AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation ScienceNamed GroupsGeographicals
ViremiaMicronesiaFlavivirusFlavivirus InfectionsViral LoadSimian Acquired Immunodeficiency SyndromeSimian immunodeficiency virusMacaca mulattaHIV InfectionsHIV-1RNA, ViralAntibodies, ViralVirus ReplicationCytomegalovirus InfectionsBK VirusCD4 Lymphocyte CountAntiretroviral Therapy, Highly ActiveDNA, ViralAnti-HIV AgentsCD4-Positive T-LymphocytesViral VaccinesPolyomavirus InfectionsSAIDS VaccinesDengue VirusFlaviviridae InfectionsDengueHepatitis CGB virus CAntiviral AgentsCytomegalovirusCD8-Positive T-LymphocytesHIVVirus SheddingDNA Virus InfectionsNeutralization TestsHepacivirusPorcine Reproductive and Respiratory SyndromeAntibodies, NeutralizingWest Nile FeverWest Nile virusPolymerase Chain ReactionOrganophosphonatesHepatitis, Viral, HumanAIDS VaccinesCircoviridae InfectionsHIV AntibodiesPorcine respiratory and reproductive syndrome virusMacaca nemestrinaVaccines, AttenuatedHepatitis C AntibodiesGene Products, envAntigens, ViralTime FactorsMacacaYellow fever virusTorque teno virusAcquired Immunodeficiency SyndromeAnti-Retroviral AgentsGene Products, gagDisease Models, AnimalHepatitis, Viral, AnimalAlphavirus InfectionsWest Nile Virus VaccinesPlasmaHIV Long-Term SurvivorsCircovirusMolecular Sequence DataDrug Resistance, ViralHepatitis AntibodiesFlaviviridaeDengue VaccinesYellow Fever VaccineLeukocytes, Mononuclear
InfectionDENVMicrocephalyChikungunya virusCongenitalCHIKVDengue virusOutbreakFlavivirusArbovirusEpidemicOutbreaksSingle-strandedInfectionsFlavivirusesRhesus monkey2016SymptomsIsolatesAntiviralBrazilReplicationGenomeNeurological disordersArbovirusesEpidemicsPregnantPoorlyCasesVectorsMortalityStrainsCytokineManifestationsVitroComplicationsAcuteNewbornMethodsGenomicDetection
Infection57
  • Clinical timeline for a 22-year-old pregnant woman who had suspected Zika virus infection. (cdc.gov)
  • The generation of ZIKV genomes has been challenging due to the transient viremia upon infection . (caddecentre.org)
  • Both CHIKV and ZIKV related deaths are usually associated with Guillain-Barré syndrome [ 2 ] although recently ten death cases of ZIKV infection unrelated to the Guillain-Barré syndrome have been confirmed in adults [ 2 ]. (biomedcentral.com)
  • However, host immunity- and immune-mediated pathogenesis in ZIKV infection are not well understood. (biomedcentral.com)
  • Whether IL-22 plays, a role in ZIKV infection is unknown. (biomedcentral.com)
  • The cellular source of IL-22 was identified in IFNAR -/- mice and wild-type (WT) neonatal mice during ZIKV infection. (biomedcentral.com)
  • We found that γδ T cells were the main source of IL-22 during ZIKV infection in both the spleen and brain. (biomedcentral.com)
  • ZIKV infection also induced the activation of microglia and astrocytes in vitro. (biomedcentral.com)
  • ZIKV infection is a major concern for public health by virtue of its spread to South and Central America in 2014, leading to thousands of human infections in Brazil [ 4 ]. (biomedcentral.com)
  • Recent studies demonstrate that several types of brain cells are the targets of ZIKV infection. (biomedcentral.com)
  • Astrocytes are critical for host defense during ZIKV infection, as they are the first cells targeted by ZIKV in the brain [ 10 ]. (biomedcentral.com)
  • Zika virus (ZIKV) infection usually is mild and self-limited. (medscape.com)
  • Multiple antiviral drugs are under investigation for treatment of ZIKV infection. (medscape.com)
  • netic and serologic properties of the ZIKV associated with In 1977, ZIKV infection was confi rmed among 7 pa- this epidemic. (folkhalsomyndigheten.se)
  • Z ported human infections indicated that clinical characteris- ika virus (ZIKV) is a mosquito-transmitted virus in the tics of infection with ZIKV included fever, headache, mal- family Flaviviridae and genus Flavivirus . (folkhalsomyndigheten.se)
  • Several ZIKV human recent fl avivirus infection in several patients. (folkhalsomyndigheten.se)
  • The current scenario regarding the widespread Zika virus (ZIKV) has resulted in numerous diagnostic studies, specifically in South America and in locations where there is frequent entry of travelers returning from ZIKV-affected areas, including pregnant women with or without clinical symptoms of ZIKV infection. (frontiersin.org)
