• Cara Therapeutics, Inc. (Nasdaq: CARA), a commercial-stage biopharmaceutical company leading a new treatment paradigm to improve the lives of patients suffering from pruritus, today announced financial results and operational highlights for the second quarter ended June 30, 2023. (biospace.com)
  • ET to report second quarter 2023 financial results and provide a corporate update. (biospace.com)
  • In this paper we show that one can impose such a poset-stratified space structure on the homotopy set $[X, Y ]$ of homotopy classes of continuous maps by considering a canonical but nontrivial order (preorder) on it, namely we can capture the homotopy set $[X, Y ]$ as an object of the category of poset-stratified spaces. (intlpress.com)
  • Furthermore via homology and cohomology the homotopy set $[X, Y ]$ can have other poset-stratified space structures. (intlpress.com)
  • In this paper, we study the homotopy type of the CW-complexes in connection with the diagonality of magnitude homology groups. (intlpress.com)
  • We prove that the Asao-Izumihara complex is homotopy equivalent to a wedge of spheres for pawful graphs introduced by Y. Gu. (intlpress.com)
  • The result can be considered as a homotopy type version of Gu's result. (intlpress.com)
  • Different computational methods have been designed for estimating protein function based on the information generated from sequence similarity, subcellular localization, phylogenetic profiles, mRNA expression profiles, homology modelling etc. [ 15 ]. (biomedcentral.com)
  • Random Amplified Polymorphic DNA (RAPD)-PCR was used for a phylogenetic study to check the homology of pairs of isolates. (biomedcentral.com)
  • Phylogenetic results indi! (helsinki.fi)
  • In the first year of the project, eight schools participated, and 90 positive cultures were re-cultured and arrayed on agar plates to obtain yeast isolates. (awri.com.au)
  • While the homology of the isolates was low among different patients during hospitalization, identical (9%) and similar (21%) RAPD-PCR patterns were detected between pairs of isolates from each patient. (biomedcentral.com)
  • A different nucleotide sequence in the DNA strand results in a different protein expressed in the cell. (wikipedia.org)
  • In order for yeast cells to undergo homology directed repair there must be present in the same nucleus a second DNA molecule containing sequence homology with the region to be repaired. (wikipedia.org)
  • As part of a directed effort to discover novel G protein-coupled receptors through homology searching of expressed sequence tag databases, we identified a partial clone (GPCR97) that had significant homology to biogenic amine receptors. (aspetjournals.org)
  • Bona fide CRISPR‐Cas targets are expected to have (i) complete or nearly complete sequence homology to a 7 nt seed sequence (Semenova et al. (america2049.com)
  • A homology search against the M. tuberculosis database identified nine additional secretory protein homologs that lacked a secretory signal sequence. (cdc.gov)
  • Homology Medicines, Inc. (Nasdaq: FIXX), a genetic medicines company, announced today six presentations supporting its gene editing, gene therapy and GTx-mAb programs at the American Society of Gene & Cell Therapy (ASGCT) 26th Annual Meeting. (biospace.com)
  • Rosen Law Firm, a global investor rights law firm, reminds purchasers of the securities of Homology Medicines, Inc. (NASDAQ: FIXX) between June 10, 2019 and February 18, 2022, inclusive (the "Class Period"), of the important May 24, 2022 lead plaintiff deadline . (globenewswire.com)
  • From accessing medicines to intellectual property to drug safety, PhRMA is devoted to advancing public policies that support innovative medical research, improve treatments and yield real results. (wgc2010.sk)
  • There was no significant difference in overall survival between patients with high and those with low CDK2AP1 mRNA levels after a median follow-up of 10 years (Kaplan-Meier analysis, p=0.872). (cancerindex.org)
  • Conversely, the transcription of COX-2 yields a 4.5-kb mRNA that encodes a 70-kd protein with roughly 70-75% homology to the COX-1 protein. (medscape.com)
  • The core of my project is an attempt to discover a structural homology between the working mechanisms of the material and symbolic economies of contemporary Russia. (wiko-berlin.de)
  • 11] The resultant mutations were interpreted to result in local structural changes in the ACVR1 protein, as revealed by interrogating homology models of the native and mutated ACVR1 kinase domains. (medscape.com)
