Sodium oxybateParalysisExcessive Daytime Sleepiness and CHallucinationsKnown as cataplexyEpisodes of cataplexyAssociated with narcolepsyWeekly number of cataplexy attacksPatients with narcolepsyJazz PharmaceuticalsSSRIsXywavWakixPeople with narcolepsyHypnagogicExperiences cataplexySymptom of narcolepsyEveryone with narcolepsyAntidepressantsReducing episodesOral solutionType of narcolepsySleepinessModafinilSymptoms of narcolepsyTreatmentOccurEmotionsInterestinglyMedicationLossHypocretinTotal body collapseMedicationsNarcolepticsSeizuresSufferCollapseExperienceSevereGenetic
Sodium oxybate24
- It is commonly used in the form of a salt, such as sodium γ-hydroxybutyrate (NaGHB, sodium oxybate, or Xyrem) or potassium γ-hydroxybutyrate (KGHB, potassium oxybate). (wikipedia.org)
- GHB is the active ingredient of the prescription medication sodium oxybate (Xyrem). (wikipedia.org)
- Sodium oxybate is approved by the U.S. Food and Drug Administration for the treatment of cataplexy associated with narcolepsy and excessive daytime sleepiness (EDS) associated with narcolepsy. (wikipedia.org)
- If antidepressants don't work, sodium oxybate (Xyrem) is often the next choice. (healthline.com)
- Sodium oxybate (Xyrem) works well to control cataplexy. (nih.gov)
- The Xywav formulation has 92% less sodium than sodium oxybate (Xyrem), which was approved in 2002. (medpagetoday.com)
- Sodium oxybate (Xyrem, generic) for cataplexy as well as for EDS. (adam.com)
- Jazz Pharmaceuticals' Xyrem (sodium oxybate) Oral Solution has received marketing approval for use in treating excessive daytime sleepiness in patients with narcolepsy. (drugtopics.com)
- A Safety and Efficacy Study of Xyrem (Sodium Oxybate) to Treat Fibromyalgia. (neuly.com)
- Safety and Efficacy Study of Xyrem (Sodium Oxybate) in Subjects With Fibromyalgia. (neuly.com)
- Medications such as sodium oxybate ( Xyrem ) and venlafaxine (Effexor) can help prevent cataplexy. (healthline.com)
- In 2002, a new drug, Xyrem (sodium oxybate), was approved for the safe and effective treatment of cataplexy. (narcolepsyafricafoundation.org)
- A prescription variant of GHB, known as sodium oxybate (Xyrem), is employed to address excessive daytime sleepiness associated with narcolepsy. (welevelup.com)
- For patients seven years and older with cataplexy and/or excessive daytime sleepiness, XYWAV® (calcium, magnesium, potassium, and sodium oxybates), the first and only FDA approved low-sodium oxybate, is an option. (newsdaytonabeach.com)
- The exact way XYWAV works for the treatment of cataplexy and EDS in patients with narcolepsy is unknown, but it contains 92% less sodium than the higher-sodium oxybate, XYREM® (sodium oxybate) oral solution. (newsdaytonabeach.com)
- Currently, medically formulated GHB sodium oxybate (Xyrem®) is approved in different countries for such varied uses as general anaesthesia, the treatment of alcohol withdrawal and addiction, and cataplexy associated with narcolepsy. (neuly.com)
- As expected, initial cataplexy rates differed based on prior therapy at study entry, with participants taking sodium oxybate only or sodium oxybate and an antidepressant/anticataplectic reporting the least cataplexy at study entry. (wakeupnarcolepsy.org)
- In participants taking sodium oxybate only at study entry, cataplexy was stable with JZP-258 treatment across the open-label treatment titration and optimization period and the stable dose period (SDP). (wakeupnarcolepsy.org)
- In those taking sodium oxybate and an antidepressant/anticataplectic at study entry, cataplexy was stable during initial titration of JZP-258, increased during taper and discontinuation of the other anticataplectic, and stabilized during SDP. (wakeupnarcolepsy.org)
- XYWAV is the first and only lower-sodium oxybate approved by the FDA to treat cataplexy or excessive daytime sleepiness in people 7 years and older with narcolepsy. (xywav.com)
- How is XYWAV different from XYREM ® (sodium oxybate) oral solution? (xywav.com)
- Calcium, magnesium, potassium, and sodium oxybate is available only through a restricted distribution program called the Xywav and Xyrem REMS Program. (medlineplus.gov)
