Year that multipotent adult progenitor cells stem cells. Medical search. Frequent questions

There are two basic types of stem cell: adult stem cells, which are limited in their ability to differentiate, and embryonic stem cells (ESCs), which are pluripotent and have the capability of differentiating into any cell type. (wikipedia.org)
Embryonic stem cells or induced pluripotent stem cells (iPSCs) are also utilized for AKI recovery. (biomedcentral.com)
Stem cells, including embryonic stem cells (ESCs) and adult stem cells, have the potential of self-renewal and differentiation into multiple cell types and therefore hold great promise in regenerative medicine [ 11 - 13 ]. (biomedcentral.com)
Efficient generation of retinal progenitor cells from human embryonic stem cells. (hkjo.hk)
XI - embryonic stem cells: embryonic cells that are capable of modifying the cells of any organism tissue. (hinxtongroup.org)
Stem cells are classified into two main: embryonic stem cells, which are found in the embryos and adult stem cells, found in adult tissues. (bvsalud.org)
Embryonic stem cells are present only in the early stages of development and are able to generate any cell type (Pluripotent Stem Cells). (bvsalud.org)

Epidermal growth factor (EGF) and fibroblast growth factor (FGF) are mitogens that promote neural progenitor and stem cell growth in vitro, though other factors synthesized by the neural progenitor and stem cell populations are also required for optimal growth. (wikipedia.org)
Novel genetic approaches have been implemented to identify and prospectively track primitive germ cell populations in the adult testis of both mice and humans, using a combination of in vitro and in vivo systems. (ny.gov)
Furthermore, the identification of mechanical properties distinct to stem cells could result in more successful sorting procedures to enrich multipotent progenitor cell populations. (duke.edu)
Current knowledge of cellular behavior is mainly acquired by studies concerning homogenous populations of cells cultured as monolayers. (intechopen.com)
Areas of research focus are beta cell replacement therapies for the treatment of diabetes, the identification of lung progenitor cell populations involved in lung repair, and in the diagnosis of pancreatic cancer. (ohsu.edu)
and 3) facilitate the purification of cell culture expanded cell populations for cell-based therapies. (ohsu.edu)
The development of therapeutic strategies for use of neural stem cells may rely on the ability to recruit or reprogram endogenous neural stem cells within the adult brain or may be achieved through the transplantation of identified populations of neural stem cells into injured brain regions. (neurorenew.com)
In this study, we present integrated quantitative proteome, transcriptome, and methylome analyses of hematopoietic stem cells (HSCs) and four multipotent progenitor (MPP) populations. (lu.se)
Classical markers for hematopoietic stem cells (HSCs), such as CD90 and CD49F, were largely preserved, whereas CD135 (FLT3) and CD123 (IL3R) had a ubiquitous expression pattern capturing heterogenous populations. (lu.se)
The findingssupport the hypothesis that G-CSF mobilizes two distinct stem cell populations, one from the bone marrow andthe other from the spleen. (fliphtml5.com)

Stem cells are characterized by their capacity to differentiate into multiple cell types. (wikipedia.org)
Adult NSCs differentiate into new neurons within the adult subventricular zone (SVZ), a remnant of the embryonic germinal neuroepithelium, as well as the dentate gyrus of the hippocampus. (wikipedia.org)
These neurospheres can differentiate to form the specified neurons, glial cells, and oligodendrocytes. (wikipedia.org)
I find it remarkable that we all have pockets of cells in our brains that can grow and differentiate throughout our lives and even after death," said Fred Gage , a professor at The Salk Institute and senior author of the study, which appears in the current Nature. (salk.edu)
Importantly, the recovered cells had the ability to differentiate into different types of brain cells. (salk.edu)
In addition to isolating single cells in order to determine if true stem cells are present in adult brain tissue, Gage also plans to transplant recovered cells into animals to test if the cells can survive and differentiate in vivo. (salk.edu)
Neural stem cells can also give rise to neural progenitor cells, which proliferate rapidly during their short lives and then 'differentiate' into neurons or glia. (elifesciences.org)
Since neurosphere-forming cells can self-renew and differentiate into neurons and glia, the ability of cells to form neurospheres has generally been taken as evidence that they are stem cells. (elifesciences.org)
Normal erythropoiesis begins with multipotent hematopoietic stem cells, which differentiate into erythroid progenitors, eventually to develop into the mature red blood cells. (medscape.com)
Stem cells have the ability to differentiate into specialised cells and have been transplanted into patients in an effort to treat various diseases. (biomedcentral.com)
Such cells from different sources can proliferate and differentiate into different lineages (e.g. osteogenic, chondrogenic and adipogenic) after suitable stimulation. (scirp.org)
In the last decade, cortical adult neurogenesis and its neural stem cells (NSCs), which are self-renewing and can generate neurons, astrocytes and oligodendrocytes, and neural progenitor cells (NPCs), which have a tendency to differentiate into certain types of neurons, have been found in the cerebral cortex of adult mammals 3 . (jneurology.com)
Multipotent retinal progenitors express developmental markers, differentiate into retinal neurons, and preserve light-mediated behavior. (hkjo.hk)
As needed, the stem cells differentiate to become a particular kind of cell-a white blood cell, red blood cell, or platelet. (medscape.com)
T lymphocytes originate via lymphoid stem cells that migrate to the thymus and differentiate under the influence of the thymic hormones thymopoietin and thymosin. (medscape.com)