  • This situation has created an alarming public health emergency of international concern requiring the detection of this life-threatening viral candidate due to increased cases of newborn microcephaly associated with ZIKV infection. (frontiersin.org)
  • Previously, only sporadic cases of negligible concern associated with human ZIKV infection were reported ( Hayes, 2009 ). (frontiersin.org)
  • Considering the calamity of ZIKV infection, there is an urgent need to develop rapid detection methods for ZIKV along with DENV, which shares common clinical symptoms with ZIKV. (frontiersin.org)
  • You can't do infection of DENV then ZIKV in Macaques and say it's the best test of ADE. (microbe.tv)
  • In the seminal set of rhesus macaque studies published by Halstead et al (1973), they found that primary infection with any of the four DENV serotypes followed by subsequent infection with DENV-1 or DENV-4 a year later actually caused partial protection (reduced viremia and better HAIs). (microbe.tv)
  • If I (and 9 of my friends) get infected with DENV-1, and I pool our sera together, and then inject THAT pooled sera into macaques in the right titration followed by subsequent infection with DENV or ZIKV, then I've hedged my bets against some of that inherent biovariability! (microbe.tv)
  • Until someone A) does passive transfer of anti-DENV sera in macaques followed by ZIKV infection showing no enhancement (with large n) or B) shows clear evidence of primary - secondary infection enhancement from DENV - DENV side by side with no enhancement from DENV - ZIKV, I don't think there's a good reason to believe these macaque models track directly with human disease. (microbe.tv)
  • Many medically important and emergent arboviruses (arthropod-borne viruses) originated in non-human primates (NHPs), which typically show no clinical signs of infection but become viraemic and help maintain the virus in nature [ 1 ]. (biomedcentral.com)
  • ZIKV infection diagnosis relies on serology-which is challenging due to cross-reactions with other flaviviruses and/or absence or low titer of IgM and IgG antibodies at early phase of infection- virus isolation, which is labor intensive, time consuming and requires appropriate containment. (biomedcentral.com)
  • Therefore, real-time RT-PCR (rRT-PCR) is an appealing option as a rapid, sensitive and specific method for detection of ZIKV in the early stage of infection. (biomedcentral.com)
  • This assay is a useful tool for detection of ZIKV infection in regions where a number of other clinically indistinguishable arboviruses like dengue or chikungunya co-circulate. (biomedcentral.com)
  • Further studies are needed to validate this assay in clinical positive samples collected during acute ZIKV infection. (biomedcentral.com)
  • The non-specific clinical presentation can be confused with most other arboviruses particularly dengue and chikungunya virus infection. (biomedcentral.com)
  • The apparently mild acute infection was associated with serious consequences, such as the increase in the number of cases of Guillain-Barre (already seen after the French Polynesia epidemic) and microcephaly, in ZIKV epidemic regions. (tts.org)
  • Infection with ZIKV is asymptomatic in most people. (tts.org)
  • Be aware that ZIKV infection results in an asymptomatic viremia in most people, consequently, donors travelling from epidemic regions might be infected. (tts.org)
  • More recently, unexpected outbreaks of ZIKV infection have occurred in Brazil and rapidly spread from South America to Central-American and Asian countries, involving millions of residents. (datexis.com)
  • As the increasing cases of ZIKV sexual transmission and multiple harmful outcomes to fetuses have been reported, women who are pregnant or trying to conceive are now regarded as at especially high risk for ZIKV infection, and thus the need for effective treatments has become ever more pressing. (datexis.com)
  • With the increasing recognition of the epidemiology and pathogenicity of ZIKV infection, it is urgent to develop potent therapies. (datexis.com)
