Young rats sprague dawley. Medical search. Frequent questions

However, an HEV strain recently isolated from rats was unique and only distantly related to known strains ( 11 ). (cdc.gov)

Timed-pregnant Sprague-Dawley rats (Charles River Laboratories, Raleigh, NC) were obtained on gestation day (GD) 0. (europa.eu)

The acute oral toxicity of alkenes, C11 -15 (Internal Olefin 114 LP11) was investigated using two groups of four male and four female Wistar rats, age approximately 12 weeks. (europa.eu)
In the first study (Rinehart, 1967), groups of ten male albino Wistar rats were administered 0, 5000, or 10,000 mg/kg bw C12-16 alpha olefin blend. (europa.eu)
Sprague Dawley [13538] and Wistar rats [130,139,140] have also been utilized as physiologically aged models by various authors. (adenosine-kinase.com)

RESULTS: Old rats had low TAK1 expression and were more susceptible to surgery-induced POCD and neuroinflammation than young rats. (imperial.ac.uk)
TAK1 inhibition exacerbated surgery-induced pRIPK1 expression, neuroinflammation and cognitive dysfunction in young rats, and this effect was reversed by a RIPK1 inhibitor. (imperial.ac.uk)
Conversely, genetic TAK1 overexpression attenuated surgery-induced pRIPK1 expression, neuroinflammation and cognitive dysfunction in old rats. (imperial.ac.uk)
CONCLUSION: Ageing-related decreases in TAK1 expression may contribute to surgery-induced RIPK1 overactivation, resulting in neuroinflammation and cognitive impairment in old rats. (imperial.ac.uk)
Capsaicin attenuates excitotoxic-induced neonatal brain injury and brain mast cell-mediated neuroinflammation in newborn rats. (cabi.org)

In scientific research, xylazine is a component of the most common anesthetic, ketamine-xylazine (see rodent cocktail), which is used in rats, mice, hamsters, and guinea pigs. (wikipedia.org)
Animals received ssniff SM R/M "Autoclavable complete diet for rats and mice - breeding and maintenance" produced by ssniff Spezialdiäten GmbH, D-59494 Soest Germany (Batch No.: 278 5652, expiry date: 30 November 2016), ad libitum, and tap water from the municipal supply, as for human consumption from a 500 ml bottles, ad libitum. (europa.eu)
Following the cecal ligation and puncture (CLP) procedure, intravenous dosing of AVR-25 (10 mg/kg, 6-12 h post-CLP) alone and in combination with antibiotic imipenem protected both young adult (10-12 week old) and aged (16-18 month old) mice against polymicrobial infection, organ dysfunction, and death. (nature.com)

Osteochondrosis occurs in a variety of domestic species, primarily as a lesion of young, rapidly growing animals, and is thought to be influenced by dietary, hormonal, anatomic, and genetic factors. (nih.gov)

Methods: Young adult, female Sprague-Dawley rats were used. (cdc.gov)
METHODS: Young (2-month-old) and old (24-month-old) Sprague-Dawley rats were subjected to splenectomy under isoflurane anaesthesia. (imperial.ac.uk)
Methods In order to attain our objectives, we utilized young adult male Sprague-Dawley rats. (bmj.com)
Methods A total of 36 8- to 10-week-old adult female Sprague-Dawley rats weighing 250 to 300 g were used. (bezmialem.edu.tr)
Methods: A total of 120 healthy male Sprague-Dawley rats were sacrificed, which aged4-5 months with body mass of 230-270 g. (cabi.org)

meats, biological trials were conducted on Albino rats of the Sprague-Dawley albino rats. (who.int)