Quiescent stem cells are Type B that are able to remain in the quiescent state due to the renewable tissue provided by the specific niches composed of blood vessels, astrocytes, microglia, ependymal cells, and extracellular matrix present within the brain. (wikipedia.org)
Tissue engineering and cell therapy approaches aim to take advantage of the repopulating ability and plasticity of multipotent stem cells to regenerate lost or diseased tissue. (tau.ac.il)
Recently, stage-specific embryonic kidney progenitor tissue was used to regenerate nephrons. (tau.ac.il)
The Organoid group, previously Clevers group, studies the molecular mechanisms of tissue development and cancer of various organs using organoids made from adult Lgr5 stem cells. (hubrecht.eu)
These cells represent the epithelial stem cells of the small intestine and colon (23), the hair follicle (24), the stomach (28) and many other tissue stem cell types. (hubrecht.eu)
Their findings indicate that postmortem tissue may be a potential source of multipotent stem cells, with a variety of uses and applications. (salk.edu)
Previous attempts to recover progenitor cells from adult tissue had failed, but the Gage laboratory applied growth factors to extracted tissue that appear to have made a crucial difference. (salk.edu)
The investigators obtained postmortem or biopsy tissue from 23 individuals, ranging in age from 11 weeks to 72 years old. (salk.edu)
Tissue from older individuals yielded fewer proliferating cells. (salk.edu)
This study employed a pool of cells from extracted tissue," said Gage. (salk.edu)
Testing in whole animals is the only way to know if adult tissue can be a source of stem or progenitor cells for transplant purposes to treat neurodegenerative disease," said Gage. (salk.edu)
An adult source of stem cells would circumvent the need to derive such cells from fetal tissue, currently an issue of ethical debate. (salk.edu)
The acute-phase HGF-treated group exhibited vascularization, diverse anti-inflammatory effects, and activation of endogenous neural stem cells after SCI, which collectively contributed to tissue preservation. (biomedcentral.com)
We isolated a new population of stem cells from human orofacial tissue gingiva, a tissue source easily accessible from the oral cavity, namely GMSC, which exhibited clonogenicity, self-renewal, and multipotent differentiation capacities. (ca.gov)
Unlike some other tissues, it has not been possible to identify or purify neural stem cells directly from the tissue. (elifesciences.org)
Our limited understanding of the complex cellular composition, anatomy, and function of this tissue has slowed the establishment of effective tissue regenerative (repair) and/or cell replacement (transplantation) therapies. (ohsu.edu)
Our laboratory, in collaboration with the laboratory of Jeffrey Whitsett, M.D., at the Cincinnati Children's Hospital, is generating and characterizing a panel of monoclonal antibodies targeting cell-surface markers on different subsets of pulmonary cells involved in the process of pulmonary tissue regeneration. (ohsu.edu)
Stem cell therapy raised hope of overcoming these issues, but created new risks including tumour formation and limited benefit if the desired target tissue does not form. (biomedcentral.com)
This article details the potential health risks of 3-dimensional organoid and tissue therapy versus dissociated stem cell therapy. (biomedcentral.com)
The current ethical and regulatory issues surrounding 3-dimensional organoid and tissue therapy are presented with a focus on the highly influential FDA and International Society of Stem Cell Research (ISSCR) guidelines. (biomedcentral.com)
Stem cells can be obtained from a donor or be autologous, eliminating any issues from the use of animals in tissue harvesting. (biomedcentral.com)
It is therefore expected that clinical trials implanting more complex 3-dimensional stem cell-derived tissue constructs (SCTCs) in humans will occur in the near future, including a recent report of autologous intestinal epithelial organoids being implanted into a patient with ulcerative colitis (jRCTb032190207) [ 2 ]. (biomedcentral.com)
Critical to the hypothesis is the experimental fact that human endometrial-derived stem cells (hEnSCs) as multipotent accessible source of cells are known as useful cell candidates in the field of nerve tissue engineering. (scirp.org)
These novel differentiated cells in fibrin gel might open new opportunities for the management of cell survival and neurotrophic potential in tissue engineering approaches for nerve repair. (scirp.org)
If the underlying ischaemia is not sufficiently resolved it can lead to tissue damage, with subsequent cell death. (biomedcentral.com)
This review will examine the clinical potential of several stem and progenitor cells that may be utilised to regenerate defunct or damaged vasculature and restore blood flow to the ischaemic tissue. (biomedcentral.com)
This leads to hypoxia and tissue damage as a consequence of the build up of waste metabolites and may result in cell death [ 1 ]. (biomedcentral.com)
Cells for vascular therapy must be able to home to ischaemic or damaged tissue and engage in vessel formation alone or in unison with resident vasculature to achieve a controlled and functional reperfusion event, without causing pathological angiogenesis (for example, proliferative retinopathy in the vitreous of the eye). (biomedcentral.com)
A cell therapy approach should be aimed at promoting revascularisation of ischaemic tissue. (biomedcentral.com)
There is a therapeutic window in which to deliver the cells, to avoid extensive tissue damage, fibrosis and necrosis. (biomedcentral.com)
Ando, W., Heard, B., Nakamura, N., Frank, C.B. and Hart, D.A. (2012) Ovine Synovial Membrane-Derived Mescenchymal Progenitor Cells Retain the Phenotype of the Original Tissue That Was Exposed to in Vivo Inflammation: Evidence for a Suppressed Chondrogenic Differentiation Potential of the Cells. (scirp.org)
Objective: Several countries have used mesenchymal stem cells (MSCs) in clinical trials for treating Coronavirus-19 (COVID-19) patients, considering their therapeutic effects through tissue repair and anti-inflammatory mechanisms. (istanbul.edu.tr)
Equine mesenchymal stem cells from bonemarrow, adipose tissue and umbilical cord:immunophenotypic characterization anddifferentiation potential. (sciendo.com)
Osteogenic proliferation and differentiation of canine bone marrow and adipose tissue derived mesenchymal stromal cells and the influence of hypoxia. (sciendo.com)
Adipose Tissue- and Bone Marrow-Derived Mesenchymal Stem Cells from Sheep: Culture Characteristics. (sciendo.com)
Eric Jenkins, Senior Medical Director and Head of Clinical Operations at Athersys, explained that the cells are not mesenchymal stem cells - adult stem cells traditionally found in bone marrow and other connective tissue - but are a different type of adult bone marrow stem cell called multipotent adult progenitor cells, and have greater growth potential in the lab. (labiotech.eu)
Rejuvenation therapies aim to reverse or repair age-related cellular changes such as molecular waste, calcification , tissue stiffening , loss of stem cell function , genetic alterations, and impaired energy production . (fightaging.org)
Microglia-the resident immune cells of the brain-are activated after brain lesions, e.g., cerebral ischemia, and polarize towards a classic "M1" pro-inflammatory or an alternative "M2" anti-inflammatory phenotype following characteristic temporo-spatial patterns, contributing either to secondary tissue damage or to regenerative responses. (biomedcentral.com)
On the one hand, this (sterile) neuroinflammation eliminates degenerating tissue, thus supporting a restorative milieu for neuroprotection, axonal regeneration, remyelination, and stem cell-mediated tissue repair. (biomedcentral.com)
In a resting state, microglia are involved in the maintenance of cell homeostasis surveying their microenvironment and communicating with the neuronal tissue via extremely motile processes and protrusions [ 8 ]. (biomedcentral.com)
Thus, it has been shown that early EPCs release cytokines that promote tissue regeneration and neovasculogenesis, whereas late EPC and endothelial colony forming cells (ECFCs) contribute to the formation of blood vessels and stimulate tube formation. (intechopen.com)
Mariano García Arranz has the following conflict of interest: MGA is inventor on 2 patents entitled "Identification and isolation of multipotent cells from non-osteochondral mesenchymal tissue" (10157355957US) and "Use of adipose tissue-derived stromal stem cells in treating fistula" (US11/167061). (wjgnet.com)
As a result of being capable of differentiating into a variety of cell types, it can be presumed that stem cell therapy has an advantage when compared to other tissue repair methods. (bvsalud.org)
The aim of this paper is to provide a review about current and future materials for scaffolds to carry stem cells in tissue engineering in Dentistry, especially for bone tissue repair. (bvsalud.org)
The ability to restore cells and tissue function without the need of immunosuppressive drugs and without the concern for tissue compatibility makes Mesenchymal Stem Cells (MSCs, usual acronym) a strong promise for the future. (bvsalud.org)
For stem cells to be used in tissue engineering a scaffold is essential to provide the necessary support for the transport of nutrients, oxygen and the elimination of metabolic waste 30 , promoting a conducive environment for cell growth and differentiation. (bvsalud.org)
The high regeneration potential has aroused a great interest in the scientific community 3 , due to its many clinical applications in cell therapy or tissue engineering. (bvsalud.org)
Cell therapy is a therapy where cellular material is injected systemically or directly into the injured tissue, to promote local repair or to restore systemic health. (bvsalud.org)
[ 1 ] The average weight of this tissue is about 4% of the total body weight, or 2.6 kg in an adult weighing 65 kg. (medscape.com)
Bone marrow consists of stem cells, which are large, "primitive," undifferentiated cells supported by fibrous tissue called stroma. (medscape.com)
There are 2 main types of stem cells and, therefore, the bone marrow consists of 2 types of cellular tissue. (medscape.com)