  • Currently, there are no vaccines or therapeutic drugs approved to treat ZIKV infection, although great progress has been achieved. (datexis.com)
  • Many already-approved drugs have been discovered to significantly inhibit ZIKV infection, but few can be safely used by pregnant women because most are highly toxic. (datexis.com)
  • To determine the ready-to-use inhibitors for ZIKV infection, we screened a drug library consisting of FDA-approved medical drugs with good safety, and erythromycin estolate (Ery-Est), which could be safely used by pregnant women, was found to inhibit ZIKV infection efficiently. (datexis.com)
  • For example, clarithromycin and the macrolide therapy have been utilized to treat respiratory syncytial virus and Middle East respiratory syndrome coronavirus (MERS-CoV) infection respectively, and ivermectin and azithromycin (Azi) were identified to effectively inhibit ZIKV infection. (datexis.com)
  • These include dengue fever in 2012, Chikungunya fever in 2014 and Zika virus infection (ZIKV) in 2016. (zikaction.org)
  • The presence of Zika virus (ZIKV) infection has been associated with microcephaly in multiple studies, although little is known about ZIKV shedding in congenitally infected infants. (zikaction.org)
  • Large population-based studies will help to elucidate ZIKV epidemiology, vertical transmission, risks to the fetus of maternal ZIKV infection and natural history of congenital and non-congenital ZIKV infection as provided by the activities in the "ZIKAction" research consortium in Latin America, Europe and the Caribbean, which was recently funded by the European Commission. (zikaction.org)
  • This case series of two pregnant women infected with the Zika virus in Barcelona, Spain and provides an algorithm for diagnosing pregnant women with suspected ZIKV infection in non-endemic areas. (zikaction.org)
  • This study on a cohort of Haitian children presenting with undifferentiated febrile illness three cases of ZIKV infection were identified in a single week, supporting the presence of an outbreak in the region. (zikaction.org)
  • Mosquitoes belonging the Aedes ge- man cases were reported until 2007 when ings provided up-to-date information nus, particularly Aedes aegypti and Aedes the first Zika outbreak was reported in on ZIKV infection and its complications albopictus , which are the species most in- Yap, Micronesia ( 2 ). (who.int)
  • Zika virus infection with prolonged maternal viremia and fetal brain abnormalities. (rjppd.org)
  • 4) Cotton-rats, guineapigs and rabbits show no clinical signs of infection after intracerebral inoculation of late passage mouse brain virus. (paho.org)
  • Zika virus (ZIKV) infection is a global public health concern linked to adult neurological disorders and congenital diseases in newborns. (biomedcentral.com)
  • However, the mechanisms of LD formation and their roles in ZIKV infection in neural cells are still unclear. (biomedcentral.com)
  • Pharmacological inhibition of DGAT-1 decreased LD accumulation and ZIKV replication in vitro in human cells and in an in vivo mouse model of infection. (biomedcentral.com)
  • Moreover, we observed that inhibition of DGAT-1 inhibited the weight loss and mortality induced by ZIKV infection in vivo. (biomedcentral.com)
  • Our results reveal that LD biogenesis triggered by ZIKV infection is a crucial step for ZIKV replication and pathogenesis in neural cells. (biomedcentral.com)
  • However, the role of LDs during ZIKV infection is still poorly explored. (biomedcentral.com)
  • We hypothesize that LDs may contribute to ZIKV infection-induced neuropathology. (biomedcentral.com)
  • Here, we demonstrate that ZIKV infection alters cellular lipid metabolism in human neural cells, decreasing lipogenesis and increasing de novo lipid synthesis and remodeling. (biomedcentral.com)
  • We report 3 cases of perinatal Zika infection identified during the epidemic in Colombia and provide detailed descriptions of clinical features, diagnosis, and neurodevelopmental outcome at 18 months of age (corrected). (cdc.gov)
DENV10
  • All of these studies are investigating whether or not anti-DENV immunity can enhance ZIKV, but they aren't following the experimental design that showed the gold standard of DENV enhancing DENV. (microbe.tv)