- Calcium, magnesium, potassium, and sodium oxybate is used to treat attacks of cataplexy (episodes of muscle weakness that begin suddenly and last for a short time) and excessive daytime sleepiness in adults and children 7 years of age and older who have narcolepsy (a sleep disorder that may cause extreme sleepiness, sudden uncontrollable urge to sleep during daily activities, and cataplexy). (medlineplus.gov)
- How have branded agents such as pitolisant (Harmony Biosciences' Wakix), solriamfetol (Jazz Pharmaceuticals' Sunosi), and sodium oxybate (Jazz Pharmaceuticals' Xyrem) been integrated into the treatment algorithm, and what is their source of business? (clarivate.com)
Paralysis9
- episodes of cataplexy, sleep paralysis, and hallucinations. (nih.gov)
- Narcolepsy is characterized by the classic tetrad of excessive daytime sleepiness (EDS), cataplexy, hypnagogic hallucinations, and sleep paralysis. (medscape.com)
- The classic symptoms of the disorder, often referred to as the "tetrad of narcolepsy," are cataplexy , sleep paralysis , hypnagogic hallucinations , and excessive daytime sleepiness. (sleepdisordersresource.com)
- [ citation needed ] Cataplexy is generally considered to be unique to narcolepsy and is analogous to sleep paralysis in that the usually protective paralysis mechanism occurring during sleep is inappropriately activated. (sleepdisordersresource.com)
- Narcoleptics who experience cataplexy, hallucinations, and sleep paralysis are diagnosed to have REM related abnormalities. (ghostbed.com)
- When the muscle paralysis associated with REM sleep occurs spontaneously during waking hours this is known as cataplexy. (nestmaven.com)
- Narcolepsy is a sleep disorder that causes excessive daytime sleepiness, hallucinations, cataplexy, and sleep paralysis. (neurologysleepcentre.com)
- In addition to daytime sleepiness, symptoms can include hallucinations, sleep disruption, sleep paralysis, and cataplexy, where all the muscles suddenly lose their tension and stiffness, leading to the loss of voluntary muscle control. (carusoinsights.com)
- it is differentiated from narcolepsy by lack of cataplexy, hypnagogic hallucinations, and sleep paralysis. (merckmanuals.com)
Excessive Daytime Sleepiness and C4
- Below are some important considerations that narcolepsy patients with excessive daytime sleepiness and cataplexy can refer to when speaking with their doctor about their sodium intake, which is a modifiable risk factor for heart health. (newsdaytonabeach.com)
- Oxybate-containing medications are a treatment option for people with narcolepsy who have excessive daytime sleepiness and cataplexy. (newsdaytonabeach.com)
- I would definitely recommend to others who are struggling with excessive daytime sleepiness and cataplexy in narcolepsy to talk to their doctor about trying XYWAV to see if it may help them like it helped me," Grace says. (newsdaytonabeach.com)
- A number of therapies from a range of drug classes are available to address the symptoms of narcolepsy, which include excessive daytime sleepiness and cataplexy. (clarivate.com)
Hallucinations1
- One should see a doctor when he/she is experiencing excessive daytime sleepiness, hallucinations, sleep attacks, or cataplexy. (neurologysleepcentre.com)
Known as cataplexy5
- [1] About 70% of those affected also experience episodes of sudden loss of muscle strength, known as cataplexy . (sleepdisordersresource.com)
- Type 1 narcolepsy is characterized by sleepiness that is accompanied by sudden loss in muscle tone, otherwise known as cataplexy. (annapolispulmonary.com)
- This is known as cataplexy and can often be mistaken for being seizure activity, especially in children. (epainassist.com)
- Type 1 features a sudden loss of muscle tone, known as cataplexy. (healthline.com)
- The central nervous system disease of narcolepsy can also cause a sudden muscle tone loss known as cataplexy. (ghostbed.com)
Episodes of cataplexy4
- Most people who experience episodes of cataplexy also have narcolepsy, a chronic condition that causes uncontrollable episodes of sleep. (healthline.com)
- But not everyone with narcolepsy experiences episodes of cataplexy, and not everyone who experiences cataplexy has narcolepsy. (healthline.com)
- Most people who experience episodes of cataplexy have narcolepsy. (healthline.com)
