The rapidly developing Zika virus (ZIKV) outbreak has research groups, government agencies, and industry is all striving to develop a response plan to contain and ultimately prevent ZIKV spread. (jcvi.org)
Zika virus (ZIKV) statistics in Honduras are the highest among countries in Central America. (emerald.com)
Zika virus (ZIKV) is an emerging human pathogen. (uams.edu)
Zika virus (ZIKV) was declared as "Public Health Emergency of International Concern" in 2016. (gsu.edu)
The current scenario regarding the widespread Zika virus (ZIKV) has resulted in numerous diagnostic studies, specifically in South America and in locations where there is frequent entry of travelers returning from ZIKV-affected areas, including pregnant women with or without clinical symptoms of ZIKV infection. (frontiersin.org)
J amaica Minister of Health, Dr. the Hon. Christopher Tufton [/su_pullquote]Minister of Health, Dr. the Hon. Christopher Tufton, says Jamaica will shortly be participating in a number of clinical trials in the drive to find a vaccine to treat the Zika Virus (ZIKV) . (caricom.org)
ZIKV was initially limited to sporadic transmission in Africa and Southeast Asia, and it was not until the 2007 outbreak of Zika virus illness on Yap Island, Federated States of Micronesia that people realized the virus was extending [4] . (cusabio.com)
Zika virus (ZIKV), a mosquito-borne transplacentally transmissible flavivirus, is an enveloped virus with an ~10.8 kb plus-strand RNA genome that can cause neurological disease. (mdpi.com)
The rapid development of a safe and effective vaccine to prevent the Zika virus (ZIKV) is a global priority, as infection in pregnant women has been shown to lead to fetal microcephaly and other major birth defects. (news-medical.net)
The health ministry is continuing to urge women to delay pregnancy until further notice in light of the threat that Zika virus ( ZIKV ) poses to newborn babies. (jamaica-gleaner.com)
The Zika Virus (ZIKV) happens to be one of the recent infections investigated after the Ebola pandemic. (amrita.edu)
Zika virus (ZIKV) has emerged as a global pathogen causing significant public health concern. (korea.ac.kr)
Zika virus (ZIKV) infection usually is mild and self-limited. (medscape.com)
Moreover, any approved anti-Zika drug should be reasonably-priced as the majority of the ZIKV circulation occurs in tropical and sub-tropical countries with limited-resources. (medscape.com)
Here, we begin to address this question, examining ADAR expression in publicly available datasets of congenital infections of human cytomegalovirus (HCMV) microarray expression data, as well as mouse cytomegalovirus (MCMV) and mouse / human induced pluripotent neuroprogenitor stem cell (hiNPC) Zika virus ( ZIKV ) RNA-seq data. (bvsalud.org)
Open in a separate window Number 3 2-D08 inhibits the replication of Zika computer virus (ZIKV) in U251 and Huh-7 cells. (bso14.org)
The Zika virus (ZIKV) outbreak that occurred in multiple countries was linked to increased risk of nervous system injuries and congenital defects. (biomedcentral.com)
181B potentially associated with Zika virus (ZIKV) has highlighted the urgent need to identify individuals infected with ZIKV. (who.int)
Project Summary Zika virus (ZIKV) is primarily transmitted to people through the bite of an infected mosquito from the Aedes genus, mainly Aedes aegypti, although the virus can also be transmitted through sexual intercourse. (hhs.gov)
Even more troubling, vertical transmission of ZIKV is not limited to microcephaly alone, but it is now directly linked to multiple, albeit still severe, dysfunctions in the development of the brain and the eyes, called the Congenital Zika Syndrome. (hhs.gov)
Zika virus (ZIKV) is mainly transmitted through Aedes mosquito bites, but sexual and post-transfusion transmissions have been reported. (springer.com)
For this purpose, Shi's laboratory developed an attenuated Zika vaccine that they named ZIKV-LAV. (medicalnewstoday.com)
In tests, ZIKV-LAV was non-virulent and protected both mice and non-human primates against Zika infection. (medicalnewstoday.com)
