• In this study, we demonstrate that PPan is expressed maternally as well as in the eye and cranial neural crest cells (NCCs) during early Xenopus laevis development. (silverchair.com)
  • The developmental capacity of nuclei taken from differentiating endoderm cells of Xenopus laevis. (springer.com)
  • The embryo of the frog Xenopus laevis is widely used as a model of cell polarization, migration, and morphogenesis due to its unique experimental advantages. (nature.com)
  • Here we reveal the expression patterns of the two MyoD genes in Oreochromis ( Alcolapia) alcalica using in situ hybridisation. (mdpi.com)
  • Kolpakova A*, Katz S*, Keren A, Rojtblat A, Bengal E . (2013) Transcriptional Regulation of Mesoderm Genes by MEF2D during Early Xenopus Development . (technion.ac.il)
  • Heart development (myocardium differentiation, Skeletal muscle development (alpha-actin of skeletal muscles),) Smooth muscle development (alpha-actin of smooth muscles), Regulation of myosin heavy chain genes, cardiac muscular genes troponin T and I Regulation of proliferation, Regulation of apoptosis, Protein Kinase A (pKA) can phosphorylate TEAD1 at serine 102, after the TEA domain. (wikipedia.org)
  • TEAD proteins require cofactors to induce the transcription of target genes. (wikipedia.org)
  • Separately, E2a is necessary to drive transcription of Smad2 /3 target genes, including critical regulators of dorsal cell fate and morphogenesis. (xenbase.org)
  • Activation of muscle-specific genes in pigment, nerve, fat, liver, and fibroblast cell lines by forced expression of MyoD. (springer.com)
  • DDX5 is required for cell proliferation by controlling the transcription of genes expressing DNA replication proteins in cancer cells in which the DDX5 locus is amplified, and this has uncovered a dependence on DDX5 for cell proliferation. (aacrjournals.org)
  • With roughly 30,000 genes in mammalian genomes, fection with a vector encoding MyoD (Tapscott et al. (lu.se)
  • Keren, A., Keren-Politansky, A., and Bengal, E . (2008) A p38 MAPK-CREB pathway functions to pattern mesoderm in Xenopus . (technion.ac.il)
  • Here, we show that in Xenopus, Fry plays a role in morphogenetic processes during gastrulation, in addition to its previously described function in the regulation of dorsal mesoderm gene expression. (nature.com)
  • At the beginning of Xenopus gastrulation, the presumptive anterior mesoderm cells located at the dorsal marginal zone (DMZ) roll inward at the midline of the blastopore lip in a process called involution. (nature.com)
  • It has been shown that TEAD/VGLL1 complexes promote anchorage-independent cell proliferation in prostate cancer cell lines suggesting a role in cancer progression Moreover, VGLL2 interaction with TEAD1 activates muscle promoter upon C2C12 differentiation and enhances MyoD-mediated myogenic in 10T1/2. (wikipedia.org)
  • Muscle homeostasis is regulated by multiple cytoskeletal proteins and myogenic transcriptional programs responding to endogenous and exogenous signals influencing cell structure and function. (bvsalud.org)
  • During gastrulation in Xenopus , the head ectoderm is subdivided into the central nervous system (CNS) anlage (neural plate) and the non-CNS ectoderm (i.e. epidermis, placodes and neural crest). (biologists.com)
  • E2a is necessary for Smad2 /3-dependent transcription and the direct repression of lefty during gastrulation. (xenbase.org)
  • This family of proteins includes a wide variety of classes, including CYCLIN-DEPENDENT KINASES, mitogen-activated kinases, CYCLINS, and PHOSPHOPROTEIN PHOSPHATASES as well as their putative substrates such as chromatin-associated proteins, CYTOSKELETAL PROTEINS, and TRANSCRIPTION FACTORS. (lookformedical.com)
  • Antibody reactivity against recominant protein and cell lysate for WB. (novusbio.com)
  • Tamir, Y., and Bengal E . (2000) Phosphoinositide 3-kinase induces the transcriptional activity of MEF2 proteins during muscle differentiation . (technion.ac.il)
  • In both cases the interaction of the proteins leads to increased TEAD transcriptional activity. (wikipedia.org)
  • Zetser, A., Gredinger, E., and Bengal, E. (1999) p38 mitogen-activated protein kinase promotes skeletal muscle differentiation: participation of the MEF2C transcription factor . (technion.ac.il)
  • This encoded protein is expressed in many tissues, among them skeletal muscle, thymus, B- and T-cells, and may participate in regulating lineage-specific gene expression through the formation of heterodimers with other bHLH E-proteins. (novusbio.com)
  • Since actin is an essential component in cytoskeleton dynamics, actin-binding proteins (ABPs) have been recognized as crucial players in skeletal muscle health and diseases. (bvsalud.org)
  • PARP can also ADP-ribosylate the TEAD proteins and make the chromatin context favorable to transcription through histone modification, SRF (Serum response factor) and TEAD1 together regulate gene expression. (wikipedia.org)