- In certain cases, narcolepsy presents with sudden episodes of cataplexy (partial or total loss of muscle control). (nestmaven.com)
Associated with narcolepsy1
- In 2005, Xyrem was also approved to treat EDS associated with narcolepsy. (narcolepsyafricafoundation.org)
Weekly number of cataplexy attacks1
- The primary endpoint was the change in the weekly number of cataplexy attacks, and the key secondary endpoint was the change in the Epworth Sleepiness Scale (ESS) score with JZP-258 compared to placebo. (sleepreviewmag.com)
Patients with narcolepsy4
- Around 90% of patients with narcolepsy type 1 (narcolepsy with cataplexy) and half of patients with narcolepsy type 2 (narcolepsy without cataplexy) carry a specific genetic variation, called a haplotype, in an immune system gene (HLA-DQB1*06:02). (adam.com)
- The Schedule III drug was approved originally for treating cataplexy in patients with narcolepsy. (drugtopics.com)
- A clinical trial demonstrated the efficacy and safety of XYWAV for the treatment of cataplexy and excessive daytime sleepiness in adult patients with narcolepsy. (xywav.com)
- Neurotrials Research is seeking patients with narcolepsy with or without cataplexy who experience excessive daytime sleepiness to evaluate the long-term safety and tolerability of an investigational drug. (neurotrials.com)
Jazz Pharmaceuticals3
- Positive data from the Phase 3 study of Jazz Pharmaceuticals plc's investigational medicine, JZP-258, for the treatment of cataplexy and excessive daytime sleepiness (EDS) in adults with narcolepsy were presented at World Sleep 2019 in Vancouver, Canada. (sleepreviewmag.com)
- We are pleased with the positive results from the Phase 3 study of JZP-258, which demonstrate the efficacy of JZP-258 for the treatment of cataplexy and excessive daytime sleepiness in narcolepsy," says Jed Black, MD, senior vice president, Sleep and Neuroscience at Jazz Pharmaceuticals and adjunct professor, Stanford University Medical Center, Stanford Center for Sleep Sciences and Medicine, in a release. (sleepreviewmag.com)
- DUBLIN, SEPTEMBER 25, 2019 - Jazz Pharmaceuticals plc (Nasdaq: JAZZ) announced today that positive data from the Phase 3 study of its investigational medicine, JZP-258, for the treatment of cataplexy and excessive daytime sleepiness (EDS) in adults with narcolepsy were presented at World Sleep 2019 in Vancouver, Canada. (wakeupnarcolepsy.org)
SSRIs2
- [1] Tricyclic antidepressants and selective serotonin reuptake inhibitors (SSRIs) may improve cataplexy. (sleepdisordersresource.com)
- Vivactil, Tofranil, etc.) and serotonin reuptake inhibitors (SSRIs) have traditionally been used for treatment of cataplexy and other REM symptoms. (narcolepsyafricafoundation.org)
Xywav5
- Because of the risk of CNS depression, abuse and misuse, XYWAV is available only by prescription, and filled through the central pharmacy in the XYWAV and XYREM REMS. (newsdaytonabeach.com)
- Now, we've got clinical experience with the drug in terms of transitioning patients from Xyrem to Xywav, the lower sodium moiety. (neurologylive.com)
- Does XYWAV taste the same as XYREM? (xywav.com)
- Can I change from XYREM treatment to XYWAV? (xywav.com)
- Because of the risk of central nervous system (CNS) depression, abuse, and misuse, XYWAV is available only through a restricted distribution program called the XYWAV and XYREM REMS. (xywav.com)
Wakix1
- Subsequently, in 2020, WAKIX was approved by the FDA for the treatment of cataplexy. (carusoinsights.com)
People with narcolepsy2
- Some people with narcolepsy also have a condition called cataplexy. (healthline.com)
- Besides EDS, people with narcolepsy type 1 also have cataplexy, which is a sudden but temporary muscle weakness, sometimes brought on by laughter or other emotions. (adam.com)
Hypnagogic1
- Individuals encountering exorbitant tiredness during the day, cataplexy, rest loss of motion, and hypnagogic mind flights are viewed as experiencing narcolepsy. (wbsofts.com)
Experiences cataplexy2
- Not everyone who experiences cataplexy has narcolepsy. (healthline.com)
- If it is found that the individual has hypocretin deficiency, experiences cataplexy, and has short REM sleep sleep latency, the person is diagnosed with Narcolepsy. (neurologysleepcentre.com)
Symptom of narcolepsy3
