The YadA protein domain, is a form of trimeric autotransporter adhesins (TAAs). (wikipedia.org)
The Oca (Oligomeric coiled-coil adhesin) family is a subgroup of the bacterial trimeric autotransporter adhesins, which includes structurally related proteins, such as YadA of Yersinia enterocolitica and NadA of Neisseria meningitidis. (nih.gov)
Yersinia6
In molecular biology, YadA is a protein domain which is short for Yersinia adhesin A. These proteins have strong sequence and structural homology, particularly at their C-terminal end. (wikipedia.org)
YadA is found in three pathogenic species of Yersinia, Y. pestis, Y. pseudotuberculosis, and Y. enterocolitica. (wikipedia.org)
The YadA domain is encoded for by a virulence plasmid in Yersinia, which encodes a type-III secretion (T3S) system consisting of the Ysc injectisome and the Yop effectors. (wikipedia.org)
The importance of adhesins to YadA function and Yersinia survival is huge. (wikipedia.org)
Additionally, bacteria have the ability to regulate adhesion expression, meaning that when Yersinia no longer requires YadA, it can be turned off. (wikipedia.org)
YadA, an adhesin from Yersinia, was the first member of this family to be characterised. (wikipedia.org)
however, bacterial adherence and subsequent colonization of the intestinal epithelium also contribute to STEC virulence. (cdc.gov)
Biofilm formation2
Attachment further allows more interactions and increase of biofilm formation to aid bacterial colonization. (wikipedia.org)
2012) A positive correlation between bacterial autoaggregation and biofilm formation in native Sinorhizobium meliloti isolates from Argentina. (aimspress.com)
Oligomeric1
YadA is an example of an oligomeric coiled-coil adhesion (Oca). (wikipedia.org)
Proteins3
The YadA protein domain adheres to the following substrates: epithelial cells extracellular matrix collagen cellular fibronectin laminin The C-terminal domain consists of 120 amino acids which belong to a family of surface-exposed bacterial proteins. (wikipedia.org)
Alternatively, we demonstrated that expression of HadA confers to a non-invasive Escherichia coli strain the ability to adhere to human cells and to extracellular matrix proteins and to induce in vitro bacterial aggregation and microcolony formation. (nih.gov)
Bacterial outer membrane proteins primarily contain outer membrane protein A, porin C and F, being the major immunogenic proteins, and widely present in Gram-negative Enterobacteriaceae [ 8 ]. (biomedcentral.com)
Pathogenesis1
By secreting different classes of effectors, including cytolysins and adhesins, TPS systems play important roles in bacterial pathogenesis and host interactions. (bvsalud.org)
Translocation1
Autotransporter translocation to the bacterial outer surface, also known as type V secretion, involves formation of a ß-barrel autotransporter domain in the periplasm that inserts into the outer membrane to form a pore through which the N-terminal passenger domain is passed and exposed on the outer surface. (bvsalud.org)
Autotransporter1
In this study, we searched in silico for novel members of this family in bacterial genomes and identified HadA (Haemophilus adhesin A), a trimeric autotransporter expressed only by Haemophilus influenzae biogroup aegyptius causing Brazilian purpuric fever (BPF), a fulminant septicemic disease of children. (nih.gov)
Eukaryotic1
Upon contact with a eukaryotic target cell, the adhesins YadA or Inv interact with integrins and the bacterium docks at the cell's surface. (nih.gov)
Phagocytosis2
Additionally, by forming the fibrillar matrix, the YadA domain protects the bacteria by facilitating agglutination resistance, serum resistance, complement inactivation and phagocytosis resistance. (wikipedia.org)
The biotypes of Y. enterocolitica are divided into three groups according to the bacterial pathogenic properties: non-pathogenic biotype 1A, weakly pathogenic biotypes 2-5, and highly pathogenic biotype 1B [ 4 ]. (biomedcentral.com)
Strains1
The existence of less virulent bacterial strains that cause mild atypical bartonellosis has been suggested, meaning Carrion's disease is under-reported [ 1 ]. (biomedcentral.com)
Aggregation1
2014) Antibiotics promote aggregation within aquatic bacterial communities. (aimspress.com)
Outer2
YadA is a collagen-binding outer membrane protein. (wikipedia.org)
YadA is a homotrimeric outer membrane protein which forms part of the fibrillar matrix. (wikipedia.org)
Survival1
2006) Biological Trojan horse: Antigen 43 provides specific bacterial uptake and survival in human neutrophils. (aimspress.com)
Species1
We discuss in detail the specific regulatory networks identified in various bacterial species and emphasize the importance of understanding the context-dependent regulation of TPS systems. (bvsalud.org)
Cells1
The aim of the work was to obtain an AT877-based system for displaying EsOgl on the surface of bacterial cells. (bvsalud.org)
Surface2
It forms the fibrillar matrix on the bacterial cell surface. (wikipedia.org)
The surface is entirely covered in the YadA lollipop structures. (wikipedia.org)