  • If this method of testing ADE (serial infections in rhesus macaques) fails to show DENV - DENV enhancement (a comparably well characterized and understood clinical phenomena), how can we expect it to show enhancement in DENV - ZIKV? (microbe.tv)
  • Some arboviruses, like dengue (DENV), chikungunya (CHIKV) and Zika (ZIKV), have become fully adapted to urban cycles and no longer require NHPs, forest mosquitoes and a sylvatic cycle for their maintenance [ 7 ]. (biomedcentral.com)
  • Until the Zika virus (ZIKV) outbreaks in the Americas led to the recognition of non-mosquito-borne transmission, most reports on flavivirus transmission via non-vector routes have been on DENV, with rare reports on other flaviviruses. (biomedcentral.com)
  • The effect of vertical transmission of DENV on infants is highly relevant given the concern resulting from the recognition of ZIKV to cause adverse fetal outcomes including microcephaly. (biomedcentral.com)
  • They are transmitted through blood-feeding insects such as mosquitoes and ticks, and include viruses such as chikungunya virus (CHIKV), dengue virus (DENV), West Nile virus (WNV), Zika virus (ZIKV), yellow fever virus (YFV), and eastern equine encephalitis virus (EEEV). (encyclopedia.pub)
  • Zika virus (ZIKV) is a RNA virus of the Flaviviridae family, genus Flavivirus, which includes other well-known arboviruses such as West Nile virus (WNV), dengue virus (DENV) and yellow fever virus (YFV), the latter two also transmitted by Aedes mosquitoes. (tts.org)
  • Clinical presentation may help in the differential diagnosis in case of co-circulation of DENV and Chikungunya (CHKV). (tts.org)
  • The main signs and symptoms observed in infections caused by ZIKV, DENV and CHKV are shown in the table below. (tts.org)
  • ZIKV is transmitted by arthropods (mosquitoes genus Aedes ) as it happens for YFV, West Nile virus (WNV), Japanese encephalitic virus (JEV) and DENV. (biomedicineandprevention.com)
Microcephaly3
  • Brazil has reported the highest number of ZIKV cases worldwide and most cases associated with microcephaly and other birth defects. (caddecentre.org)
  • Genomes from microcephaly cases have been notoriously difficult to obtain because of low viremia in the babies born with the condition and the low overall risk for microcephaly per pregnancy despite very high attack rates . (caddecentre.org)
  • Microcephaly, the most worrying abnormality caused by ZIKV, is a fetal neurodevelopmental defect with resulting physical and learning disabilities, greatly impacting the quality of life of affected children. (datexis.com)
Chikungunya virus1
  • Both dengue fever virus (DFV) and zika virus (ZIKV) are flaviviruses whereas chikungunya virus (CHIKV) belongs to the alphavirus familiae [ 1 ]. (biomedcentral.com)
Congenital3
  • The Zika virus (ZIKV) outbreak that occurred in multiple countries was linked to increased risk of nervous system injuries and congenital defects. (biomedcentral.com)
  • Research groups in ZikaPLAN conduct clinical studies to investigate Zika's connection with congenital syndromes and neurological complications, as well as the pathogenesis of severe cases. (pasteur.fr)
  • ZIKV was found to be associated with Guillain-Barré syndrome in the epidemics of French Polynesia, and further damage caused by ZIKV, including severe congenital malformation, optic nerve abnormality, and reproductive system injury, have been discovered in recent ZIKV outbreaks. (datexis.com)
CHIKV5
  • In fact, serologic surveys have demonstrated that outbreaks attributed to dengue in the past have actually turned out to be CHIKV or ZIKV infections. (biomedcentral.com)
  • DFV and CHIKV are genetically distant relatives, however ZIKV is closely related to dengue and often cross reacts on DFV serology or on some rapid assays that are available at some posts [ 1 ]. (biomedcentral.com)
  • DFV and ZIKV are asymptomatic in approximately 75% of infections, in contrast to CHIKV where patients are symptomatic in 75-95% of infections [ 1 ]. (biomedcentral.com)
  • In both ZIKV and CHIKV there is a more common involvement of the anterior segment including conjunctivitis, uveitis and increased intra-ocular pressure (IOP). (biomedcentral.com)