Imani Duncan-Price was on the ground in the community of Wickie Wackie on Saturday helping with garbage clean-up, as well as a door-to-door sensitisation programme aimed at getting residents in the East Rural St Andrew constituency up to speed about the threat from the Aedes aegypti mosquito, vector for the dreaded Zika virus (ZIKV). (jamaica-gleaner.com)
Zika virus (ZIKV) is an arbovirus (mosquito-borne), first detected in Uganda in the 1940s. (news-medical.net)
Since 2015, the most recent Zika virus (ZIKV) epidemic has spread to more than 80 countries and territories. (cdc.gov)
Zika virus (ZIKV) is an emerging infectious disease that was first identified in 1947, and that has more recently become a major public health threat around the world. (justia.com)
Zika virus (ZIKV) is a mosquito-borne pathogen that caused a major epidemic in the Americas in 2015-2017. (imperial.ac.uk)
We combined multiple data sources to improve estimates of ZIKV infection attack rates (IARs), reporting rates of Zika virus disease (ZVD) and the risk of ZIKV-associated NC for 28 capital cities in Colombia. (imperial.ac.uk)
In the alarming context of risk of Zika virus (ZIKV) transmission in the Euro-Mediterranean area, there is a need to examine whether capacities to detect, diagnose and notify ZIKV infections in the region are in place and whether ongoing capacity-building initiatives are filling existing gaps. (biomedcentral.com)
The first round of this global EQAP took rus (YFV) and Zika virus (ZIKV), and alphaviruses like place in 2016 as a continuation and global expansion chikungunya virus (CHIKV), are major threats to hu- of an EQAP initially developed in the WHO Western man health worldwide. (who.int)
4 ). Zika virus disease has seemingly not made its way to It assessed laboratory proficiency to detect DENV, CHIK, the Region, although the Aedes vectors are present in the ZIKV and YFV (supplementary) by polymerase chain countries mentioned and suitable habitats may be found reaction (PCR). (who.int)
Organization, 2016 (http://www.who.int/mediacentre/news/ statements/2016/emergency-committee-zika-microcephaly/en/, accessed 21 March 2016). (who.int)
http://www.who.int/csr/resources/publications/zika/laboratory- testing/en/, accessed 28 March 2016). (who.int)
http://www.who.int/emergencies/zika-virus/situation-report/en/, accessed 21 March 2016). (who.int)
Zika virus (ZIKV) is a mosquito-borne fl avivirus fi rst studies in the absence of epidemics ( 6 - 8 ). (folkhalsomyndigheten.se)
Zika virus (ZIKV), a flavivirus transmitted by Aedes species mosquitoes, was first identified in the Zika Forest by the Virus Research Institute in Uganda in a non-human primate in 1947 and from Aedes africanus mosquitoes in 1948. (cdc.gov)
Due to the rapidly evolving epidemic of Zika virus infection, the Council of State and Territorial Epidemiologists (CSTE) Executive Board developed an interim position statement to establish standardized case definitions for Zika virus disease and ZIKV congenital infection dated February 26, 2016, and to add these conditions to the Nationally Notifiable Diseases List. (cdc.gov)
Zika virus ( ZIKV )] infection in pregnancy appears to be the cause of a recognizable pattern of congenital anomalies that is consistent and unique," write Cynthia A. Moore, MD, PhD, from the Division of Congenital and Developmental Disorders, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia, and colleagues. (medscape.com)
Infection42
As of October 12, 2016 the Centers for Disease Control and Prevention reported 3,936 cases of ZIKV infection, with two Florida cities identified as the Ground Zero for local transmission. (jcvi.org)
In each area, additional funding would accelerate our efforts to understand and ultimately control ZIKV infection in the human population. (jcvi.org)
We developed ZIKV NS1 IgM and IgG capture ELISAs and applied four indicators: IgM values, capture IgM/IgG ratios, IgG avidity, combined IgG avidity and capture IgM/IgG ratios, to differentiate ZIKV recent and past infection for a cohort of serum collected in ZIKV epidemic regions of Bogota, Colombia. (gsu.edu)
