• Following treatment with xylazine, the heart rate is decreased and a transient change in the conductivity of the cardiac muscle may occur, as evidenced by a partial atrioventricular block. (medi-vet.com)
  • In horses and Cervidae under the influence of xylazine, the respiratory rate is reduced as in natural sleep. (medi-vet.com)
  • Objective-To evaluate cardiopulmonary effects of glycopyrrolate in horses anesthetized with halothane and xylazine.Animals-6 horses.Procedure-Horses were allocated to 2 treatment groups in a randomized complete block design. (unesp.br)
  • Glycopyrrolate administration was associated with impaction of the large colon in I horse and low intestinal auscultation scores lasting 24 hours in 3 horses.Conclusions and Clinical Relevance-The positive chronotropic effects of glycopyrrolate resulted in improvement of hemodynamic function in horses anesthetized with halothane and xylazine. (unesp.br)
  • Clinical curio: self medication with xylazine. (bmj.com)
  • Lewis S , O'Callaghan C L , Toghill P J . Clinical curio: self medication with xylazine. (bmj.com)
  • Results from early human clinical studies confirmed that xylazine has several central nervous system depressant effects. (wikipedia.org)
  • The clinical use of xylazine may result in morbidity and mortality in small ruminants, and it was suspected that exposure to changes in environmental temperature may contribute to these effects. (up.ac.za)
  • It is concluded that apart from changes in body temperature, changes that occurred in clinical and pharmacokinetic variables after xylazine administration, were independent of the three environmental temperature and humidity conditions. (up.ac.za)
  • Sedative and clinical effects of the pharmacopuncture with xylazine in dogs. (semanticscholar.org)
  • When used at dosages appropriate for adult animals, ketamine-xylazine anesthetics led to a high rate of respiratory failure, increased apoptotic activity in the corneal epithelium, and irreversible corneal calcification in P14 rat pups. (arvojournals.org)
  • Perhaps the most unusual, yet largest amount of drugs police say they seized during the investigation is nearly 9 kilograms of xylazine, a kind of animal tranquilizer Police Chief Timothy Altomare said was being used to cut heroin. (baltimoresun.com)
  • The Journal of Urban Health mentions that in humans, xylazine can cause effects that are similar to opioids such as heroin. (areterecovery.com)
  • Heroin users sometimes use xylazine without knowing this because they buy heroin expecting it to be pure, but xylazine may be an active ingredient that has been added or mixed into it. (areterecovery.com)
  • However, many heroin users knew that a new heroin supply was available that had been cut with xylazine. (areterecovery.com)
  • In Puerto Rico, heroin users also mentioned that it was getting hard to find heroin that does not contain xylazine. (areterecovery.com)
  • Long-term consequences of xylazine use (either alone or with heroin) still need to be studied. (areterecovery.com)
  • However, the case study from the Journal of Urban Health mentioned that 21.1 percent of people in their sample reported overdoses on heroin that was cut with xylazine. (areterecovery.com)
  • In addition, people who use heroin or speedball that has been cut with xylazine are at higher risk of skin lesions than people who use heroin on its own. (areterecovery.com)
  • Users of xylazine worldwide often take it along with heroin. (areterecovery.com)
  • NIDA reports that people do use xylazine (alone or with heroin) on a consistent basis. (areterecovery.com)
  • Xylazine is very similar to drugs such as phenothiazine, tricyclic antidepressants, and clonidine. (wikipedia.org)
  • For example, xylazine and clonidine suppress uptake of MIBG, a norepinephrine analog, in neuroblastoma cells. (wikipedia.org)
  • When 200 units of soluble insulin were given 20 minutes after similar doses of xylazine there was a rapid fall in blood glucose and a reduction in the rate of glucose production by the liver. (bmj.com)
  • 0.05) different 15 minutes after xylazine administration and continued to be so for the duration of the observation period. (up.ac.za)
  • 0.05) in the 24° and 34°C environments from 15 minutes after xylazine administration. (up.ac.za)
  • 0.05) from 15 minutes after xylazine administration for the duration of the observation period in all three environments. (up.ac.za)
  • 0.05) changes occurred after xylazine administration in acid-base balance and arterial blood gas variables independent of environmental conditions. (up.ac.za)
  • Torruella wrote that drug is sometimes referred to as anestesia de caballo , or horse anesthetic, in Puerto Rico and "some associations have been made between the use of xylazine and open skin ulcers. (baltimoresun.com)
  • Moreover, xylazine caused a significant decrease in the levels of Asp secreted by neurons at 20 min, but gradually returned to the level of the control group. (sciendo.com)
  • Due to xylazine's highly lipophilic nature, xylazine directly stimulates central α2 receptors as well as peripheral α-adrenoceptors in a variety of tissues. (wikipedia.org)
  • α2-Adrenoceptor subtypes were highly expressed on P14, in line with rodents' age-specific sensitivity to xylazine. (arvojournals.org)
  • There were photos of luxury cars, a handful of firearms and a whole table filled with various opioids, including nearly 9 kilograms of an animal tranquilizer called xylazine. (baltimoresun.com)
  • However, when used at a conventional dosage, xylazine (an α2-adrenoceptor) can cause irreversible corneal calcification, especially among young rodents. (arvojournals.org)