TLR4 modulating activity that delicately balances the immune system and the production of anti-inflammatory and pro-inflammatory cytokines in a murine model of peritonitis. (nature.com)
Secretion3
- In vitro analysis using human adipose derived stem cells (hADSCs) showed that mTNs effectively scavenged reactive oxygen species (ROS) and enhanced osteogenesis of hADSCs by inducing secretion of alkaline phosphatase. (springeropen.com)
- We now show that HGE bacteria, and the HGE-44 protein, induce IL-8 secretion in a promyelocytic (HL-60) cell line that has been differentiated along the neutrophil lineage with retinoic acid and in neutrophils. (neuroprobe.com)
- They are often derived from the cell wall of gram-negative bacteria and induce immunoglobulin secretion. (lookformedical.com)
Neutrophil3
- XID mice, which have a point mutation in the Btk gene had reduced neutrophil and monocyte recruitment to the peritoneum following zymosan challenge. (ox.ac.uk)
- Interleukin-8 (IL-8) is a chemokine that induces neutrophil migration to sites of infection for host defense against pathogens. (neuroprobe.com)
- Store-operated calcium entry" (SOCE) into cells is one of the major intracellular signaling responses that induce neutrophil activation. (ucsf.edu)
Monocyte1
- Detailed metabololipidomics analysis in human monocyte-derived macrophages showed that CBD (i) upregulates exotoxin-stimulated generation of SPMs, (ii) suppresses 5-lipoxygenase (LOX)-mediated leukotriene production, and (iii) strongly induces SPM and 12/15-LOX product formation in resting cells by stimulation of phospholipase A 2 -dependent PUFA release and through Ca 2+ -independent, allosteric 15-LOX-1 activation. (therichardrosereport.com)
Mice1
- Male C57BL/6 J mice were subjected to either sham surgery, surgical vagotomy, or electrical vagus nerve stimulation followed by intraperitoneal injection of the TLR2 agonist zymosan. (biomedcentral.com)
Cytokines1
- This can be recapitulated in vitro by treating MSCs with inflammatory cytokines TNF α and IFN γ , which induce indoleamine 2,3-dioxygenase (IDO) and TNF-stimulated gene-6 (TSG-6). (biomedcentral.com)
Inhibition1
- All compounds showed levels of inhibition of zymosan-induced peritonitis comparable or superior to indomethacin, indicating an expressive anti-inflammatory profile. (unlp.edu.ar)
Macrophage4
- Here, we explored whether PPARγ (peroxisome proliferator-activated receptor gamma) can be packaged into macrophage exosomes to mediate intercellular communication and regulate peritonitis. (bvsalud.org)
- RESULTS: In this study, using stable Raw264.7 cells overexpressing GFP-FLAG-PPARγ (OE-PPARγ), we found that PPARγ inhibited LPS-induced inflammatory responses in Raw264.7 cells and that PPARγ was incorporated into macrophage exosomes during this process. (bvsalud.org)
- Oxidized low-density lipoprotein (ox-LDL)-induced macrophage activation is critical for the formation of atherosclerosis plaque. (biomed.news)
- However, the association between SCFAs and ox-LDL-induced macrophage activation with respect to the formation of atherosclerosis plaque has not yet been elucidated. (biomed.news)
Immunoglobulin1
- The immunoprecipitates of the aliquots of bacterial culture containing imipenem or complement with anti-PNR immunoglobulin G (IgG) induced a twofold-higher IL-8 production than did the immunoprecipitates of the aliquots of bacterial culture with a control IgG. (neuroprobe.com)
Oxidative1
- Protective effect of electrolyzed reduced water on the paraquat-induced oxidative damage of human lymphocyte DNA. (h2bev.com)
MSCs2
- The immunomodulatory property of MSCs is induced or licensed by inflammatory factors such as TNF α , IFN γ , and IL1. (biomedcentral.com)
- Our group specializes in determining the cellular and molecular mechanisms of beneficial effects of mesenchymal stem cells (MSCs) in diseases that include heart disease, diabetes, and peritonitis. (tamu.edu)
Efficacy1
- Herein, the efficacy of MSX in a peritonitis mouse model was evaluated in a dose-finding study and the underlying mechanisms were explored using data-independent acquisition (DIA) proteomics assay. (bvsalud.org)
Bacterial2
- Bacterial killing of P. aeruginosa by antimicrobial agents induced PNR release and mediated IL-8 production in human bronchial epithelial (BET-1A) cells. (neuroprobe.com)
- Thus, new therapeutic approaches are needed to effectively inhibit the hyperinflammation produced by the overwhelming cytokine response during bacterial infection without developing resistance to secondary infection in abdominal infections like peritonitis. (nature.com)
Significantly2
- All studied compounds significantly inhibited acetic acid-induced writhing response. (unlp.edu.ar)
- Furthermore, DIA proteomics analyses identified a panel of proteins that were significantly altered (both up- and down-regulated) in the peritonitis group, which were counteracted by the MSX treatments. (bvsalud.org)