The specificity for differentiating ZIKV recent and past infection using each of the four indicators is: 62.50%, 84.21%, 58.33%, and 47.37%, respectively. (gsu.edu)
This situation has created an alarming public health emergency of international concern requiring the detection of this life-threatening viral candidate due to increased cases of newborn microcephaly associated with ZIKV infection. (frontiersin.org)
Previously, only sporadic cases of negligible concern associated with human ZIKV infection were reported ( Hayes, 2009 ). (frontiersin.org)
Considering the calamity of ZIKV infection, there is an urgent need to develop rapid detection methods for ZIKV along with DENV, which shares common clinical symptoms with ZIKV. (frontiersin.org)
Thus, host skin cells are permissive to ZIKV infection and are the first line of defense against the virus. (korea.ac.kr)
Here, we examined the role and mechanisms of antiviral skin immunity against ZIKV infection. (korea.ac.kr)
ZIKV infection (African lineage MR766) in human dermal fibroblasts, human epidermal keratinocytes, and HaCaT keratinocytes resulted in distinct expression changes in RIG-I-like receptors, such as RIG-I and MDA5. (korea.ac.kr)
Asian lineage ZIKV (PRVABC59) infection also showed a distinct pattern of antiviral immunity in human skin cells, compared with other ZIKV strains. (korea.ac.kr)
Multiple antiviral drugs are under investigation for treatment of ZIKV infection. (medscape.com)
JNK pathway restricts DENV2, ZIKV and CHIKV infection by activating complement and apoptosis in mosquito salivary glands. (pasteur.fr)
However, host immunity- and immune-mediated pathogenesis in ZIKV infection are not well understood. (biomedcentral.com)
Whether IL-22 plays, a role in ZIKV infection is unknown. (biomedcentral.com)
The cellular source of IL-22 was identified in IFNAR -/- mice and wild-type (WT) neonatal mice during ZIKV infection. (biomedcentral.com)
We found that γδ T cells were the main source of IL-22 during ZIKV infection in both the spleen and brain. (biomedcentral.com)
ZIKV infection also induced the activation of microglia and astrocytes in vitro. (biomedcentral.com)
ZIKV infection is a major concern for public health by virtue of its spread to South and Central America in 2014, leading to thousands of human infections in Brazil [ 4 ]. (biomedcentral.com)
Recent studies demonstrate that several types of brain cells are the targets of ZIKV infection. (biomedcentral.com)
Astrocytes are critical for host defense during ZIKV infection, as they are the first cells targeted by ZIKV in the brain [ 10 ]. (biomedcentral.com)
Because ZIKV continues to spread through the Americas, a better understanding of ZIKV pathology along with an efficient means to treat the infection is urgently needed. (hhs.gov)
Importantly, a physiologically-relevant SJL mouse model of ZIKV vertical transmission and chronic infection is employed in our in-depth studies, rather than interferon-knockout animals that perish in a few days post-infection. (hhs.gov)
Our Specific Aims are: (1) Determine the dynamics of fetal brain infection and investigate perinatal consequences following ZIKV vertical transmission in SJL mice, (2) Determine structural and functional consequences to the adult brain following congenital ZIKV infection in SJL mice, and (3) Determine the best treatment regimens for ZIKV infection using inhibitors of different stages of the viral life cycle and their combinations to prevent vertical transmission of ZIKV. (hhs.gov)
During acute infection, ZIKV is detectable in most organs and body fluids including human semen. (springer.com)
So far, the consensus is that ZIKV infection in the testes or epididymis might affect sperm development and, consequently, male fertility. (springer.com)
This manuscript provides an updated overview of the cellular and molecular mechanisms of ZIKV infection and reviews data on ZIKV persistence in semen and associated risks to the male reproductive system described in human and animal models studies. (springer.com)