In particular, we focus on the therapeutic potential of endothelial progenitor cells as an exciting new option for the treatment of ischaemic diseases. (biomedcentral.com)
Human endothelial progenitor cells (hEPCs) are adult stem cells, located in the bone marrow and peripheral blood. (intechopen.com)
Different phenotypes and subtypes of endothelial progenitor cells (EPCs), such as early and late EPCs, have been described according to their functionality. (intechopen.com)

In mammals, physiological Wnt signaling is intimately involved with the biology of adult stem cells and self-renewing tissues (18,19). (hubrecht.eu)
These epithelial organoid cultures are genetically and phenotypically extremely stable, allowing transplantation of the cultured offspring of a single stem cell, as well as disease modeling by growing organoids directly from diseased patient tissues (32, 47, 53). (hubrecht.eu)
The cells derived from these tissues constitute a model system for studying the brain cell biology of these disorders, according to Gage. (salk.edu)
Somatic base substitution mutation rates in intestinal epithelial cells were elevated 2 to 4-fold in all individuals, except for one showing a 31-fold increase, and were also increased in other tissues. (bvsalud.org)
Following cell transplantation into a favorable environment, the transplanted NS/PCs survived well, facilitating remyelination and neuronal regeneration in host tissues. (biomedcentral.com)
Cell-based therapy using systemic infusion of GMSC in experimental colitis significantly ameliorated both clinical and histopathological severity of the colonic inflammation, restored the injured gastrointestinal mucosal tissues, reversed diarrhea and weight loss, and suppressed the overall disease activity in mice. (ca.gov)
Recently, MSCs isolated from bone marrow (bmMSCs) were shown to be a blend of distinct cells and MSCs isolated from different tissues show besides some common features also some significant differences. (hindawi.com)
Stem cell therapies hold immense promise in addressing these ailments by regenerating damaged tissues and organs. (imarcgroup.com)
The transplantation of iPSC-derived RPCs decreased the levels of biomarkers indicative of renal injury and attenuated the necrosis and apoptosis of renal tissues, but resulted in the up-regulation of renal tubules formation, cell proliferation, and the expression of pro-renal factors. (biomedcentral.com)
The National Academies of Sciences, Engineering and Medicine have also released guidance for "Human Embryonic Stem Cell Research" (2005 and updated in 2010) which provides no guidance on induced pluripotent stem cells (iPSCs) [ 3 ], and "The emerging field of human neural organoids, transplants, and chimeras" (2021) which didn't include other stem cell-derived tissues and deliberately excluded transplantation of organoids in humans [ 4 ]. (biomedcentral.com)
In July 2022, the European Union released a Proposal [ 5 ] to significantly change its regulation of cells and tissues and repeal Directive 2004/23/EC, the cornerstone of such regulation for the last two decades. (biomedcentral.com)
In vascular medicine, various stem cells and adult progenitors have been highlighted as having a vasoreparative role in ischaemic tissues. (biomedcentral.com)
The evaluation of the most suitable timing of cell delivery as well as the number of cells needed to integrate into resident vasculature and promote revascularisation of specific tissues requires careful optimisation and evaluation. (biomedcentral.com)
Mesenchymal stem/progenitor cells (MSC/MPC) are found in many tissues and fluids including bone marrow, adipose tissues, muscle, synovial membranes, synovial fluid, and blood. (scirp.org)
Li, L. and Jiang, J. (2011) Regulatory Factors of Mesenchymal Stem Cell Migration into Injured Tissues and Their Signal Transduction Mechanisms. (scirp.org)
Comparison of human mesenchymal stromal cells from four neonatal tissues: Amniotic membrane, chorionic membrane, placental decidua and umbilical cord. (sciendo.com)
hEPCs have been used for cell-based therapies due to their capacity to contribute in the re-endothelialization of injured blood vessels and neovascularization in ischemic tissues. (intechopen.com)
Mesenchymal Stem Cells (MSCs) can be isolated from several body tissues, including dental tissues. (bvsalud.org)
Stem cells from dental tissues have a real potential in Advanced Therapies. (bvsalud.org)
Until now, several progenitor cells derived from dental tissues have been isolated and characterized ( table I ). (bvsalud.org)
Stem cells derived from dental tissues are isolated from specialized tissues and have a strong ability to give rise to other cell lines, but with a different potential of bone marrow stem cells 16 . (bvsalud.org)
Adult stem cells are found in differentiated tissues and are able to generate specialized cells in some types of tissues (Multipotent Stem Cells). (bvsalud.org)
When the oxygen content of body tissues is low, if there is loss of blood or anemia, or if the number of red blood cells decreases, the kidneys produce and release erythropoietin, a hormone that stimulates the bone marrow to produce more red blood cells. (medscape.com)

These data define a unique phenotype for adult kidney-derived cells, which have potential as stem cells and may contribute to the regeneration of injured kidneys. (tau.ac.il)
In response to acute injury, the adult kidney shows some level of regeneration characterized by the proliferation of the surviving cells and the replacement of the necrotic tubular cells with functional tubular epithelium [ 3 ]. (biomedcentral.com)
Schwann cells (SCs) have important roles in development, myelination and regeneration in the peripheral nervous system. (scirp.org)
The use of cell therapy for vascular regeneration offers an exciting new prospect in regenerative medicine. (biomedcentral.com)
Nerve repair, replacement, and regeneration have become possible with the development of stem cell technology and progress has been made in treating PD with stem cell transplantation. (biomedcentral.com)
Guz Y, Nasir I, Teitelman G. Regeneration of pancreatic b-cells from intra-islet precursor cells in an experimental model of diabetes. (ejournals.ca)
These cells can be differentiated into mature endothelial cells, which are involved in processes of angiogenesis and vessel regeneration. (intechopen.com)
The combination of inductive scaffold materials with stem cells might optimize the approaches for bone regeneration. (bvsalud.org)

Finally, when injected directly into the renal parenchyma, shortly after ischemic/reperfusion injury, renal Sca-1 + Lin - cells, derived from ROSA26 reporter mice, adopt a tubular phenotype and potentially could contribute to kidney repair. (tau.ac.il)
Kondziolka and colleagues used N-Tera 2 cells derived from a lung metastasis of a human testicular germ cell tumour that when treated with retinoic acid generate postmitotic neurons that maintain a fetal neuronal phenotype indefinitely in vitro (LBS neurons). (bmj.com)
Recent studies also suggest that cellular mechanical properties may provide novel biological markers, or 'biomarkers,' of cell phenotype, reflecting specific changes that occur with disease, differentiation, or cellular transformation. (duke.edu)
The correct cell must be chosen for its phenotype, cell characteristics and biological functions. (biomedcentral.com)
5. Waterman RS, Tomchuck SL, Henkle SL, Betancourt AM. A new mesenchymal stem cell (MSC) paradigm: polarization into a pro-inflammatory MSC1 or an Immunosuppressive MSC2 phenotype. (istanbul.edu.tr)

To deliver on that promise, our laboratory is collaborating with the laboratories of Markus Grompe, M.D., OHSU, and Gordon Keller, Ph.D., University Health Network, Toronto, Canada, in the development and characterization of monoclonal antibodies directed against cell surface molecules expressed by pancreatic cell subsets as well as pancreatic progenitor cells derived from pluripotent stem cells. (ohsu.edu)