To assess the developmental neurotoxicity of more realistic TRAP exposures, we exposed male and female rats during gestation and early postnatal development to TRAP drawn directly from a traffic tunnel in Northern California and delivered to animals in real-time. (nature.com)
2000 mg/kg body weight in male and female Sprague Dawley rats (OECD 402). (europa.eu)
Female Sprague-Dawley rats were starved for 24 h and then given [14C] test substance (0.8 mg/kg) as an aqueous solution by gastric intubation. (europa.eu)
Moreover, we reveal that, in male and female rats, this action depends on M-like potassium conductance. (jneurosci.org)
Finally, in a model of binge-eating in female rats, RXFP3 blockade within the PVN prevented binge-eating behavior. (jneurosci.org)
These data demonstrate a direct RLN3/RXFP3 action in the PVN of male and female rats, identify the associated ionic mechanisms, and reveal that hypothalamic RLN3/RXFP3 signaling regulates binge-eating behavior. (jneurosci.org)
Using a model of binge-eating, we demonstrated that relaxin-3/RXFP3 signaling in the hypothalamic paraventricular nucleus (PVN) is necessary for the expression of binge-eating behavior in female rats. (jneurosci.org)
Moreover, we elucidated the neuronal mechanism of RLN3/RXFP3 signaling in PVN in male and female rats and characterized sex differences in the RLN3 innervation of the PVN. (jneurosci.org)
This study investigated effects of cessation of exercise and honey supplementation on bone properties in young female rats. (blogspot.com)
In an acute oral toxicity study, groups of fasted Fisher 344 rats (5 male, 5 female) were given a single oral dose via gavage of hex-1-ene (Neodene 6) at doses of 0, 1000, 1800, 3200, or 5600 mg/kg bw and observed for 14 days (Albert et al. (europa.eu)
In the first investigation, groups of fasted, male and female Fischer 344 rats (5/sex) were given a single oral dose of undiluted Neodene 8 Alpha Olefin (oct-1-ene) at 5.0 mL/kg via oral intubation (Wilborn, 1983). (europa.eu)
5.0 mL/kg (equivalent to 3575 mg/kg bw using a density of 0.7149 mg/cm3 for oct-1 -ene) in male and female rats. (europa.eu)
Sixty one plants reputed to have anti-fertility activity were tested on female Sprague-Dawley rats, in order to isolate active compounds with a potential for use in human fertility regulation. (who.int)

Sprague-Dawley rats were exposed (parental, F1, and F2 generations) from gestation day 0 of the parental generation to postnatal day (PND) 6 of the F2 generation to a realistically proportioned mixture of THMs and HAAs at 0, 500×, 1,000×, or 2,000× of the U.S. Environmental Protection Agency's maximum contaminant levels (MCLs). (europa.eu)

The results demonstrated that Cd exposure disrupted the balance between the blood and intestinal flora in Sprague-Dawley (SD) rats, with a significant increase in gut microbiota ( Clostridia_UCG_014 , NK4A214_group ) and blood microbiome ( Corynebacterium , Muribaculaceae ). (frontiersin.org)
Histopathological and immunohistochemical assessments showed that young plasma had a protective effect on the intestinal tissues of aged rats, increasing cell density and reducing inflammation. (yyu.edu.tr)
These findings underscore the therapeutic potential of young plasma for mitigating age-related changes and inflammation in the intestinal tract. (yyu.edu.tr)

The absorption, distribution and excretion of test substance was determined by performing in vivo study in rats. (europa.eu)
We tested the in vivo effects of D alone (1.2 ml/kg bw/d), but also prior to and during 8 days of R intoxication (at 135 mg/kg bw/d) in a total of 4 groups of 40 adult Sprague-Dawley male rats each. (biomedcentral.com)
Sprague-Dawley (SD) rat models with SCI were established in vivo . (silverchair.com)
In the in vivo SD rat model, Gal-3 expression level was up-regulated. (silverchair.com)

Spinal cord injury (SCI) often occurs in young and middle-aged population. (silverchair.com)
Influence of chronic electroconvulsive seizures on plasticity-associated gene expression and perineuronal nets within the hippocampi of young adult and middle-aged Sprague-Dawley rats. (hutmentlab.com)