Studies have linked maternal ZIKV infection during the first two trimesters to microcephaly. (news-medical.net)
She tested negative for ZIKV infection and remained asymptomatic. (cdc.gov)
While only one exposure resulted in infection, the reports underscore the continued need for good infection prevention practices in laboratories and other biomedical research facilities manipulating ZIKV. (cdc.gov)
The methods and compositions of this invention provide a means for prevention of ZIKV infection by immunization with live attenuated, immunogenic viral vaccines against ZIKV and/or Dengue virus. (justia.com)
netic and serologic properties of the ZIKV associated with In 1977, ZIKV infection was confi rmed among 7 pa- this epidemic. (folkhalsomyndigheten.se)
Z ported human infections indicated that clinical characteris- ika virus (ZIKV) is a mosquito-transmitted virus in the tics of infection with ZIKV included fever, headache, mal- family Flaviviridae and genus Flavivirus . (folkhalsomyndigheten.se)
Several ZIKV human recent fl avivirus infection in several patients. (folkhalsomyndigheten.se)
In 2007, an outbreak of ZIKV disease occurred on Yap Island, Federated States of Micronesia and the ensuing investigation included the first population-based epidemiological study of ZIKV infection and disease. (cdc.gov)
Additionally, numerous asymptomatic persons, particularly pregnant women are tested for ZIKV infection and will meet laboratory criteria for infection. (cdc.gov)
Because asymptomatic infection might be epidemiologically significant, revisions to the interim surveillance case definitions are proposed to include ZIKV infections without disease. (cdc.gov)
Congenital infections with HIV, varicella-zoster, and rubella virus may cause microcephaly, but distinctive findings such as hepatomegaly and rash help differentiate these from ZIKV infection. (medscape.com)
Clinical, epidemiologic, and laboratory evidence thus far is sufficient to determine that ZIKV infection can be transmitted from a pregnant woman to the fetus, resulting in microcephaly and serious brain anomalies. (medscape.com)
This is the first review characterizing the full spectrum of congenital abnormalities related to prenatal ZIKV infection. (medscape.com)
In particular, more data are needed on infants with congenital ZIKV infection who do not have microcephaly at birth and the brain findings in these infants," the reviewers conclude. (medscape.com)
They identified 34 published reports of congenital anomalies occurring in fetuses or infants with presumed or laboratory-confirmed intrauterine ZIKV infection. (medscape.com)
Infections18
JCVI, through an existing NIH funded grant, is working with the Biodefense and Emerging Infections Research Resources Repository (BEI Resources) to provide high quality sequence data for publically available ZIKV strains. (jcvi.org)
12 weeks post symptom onset) is a significant challenge of serological test, which is widely used to detect ZIKV infections. (gsu.edu)
The sensitivity for differentiating ZIKV recent and past infections using each of the four indicators is: 54.78%, 54.88%, 40.68%, and 31.25%, respectively. (gsu.edu)
Recent outbreaks of ZIKV infections have become fatal on a daily basis in the Americas, where this obscure viral candidate has been placed at the forefront of global healthcare. (frontiersin.org)
The reported occurrences of ZIKV infections are thought to be transmitted mainly by the mosquito species Aedes aegypti and Aedes albopictus . (frontiersin.org)
ZIKV infections in humans principally occur via mosquito bites. (korea.ac.kr)
Additionally, ZIKV infections in human neural progenitor cells induced the robust activation of RIG-I-like receptor-mediated signaling, followed by highly enhanced IFN-stimulated gene expression. (korea.ac.kr)
Changes in ADAR RNA editing patterns in CMV and ZIKV congenital infections. (bvsalud.org)
In all mouse infections cases, the number of editing sites was significantly increased in infected samples, albeit this was not the case for hiNPC ZIKV samples. (bvsalud.org)