Differences in the size of the central nervous system are among the most important distinctions between the species and thus mutations in the genes that regulate the size of the neural stem cell compartment are among the most important drivers of vertebrate evolution. (wikipedia.org)
Neural stem cell proliferation declines as a consequence of aging. (wikipedia.org)
Because FOX proteins regulate neural stem cell homeostasis, FOX proteins have been used to protect neural stem cells by inhibiting Wnt signaling. (wikipedia.org)
Such a cell would be a neural stem cell by a strict definition. (salk.edu)
Neurosphere formation is commonly used as a surrogate for neural stem cell (NSC) function but the relationship between neurosphere-initiating cells (NICs) and NSCs remains unclear. (elifesciences.org)
Her research program encompasses the early neural stem cell niche, neural tube closure, cerebrospinal fluid (CSF), metabolism, and cortical neuronal development. (stanford.edu)
Our research program encompasses the early neural stem cell niche, neural tube closure, CSF, metabolism, and cortical neuronal development. (stanford.edu)
Within the neural stem cell niche of the mouse olfactory epithelium, we identified a combination of extracellular matrix (ECM) receptors that regulate adhesion and mitosis in non-neural stem cells [intercellular adhesion molecule-1 (ICAM-1), β 1 , β 4 , and α-1, -3, and -6 integrins] and on horizontal basal cells (HBCs), candidate olfactory neuro-epithelial progenitors. (syr.edu)

Human induced pluripotent stem cell-derived neural stem/progenitor cell (hiPSC-NS/PC)-based cell transplantation has emerged as a groundbreaking method for replacing damaged neural cells and stimulating functional recovery, but its efficacy is strongly influenced by the state of the injured spinal microenvironment. (biomedcentral.com)
Today, more than 50 years after the first successful bone marrow transplantation, clinical application of hematopoietic stem cells is a routine procedure, saving the lives of many every day. (hindawi.com)
Transplantation of ACE2 - Mesenchymal Stem Cells Improves the Outcome of Patients with COVID-19 Pneumonia. (istanbul.edu.tr)

They are capable of forming multipotent neurospheres when cultured in vitro. (wikipedia.org)
Through fluorescence-activated cell sorting, microarray analysis, in vitro differentiation assays, mixed lymphocyte reaction, and a model of ischemic kidney injury, this study sought to identify and characterize multipotent organ stem/progenitor cells in the adult kidney. (tau.ac.il)
In vitro, they are plastic adherent and slowly proliferating and result in inhibition of alloreactive CD8 + T cells, indicative of an immuneprivileged behavior. (tau.ac.il)
Lgr5 resides in Wnt receptor complexes and mediates signaling of the Wnt-agonistic R-spondins (31), explaining the unique dependence of Lgr5 stem cells on secreted R-spondins in vivo and in vitro. (hubrecht.eu)
Expansion of MSCs was shown to be limited to a few passages of in vitro culture and the cells underwent replicative senescence [ 11 ]. (hindawi.com)
Therefore, available in vitro protocols for expansion of MSCs do not yield true stem cells. (hindawi.com)
A defined synthetic mixture of amino acids, salts, carbohydrates, vitamins and serum was shown to support cells in vitro[ 3 ], thus unifying a major variable in cell culturing experiments and providing a possibility for rapid development of this novel method. (intechopen.com)
2018). Development of bovine embryos in vitro in coculture with murine mesenchymal stem clls and embryonic fibroblasts. (sciendo.com)
HBCs thus possess a conserved adhesion receptor expression profile similar to non-neural stem cells, preferential self-replication in an in vitro environment mimicking their in vivo niche, and contain subpopulations of cells that can produce multiple differentiated neuronal and glial progeny from within and beyond the olfactory system in vitro. (syr.edu)
Subsequent in vitro and in vivo studies have demonstrated the initial steps of cancer cell invasion and dissemination by disrupting the integrity of the myoepithelial belt that encircles the LECs [ 7 , 8 , 9 , 10 , 11 ]. (biomedcentral.com)

12 Bang and colleagues reported the safety and feasibility of intravenous infusion of autologous mesenchymal stem cells (MSCs) with no reported adverse effects in five patients treated with intravenous MSCs. (bmj.com)
Human orofacial bone-derived mesenchymal stem cells (OMSCs) showed distinct differentiation traits from mesenchymal stem cells (MSCs) derived from long bones, mouse OMSCs have not been isolated due to technical difficulties, which in turn precludes using mouse models to study orofacial diseases. (ca.gov)
However, transplanting other than hematopoietic stem and progenitor cells is still limited to a few applications, and it mainly applies to mesenchymal stromal cells (MSCs) isolated from bone marrow. (hindawi.com)
We therefore briefly discuss differences found in subsets of human bmMSCs and in MSCs isolated from some other sources and touch upon how this could be utilized for cell-based therapies. (hindawi.com)
The MSCs have been described for the first time as colony forming fibroblasts (CFU-F), a rare population of cells residing in the bone marrow of guinea-pigs or mice [ 1 , 2 ]. (hindawi.com)
Human bmMSCs were described in the late nineties as well [ 6 ] and at the same time a breakthrough study investigated the expression of typical cell surface markers and the proliferation and differentiation properties of human MSCs in more detail [ 7 ]. (hindawi.com)
In the last 20 years, a huge number of studies investigated phenotypic features and facts of MSCs. (hindawi.com)
Overview of studies published regarding MSCs using the term "stem cell" or "stromal cell" in the last 20 years accessed by a web search in July 2015 (Google Scholar). (hindawi.com)
It seems that the term "stem cell" became more popular although the "stemness" was only shown in a more strict sense for MSCs involved in osteogenesis and bone repair. (hindawi.com)
When the biological properties of MSCs were explored in more detail, questions arose whether these cells met the criterion of a true stem cell [ 8 ]. (hindawi.com)
Nowadays, experts agree that MSCs may generate upon appropriate stimulation quite different mature cells including osteoblasts, chondrocytes, tenocytes, adipocytes, smooth muscle cells, and stromal cells of the bone marrow [ 9 ]. (hindawi.com)
MSCs were also investigated for stem cell qualities in vivo. (hindawi.com)
It was previously believed that the main pathogenic mechanism of PD was the loss of dopaminergic neurons and most researchers considered that the therapeutic effect of MSCs on PD was attributable to their cell replacement ability [ 21 , 22 ]. (biomedcentral.com)

Age-related change in human haematopoiesis causes reduced regenerative capacity1, cytopenias2, immune dysfunction3 and increased risk of blood cancer4-6, but the reason for such abrupt functional decline after 70 years of age remains unclear. (bvsalud.org)
The global stem cell manufacturing market is influenced by increasing investments in stem cell research and regenerative medicine by governments and private organizations. (imarcgroup.com)
The global stem cell manufacturing market is experiencing a significant upsurge due to the substantial investments pouring into stem cell research and regenerative medicine. (imarcgroup.com)
As a stem cell and developmental molecular biologist, Dr. Fame is dedicated to broad collaboration focused on translating an understanding of neural development and CSF biology into regenerative strategies for the treatment of neurodevelopmental disease. (stanford.edu)
Stem cell therapy is one approach to regenerative medicine. (biomedcentral.com)
Stem cells of adult regenerative organs share a common goal but few established conserved mechanisms. (syr.edu)

Haematopoietic stem cells or multipotent progenitors (HSC/MPPs) accumulated a mean of 17 mutations per year after birth and lost 30 base pairs per year of telomere length. (bvsalud.org)
Haematopoiesis in adults less than 65 years of age was massively polyclonal, with high clonal diversity and a stable population of 20,000-200,000 HSC/MPPs contributing evenly to blood production. (bvsalud.org)