In the present study, we investigated the effects of Cd exposure on microbiota and serum metabolism in rats by omics analysis. (frontiersin.org)
We have previously demonstrated that very low levels of Roundup (0.1 ppb in tap water) exert endocrine-disrupting effects, such as sex hormone imbalances and hepatorenal toxicities, in mature rats after chronic exposure [ 19 ]. (biomedcentral.com)
Age-related long-term response in rat thyroid tissue and plasma after internal low dose exposure to 131I. (scilifelab.se)
The aims of this study were to compare 131I irradiation-dependent differences in RNA and protein expression in the thyroid and plasma of young and adult rats, and identify potential age-dependent biomarkers for 131I exposure. (scilifelab.se)
Rats were euthanized at 7, 12, and 24wk to evaluate local and systemic immune markers corresponding to the baseline, exposure, and recovery phases of the study, respectively. (cdc.gov)
In BN rats, resolution of immune alterations was further compromised by HF diet, as many exposure-induced alterations in local/systemic immune markers were still evident in HF/WF animals at 24wk. (cdc.gov)
Collectively, HF diet appeared to have a greater impact on global immune status and exposure-induced lung injury in SD rats, but a more pronounced effect on inflammation resolution in BN rats. (cdc.gov)

Early studies have Butoconazole medchemexpress demonstrated that testicular fragments, also as Leydig cells purified from aged Brown-Norway rats, exhibit a lowered maximal hCG-stimulated testosterone production compared to those of young adults [123,124]. (adenosine-kinase.com)
Accordingly, male Sprague-Dawley (SD) and Brown Norway (BN) rats were maintained on either regular (Reg) or high fat (HF) diets for 24wk. (cdc.gov)

Fourier transform infrared (FTIR) spectroscopy, linear discriminant analysis and support vector machine (SVM) techniques were employed to analyse the lipid, protein, and nucleic acid indices in young and aged rats. (yyu.edu.tr)

Biliary excretion was studied by means of a polyethylene cannula inserted into the common bile duct of rats anaesthetized with sodium pentobarbitone (40 mg/kg, ip). (europa.eu)

Bone - Osteochondrosis in a male F344/N rat from a chronic study. (nih.gov)

Young adult male Sprague-Dawley rats were fed one of twelve moderate-fat diets (25% of total energy) for 8weeks. (nih.gov)
Twelve young (5 weeks) and twelve adult Sprague Dawley rats (17 weeks) were i.v. injected with 50 kBq 131I (absorbed dose to thyroid = 0.1 Gy), and sixteen unexposed age-matched rats were used as controls. (scilifelab.se)

In male rats, TRAP significantly increased hippocampal neurogenesis, while in females, TRAP increased granule cell layer width. (nature.com)
Sood A, Chaudhari PR, Tiwari P, Shah S, Vaidya VA (2022), Acute immobilization stress evokes sexually dimorphic peripheral and hippocampal neuroimmune responses in adult rats. (hutmentlab.com)

In a study on rats, this pomegranate - cacao combination boosted total testosterone levels by over 72% after just six weeks. (lifeextension.com)

Experimental rats were trained in one of two repetitive tasks. (cdc.gov)

Following euthanasia using Nembutal (120 mg/kg body weight), rats were perfused intracardially with 4% paraformaldehyde. (cdc.gov)
1990]). Male Sprague-Dawley rats, 1 month old, were deeply anesthetized with Nembutal (10 mg/100 g body weight). (cellimagelibrary.org)

In this study, we measured hepatic parameters, including various cytochrome P450 enzymes, blood parameters, and locomotor activities in the adult Sprague-Dawley rat after R and/or D treatments. (biomedcentral.com)

We have isolated a genetically similar HEV from urban rats in Los Angeles, California, USA, and characterized its ability to infect laboratory rats and nonhuman primates. (cdc.gov)

Subsequently, in collaborations with the County of Los Angeles Department of Health (Los Angeles, CA, USA) Vector Management Program, we succeeded in transmitting to laboratory rats 2 strains of HEV from rats from Los Angeles but were again unable to obtain genomic sequence ( 14 ). (cdc.gov)