Accordingly, the focus of our MPI research proposal is to greatly increase our understanding of the changes to brain pathology caused by long-term ZIKV infections, and a practical means to control the virus in a pharmacologically-beneficial manner by repurposing the current FDA-approved anti-viral and anti-malarial pharmaceuticals as cocktails. (hhs.gov)
No vaccine exists today to prevent ZIKV infections. (justia.com)
Although the majority of ZIKV infections are asymptomatic, the virus has been associated with congenital birth defects and neurological complications (NC) in adults. (imperial.ac.uk)
The estimated ZVD reporting rate was 0.013 (95% CrI: 0.004-0.024), and 0.51 (95% CrI: 0.17-0.92) cases of ZIKV-associated NC were estimated to be reported per 10 000 ZIKV infections. (imperial.ac.uk)
Considering this alarming context, the ECDC recently issued a ZIKV risk assessment for continental Europe, estimating an increasing number of travel-related reported ZIKV infections, and indicating a risk of transmission from imported cases by the Aedes albopictus mosquito species [ 13 ], now established in many parts of the European Union (EU), primarily around the Mediterranean [ 14 ]. (biomedcentral.com)
This finding raises the issue of whether capacities to detect, diagnose and notify ZIKV infections in the region are in place and whether ongoing capacity-building initiatives are filling existing gaps. (biomedcentral.com)
It was estimated that 75% (attack rate) of the island's inhabitants were infected with ZIKV resulting in 18% symptomatic and 82% asymptomatic infections. (cdc.gov)
Public health jurisdictions are encouraged to evaluate, report, and monitor identified ZIKV infections, particularly in pregnant women, that don't meet the clinical criteria of the confirmed and probable congenital and non-congenital disease case classifications. (cdc.gov)
To date, hematologic, hepatic, or renal laboratory abnormalities have not been reported in infants with congenital ZIKV infections. (medscape.com)
Virus7
The sequences of 196 published ZIKV genomes were used to assess whether recently proposed mechanistic explanations for microcephaly are supported by molecular level changes that may have increased its virulence since the virus left Africa. (uams.edu)
Dr. Tufton also told the gathering that Jamaica is among some 65 countries fighting ZIKV, and Jamaicans must appreciate the fact that the virus will continue to spread for a while. (caricom.org)
Meanwhile, Dr. Tufton said the Government is determined to empower citizens to fight ZIKV through the free flow of information at all levels, and that once persons are informed, they will be better able to tackle the virus. (caricom.org)
ZIKV is a mosquito-borne, single positive-stranded RNA virus of the Flaviviridae family, genus Flavivirus. (cusabio.com)
In the light of the identified gaps in our accumulated knowledge on the subject, we highlight the importance for couples seeking ART to follow the constantly revised guidelines and the need of specific ZIKV diagnosis tools for semen screening to contain ZIKV virus spread and make ART safer. (springer.com)
ZIKV has recently been shown to cause devastating neurological damage in infants and serious complications in adults in some cases, and may have other effects that have not yet been identified or definitively linked to the virus. (justia.com)
Vaccine development approaches for ZIKV include but are not limited to inactivated virus (dead virus), live attenuated virus (weakened virus), recombinant viral vectors (weakened virus with target genes added), and subunit (portion of a virus) as well as mRNA- and DNA-based (gene-targeted). (justia.com)
Microcephaly3
The mechanisms behind these teratogenic effects are unknown, although epidemiological evidence suggests that microcephaly is not associated with the original, African lineage of ZIKV. (uams.edu)
There is scientific consensus that ZIKV is a causative agent of microcephaly, a birth defect in children born to infected mothers and neuroimmune Guillain-Barré syndrome in infected adults. (hhs.gov)
