• We have studied the human gamma delta T-cell response to Yersinia enterocolitica, a facultative intracellular bacterium which causes gastroenteritis and, particularly in human leucocyte antigen (HLA)-B27+ individuals, reactive arthritis (ReA). (nih.gov)
  • Yersinia enterocolitica is a Gram-negative bacillus-shaped bacterium, belonging to the family Enterobacteriaceae. (wikipedia.org)
  • Yersiniosis is an infectious disease caused by a bacterium of the genus Yersinia . (algomapublichealth.com)
  • Yersinia enterocolitica is an enteropathogenic bacterium that causes gastrointestinal disorders, as well as extraintestinal manifestations. (jimmunol.org)
  • Yersinia enterocolitica , a gram-negative bacterium, is responsible for 50% of all the clinical sepsis episodes that occur as a result of transfusion of contaminated red blood cells (RBCs) ( 19 ). (asm.org)
  • The ability of Y. enterocolitica to contaminate RBCs can be attributed to its being a psychrophilic bacterium that can survive well at refrigerator temperatures, using dextrose and iron from the blood. (asm.org)
  • Coloured scanning electron micrograph (SEM) of Yersinia enterocolitica is a Gram-negative, facultatively anaerobic, rod prokaryote in the family Enterobacteriaceae. (sciencephoto.com)
  • The diseases caused include self-limiting gastroenteritis, fatal septicemia (Guinet, et al 2011), and further extra-intestinal complications caused by virulent Y. enterocolitica , such as liver and spleen abscesses, pneumonia, (to learn more about pneumonia click here ! (uwlax.edu)
  • Moreover, YadA-mediated cell adherence supports the function of the protein secretion-translocation machinery to inject yersinia outer membrane proteins (Yops) into host cells, resulting in paralysis of professional phagocytes ( 7 ). (asm.org)
  • Single-molecule trajectories, measured in wild-type and mutant Yersinia enterocolitica cells, reveal that both SctQ and SctL exist in several distinct diffusive states in the cytosol, indicating that these proteins form stable homo- and hetero-oligomeric complexes in their native environment. (rsc.org)
  • To subvert the host's immune response, Y. enterocolitica uses a type III secretion system consisting of an injectisome and effector proteins, called Yersinia outer proteins (Yops), that modulate activation, signaling, and survival of immune cells. (jimmunol.org)
  • After establishing contact with specific host cells, Yersinia target some Yop proteins directly into the eukaryotic cytosol where these virulence factors exert their cytotoxic functions ( 2-4 ). (sciencemag.org)
  • Secretion of the hybrid proteins was measured by immunoblot analysis of the sedimented cells or medium of Yersinia cultures induced by temperature shift (37°C) and low calcium concentration ( 18 ). (sciencemag.org)
  • Here we present the first three-dimensional structure of Yersinia enterocolitica and Shigella flexneri injectisomes in situ and the first structural analysis of the Yersinia injectisome. (elifesciences.org)
  • Virulent Yersinia bacilli were demonstrated in the intestinal mucosa and in the lymphoid tissue of the submucosa associated with macrophages in patients with chronic ileitis and arthritis, in granulomatous centres of lymph nodes in patients with chronic lymphadenopathy and in portal infiltrates in a patient with chronic hepatitis. (nih.gov)
  • Y. enterocolitica causes a broad range of diseases ranging from acute bowel disease to extraintestinal manifestations such as reactive arthritis and uveitis. (asm.org)
  • Yersinia enterocolitica is a zoonotic pathogen widely distributed in nature that can cause acute gastroenteritis and mesenteric lymphadenitis mimicking appendicitis ( 4 ). (asm.org)
  • it is hypothesized that initial contamination results from transient bacteremia in donors with Y. enterocolitica diarrhea (or who are convalescing from Y. enterocolitia diarrhea), with the organism then multiplying during refrigerated storage. (oncologynurseadvisor.com)
  • Animals (pigs, birds, beavers, cats, and dogs) carry Yersinia enterocolitica and can cause contamination of soil and water, which in turn can contaminate foods of all types. (osu.edu)
  • The TaqMan assay is easy to perform, takes 2 h, and has the potential for use in the rapid detection of Y. enterocolitica contamination in stored blood units. (asm.org)
  • Crohn's disease has also been misdiagnosed when Yersinia enterocolitica is the cause of symptoms. (osu.edu)
  • We found higher expression of Gal-1 in the spleen and Peyer's patches of mice infected orogastrically with Y. enterocolitica serotype O:8 compared with noninfected hosts. (jimmunol.org)
  • Our results suggest that gamma delta T cells can be involved in immunity to Yersinia enterocolitica and should be taken into account when considering immunopathological mechanisms leading to reactive arthritis. (nih.gov)
  • We studied two type III secretion substrates, YopE and YopN, in Yersinia enterocolitica by analyzing translational fusions to cytoplasmic neomycin phosphotransferase (Npt) ( 16 ). (sciencemag.org)
  • The prevalence of elevated antibody titers against Yersinia enterocolitica was studied in normal subjects, patients with a variety of nonthyroidal illnesses, and patients with thyroid disease. (annals.org)
  • Pigs, in particular, are commonly colonized with Y. enterocolitica, with some studies reporting isolation of the organism from up to 90% of pork tongues/tonsils after slaughter. (oncologynurseadvisor.com)
  • Primers and a probe based on the nucleotide sequence of the 16S rRNA gene from Y. enterocolitica were designed. (asm.org)
  • The distribution of Yersinia enterocolitica in slaughtered pigs in China was studied. (asm.org)
  • We have identified four genes, irp1 , irp3 , irp4 , and irp5 , on a 13-kb chromosomal DNA fragment of Y. enterocolitica O8, WA-314. (asm.org)
  • Whole-blood samples were spiked with various numbers of Y. enterocolitica cells, and total chromosomal DNA was extracted. (asm.org)
  • AF366378 Yersinia enterocolitica 16S ribosomal RNA gene, partial sequence. (atcc.org)
  • The work aimed to study the morphology of colonies and their comparison by features of the formation of Yersinia enterocolitica biofilms. (veterinaryworld.org)
  • With stereoscopic microscopy of the colonies of Y. enterocolitica , the S-forms had an elevated intensely colored center, radial striation along the periphery, smooth edges, d ≤ 1.0 mm. (veterinaryworld.org)
  • Thus, we need to pay attention to which forms of colonies do Y. enterocolitica form on solid nutrient media: S- or R-forms. (veterinaryworld.org)
  • Yersinia enterocolitica accounts for 50% of the clinical sepsis episodes caused by the transfusion of contaminated red blood cells. (asm.org)
  • A marked proliferation of that cytotoxic gamma delta T cells is seen when Yersinia-infected lymphoblastoid cell lines or fixed intact Yersinia are added to cultures of mononuclear cells derived from the synovial fluid of ReA patients or from the peripheral blood of healthy donors. (nih.gov)
  • The in situ structures of the Y. enterocolitica and S. flexneri injectisomes had similar dimensions and were significantly longer than the isolated structures of related injectisomes. (elifesciences.org)
  • The results indicated that YopE is not modified upon export by the Yersinia type III machinery ( 11 ). (sciencemag.org)
  • The optical density of the Y. enterocolitica S-form showed that this type of microorganism belongs to the moderate producers of biofilms since the optical density of the sample (density of the sample - Ds) exceeded the optical density of control (density of the control - Dc) by 3 times. (veterinaryworld.org)