  • The purpose of this review is to provide an overview of most prevalent arboviruses in Brazil (DFV, ZIKV, CHIKV) regarding the main features, physiopathology, and ocular involvement (Table 1 ). (biomedcentral.com)
Dengue virus1
Outbreak4
  • ZIKV was initially limited to sporadic transmission in Africa and Southeast Asia, and it was not until the 2007 outbreak of Zika virus illness on Yap Island, Federated States of Micronesia that people realized the virus was extending [4] . (cusabio.com)
  • Although ZIKV was isolated from a rhesus monkey in the Zika forest of Uganda in 1947, the virus was largely ignored until 2007 when it caused an epidemic on the island of Yap in Micronesia and Gabon [1] followed by an outbreak in French Polynesia during 2013 [2] . (tts.org)
  • A. hensilii has been the principal vector during the ZIKV outbreak in Yap State (Micronesia) in 2007. (biomedicineandprevention.com)
  • Zika Virus Outbreak in Haiti in 2014: Molecular and Clinical Data. (zikaction.org)
Flavivirus7
Arbovirus4
  • The illnesses caused by the arbovirus have very similar/overlapping clinical presentation with prominent fever, headache, rash, myalgia and arthralgia. (biomedcentral.com)
  • tory testing to the Arbovirus Diagnostic Laboratory at the Over the next 20 years, several ZIKV isolates were Centers for Disease Control and Prevention (CDC, Fort obtained from Aedes spp. (folkhalsomyndigheten.se)
  • Between 1968 and 2002, 606 strains including 10 human ZIKV strains were isolated in Central and West Africa countries and reported by the WHO Collaborating Center for Arbovirus and Viral Hemorrhagic Fever of Pasteur Institute in Dakar [ 20 ]. (biomedcentral.com)
  • Thus, ZIKV has been recognized as an emerging arbovirus and received attention globally. (datexis.com)
Epidemic6
  • These fi ndings indicated rado, USA that ZIKV was the causative agent of the Yap epidemic. (folkhalsomyndigheten.se)
  • ZIKV in their acute-phase specimen, or IgM and IgG posi- quence of ZIKV associated with this epidemic. (folkhalsomyndigheten.se)
  • Details of the epidemic, including clinical and labo- tigenic sin" phenomenon). (folkhalsomyndigheten.se)
  • However, in early 2015, when ZIKV epidemics hit the northeast region of Brazil, a populous country infested by both Aedes aegypti and A. albopictus , the epidemic showed its true colors. (tts.org)
  • Meanwhile, reports of sexual and blood transmitted ZIKV infections have increased the controversy associated with the epidemic [4],[5] . (tts.org)
  • We present the emergence of the ZIKV epidemic in Jamaica and outline the national response. (zikaction.org)
Outbreaks2
  • Recent outbreaks of ZIKV infections have become fatal on a daily basis in the Americas, where this obscure viral candidate has been placed at the forefront of global healthcare. (frontiersin.org)
  • However, since 2007, the threat to public health from ZIKV has steadily increased due to outbreaks in varying places, such as Yap Island, French Polynesia, and Micronesia. (datexis.com)
Single-stranded2
  • Like all flaviviruses, ZIKV is a single-stranded RNA virus with a positive-polarity RNA genome of approximately 11 kb. (biomedcentral.com)
  • The genome of ZIKV is a positive-sense single-stranded RNA, containing 10,794 nucleotides including 2 flanking non-coding regions (5' and 3' NCR). (biomedicineandprevention.com)
Infections4
  • Despite revised clinical classifications of dengue infections by the World Health Organization, the wide spectrum of the manifestations of dengue illness continues to pose challenges in diagnosis and patient management for clinicians. (frontiersin.org)
  • The reported occurrences of ZIKV infections are thought to be transmitted mainly by the mosquito species Aedes aegypti and Aedes albopictus . (frontiersin.org)
  • Therefore, it is important for the transplant community to be aware of the risk of ZIKV infections. (tts.org)
  • Ery-Est, one of the macrolide antibiotics, is the lauryl sulfate ester of propionyl erythromycin (Ery) (Figure 1A), and it has commonly been used for clinical bacterial infections. (datexis.com)
Flaviviruses2