Results were compared to control rats, which are considered week 0 in this study. (cdc.gov)
This study was conducted to investigate the possible role of TAK1/RIPK1 signalling in POCD development following surgery in rats. (imperial.ac.uk)
A study from Japan found that drinking carbonated water led to feelings of fullness in young females. (medicalnewstoday.com)
In the second key study, 10 fasted, male Sprague-Dawley rats received a single oral dose of undiluted oct-1-ene at 10,000 mg/kg after which the animals were observed for 14 days (Monrose, 1973). (europa.eu)
This study aims to investigate the effects of plasma exchange on the biomolecular profiles and histology of ileum and colon tissues in young and aged Sprague-Dawley male rats. (yyu.edu.tr)
Background and Study Aims Spinal cord injury (SCI) is one of the most complicated pathologies that affect active young males. (bezmialem.edu.tr)
Preliminary study of protective effect of quercetin on blood-brain barrier in rats with traumatic brain injury. (cabi.org)
Objective: To study the protective effect of quercetin(Que) on blood- brain barrier in rats with traumatic brain injury(TBI) and its molecular mechanism. (cabi.org)

For real-time polymerase chain reaction (PCR) investigations, rats in groups 1, 2, and 3 were reoperated on after the first postoperative day, whereas those in groups 4, 5, and 6 were reoperated on after postoperative day 7 and spinal cord samples from the laminectomy area were removed for gene expression analysis. (bezmialem.edu.tr)
Thirty-five adult male Sprague Dawley were divided into five groups (n=7) according to extract/drug. (researchgate.net)

Soft tissues were dissected out and frozen sectioned en bloc into 15 micrometer longitudinal sections, while bones were paraffin embedded and cut into 5 micrometer sections, before mounting on coated slides. (cdc.gov)

At 7wk, HF-fed animals exhibited several immune alterations (blood leukocyte/neutrophil number, lymph node B-cell proportionality)-effects which were more pronounced in SD rats. (cdc.gov)

Age of animals at dosing: Young healthy adult rats, 8 weeks old. (europa.eu)
Early histologic evidence of osteochondrosis includes thickening or fragmentation of the basal layer of articular cartilage and may be observed in Sprague-Dawley rats as early as six weeks of age. (nih.gov)

Projection through optical section series of filled astrocyte in the adult rat dentate gyrus. (cellimagelibrary.org)
Animation through optical section series of a filled astrocyte in the molecular layer of the adult rat dentate gyrus imaged using confocal microscopy. (cellimagelibrary.org)

Our laboratory has developed a rat model of repetitive and forceful reaching and grasping. (cdc.gov)
We studied their seroepidemiology but were unable to obtain genomic sequence or to transmit an agent to laboratory rats. (cdc.gov)

Various neuropeptides play important roles in the regulation of feeding behavior, including relaxin-3 (RLN3), which stimulates food intake in rats through the activation of the relaxin-family peptide-3 receptor (RXFP3). (jneurosci.org)
Dynamic interplay between social brain development and nutrient intake in young children. (cabi.org)

Additionally, the expression levels of key inflammatory mediators tumour necrosis factor-alpha and cyclooxygenase-2 significantly decreased after young plasma administration. (yyu.edu.tr)

Si several not download 101 dalmatians (penguin young definitions que l DIN page song est a la employment, prenatal kiosk females. (sbcoastalconcierge.com)
The only remarkable change observed during necropsy was bilateral luminal dilation with clear fluid in the uterus of some treated females rats. (europa.eu)
No animals died at the 5.0 mL/kg dose level, however two male rats died after receiving 10 mL/kg (females unaffected). (europa.eu)

The rats were killed 3-9 months after administration. (scilifelab.se)

Thus, based on dosimetric relationships, determinants of airway injury sites following inhalation extrapulmonary airway injury in the rat may be predictive of intrapulmonary airway injury in humans. (cdc.gov)

Results: Discrete sites of von Kossa staining were present in forelimb tendons at the level of the wrist in week 6 and 12 HRLF rats, but not in controls. (cdc.gov)
Our results showed that taurine alone or in combination with zinc provides neuroprotection in the IUI rat model. (hindawi.com)
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Pregnancy and lactation in Sprague-Dawley rats result in permanent reductions of tibia trabecular bone mineral density and structure but consumption of red rooibos herbal tea supports the partial recovery. (brocku.ca)