The mechanisms of microcephaly and other defects related to congenital ZIKV syndrome are poorly defined. (news-medical.net)
Epidemic7
However, he says these women shouldn't be told to delay pregnancy especially since ZIKV isn't an epidemic in Jamaica. (jamaica-gleaner.com)
Because of its clinical importance and rapid spread, the ZIKV epidemic was declared a public health emergency of international concern by the World Health Organization between 1 February 2016 and 18 November 2016 [4,5]. (bso14.org)
The Occupational Safety and Health Administration (OSHA) and the National Institute for Occupational Safety and Health (NIOSH) within the Centers for Disease Control and Prevention (CDC) received reports of 3 ZIKV exposure incidents among such workers, each with clear links to work tasks, during the recent epidemic. (cdc.gov)
ZVD surveillance data were combined with post-epidemic seroprevalence data and a dataset on ZIKV-associated NC in a Bayesian hierarchical model. (imperial.ac.uk)
The resulting exchanges (methodological, communication and operational) across disciplines and across countries, dedicated research on intersectoral collaboration and increasing diagnostic capacities are providing new paths and tools to public health professionals to face emerging viral threats such as a ZIKV epidemic in the Euro-Mediterranean region. (biomedcentral.com)
These fi ndings indicated rado, USA that ZIKV was the causative agent of the Yap epidemic. (folkhalsomyndigheten.se)
ZIKV in their acute-phase specimen, or IgM and IgG posi- quence of ZIKV associated with this epidemic. (folkhalsomyndigheten.se)
In Pennsylvania in 2016, a needlestick injury to a woman who was manipulating ZIKV samples as part of a vaccine trial. (cdc.gov)
2. In New York in 2016, a bite from a ZIKV-infected mouse to 36-year-old man's finger as he was injecting an experimental drug into the mouse. (cdc.gov)
Western Pacific Surveillance and Response Journal , &task=doc_download&Itemid=270&gid=30176&lang=en, accessed 21 March 2016). (who.int)
DENV1
As the NS5 protein is definitely highly conserved among flaviviruses, we consequently hypothesized that SIMs similar to the one found in the DENV NS5 protein may also be present in the NS5 proteins of ZIKV and additional flaviviruses [1]. (bso14.org)
Aedes2
It's one-on-one," she disclosed, alluding to the efforts of people such as Patricia Morgan, councillor for the Dallas division, who was going door to door telling people about the need to clean up their area and distributing brochures with information about the dangers of ZIKV and the breeding habits of the Aedes aegypti . (jamaica-gleaner.com)
tory testing to the Arbovirus Diagnostic Laboratory at the Over the next 20 years, several ZIKV isolates were Centers for Disease Control and Prevention (CDC, Fort obtained from Aedes spp. (folkhalsomyndigheten.se)
Serum1
Over the upcoming year, JCVI anticipates screening both retrospective and prospective human serum samples for ZIKV, with the assumption that many of these samples are from individuals infected with other viral diseases (e.g. (jcvi.org)
Outbreak2
We provide an updated summary of the impact of the recent ZIKV outbreak on human-ART, weighing on current recommendations and diagnostic approaches, both available and prospective, with special emphasis on mass spectrometry-based biomarker discovery. (springer.com)
Therefore, these three factors need to be considered while assessing the risk of a ZIKV outbreak occurring in the Euro-Mediterranean area. (biomedcentral.com)
Clinical3
GSK484 hydrochloride The strategies utilized by ZIKV to evade the host immune response and replicate efficiently in a broad range of human cell types to cause these protean clinical manifestations are incompletely recognized [6,7]. (bso14.org)
To determine the role of IL-22, we challenged 1-day-old WT and IL-22 -/- mice with ZIKV and monitored clinical manifestations. (biomedcentral.com)
Enrolled in other clinical research (including other ZIKV research) requiring blood collection, which in combination with ZIP 2.0 evaluations, would exceed the lesser of 50 mL or 3 mL per kg in an 8-week period and/or blood collection would be required more frequently than two times per week. (who.int)