  • Nucleosomes impose a block to transcription that can be overcome in vivo by remodeling complexes such as SNF/SWI and histone modification complexes such as SAGA. (sdbonline.org)
  • The variant histone H2A.Z regulates gene transcription, and deletion of the gene encoding H2A.Z strongly increases the requirement for SNF/SWI and SAGA. (sdbonline.org)
  • The histone H2A.F/Z (H2AZ) variant is a functionally distinct, highly conserved histone subgroup that likely represents a separate evolutionary lineage of histone H2A proteins. (sdbonline.org)
  • A histone chaperone protein that plays a role in the deposition of NUCLEOSOMES on newly synthesized DNA. (lookformedical.com)
  • and nonhistone proteins (CHROMOSOMAL PROTEINS, NON-HISTONE) found within the nucleus of a cell. (lookformedical.com)
  • A retinoblastoma-binding protein that is involved in CHROMATIN REMODELING, histone deacetylation, and repression of GENETIC TRANSCRIPTION. (lookformedical.com)
  • It is found as a subunit of protein complexes that are in involved in the enzymatic modification of histones including the Mi2 and Sin3 histone deacetylase complexes and the polycomb repressive complex 2. (lookformedical.com)
  • Molecular analysis suggested that Esc2p contributed to silencing in a manner similar to Sir1p and probably helped recruit or stabilize the other Sir proteins, while Htz1p present at HMR assembled a specialized chromatin structure necessary for silencing (Dhillon, 2000). (sdbonline.org)
  • These results describe a novel pathway for regulating transcription using variant histones to modulate chromatin structure (Santisteban, 2000). (sdbonline.org)
  • Alter J, Bengal E. (2011) Stress-Induced C/EBP Homology Protein (CHOP) Represses MyoD Transcription to Delay Myoblast Differentiation . (technion.ac.il)
  • Ostrovsky O., Bengal, E .*, and Aronheim, A.* (2002) Induction of Terminal Differentiation by the c-Jun Dimerization Protein JDP2 in C2 Myoblasts and Rhabdomyosarcoma Cells . (technion.ac.il)
  • Tamir, Y., and Bengal, E. (1998) p53 protein is activated during muscle differentiation and participates with MyoD in the transcription of muscle creatine kinase gene . (technion.ac.il)
  • In Aspergillus nidulans, the TEA domain protein ABAA regulates the differentiation of conidiophores. (wikipedia.org)
  • Finally in Xenopus it has been demonstrated that the ortholog of TEAD1 regulates muscle differentiation. (wikipedia.org)
  • The MyoD gene was duplicated during the teleost whole genome duplication and, while a second MyoD gene ( MyoD2 ) was subsequently lost from the genomes of some lineages (including zebrafish), many fish lineages (including Alcolapia species) have retained both MyoD paralogues. (mdpi.com)
  • We report our analysis of MyoD1 and MyoD2 protein sequences from 54 teleost species, and show that O. alcalica , along with some other teleosts, include a polyserine repeat between the amino terminal transactivation domains (TAD) and the cysteine-histidine rich region (H/C) in MyoD1. (mdpi.com)
  • Proteins obtained from the species SACCHAROMYCES CEREVISIAE. (lookformedical.com)
  • Ciechanover, A., Breitschopf, K., Abu Hatoum, O., and Bengal E. (1999) Degradation of MyoD by the ubiquitin pathway: regulation by specific DNA-binding and identification of a novel site for ubiquitination . (technion.ac.il)
  • This pathway can be potentiated by R-spondins, a family of proteins that bind RNF43/ZNRF3 E3 ubiquitin ligases and LGR4/5 receptors to prevent Frizzled degradation. (xenbase.org)
  • It is the H3 helix that enables TEAD proteins to bind DNA. (wikipedia.org)
  • It allows the binding of cofactors and has been called the YAP1 binding domain, because it is its ability to bind this well-known TEAD proteins co-factor that led to its identification. (wikipedia.org)
  • e.g. they bind selectively to DNA, stimulate transcription resulting in tissue-specific RNA synthesis and undergo specific changes in response to various hormones or phytomitogens. (lookformedical.com)
  • Proteins which bind to DNA. (lookformedical.com)
  • The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases. (lookformedical.com)
  • Once this complex is formed, these two proteins can regulate the alpha-myosin heavy chain (α-MHC) gene expression. (wikipedia.org)
  • Understanding the proteins that regulate the 5-HT1A promoter will lead to insights on receptor regulation and provide new therapeutic targets relevant to depression, anxiety, obsessive compulsive disorder and other mental illnesses. (vdocuments.net)
  • The 48 kDa subunit, RETINOBLASTOMA-BINDING PROTEIN 4, is also a component of several other protein complexes involved in chromatin remodeling. (lookformedical.com)
  • Although initially discovered as a retinoblastoma binding protein it has an affinity for core HISTONES and is a subunit of chromatin assembly factor-1 and polycomb repressive complex 2. (lookformedical.com)