WAT is characterised by its capacity to adapt and expand in response to surplus energy through processes of adipocyte hypertrophy and/or recruitment and proliferation of precursor cells in combination with vascular and extracellular matrix remodelling. (springer.com)
Figure 2: Human DG proliferation declines sharply during infancy and a layer of proliferating progenitors does not form in the SGZ. (nature.com)
Our results revealed that iPSC-derived RPCs can protect AKI rat from renal function impairment and severe tubular injury by up-regulating the renal tubules formation, promoting cell proliferation, reducing apoptosis, and regulating the microenvironment in the injured kidney. (biomedcentral.com)
Our findings reveal ErbB activation as a strong inductive signal for stem-cell proliferation. (nature.com)
Splenomegaly might reflect dramatic G-CSF-inducedG-CSF stimulation also in multiple studies shows faster recovery of Hox11+ stem cell proliferation. (fliphtml5.com)

One sentence summary Murine hematopoietic stem cells display transcriptional heterogeneity that is quantitatively altered with age and leads to the age-dependent myeloid bias evident after inflammatory challenge. (biorxiv.org)
We have thus demonstrated a previously unrecognised heterogeneity in dermal papilla cells and shown that Sox2-positive cells specify particular hair follicle types. (biologists.com)
Hart, D.A. (2014) Why Mesenchymal Stem Cell/Progenitor Cell Heterogeneity in Specific Environments? (scirp.org)
Blood formation occurs in waves that overlap in time and space, adding to heterogeneity, which necessitates single-cell approaches. (lu.se)

GMSC can function as an immunomodulatory and anti-inflammatory component of the immune system in vivo and is a promising cell source for cell-based treatment in experimental inflammatory diseases. (ca.gov)
Our study suggests that both OMSCs and host cells contribute to bone formation in vivo. (ca.gov)
Pre-GEPCOT cells could not form neurospheres but expressed the stem cell markers Slc1a3-CreER T , GFAP-CreER T2 , Sox2 CreERT2 , and Gli1 CreERT2 and were long-lived in vivo. (elifesciences.org)

Cells recovered from healthy individuals could provide a model for understanding how to stimulate and guide the normal processes of brain cell growth and differentiation," he said, "lending insight to how growth might be stimulated in people suffering from neurodegenerative diseases such as Alzheimer's or Parkinson's. (salk.edu)
This driver is fueled by the promising prospects of stem cell therapies in addressing previously untreatable conditions, such as neurodegenerative diseases and spinal cord injuries. (imarcgroup.com)

Batsali, A.K., Kastrinaki, M.C., Papadaki, H.A. and Pontikoglou, C. (2013) Mesenchymal Stem Cells Derived from Wharton's Jelly of the Umbilical Cord: Biological Properties and Emerging Clinical Applications. (scirp.org)

Preclinical studies suggest that cell therapy may be safe and effective in improving functional outcomes. (bmj.com)
Several recent clinical trials have reported safety and some improvement in outcomes following cell therapy administration in ischaemic stroke, which are reviewed. (bmj.com)
Cell therapy may provide a promising new treatment for stroke reducing stroke-related disability. (bmj.com)
Further investigation is needed to determine specific effects of cell therapy and to optimise cell delivery methods, cell dosing, type of cells used, timing of delivery, infarct size and location of infarct that are likely to benefit from cell therapy. (bmj.com)
Cell therapy is one approach to enhancing recovery after stroke. (bmj.com)
9 Clinical trials of cell therapy completed in the 2000s mostly treating small cohorts of patients with chronic stroke demonstrated adequate safety and a suggestion of efficacy with the use of cell therapy. (bmj.com)
13 These early clinical trials mostly focused on chronic subcortical strokes, but more recent trials are now investigating cell therapy for treatment of both cortical and subcortical infarcts. (bmj.com)
Cell-based therapy with mesenchymal stem cells or renal progenitor cells (RPCs) resident in the kidney has appeared to be an effective strategy for the treatment of AKI. (biomedcentral.com)
However, the supply of donor-derived islets will never meet the needs of the large number of patients who could potentially benefit from this cell-based therapy. (ohsu.edu)
Finally, one should consider cell choice, a critical aspect of any cell therapy. (biomedcentral.com)
In this review, we summarized the progression of the neuroimmune response in PD based on recent studies and focused on the use of mesenchymal stem cell (MSC) therapy and challenges as a strategy of disease-modifying therapy with multiple targets. (biomedcentral.com)
Therapeutic Applications of Bone Marrow-Derived Stem Cells in Neurologic Injury and Disease" chapter in Cell Therapy, Stem Cells and Brain Repair, edited by Sandberg et. (umn.edu)
Mesenchymal stem cells - a promising therapy for Acute Respiratory Distress Syndrome. (istanbul.edu.tr)
Could Cell Therapy Target the Symptoms of Severe Covid-19? (labiotech.eu)
Could cell therapy provide an answer to this dilemma? (labiotech.eu)
Cell therapy has shown promise for treating ARDS, which (even before Covid-19) affected 500,000 people a year across Europe, the US, and Japan. (labiotech.eu)
Multistem is an 'off the shelf' cell therapy derived from bone marrow donations. (labiotech.eu)
Athersys' cell therapy is being trialed for reducing the damaging inflammation seen in stroke patients. (labiotech.eu)
The study showed that treatment with the cell therapy reduced mortality from 40% to 25% in these very sick patients. (labiotech.eu)
Similar to Athersys' therapy, Pluristem's cells are delivered 'off the shelf' and also have the ability to regulate the immune system to potentially calm the excessive immune activation seen in Covid-19 ARDS patients. (labiotech.eu)
This chapter provides an overview of the key role of hEPC in promoting angiogenesis and their potential use for cell therapy. (intechopen.com)
Mora MV, Ibán MAR, Heredia JD, Laakso RB, Cuéllar R, Arranz MG. Stem cell therapy in the management of shoulder rotator cuff disorders. (wjgnet.com)

Here we sequenced 3,579 genomes from single cell-derived colonies of haematopoietic cells across 10 human subjects from 0 to 81 years of age. (bvsalud.org)

In animal models, delivery of several different types of stem cells reduce infarct size and improve functional outcomes. (bmj.com)
This study demonstrated safety and feasibility of stereotactic cell implantation, although there was no significant improvement in functional outcomes. (bmj.com)
Functional neurogenesis in the adult hippocampus. (nature.com)
Nephron progenitors, the cell population that give rise to the functional unit of the kidney, are metabolically active and self-renew under glycolytic conditions. (lww.com)

Our research focuses on characterising the stem and progenitor cells that build the hypothalamus and characterising the molecular networks that direct hypothalamic morphogenesis, growth and differentiation. (sheffield.ac.uk)
Fu T, Towers M & Placzek M (2017) Fgf10(+) progenitors give rise to the chick hypothalamus by rostral and caudal growth and differentiation. . (sheffield.ac.uk)

The molecular mechanisms by which such stem cells preserve the ability to switch to a pluripotent state are being investigated. (ny.gov)
There are two types of stem cell manufacturing: embryonic stem cell production, derived from early-stage embryos, and induced pluripotent stem cell (iPSC) production, which reprograms adult cells to an embryonic-like state. (imarcgroup.com)
Induced pluripotent stem cells (iPSCs) are a type of newly defined stem cell with properties similar to those of ESCs in terms of self-renewal and differentiation. (biomedcentral.com)