Viral vectors carrying the DNA for human α-synuclein were injected into the rat vagus nerve to trigger protein overexpression in the medulla oblongata and consequent spreading of human α-synuclein toward pons, midbrain and forebrain. (biomedcentral.com)
Interneuronal α-synuclein transfer, which underlies protein spreading from the medulla oblongata to more rostral brain regions in this rat model, is not a mere consequence of passive release from damaged or dead neurons. (biomedcentral.com)

Six healthy young men performed 12 sets of 6- to 12-RM elbow flexion exercises with one arm while the opposite arm served as a control. (researchgate.net)

OA immunoreactivity increased in osteoclasts, periosteal cells, osteoctyes and osteoblasts, as well as in chondrocytes, tendon fi broblasts and mast cells, in 6-12 week HRLF rat radius and ulna. (cdc.gov)

Additionally, we developed an in situ rat alveolar fossa implantation model to evaluate the long-term therapeutic effects of NAC in bioroot transplantation. (biomedcentral.com)

however, diet appeared to preferentially impact SD rats at this time point, as several inflammatory markers (lymph node cellularity, lung neutrophils) were further elevated in HF over Reg animals. (cdc.gov)

AlexaFluor 568 hydrazide and AlexaFluor 568- and 488-conjugated goat anti-rat and anti-mouse secondary antibodies (highly cross-absorbed) were obtained from Molecular Probes (Eugene, OR). (cellimagelibrary.org)

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Honey was given to the rats at a dosage of 1 g/kg body weight/rat/day via force feeding for 7 days/week. (blogspot.com)

Title : Thalamocortical Dysfunction and Thalamic Injury after Asphyxial Cardiac Arrest in Developing Rats Personal Author(s) : Shoykhet, Michael;Simons, Daniel J.;Alexander, Henry;Hosler, Christina;Kochanek, Patrick M.;Clark, Robert S. B. (cdc.gov)

Morphologic investigation of osteochondrosis induced by ofloxacin in rats. (nih.gov)

Rat HEV was not transmissible to rhesus monkeys, suggesting that it is not a source of human infection. (cdc.gov)
Rats are particularly interesting as a potential source of human infections because although they are not a human food, they have a high seroprevalence of antibodies against HEV ( 12 , 13 ) and they are ubiquitous and in close contact with humans everywhere. (cdc.gov)

The rats were administered the extracts from day 1-10post- coitally and the anti- fertility effect was assessed on the sixteenth day at autopsy. (who.int)

The rats were then put on stock diet for 7 from the local market and dried in a hot days prior to the experiment. (who.int)
At the end of 10 days trial, all the rats were to each diet. (who.int)
The rats were fed the allotted killed with an overdose of chloroform and diet ad libitum for a period of 10 days. (who.int)

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Osteochondrosis occurs as a spontaneous lesion in aged rats, although lesions may sporadically occur earlier in life. (nih.gov)

2005). In both rats (Hubbs combination, was measured in the upper respiratory tract of et al. (cdc.gov)

Anatomy36

Organisms18

Diseases17

Chemicals and Drugs65

Analytical, Diagnostic and Therapeutic Techniques and Equipment30

Psychiatry and Psychology8

Phenomena and Processes56

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture4

Health Care4

Strain1

Charles River Labora1

Wistar3

Neuroinflammation5

Mice3

Species1

Methods5

Albino1

Female13

Gestation1

Intestinal3

Vivo4

Middle-aged2

Exposure7

Brown-Norway2

Indices1

Polyethylene1

Chronic1

Twelve2

Hippocampal2

Boosted total testosterone1

Experimental1

Nembutal2

Parameters1

Infect1

Subsequently1

Study8

Groups2

Tissues1

Alterations1

Weeks2

Adult rat2

Laboratory2

Intake2

Significantly1

Females3

Months1

Inhalation1

Results3

Bone1

Protein2

Healthy1

Mast1

Additionally1

Animals1

Molecular1

Body2

Injury1

Investigation1

Source2

Effect1

Days3

Main1

Occurs1

Combination1