  • Due to the structural and biochemical homology between IGF-2 and insulin, elevated levels of IGF-2 can result in hypoglycemia. (medscape.com)
  • Proximal to the duster of genes believed to encode the apparatus are two genes with homology to a two-component regulatory system, YsrRS. (usda.gov)
  • And as a surge of genetic data has become available in recent years, scientists have realized that not just individual genes but entire genetic pathways are often conserved across disparate organisms. (googleapis.com)
  • Mammalian neuropeptide Y receptors (NPYRs) show significant homology with sNPFR1 (ref. 7 ) and treatment of rat insulinoma cells with the mammalian sNPF orthologue NPY enhances their expression of insulin 5 . (nature.com)
  • Homology analysis showed the highest similarity to M2 muscarinic acetylcholine receptors and overall low homology to all other biogenic amine receptors. (aspetjournals.org)
  • It shares homology with the mating-type protein, Mc, from the fission yeast Schizosaccharomyces pombe and a conserved DNA-binding motif present in the nuclear high-mobility-group proteins HMG1 and HMG2. (nih.gov)
  • The GPCR97 clone was used to probe a human thalamus library, which resulted in the isolation of a full-length clone encoding a putative G protein-coupled receptor. (aspetjournals.org)
  • This gene is conserved and Y-specific among a wide range of mammals, and encodes a testis-specific transcript. (nih.gov)
  • Alternative splicing results in multiple transcript variants encoding distinct isoforms. (cancerindex.org)
  • In our last post in this series on topology, we defined the homology group. (jeremykun.com)
  • Because many laboratories use tests that do not routinely distinguish Mycobacterium tuberculosis from closely related species, these laboratories report culture results as being positive or negative for " Mycobacterium tuberculosis complex. (cdc.gov)
  • A search of a 35-kilobase region of the human Y chromosome necessary for male sex determination has resulted in the identification of a new gene. (nih.gov)
  • Recently, the Ysa (Yersinia secretion apparatus) TTSS was discovered on the Y. enterocolitica chromosome and implicated as a virulence determinant. (usda.gov)
  • For organisms that are diploid (meaning they have two sets of each chromosome) having more than two sets of chromosomes often results in problems with cell function. (umn.edu)
  • In human meiosis, each of the resulting cells has only one of each of your 23 chromosome pairs instead of 23 complete pairs of chromosomes. (umn.edu)
  • However, human males are typically characterized by having an X chromosome and a Y chromosome. (umn.edu)
  • In the budding yeast Saccharomyces cerevisiae homology directed repair is primarily a response to spontaneous or induced damage that occurs during vegetative growth. (wikipedia.org)
  • Homology analysis indicates at least 37 different species of yeast across the dataset, with some species present in more than one sample. (awri.com.au)
  • the researchers take advantage of this newly described genetic homology to demonstrate an evolutionary approach to drug discovery. (googleapis.com)
  • Hu Y , Liu F , Lin IY , Gao GF , Zhu B . Dissemination of the mcr-1 colistin resistance gene. (cdc.gov)
  • This gene has been termed SRY (for sex-determining region Y) and proposed to be a candidate for the elusive testis-determining gene, TDF. (nih.gov)
  • S. Gomi, C. E. Zhou, W. Y. Yih, K. Majima, Maeda S. (1997) Deletion analysis of four of eighteen late gene expression factor gene homologues of the baculovirus, BmNPV. (scirp.org)
  • The result showed that the bacterium expression system was suitable for the virus gene expression. (scirp.org)
  • [ 13 ] . A patient from Japan with an ACVR1 gene mutation had normal development until age 17 years and a mild clinical course. (medscape.com)
  • ExperimentalDesign: We investigated ERh by immunohistochemistry in 353 stage II primary breast tumors from patients treated with 2 years adjuvant tamoxifen, and generated gene expres- sion profiles for a representative subset of 88 tumors. (lu.se)
  • Recently, Asao and Izumihara introduced CW-complexes whose homology groups are isomorphic to direct summands of the graph magnitude homology group. (intlpress.com)
  • Over the past 170 years, the study of graph coloring has led to the development and discovery of some rich and beautiful mathematics. (southalabama.edu)
  • These results demonstrate AKAP12 as a central regulator of meningioma aggressiveness with a possible role in progression. (nature.com)