Mouse1
- In the late phase (4-8 hrs) of mouse zymosan-induced peritonitis and rat carrageenan-induced pleurisy, PG levels in males were higher versus females, seemingly due to higher PG production in infiltrated neutrophils. (unisa.it)
Infection1
- These results demonstrate that HGE bacteria induce IL-8 production by host cells and, paradoxically, appear to exploit this chemokine to enhance infection. (neuroprobe.com)
Patients2
- Thrombocytopenia following peritonitis in surgical patients. (cornell.edu)
- Introduction Primary peritonitis (PP) is peritonitis occurring in patients without underlying causes such as perforated viscus, preexisting ascites, or nephrosis. (omeka.net)
Cells2
- BACKGROUND: Intercellular communication between macrophages and peritoneal mesothelial cells (PMCs) has been suggested as a key factor regulating peritonitis development. (bvsalud.org)
- We have recently reported that nitrite reductase, a bifunctional enzyme located in the periplasmic space of Pseudomonas aeruginosa , could induce interleukin-8 (IL-8) generation in a variety of respiratory cells, including bronchial epithelial cells (K. Oishi et al. (neuroprobe.com)
Phagocytosis1
- interaction and IL-10 constrain inflammation-induced macrophage phagocytosis of healthy self-cells. (omicsdi.org)
Oxidative stress1
- Studies in Alzheimer's disease animal models, in stroke patients and in human retina pigment epithelial cells (RPE) have shown that PD1 can potentially reduce inflammation induced by oxidative stress and inhibit the pro-apoptotic signal, thereby preventing cellular degeneration. (wikipedia.org)
Liver injury5
- 6. Propofol attenuates inflammatory response and apoptosis to protect d-galactosamine/lipopolysaccharide induced acute liver injury via regulating TLR4/NF-κB/NLRP3 pathway. (nih.gov)
- 7. Protective effects of morin on lipopolysaccharide/d-galactosamine-induced acute liver injury by inhibiting TLR4/NF-κB and activating Nrf2/HO-1 signaling pathways. (nih.gov)
- 11. Protective Effects of Sesquiterpenoids from the Root of Panax ginseng on Fulminant Liver Injury Induced by Lipopolysaccharide/d-Galactosamine. (nih.gov)
- 14. Protective effects of tenuigenin on lipopolysaccharide and d-galactosamine-induced acute liver injury. (nih.gov)
- 17. Hepatoprotective effect of chiisanoside from Acanthopanax sessiliflorus against LPS/D-GalN-induced acute liver injury by inhibiting NF-κB and activating Nrf2/HO-1 signaling pathways. (nih.gov)
Intestinal1
- [ 40 ] This resulted in a phenotype characterized by decreased fatty acid uptake in the mesenteric lymph nodes, increased chylous ascite formation, fibrinopurulent peritonitis, intestinal fibrosis and cachexia. (medscape.com)
Peritoneal1
- Fungal peritonitis in a patient on peritoneal dialysis (PD) is a refractory injury accompanied by severe inflammation, predisposing patients to a poor prognosis. (nih.gov)
Inflammatory2
- 10. Quercetin disrupts tyrosine-phosphorylated phosphatidylinositol 3-kinase and myeloid differentiation factor-88 association, and inhibits MAPK/AP-1 and IKK/NF-κB-induced inflammatory mediators production in RAW 264.7 cells. (nih.gov)
- Further, the in vivo performance of the compounds and compositions were studied under two in vivo inflammatory models (LPS-induced endotoxaemia and carrageenan-induced paw oedema). (bvsalud.org)
264.7 cells1
- When the culture broth extract of P. polonicum (EEPP) was subjected to LPS-induced cytokines expression (ELISA in RAW 264.7 cells), it exhibited inhibition of TNF-α, IL-6 and IL-1ß and this encouraged us to do chemical investigation on EEPP to explore the bioactive components. (bvsalud.org)
Inhibitor1
- Treating with a water soluble and highly selective iNOS inhibitor, 1400W, for 3 days significantly reduced OPNA-induced brain changes in those animals that had mild-moderate SE in the rat DFP model. (bvsalud.org)
Ameliorates1
- 9. Pretreatment of lipopolysaccharide (LPS) ameliorates D-GalN/LPS induced acute liver failure through TLR4 signaling pathway. (nih.gov)
Injury2
- Defective clearance of necrotic tissue interferes with amelioration of tissue injury and induces abnormal tissue remodeling. (nih.gov)
- However, MCMs alone are inadequate to prevent OPNA-induced brain injury and behavioral dysfunction in survivors. (bvsalud.org)
Models1
- Here, we investigated potential roles of AIM in prevention of progression of fungal peritonitis models. (nih.gov)
Production1
- We have previously shown that OPNA exposure-induced SE increases the production of inducible nitric oxide synthase (iNOS) in glial cells in both short- and long- terms. (bvsalud.org)
Effect1
- 15. Hepatoprotective effect of cryptotanshinone from Salvia miltiorrhiza in D-galactosamine/lipopolysaccharide-induced fulminant hepatic failure. (nih.gov)