Vaccine4
The established vaccine technology at JCVI and our ability to rapidly identify and sequence ZIKV would allow the institute to pursue novel ZIKV vaccine platforms. (jcvi.org)
Also, now that they understand a little more about how the vaccine kills GSCs, they might tinker with ZIKV-LAV to make it more deadly to GSCs. (medicalnewstoday.com)
(http://www.who.int/entity/immunization/global_vaccine_action_plan/GVAP_doc_2011_2020/en/index.html, accessed 13 March 2018). (who.int)
http://www.who.int/immunization/global_vaccine_action_plan/previous_secretariat_reports_immunization_scorecards/en/ (accessed 13 March 2018). (who.int)
Antiviral3
Furthermore, ZIKV NS1 directly interacted with RIG-I or MDA5 and down-regulated RIG-I-like receptor-mediated antiviral signaling pathways. (korea.ac.kr)
Our findings provide important insights into ZIKV tropism and subsequent antiviral signaling pathways that regulate ZIKV replication in human dermal fibroblasts and human epidermal keratinocytes. (korea.ac.kr)
From these data, they concluded that in cells treated with ZIKV-LAV, an antiviral response was sparked, leading to inflammation and eventual cell death. (medicalnewstoday.com)
Flaviviruses1
In this study, we investigated for the presence of SIMs in the NS5 protein of ZIKV and additional flaviviruses, and evaluated the anti-ZIKV effect of the SUMO inhibitor 2-D08. (bso14.org)
Asymptomatic1
Molecular and serologic ZIKV tests were negative and the worker remained asymptomatic. (cdc.gov)
Isolates2
These strains represent a collection of ZIKV isolates, ranging from the initial 1947 isolate from Uganda to 2015 isolates from Puerto Rico, Colombia, and Panama, Mexico, and Honduras. (jcvi.org)
JCVI is providing the gold standard annotated reference sequence for all strains available from BEI and will continue this effort as BEI obtains additional ZIKV isolates. (jcvi.org)
Vaccines3
We expect these efforts to guide the rational design of ZIKV antivirals and vaccines to treat and prevent ZIKV-induced disease. (jcvi.org)
Further, vaccines and therapeutics for ZIKV are under various stages of development. (news-medical.net)
Many entities, governmental, academic, and commercial, are actively pursuing development of ZIKV vaccines each using a different approach to address this public health need. (justia.com)
Laboratory3
This enables the implementation of laboratory trainings on techniques that are common to several arboviruses, including ZIKV, and putting into action appropriate diagnostic tools in the target region. (biomedcentral.com)
Participant's biological mother has laboratory documentation of positive ZIKV RNA test results during pregnancy through delivery delivery or the participant has laboratory documentation of ZIKV RNA or serology positive/presumptive positive/equivocal ZIKV test within 5 days of birth according to the ZIKV-exposed definitions included in the ZIP 2.0 inclusion criteria. (who.int)
As laboratory testing for ZIKV has been more widely performed, limitations of the interpretation of serologic test results, including plaque reduction neutralization testing have been recognized, necessitating revisions to the laboratory criteria of the case definitions. (cdc.gov)
Acute2
Management of acute ZIKV cases is supportive, and evidence-based therapies are lacking. (news-medical.net)
A subset of ZIKV-infected insuffi cient to confi rm ZIKV as the recently infecting fl a- patients for whom acute- and convalescent-phase paired vivirus. (folkhalsomyndigheten.se)
Strains1
Currently JCVI is working with both private and public sector funders to sequence and analyze historical and current ZIKV strains. (jcvi.org)
Mice1
Although IL-22 displayed a negligible effect on glial cells in vitro, IL-22 -/- mice mounted more vigorous ZIKV-specific CD8 + T cell responses, which led to a more effective control of ZIKV in the brain. (biomedcentral.com)
Pregnancy2
He says in addition to delaying pregnancy people who have been diagnosed with ZIKV should not have unprotected sex. (jamaica-gleaner.com)