  • The ysa locus is not found in Y. pestis or Y. pseudotuberculosis, nor in non- or low-pathogenic Y. enterocolitica strains. (usda.gov)
  • In this work, several in silico models have been built with two classes of proteasome inhibitors (PIs) by using 3D-QSAR, homology modeling, molecular docking and molecular dynamics (MD) simulations. (fdocument.org)
  • NIH Director Francis Collins, a molecular biologist and born-again Christian, has recently created a National Institute of the Molecular Biology of Yahweh (NIMBY), with an annual research budget of $400/year, as part of the government's effort to support faith-based initiatives in biomedicine. (scienceblog.com)
  • The existence of the histamine H 3 receptor was demonstrated pharmacologically 15 years ago, yet despite intensive efforts, its molecular identity has remained elusive. (aspetjournals.org)
  • In the cohomology case, we get some results which are equivalent to the notion of dependence of cohomology classes (by René Thom) and we can show that the set of isomorphism classes of complex vector bundles can be captured as a poset-stratified space via the poset of the subrings consisting of all the characteristic classes. (intlpress.com)
  • The results are striking: they show that a drug that's been used as an antifungal agent for 40 years is also a vascular disrupting agent in human cells. (googleapis.com)
  • Preliminary results show 85% homology with a Presbyterian minister from Des Moines. (scienceblog.com)
  • Our results show that SLAP2 suppresses FLT3 downstream signaling pathways including AKT, ERK, p38 and STAT5 and facilitates FLT3 degradation through enhancing ubiquitination while ABL2 expression does not alter FLT3 stability or ubiquitination but partially suppresses FLT3 downstream signaling through the PI3K/AKT pathway. (lu.se)
  • Analysis of clinical presentations of Bruton disease: a review of 20 years of accumulated data from pediatric patients at Severance Hospital. (lu.se)
  • During meiosis up to one-third of all homology directed repair events occur between sister chromatids. (wikipedia.org)
  • The important phenomenon of cue-dependent relapse can occur alter years or decades of abstinence. (geocitiessites.com)
  • Regardless of the etiology, a deficiency of cyclooxygenase (COX), a key regulatory enzyme in the synthetic pathway of eicosanoid production, results in beneficial and detrimental physiologic conditions relative to imbalances of the eicosanoids. (medscape.com)
  • Simplicial homology applies to finite data in real space, and thus it is mainly used in applications. (helsinki.fi)
  • B) Year of isolation and acquisition of drug resistance. (cdc.gov)
  • The diagnosis of measles is confirmed by laboratory test results, including a positive result for measles-specific immunoglobulin M (IgM) titre, significant increase in measles-specific immunoglobulin G (IgG) titre using paired serum, the detection of measles virus (MV) by reverse transcription polymerase chain reaction (RT-PCR) or isolation of MV in cell culture. (who.int)
  • A minimally hypomorphic mutation in Btk resulting in reduced B cell numbers but no clinical disease. (lu.se)
  • These results may be highly clinically significant, because in the United States alone, f10,000 women are diagnosed annually with ERa-negative/ERh-positive breast carcinoma and may benefit from adjuvant tamoxifen. (lu.se)
  • During the study, we found out that the species has been present in collections for at least 128 years but has not been formally described. (helsinki.fi)
  • These 7 species are approximately identical in DNA homology studies. (cdc.gov)
  • The Alliance provides the results of all methods that have been benchmarked by the Quest for Orthologs Consortium (QfO). (yeastgenome.org)
  • These tasks were approached with computational methods: homology modeling, docking, ligand-based pharmacophore modeling and virtual screening. (helsinki.fi)
  • Persistent homology is motivated by the question of which scale is the most essential to study data shape. (helsinki.fi)
  • As the Dilp peptides are secreted and circulated in the body, they activate the insulin signalling cascade in target tissues resulting in body growth 2 . (nature.com)
  • Here we report the results of a Drosophila UAS-miRNA library screen that identifies the conserved miR-9a as a regulator of insulin signalling and body growth. (nature.com)
  • He spent the first 18 months of a two-year 1958-60 NSF Fellowship at the Institute for Advanced Study in Princeton, New Jersey, and the last six months at the Instituto de Mathematica Pura e Aplicada in Rio de Janeiro, Brazil. (maa.org)