  • The NS5 protein coding regions of African ZIKV isolates were sequenced and aligned with representative flaviviruses sequences from GenBank to design primers and probe from conserved regions. (biomedcentral.com)
  • The assay was shown to detect 37 ZIKV isolates covering a wide geographic in Africa and Asia over 36 years but none of the 31 other flaviviruses tested showing high analytical specificity. (biomedcentral.com)
Rhesus monkey2
  • ZIKV, an emerging neglected virus, was first documented in 1947 when it was isolated from a sentinel rhesus monkey stationed on a tree platform in the Zika forest, Uganda [ 12 ]. (biomedcentral.com)
  • ZIKV was initially isolated from a sentinel rhesus monkey in Zika forest, Uganda in 1947, and had been perceived as a less harmful virus with sporadically infected human cases, which showed mild symptoms, including fever, malaise, rash, and conjunctivitis. (datexis.com)
20161
  • Up until February 3rd 2016, 35 cases of travel-associated ZIKV diseases had been reported in the US [6] . (tts.org)
Symptoms1
  • the authors compared the hallmarks of clinical ADE (like viremia, clinical symptoms and cytokine levels) in both dengue naïve and exposed patients and showed no evidence of ADE. (glopid-r.org)
Isolates1
  • In this study, we described a one step rRT-PCR for ZIKV which can detect a wider genetic diversity of ZIKV isolates from Asia and Africa. (biomedcentral.com)
Antiviral1
  • Antiviral activity was identified when 2′-C-methylated nucleosides were tested, suggesting that these compounds might represent promising lead candidates for further development of specific antivirals against ZIKV. (paho.org)
Brazil4
  • Transmission of ZIKV in the Americas was first confirmed in May 2015 in northeast Brazil . (caddecentre.org)
  • However, phylogenetic and molecular clock analyses show a single introduction of ZIKV into northeast Brazil, most likely from the Pacific Islands, by February 2014 . (caddecentre.org)
  • The role of northeast Brazil in the establishment of ZIKV in the Americas is further supported by geographic analysis of ZIKV transmission potential and by estimates of the basic reproduction number of the virus . (caddecentre.org)
  • LHep-YF is marked by the rebound in liver enzymes and non-specific clinical manifestations around 30-60 days after YF symptom onset.METHODS: Here we have characterized the clinical course and risk factors for LHep-YF using data from a representative cohort of patients who survived YF in Brazil, 2017-2018. (stanford.edu)
Replication1
  • We tested a series of 2′-C- or 2′-O-methyl-substituted nucleosides, 2′-C-fluoro-2′-C-methyl-substituted nucleosides, 3′-O-methyl-substituted nucleosides, 3′-deoxynucleosides, derivatives with 4′-C-azido substitution, heterobase-modified nucleosides, and neplanocins for their ability to inhibit ZIKV replication in cell culture. (paho.org)
Genome2
  • Fortunately, novel multiplex PCR enrichment protocols enabled researchers to generate genome data in the field in 1-2 days from clinical samples using portable MinION sequencers or other sequencing platforms. (caddecentre.org)
  • First, a full-length functional ZIKV cDNA clone was engineered as a bacterial artificial chromosome, with each reporter gene under the cap-independent translational control of a cardiovirus-derived internal ribosome entry site inserted downstream of the single open reading frame of the viral genome. (mdpi.com)
Neurological disorders2
  • Meanwhile, the neurological disorders caused by ZIKV have been declared a global public health emergency by the World Health Organization (WHO). (datexis.com)
  • There is growing evidence that Zika virus (ZIKV) can cause devastating infant brain defects and other neurological disorders in humans. (paho.org)
Arboviruses1
  • As stated by Kuno & Chang [ 15 ], "The three commonly used data for identifying vertebrate reservoirs for arboviruses have been (i) virus isolation from suspected animals, (ii) relatively high antibody prevalence in the animals captured in the field and (iii) demonstration of viraemia (of higher virus titre and duration) in the suspected animals typically obtained under laboratory conditions" [ 15 ]. (biomedcentral.com)
Epidemics1
  • Zika virus (ZIKV) is a mosquito-borne fl avivirus fi rst studies in the absence of epidemics ( 6 - 8 ). (folkhalsomyndigheten.se)