This population of small cells includes a CD45-negative fraction that lacks hematopoietic stem cell and lineage markers and resides in the renal interstitial space. (tau.ac.il)
In addition, these cells are enriched for β1-integrin, are cytokeratin negative, and show minimal expression of surface markers that typically are found on bone marrow-derived mesenchymal stem cells. (tau.ac.il)
GFP + CD133 + cells had upregulated Wnt, FGF and BMP pathways and expressed neural crest markers. (biologists.com)
term pre-GEPCOT cells (based on an acronym of the markers used to isolate the cells), were long-lived and quiescent, but they lacked the ability to form colonies in culture. (elifesciences.org)
Next, we examined the renal function-related markers and renal histology to assess the therapeutic effect of the injected cells. (biomedcentral.com)
CD133+), but are rarely codetected with the neural stem dents, very few human-specific NSC markers have been cell (NSC) marker CD15. (lu.se)
2000). In *Correspondence to: Perrine Barraud, Department of Veterinary Medi- contrast, several cell surface markers have been used to cine, Neurosciences, Madingley Road, Cambridge CB3 OES, United enrich for NSCs in the rodent CNS. (lu.se)
In this study, we investigate the expression of differentiated Schwann cell markers by exposing of endometrial stem cells with induction media including FGF2/FSK/HRG/RA. (scirp.org)
Using immunocytochemistry, we show that differentiated cells express S100 and P75 markers. (scirp.org)
In this review, we provided an overview of the myoepithelial cells' histogenesis, molecular and biological markers, and physiological commitments. (biomedcentral.com)

In these regions, neural stem cells (NSCs) and neural progenitor cells (NPCs) have been reported to proliferate and produce postmitotic neurons. (jneurology.com)

NSCs are stimulated to begin differentiation via exogenous cues from the microenvironment, or stem cell niche. (wikipedia.org)
Stem cells numbers remain fixed because stem cells compete 'neutrally' for niche space (30). (hubrecht.eu)
Daughters of the small intestinal stem cells, the Paneth cells, serve as crypt niche cells by providing Wnt, Notch and EGF signals (33). (hubrecht.eu)
Overview on self-renewal or differentiation of stem cells in their respective stem cell niche. (hindawi.com)
These stem/ progenitor cells are in direct contact with the cerebrospinal fluid (CSF), which acts as part of their niche. (stanford.edu)
As ErbB-family ligands and receptors are highly expressed within the stem-cell niche 7 , we hypothesize that strong endogenous regulators must control the pathway in the stem-cell compartment. (nature.com)
Voog, J. & Jones, D. L. Stem cells and the niche: a dynamic duo. (nature.com)
Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts. (nature.com)

They display differentiation capacities and therefore qualify as multipotent progenitor cells (Figure 1 ). (hindawi.com)

These therapies should target the cellular mechanisms that underly HI brain injury, including early phase propagators of injury such as neuro-inflammation, cell death, mitochondrial dysfunction, oxidative stress, and excitotoxicity, and they should be safe for use in both term and preterm infants. (frontiersin.org)
When germ-free cell cultures became a laboratory routine, hopes were high for using this novel technology for treatment of diseases or replacement of cells in patients suffering from injury, inflammation, or cancer or even refreshing cells in the elderly. (hindawi.com)
Mesenchymal Stromal Cells: Sensors and Switchers of Inflammation. (istanbul.edu.tr)
Immunoselected STRO-3+ mesenchymal precursor cells reduce inflammation and improve clinical outcomes in a large animal model of monoarthritis. (sciendo.com)

In contrast, pre-GEPCOT cells were quiescent, expressed higher Glast, and lower EGFR and PlexinB2. (elifesciences.org)
Neural stem cells have long lives, much of which they spend in a quiescent state. (elifesciences.org)
The process is hypothesized to involve epithelial cell dedifferentiation, interstitial cell transdifferentiation and/or activation of quiescent stem cells. (biomedcentral.com)
Li, L. & Clevers, H. Coexistence of quiescent and active adult stem cells in mammals. (nature.com)

Neural stem cells (NSCs) are self-renewing, multipotent cells that firstly generate the radial glial progenitor cells that generate the neurons and glia of the nervous system of all animals during embryonic development. (wikipedia.org)
During the embryonic development of vertebrates, NSCs transition into radial glial cells (RGCs) also known as radial glial progenitor cells, (RGPs) and reside in a transient zone called the ventricular zone (VZ). (wikipedia.org)
Adult NSCs were first isolated from mouse striatum in the early 1990s. (wikipedia.org)
It is hypothesized that neurogenesis in the adult brain originates from NSCs. (wikipedia.org)
The origin and identity of NSCs in the adult brain remain to be defined. (wikipedia.org)
The stage-specific embryonic antigen 4 (SSEA4) is com- isolate the NSCs from neonatal mice and rats (Campos monly used as a cell surface marker to identify the pluri- et al. (lu.se)
2005). Finally, negative revealed that SSEA4 is detectable in the early neuroepi- selection strategies have been also developed as an alter- thelium, and its expression decreases as development native method to enrich for NSCs from both adult proceeds. (lu.se)
Recently, adult neurogenesis in the cerebral cortex is becoming clear gradually, and cortical NSCs and NPCs are identified in a few mammals. (jneurology.com)
They closely interact with endogenous neural stem cells (NSCs) residing in distinct niches of the adult brain. (biomedcentral.com)

The most highly mitotic colony-forming HBCs demonstrate multipotency, spontaneously generating more ICAM-positive presumptive HBCs, a combination of olfactory neuroglial progenitors, and neurons of olfactory and potentially nonolfactory phenotypes. (syr.edu)

This process initially occurs in fetal liver cells and subsequently takes place in the bone marrow of children and adults. (medscape.com)
Using CITE-seq (cellular indexing of transcriptomes and epitopes by sequencing), the molecular profile of established immunophenotype-gated progenitors was analyzed in the fetal liver (FL). (lu.se)

Among these is the isolation of the first line of murine stem cells [ 5 , 6 ] in 1981, followed by establishment of the first human embryonic stem cell lines by Thompson [ 7 ]. (intechopen.com)
fication and isolation via fluorescence-activated cell sort- ing (FACS). (lu.se)
This project focuses on the compelling need to generate cell-surface marker specific reagents useful for identification, study, and isolation of pulmonary stem/progenitor cells. (ohsu.edu)

2017). MMP-2 and MMP-14 Silencing Inhibits VEGFR2 Cleavage and Induces the Differentiation of Porcine Adipose-Derived Mesenchymal Stem Cells to Endothelial Cells. (sciendo.com)
2017 . DOI : 10.1002/stem.2719. (epfl.ch)
2017 . DOI : 10.1016/j.stem.2017.07.004. (epfl.ch)

Neural stem cells are more specialized than ESCs because they only generate radial glial cells that give rise to the neurons and to glia of the central nervous system (CNS). (wikipedia.org)
The most widely accepted model of an adult NSC is a radial, glial fibrillary acidic protein-positive cell. (wikipedia.org)
[ 7 ] In addition, recent gene expression profiling studies support the concept that radial glial cells from different neuroanatomic sites may be predisposed to acquiring particular genetic aberrations that result in ependymomas with site-specific genetic signatures and biologic potential. (medscape.com)