  • He then spent two years at the Institute for Advanced Study in Princeton, New Jersey, and two years at the University of California, Berkeley. (maa.org)
  • The study resulted in two types of satisfactory 3D-QSAR models, i.e. , the CoMFA model (Q 2 = 0.462, R 2 pred = 0.820) for epoxyketone inhibitors (EPK) and the CoMSIA model (Q 2 = 0.622, R 2 pred = 0.821) for tyropeptin-boronic acid derivatives (TBA). (fdocument.org)
  • Thus, like Salmonella enterica, which has two TTSS that play different roles during the infectious process, the Ysc and Ysa TTSS may play distinct roles for Y. enterocolitica. (usda.gov)
  • A painless necrotic lesion on of rickettsioses: current approaches to the developed on a finger of a 31-year- diagnosis of old and new rickettsial dis- the left fourth finger measured 3 cm2 old, healthy, female Belgian woman. (cdc.gov)
  • Here we redescribe the 508-million-year-old stem-group onychophoran Hallucigenia sparsa from the mid-Cambrian Burgess Shale. (helsinki.fi)
  • Recent results from our laboratory indicated that YsrRS are important in regulating expression of ysa in response to high salt. (usda.gov)
  • CDK2AP1 expression in disease-free patients at 10 years was more than threefold that of patients who died of breast cancer. (cancerindex.org)
  • Our results suggest that SLAP2 and ABL2 regulate FLT3 signaling and modulation of SLAP2 expression levels or targeting ABL2 could potentially synergize with FLT3 inhibitors to treat FLT3-ITD positive AML. (lu.se)
  • We will found that these provide sufficient tools to consider homology classes birth and deaths, but they are not particularly easy to use in practice. (helsinki.fi)
  • We found that its components' and essential homology classes' birth and death times correspond. (helsinki.fi)
  • An abnormal ubiquitin-proteasome is found in many human diseases, especially in cancer, and has received extensive attention as a promising therapeutic target in recent years. (fdocument.org)
  • However, a number of experimental results point to the validity of certain models. (wikipedia.org)
  • The results of the biological tests will decide how well the models represent the theory of the 11β-HSD2 selectivity. (helsinki.fi)
  • [ 3 ] Most FOP patients are bedridden by the time they are in their 30s, and they usually die before they reach 40 years of age. (medscape.com)
  • Although several FLT3 inhibitors have been developed and showed promising results in clinical trials, many patients develop drug resistance shortly after treatment starts and display poor outcome. (lu.se)
  • Results: Nine of the 13 EVD patients (age range: 22-70 years) survived. (bvsalud.org)
  • C: One Or Many Templates For Aligning To One Specific Region For Homology Modeling? (biostars.org)
  • Homology-directed repair (HDR) is a mechanism in cells to repair double-strand DNA lesions. (wikipedia.org)
  • They observed similar results in cultured human endothelial cells. (googleapis.com)
  • That is, you have 23 homologous pairs of chromosomes in almost all of the cells in your body, resulting in 46 total chromosomes. (umn.edu)
  • MolPharm articles become freely available 12 months after publication, and remain freely available for 5 years. (aspetjournals.org)
  • i) It is the result of freely chosen actions, or 'investments. (geocitiessites.com)
  • cate that equivalent structures characterized the ancestral panarthropod and, seemingly, the ancestral ecdysozoan, demonstrating the deep homology of panarthropod and cycloneuralian mouthparts, and providing an anatomical synapomorphy for the ecdysozoan supergroup. (helsinki.fi)
  • A few years later, von Euler of Sweden independently discovered similar effects of human seminal fluid on smooth muscle tissue. (medscape.com)
  • Its main tool is persistent homology, which is based on other homology theory, usually simplicial homology. (helsinki.fi)
  • South is a place where students discover and strengthen their passions, find their career paths, and form connections that result in lifelong relationships. (southalabama.edu)
  • Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page. (aspetjournals.org)
  • As a result of this institutional landscape, property relations are systematically projected into culture: from the status of a civic public good, culture is transformed into a resource for state and national construction or into property, privatized by the state or by businesses with close relations to the state. (wiko-berlin.de)