- Sometimes, cataplexy episodes are the first symptom of narcolepsy and can help lead to a diagnosis. (healthline.com)
- Cataplexy is a fascinating symptom of narcolepsy - a sudden loss of muscle tone, without loss of consciousness, often triggered by emotions. (julieflygare.com)
- Another common symptom of narcolepsy is cataplexy. (epainassist.com)
Everyone with narcolepsy1
- Not everyone with narcolepsy will experience cataplexy. (nestmaven.com)
Antidepressants2
- Most recently, the antidepressants Effexor (an SSNRI), and Strattera (an SNRI), are showing excellent results in alleviating cataplexy and reducing other REM symptoms. (narcolepsyafricafoundation.org)
- Treatment might incorporate energizers, antidepressants, and xyrem. (wbsofts.com)
Reducing episodes1
- There's no cure for cataplexy, but medications are often an effective way of reducing episodes. (healthline.com)
Oral solution1
- Jazz Pharmaceutical), an oral solution of calcium, magnesium, potassium, and sodium oxybates, for the treatment of cataplexy or excessive daytime sleepiness (EDS) in patients 7 years of age or older with narcolepsy. (neurologylive.com)
Type of narcolepsy1
- People with this type of narcolepsy also have cataplexy or the sudden loss of muscle control or muscle tone. (epainassist.com)
Sleepiness6
- The drug was first approved in 2020 for both cataplexy and excessive daytime sleepiness in people 7 years and older living with narcolepsy. (medpagetoday.com)
- In type 1 narcolepsy, people experience episodes of extreme cataplexy and sleepiness during the day because of having low levels of a protein known as hypocretin. (epainassist.com)
- There are times that cataplexy may occur prior to the sleepiness symptoms. (ghostbed.com)
- Treats loss of muscle control (cataplexy) and excessive daytime sleepiness that is caused by a sleep disorder (narcolepsy). (dream-pharmacy.com)
- Drugs such as Modafinil or armodafinil are prescribed for excessive daytime sleepiness, and drugs such as Xyrem for cataplexy. (neurologysleepcentre.com)
- Treatment Narcolepsy is characterized by chronic excessive daytime sleepiness, often with sudden loss of muscle tone (cataplexy). (merckmanuals.com)
Modafinil1
- Our Treatment Algorithms research leverages national patient-level claims data to explore the use of key therapies in narcolepsy, such as modafinil, armodafinil, and Xyrem, in both newly diagnosed and recently treated patients. (clarivate.com)
Symptoms of narcolepsy1
- Xyrem is the only medication that treats all major symptoms of narcolepsy. (narcolepsyafricafoundation.org)
Treatment7
- GHB has been used in the medical setting as a general anesthetic and as treatment for cataplexy, narcolepsy, and alcoholism. (wikipedia.org)
- Treatment for cataplexy depends on how often your episodes happen and how severe they are. (healthline.com)
- For instance, people who have mild cataplexy episodes once or twice a year might not need a formal treatment plan. (healthline.com)
- The Phase 3 study of JZP-258 was a global, double-blind, placebo-controlled, randomized-withdrawal, multicenter study evaluating the efficacy and safety of JZP-258 in the treatment of cataplexy and EDS in adults with narcolepsy. (sleepreviewmag.com)
- By Treatment, the narcolepsy with cataplexy segment had the highest market share of 37% in 2022. (precedenceresearch.com)
- By Treatment, the narcolepsy without cataplexy segment is anticipated to grow at a notable CAGR of 9.7% during the projected period. (precedenceresearch.com)
- In cataplexy treatment-naïve participants, cataplexy decreased consistently from week one of JZP-258 titration through the end of SDP. (wakeupnarcolepsy.org)
Occur3
- Treating cataplexy depends on how often episodes occur and on the severity of episodes. (healthline.com)
- In some cases, cataplexy can even occur later in the course of the disease. (epainassist.com)
- In type 2 narcolepsy, cataplexy does not occur. (neurologysleepcentre.com)
Emotions6
- Temporary and sudden muscle weakness without loss of consciousness (called cataplexy ), usually brought on by sudden or strong emotions. (adam.com)
- It's not always strong or positive emotions that cause my cataplexy. (julieflygare.com)
- Intense emotions like fear and excitement and laughing can also trigger cataplexy. (epainassist.com)