However, prior to commitment, it has been cells, it is evident that GATA-1 and PU.1 are able to specify observed that many genes are expressed at intermediate or basal erythroid and myeloid cell fates (see [16] and references therein). (lu.se)

Reninomas are exceedingly rare renin-secreting kidney tumours that derive from juxtaglomerular cells, specialised smooth muscle cells that reside at the vascular inlet of glomeruli. (bvsalud.org)
However, the delivery of the correct cell type to the precise area of injury or vascular insufficiency is difficult and many factors need to be considered. (biomedcentral.com)

In collaboration with investigators in Taiwan, we implanted one type of autologous OMSCs (periodontal ligament progenitors, PDLPs) to treat an orofacial infectious bone defect disease periodontitis. (ca.gov)
This study demonstrated clinical and experimental evidences supporting a potential efficacy and safety of utilizing autologous PDL cells in the treatment of human periodontitis. (ca.gov)
Intra-articular injection of expanded autologous bone marrow mesenchymal cells in moderate and severe knee osteoarthritis is safe: a phase I/II study. (sciendo.com)
Use of a chronic model of articular cartilage and meniscal injury for the assessment of long-term effects after autologous mesenchymal stromal cell treatment in Steep. (sciendo.com)
For induce splenomegaly in most donors and in rare, severe cases splenicautologous stem cell transplants, the use of autologous PBSCT from rupture [13,14]. (fliphtml5.com)

Early neural progenitors respond to extrinsic cues that maintain and support their potency. (stanford.edu)

A driving force behind one of our University's key research facilities, Marysia directed the MRC Centre for Developmental and Biomedical Genetics for many years and oversaw its evolution into the Bateson Centre. (sheffield.ac.uk)
Researchers are putting single-cell proteomics to work in fields like developmental biology, cell biology, cancer biology, and neuroscience. (acs.org)
Specialized ependyma of the circumventricular organs and choroid plexus cells are additional highly specialized ependymal cells that ultimately derive from this developmental pathway. (medscape.com)

To qualify as stem cells, self-renewal has to be shown as well [ 10 ]. (hindawi.com)
To explore VHL as a regulator defining nephron progenitor self-renewal versus differentiation, we bred Six2-TGC tg mice with VHL lox/lox mice to generate mice with a conditional deletion of VHL from Six2 + nephron progenitors. (lww.com)

In this Research Topic, we summarized original research and review articles that examine the more recent progress in pharmacological and cell therapies for perinatal HI brain injury. (frontiersin.org)
Increasing investments in stem cell research, rising chronic disease prevalence, advancements in biotechnology, collaborations between academia and industry, stringent regulations, and expanding awareness of stem cell therapies are stimulating the market growth. (imarcgroup.com)
Apart from this, the increasing awareness and acceptance of stem cell-based therapies among patients and healthcare professionals is augmenting the market growth. (imarcgroup.com)
Pluristem develops cell therapies made from placental cells. (labiotech.eu)
We aim to summarize emerging gene therapies for RD and their efficacy in restoring photoreceptor or bipolar cell functions. (hkjo.hk)

Hematopoietic stem cell lineage choices are decided by genetic networks that are turned ON/OFF in a switch-like manner. (lu.se)
The goal of this study was to determine the elastic and viscoelastic properties of three primary cell types of mesenchymal lineage (chondrocytes, osteoblasts, and adipocytes) and to test the hypothesis that primary differentiated cells exhibit distinct mechanical properties compared to adult stem cells (adipose-derived or bone marrow-derived mesenchymal stem cells). (duke.edu)
Is Adipocyte Differentiation the Default Lineage for Mesenchymal Stem/Progenitor Cells after Loss of Mechanical Loading? (scirp.org)
Hart, D. (2014) Is Adipocyte Differentiation the Default Lineage for Mesenchymal Stem/Progenitor Cells after Loss of Mechanical Loading? (scirp.org)
Over the past decades, luminal epithelial cell lineage has gained considerable attraction as the functionally milk-secreting units and as the most fruitful acreage for breast cancer launching. (biomedcentral.com)
Recognition of the effective involvement of the myoepithelial cells in mammary gland development and in hampering tumorigenesis has renewed the interest in investigating the biological roles of this second main mammary lineage. (biomedcentral.com)

NeuroRenew, Inc. provides consultation and training for biomedical research into the use of stem cells for brain repair and in the regulation of neurogenesis in the adult brain. (neurorenew.com)

Based on these combined insights, we have established Lgr5/R-spondin-based culture systems that allow the outgrowth of single mouse or human Lgr5 stem cells into ever-expanding organoids. (hubrecht.eu)
La Jolla, CA - Salk Institute scientists have isolated cells from the brains of human cadavers that can grow, divide and form specialized classes of brain cells. (salk.edu)
The study was done in collaboration with Phillip Schwartz and Stuart Stein at Children's Hospital of Orange County, Calif. The study, titled "Progenitor cells grown from postmortem human brain," was supported by the National Institutes of Health, the National Institute of Aging, the Lookout Fund and the Christopher Reeves Paralysis Foundation. (salk.edu)
Normal male germline stem cells exhibit striking phenotypic similarities to adult human germ cell tumor, the pathogenesis of which is also a major emphasis of the research. (ny.gov)
Despite these discrepancies, it is generally believed that the adult human hippocampus continues to generate new neurons. (nature.com)
Here we show that a defined population of progenitor cells does not coalesce in the subgranular zone during human fetal or postnatal development. (nature.com)
Scholars@Duke publication: Viscoelastic properties of human mesenchymally-derived stem cells and primary osteoblasts, chondrocytes, and adipocytes. (duke.edu)
Stem cell manufacturing is a highly sophisticated and rapidly evolving field dedicated to the controlled production of stem cells, which possess the unique ability to develop into umpteen specialized cell types within the human body. (imarcgroup.com)
2005). Notch1 and syndecan-1 potent human embryonic stem (ES) cells. (lu.se)
One recently developed reagent recognizes a molecule associated with human pancreatic cancer cells as well as precancerous lesions of the pancreas. (ohsu.edu)
These results show that for the first time, human endometrial stem cells can be differentiated into Schwann cells in 2D and 3D culture. (scirp.org)
Gimble, J.M., Bunnell, B.A. and Guilak, F. (2012) Human Adipose-Derived Cells: An Update on the Transition to Clinical Translation. (scirp.org)
Knowledge of human fetal blood development and how it differs from adult blood is highly relevant to our understanding of congenital blood and immune disorders and childhood leukemia, of which the latter can originate in utero. (lu.se)
Human cervix cells under magnification. (acs.org)
Jensen, K. B. & Watt, F. M. Single-cell expression profiling of human epidermal stem and transit-amplifying cells: Lrig1 is a regulator of stem cell quiescence. (nature.com)
For performing human cloning: Punishment by confinement from 2 (two) to 5 (five) years and fine. (hinxtongroup.org)
… "embryo" means a human organism during the first 56 days of its development following fertilization or creation, excluding any time during which its development has been suspended, and includes any cell derived from such an organism that is used for the purpose of creating a human being. (hinxtongroup.org)

II - from embryos that have been frozen for 3 (three) years or more, as of the date of publication of this Law, or that were frozen at the date of publication of this Law, after 3 (three) year period has lapsed, as of the date when it was actually frozen. (hinxtongroup.org)

Neural induction of adult bone marrow and umbilical cord stem cells. (umn.edu)