Pregnant2
  • Here, we accessed samples from 153 pregnant women (77 without and 76 with CZS) and 143 newborns (77 without and 66 with CZS) exposed to ZIKV conducted a case-control study to verify whether interferon alfa receptor 1 (IFNAR1) and interferon lambda 2 and 4 (IFNL2/4) single nucleotide polymorphisms (SNPs) contribute to CZS outcome, and characterized placenta gene expression profile at term. (bvsalud.org)
  • Thus, the safety profile for pregnant women in the development of ZIKV inhibitors must be considered a priority. (datexis.com)
Poorly1
  • However, key molecules that mediate ZIKV encephalitis are poorly understood. (biomedcentral.com)
Cases1
  • The World Health Organization, WHO, announced that millions of cases of ZIKV are likely to occur in the USA in the near future. (frontiersin.org)
Vectors1
  • These early reports drew up a set of priority actions to be criminated as vectors of ZIKV and other described the disease as relatively mild: implemented by the Member States and arboviral diseases, have been found in a about 20% of people infected with ZIKV WHO to enhance preparedness and re- number of countries in the Region in- develop mild fever, skin rash, conjuncti- sponse capacities. (who.int)
Mortality3
  • IL-22 deficiency lessened weight loss, moderated the systemic inflammatory response, and greatly improved clinical signs of neurological disease and mortality. (biomedcentral.com)
  • The writers used systematic literature reviews, references to published clinical and epidemiological studies, morbidity and mortality reports, clinical and public health guidelines, authoritative statements, personal files, and expert opinion to summarize evidence and to indicate gaps in current knowledge. (cdc.gov)
  • CONCLUSIONS: The decline in stroke mortality is real and represents a major public health and clinical medicine success story. (cdc.gov)
Strains1
  • This method was used successfully to detect ZIKV strains from field-caught mosquitoes. (biomedcentral.com)
Cytokine1
  • In addition, glial cells were cultured in vitro and infected with ZIKV in the presence of IL-22, followed by the evaluation of cell proliferation, cytokine expression, and viral loads. (biomedcentral.com)
Manifestations1
  • To determine the role of IL-22, we challenged 1-day-old WT and IL-22 -/- mice with ZIKV and monitored clinical manifestations. (biomedcentral.com)
Vitro1
  • Although IL-22 displayed a negligible effect on glial cells in vitro, IL-22 -/- mice mounted more vigorous ZIKV-specific CD8 + T cell responses, which led to a more effective control of ZIKV in the brain. (biomedcentral.com)
Complications1
  • While several immune mediators were detected in high levels in ZIKV-infected patients, in this study, the levels of interleukin 10 (IL-10), interferon γ-induced protein (IP-10) and hepatocyte growth factor (HGF) were significantly different between patients with and without neurological complications. (glopid-r.org)
Acute1
  • A subset of ZIKV-infected insuffi cient to confi rm ZIKV as the recently infecting fl a- patients for whom acute- and convalescent-phase paired vivirus. (folkhalsomyndigheten.se)
Newborn1
  • We report a case of a newborn who had continued viremia with ZIKV for at least 67 days after birth. (zikaction.org)
Methods2
  • Hence, this review reports possible methods and strategies for the fast and reliable detection of ZIKV with particular emphasis on current updates, knowledge, and new hypotheses that might be helpful for medical professionals in poor and developing countries that urgently need to address this problem. (frontiersin.org)
  • This review summarizes the currently available methods employed for the rapid detection of ZIKV and suggests an innovative approach involving the application of a liposome-based hypothesis for the development of new strategies for ZIKV detection and their use as effective biomedicinal tools. (frontiersin.org)
Genomic1
  • Genomic studies have identified more subclasses of ZIKV, pointing to three major lineages: one Asian and two African. (biomedicineandprevention.com)
Detection1
  • We have developed a rapid, sensitive and specific rRT - PCR for detection of ZIKV. (biomedcentral.com)