RNA test results and no positive ZIKV RNA test results at any time during her pregnancy through delivery. (who.int)
Participant and/or participant's biological mother previously enrolled in the ZIP study or other ZIKV cohort study approved by the sponsors. (who.int)
Americas2
More than 80 countries/territories in the Americas, Africa, and Asia have reported evidence of local vector-borne ZIKV transmission [5]. (bso14.org)
There were more than 40,000 cases of ZIKV in the Americas in 2022. (news-medical.net)
Prevention2
We here examine the actions and strategies that MediLabSecure has been implementing and how they will contribute to the prevention and control of the ZIKV threat in the Euro-Mediterranean area. (biomedcentral.com)
Centers for Disease Control and Prevention, Fort Collins, Colo- nucleotide identity with ZIKV. (folkhalsomyndigheten.se)
Diagnostic1
To distinguish between ZIKV and other viral diseases, we are developing a highly sensitive and specific ZIKV diagnostic PCR assay. (jcvi.org)
Human3
JCVI was recently awarded NIH supplemental funding to work with Sanofi-Pasteur to screen and sequence human samples suspected to be positive for ZIKV. (jcvi.org)
The ZIKV can be transmitted by two methods: human and human-to-human vectors. (amrita.edu)
Before 2007, there had been only 14 human ZIKV disease cases documented. (cdc.gov)
Poorly1
However, key molecules that mediate ZIKV encephalitis are poorly understood. (biomedcentral.com)
Sequences1
Work at JCVI is geared toward developing sensitive ZIKV diagnostics, significantly increasing the number of ZIKV genomic sequences available, and performing cutting-edge analysis on current and future sequence data. (jcvi.org)
ORGANIZATION2
The World Health Organization, WHO, announced that millions of cases of ZIKV are likely to occur in the USA in the near future. (frontiersin.org)
World Health Organization (WHO) expanded the Emergency Use Assessment and Listing (EUAL) Procedure established in July 2015, to ZIKV IVDs in order to determine their eligibility for procurement by WHO and other partners. (who.int)
20172
3. In Pennsylvania in 2017, a scalpel laceration to a 22-year-old female researcher who was harvesting chickens experimentally infected with ZIKV. (cdc.gov)
(http://www.who.int/immunization/web_2017_sage_gvap_assessment_report_en.pdf?ua=1, (accessed 13 March 2018). (who.int)
Rhesus1
ZIKV was first isolated from Rhesus macaques in Uganda in 1947. (frontiersin.org)
Protein2
ZIKV E mAb (1:400) were used for detecting ZIKV E protein in IFA. (leadgenebio.com)
Mouse ZIKV samples showed altered editing of well-established protein -recoding sites such as Gria3, Grik5, and Nova1, as well as editing sites that may impact miRNA binding. (bvsalud.org)
Detection2
Hence, this review reports possible methods and strategies for the fast and reliable detection of ZIKV with particular emphasis on current updates, knowledge, and new hypotheses that might be helpful for medical professionals in poor and developing countries that urgently need to address this problem. (frontiersin.org)
This review summarizes the currently available methods employed for the rapid detection of ZIKV and suggests an innovative approach involving the application of a liposome-based hypothesis for the development of new strategies for ZIKV detection and their use as effective biomedicinal tools. (frontiersin.org)
Clone1
First, a full-length functional ZIKV cDNA clone was engineered as a bacterial artificial chromosome, with each reporter gene under the cap-independent translational control of a cardiovirus-derived internal ribosome entry site inserted downstream of the single open reading frame of the viral genome. (mdpi.com)
Methods1
Given the new evidence on ZIKV, there is a need to revamp risk communication strategies so that they are informed by dynamic listening methods such as knowledge, attitudes, and practices. (emerald.com)
Urgent need1
There is therefore urgent need to develop biomedical interventions in parallel with ongoing public health efforts against ZIKV. (justia.com)