It levels for the hematopoietic stem cell system [1,2]. (lu.se)

The potential of intra-articular injection of chondrogenic-induced bone marrow stem cells to retard the progression of osteoarthritis in a sheep model. (sciendo.com)

The Wnt target gene encoding the transcription factor Achaete scute-like 2 controls intestinal stem cell state (26). (hubrecht.eu)

Dr. Marco Seandel's research interests focus on the influence of extrinsic signals in mediating normal stem cell and tumor cell fate in mammals, using the male germline stem cell as a model system. (ny.gov)
A region of the brain called the subventricular zone contains both neural stem cells and neural progenitor cells, and is one of only two regions of the brain where neural stem cells are found in adult mammals. (elifesciences.org)

Adipose-derived and mesenchymal stem cells exhibited similar properties to each other, but were mechanically distinct from primary cells, particularly when comparing a ratio of elastic to relaxed moduli. (duke.edu)

Some neural cells are migrated from the SVZ along the rostral migratory stream which contains a marrow-like structure with ependymal cells and astrocytes when stimulated. (wikipedia.org)
MSC mediated bone formation involves in both donor and recipient cells, but only recipient cells contribute to marrow element formation. (ca.gov)
Borlongan, C.V., Glover, L.E., Tajiri, N., Kaneko, Y. and Freeman, T.B. (2011) The Great Migration of Bone Marrow-Derived Stem Cells towards the Ischemic Brain: Therapeutic Implications for Stroke and Other Neurological Disorders. (scirp.org)
Direct molecular comparison with an adult bone marrow data set revealed that the HSC state was less frequent in FL, whereas cells with a lymphomyeloid signature were more abundant. (lu.se)
G-CSF mobilizesCD34+ hematopoietic stem cells from bone marrow into the blood. (fliphtml5.com)
Our hypothesis about a splenic stem cell contributionor maintained survival compared to bone marrow transplants, to PBSCT also derives from the observation that G-CSF mobilizationsalthough graft versus host disease (GVHD) still occurs [1]. (fliphtml5.com)
Progenitor cell (stem cell) lines in the bone marrow produce new blood cells and stromal cells. (medscape.com)
In an adult, roughly half of the bone marrow is still red. (medscape.com)
However, the yellow marrow can revert to red if there is increased demand for red blood cells, such as in instances of blood loss. (medscape.com)
Normally, only mature cells are released from the marrow into the bloodstream. (medscape.com)
These stem cells divide to eventually give rise to red blood cells, platelets, and most white blood cells in the red marrow. (medscape.com)
Bone marrow thus contains blood cells at varying stages of development. (medscape.com)
Illustration of the pelvis to show the site of bone marrow and blood cells derived from bone marrow. (medscape.com)
Similarly, the bone marrow produces and releases more white blood cells in response to infections, and it produces and releases more platelets in response to bleeding. (medscape.com)
As age progresses, more of the red bone marrow turns into yellow bone marrow and the production of new blood cells becomes more difficult. (medscape.com)
The bone marrow stroma contains mesenchymal stem cells. (medscape.com)

We were the first to link Wnt signaling with adult stem cell biology, when we showed that TCF4 gene disruption leads to the abolition of crypts of the small intestine (8), and that TCF1 gene knockout severely disables the stem cell compartment of the thymus (2). (hubrecht.eu)
4 ] in 1951 cell culturing has become one of the most widely used methods with exceptional contribution to the advances in almost all fields of contemporary biology - cell biology, genetics, cell biochemistry, physiology etc. (intechopen.com)
Measurements of cell mixtures can hide differences between cells that might be important in biology or disease studies. (acs.org)

The advantages of stem cell manufacturing are manifold, as it offers a renewable source of cells for research, drug testing, and potential therapeutic applications. (imarcgroup.com)
Additionally, innovations in genetic editing techniques, like CRISPR-Cas9, offer precise control over stem cell characteristics, further expanding their therapeutic potential. (imarcgroup.com)
Recently, there has been growing interest in the therapeutic potential of using a cell-based approach to treat vasodegenerative disorders. (biomedcentral.com)
3. Galipeau J, Sensebe L. Mesenchymal Stromal Cells: Clinical Challenges and Therapeutic Opportunities. (istanbul.edu.tr)
Therapeutic potential of mesenchymal stromal cells in the treatment of ARDS. (istanbul.edu.tr)
The potential therapeutic use of stem cells has been broadly researched in recent years. (bvsalud.org)
The stem cells from exfoliated deciduous teeth (SHEDs) have a great potential for therapeutic use because of its differentiation capability and its easy access, since the collection is performed at the physiological exfoliation stage of the deciduous teeth. (bvsalud.org)

Two other Wnt target genes, RNF43 and ZNRF3, encode stem cell-specific E3 ligases that downregulate Wnt receptors in a negative feedback loop (35). (hubrecht.eu)

In the adult mammalian brain, the subgranular zone in the hippocampal dentate gyrus, the subventricular zone around the lateral ventricles, and the hypothalamus (precisely in the dorsal α1, α2 region and the "hypothalamic proliferative region", located in the adjacent median eminence) have been reported to contain neural stem cells. (wikipedia.org)
We prospectively identified, and isolated by flow cytometry, adult mouse lateral ventricle subventricular zone (SVZ) NICs as Glast mid EGFR high PlexinB2 high CD24 −/low O4/PSA-NCAM −/low Ter119/CD45 − (GEPCOT) cells. (elifesciences.org)
When cells from the subventricular zone are cultured in a way that allows the cells to freely float around (rather than growing on a surface), a few percent form spherical colonies called neurospheres. (elifesciences.org)
have used a technique called flow cytometry to identify and isolate neural stem cells and neurosphere-forming cells directly from the subventricular zone. (elifesciences.org)
It is widely accepted that new neurons are generated throughout life, which is called adult neurogenesis, in limited regions of the adult mammalian brain, such as the hippocampal dentate gyrus and subventricular zone. (jneurology.com)
There are many reports that adult neurogenesis occurs in the subventricular zone (SVZ) and hippocampal dentate gyrus (HDG) of mammalian brains since the 1960s 1,2 . (jneurology.com)

Anatomy10

Chemicals and Drugs3

Analytical, Diagnostic and Therapeutic Techniques and Equipment5

Phenomena and Processes5

Disciplines and Occupations1

Embryonic stem7

Populations10

Differentiate15

Tissue51

Endothelial progenitor cells3

Tissues23

Regeneration8

Phenotype5

Characterization1

Neural stem8

Transplantation3

Vitro10

MSCs13

Regenerative6

MPPs2

Proliferation5

Heterogeneity4

Vivo3

Neurodegenerative2

Mesenchymal Stem Cells De1

Therapy22

Haematopoietic1

Functional4

Growth and differentiation2

Pluripotent3

Markers10

Proliferate1

Niche8

Differentiation capacities1

Inflammation4

Quiescent4

NSCs9

Phenotypes1

Fetal liver2

Isolation3

20173

Radial glial3

Erythroid1

Vascular2

Autologous5

Cues1

Developmental3

Self-renewal2

Therapies5

Lineage6

Neurogenesis in the adult brain1

Human17

Embryos1

Umbilical Cord1

Hematopoietic stem1

Bone marrow stem cells1

Controls intestinal stem cell1

Mammals2

Distinct1

Marrow16

Biology3

Therapeutic7

Receptors1

Subventricular zone6