- Strong emotions like fear or anger, or when you're laughing, may trigger cataplexy. (healthline.com)
- Strong emotions are what drives cataplexy. (ghostbed.com)
- Have received an NT1 diagnosis within the past 10 years or are experiencing NT1 symptoms (characterized by cataplexy, or the sudden loss of muscle control and muscle weakness due to strong emotions or actions, like anger or laughter, while remaining conscious). (hypersomniafoundation.org)
Interestingly1
- Interestingly, cataplexy is often triggered by experiencing an intense emotion, like laughter, anger and surprise. (nestmaven.com)
Medication3
- 9. Sexual excitement - Before medication, sexual excitement caused my cataplexy. (julieflygare.com)
- The goal is to decrease EDS and reduce occurrences of cataplexy using minimal medication, EDS and cataplexy must be treated separately. (narcolepsyafricafoundation.org)
- I started taking Xyrem that is a quite controversial medication, and there are a lot of requirements you have to meet to take it. (kaylamdouglas.com)
Loss6
- Cataplexy is a condition that causes a sudden loss of muscle control and muscle tone. (healthline.com)
- Cataplexy is characterized by episodes of a sudden loss of muscle tone and control. (healthline.com)
- Cataplexy causes episodes of muscle weakness and loss of muscle tone. (healthline.com)
- Cataplexy is a condition that causes sudden episodes of a loss of muscle control. (healthline.com)
- Cataplexy is an episodic loss of muscle function, ranging from slight weakness such as limpness at the neck or knees, sagging facial muscles, weakness at the knees often referred to as "knee buckling", [9] or inability to speak clearly, to a complete body collapse. (sleepdisordersresource.com)
- The condition of cataplexy which causes sudden loss of muscle tone can affect any of the muscles in the body. (ghostbed.com)
Hypocretin2
- Type 1 narcolepsy (narcolepsy with cataplexy), the most common form of the condition, is caused by a deficiency in the neurotransmitter hypocretin (orexin). (adam.com)
- In this type, there is an extreme deficiency of hypocretin neurons and cataplexy is major symptom. (neurologysleepcentre.com)
Total body collapse1
- This can range from the simple drooping of eyelids (known as partial cataplexy) to a total body collapse. (epainassist.com)
Medications3
- Cataplexy can be a side effect of certain medications, but this is rare. (healthline.com)
- Off-label means the medications are intended to treat symptoms of depression, but they've also been found to relieve symptoms of cataplexy. (healthline.com)
- Or, you may not come to know that you have cataplexy if your doctor has already prescribed medications to suppress it. (epainassist.com)
Narcoleptics1
- Cataplexy also has a severe emotional impact on narcoleptics, as it can cause extreme anxiety, fear, and avoidance of people or situations that might elicit an attack. (sleepdisordersresource.com)
Seizures3
- But unlike seizures, people with cataplexy remain awake and aware during their episodes. (healthline.com)
- [1] Cataplexy may be mistaken for seizures . (sleepdisordersresource.com)
- In some cases, cataplexy may resemble epileptic seizures. (sleepdisordersresource.com)
Suffer1
- Not every narcoleptic will suffer from cataplexy. (ghostbed.com)
Collapse1
- Cataplexy can be mild, where your head drops, or it can be severe, causing you to collapse. (healthline.com)
Experience4
- The drug being promoted by the sales rep was Xyrem, a powerful central nervous system depressant, approved for "narcolepsy patients who experience cataplexy" and "narcolepsy patients with excessive daytimesleepiness. (pharma-mkting.com)
- I experience minor cataplexy daily - knees buckling, jaw slackening, eyes fluttering or hands trembling. (julieflygare.com)
- People with type 1 narcolepsy experience cataplexy . (healthline.com)
- You may experience cataplexy several times a day or only once a year. (healthline.com)
Severe1
- My friend Elizabeth was diagnosed with a severe case of narcolepsy with cataplexy when she was in 6th grade. (trincoll.edu)
Genetic1
- Cataplexy can also be a symptom of some genetic conditions or the result of a stroke or brain tumor. (healthline.com)