  • The repeating structural units of chromatin, each consisting of approximately 200 base pairs of DNA wound around a protein core. (lookformedical.com)
  • In Xenopus , the non-CNS ectoderm of the head region (referred to as`cephalic non-neural ectoderm' hereafter) has several characteristic features. (biologists.com)
  • The Nodal signaling pathway has many biological functions that all converge on the transcription factors Smad2 /3. (xenbase.org)
  • Here we demonstrate that, during Xenopus anteroposterior axis specification, Rspo2 functions as a Wnt antagonist, both morphologically and at the level of gene targets and pathway mediators. (xenbase.org)
  • The furry ( fry ) gene encodes an evolutionarily conserved protein with a wide variety of cellular functions, including cell polarization and morphogenesis in invertebrates. (nature.com)
  • The Furry (Fry) gene encodes a large protein (~ 330 kDa) that is evolutionarily conserved from yeast to humans. (nature.com)
  • The mammalian genome comprises nuclear DNA (nDNA) derived from both parents and mitochondrial DNA (mtDNA) that is maternally inherited and encodes essential proteins required for oxidative phosphorylation. (regenerativemedicine.net)
  • The winged-helix transcription factor Xfoxi1a is one of the earliest markers for the preplacodal region at the mid-neurula stage. (biologists.com)
  • Transcriptional enhancer factor TEF-1 also known as TEA domain family member 1 (TEAD1) and transcription factor 13 (TCF-13) is a protein that in humans is encoded by the TEAD1 gene. (wikipedia.org)
  • In drosophila the transcription factor Scalloped is involved in the development of the wing disc, survival and cell growth. (wikipedia.org)
  • TEAD proteins and MEF2 (myocyte enhancer factor 2) interact physically. (wikipedia.org)
  • Transcription factor complexes have varied effects on cell fate and behavior, but how this diversification of function occurs is largely unknown. (xenbase.org)
  • C) Distribution of key transcription factor binding sites near the lefty locus. (xenbase.org)
  • Furthermore, we identify the transcription factor Gli1, expressed in medial IZ cells, as an antagonist of E(Spl) and Gsk3β/PKA, and demonstrate that the neurogenesis-promoting activity of Gli1 accounts for the reduced sensitivity of medial IZ progenitors to neurogenesis inhibitors and their increased propensity to differentiate. (biologists.com)
  • TEAD1 was the first member of the TEAD family of transcription factors to be identified. (wikipedia.org)
  • The stem cell field witnessed a genuine breakthrough when a combination of solely four transcription factors ( Oct3 / 4 , Sox2 , Klf4 and c-Myc, OSKM ) proved enough to revert, in vitro, the differentiated status of a variety of cell types back to pluripotency, giving rise to so-called induced pluripotent stem (iPS) cells. (springer.com)
  • 2008). Historically, this concept is highlighted by the experi- factors are key intrinsic regulators of these fate decisions and mental phenomenon of lineage reprogramming, for example, that fate choice involves modulating networks of transcription by the conversion of fibroblasts to muscles cells following trans- factors. (lu.se)
  • The evolutionary history of MyoD1 and MyoD2 is compared to the presence of this polyserine region using phylogenetics, and its functional relevance is tested using overexpression in a heterologous system to investigate subcellular localisation, stability, and activity of MyoD proteins that include and do not include the polyserine region. (mdpi.com)
  • This post-translational modification is critical for proper folding of TEAD proteins and their stability. (wikipedia.org)
  • E2a Regulates Samd2/3 Positioning at lefty and Represses lefty Transcription (A) qRT-PCR showing upregulation of lefty in E2a -depleted embryos and downregulation of gsc and xbra . (xenbase.org)
  • Indeed, TEAD proteins cannot induce gene expression on their own. (wikipedia.org)
  • Negative expression of ARID1A/BAF250A protein in MIA PaCa-2 cells is consistent with the predicted expression pattern. (cellsignal.jp)
  • We demonstrate here that the kinases Gsk3β and cAMP-dependent protein kinase A (PKA) are novel determinants of IZ formation and cooperate with E(Spl) activity in a dose-dependent manner. (biologists.com)
  • A retinoblastoma-binding protein that has an affinity for core HISTONES. (lookformedical.com)
  • A family of cellular proteins that mediate the correct assembly or disassembly of polypeptides and their associated ligands. (lookformedical.com)
  • The interaction between YAP (Yes Associated Protein 65), TAZ, a transcriptional coactivator paralog to YAP, and all TEAD proteins was demonstrated both in vitro and in vivo. (wikipedia.org)
  • The Xenopus oocyte possesses a large maternal store of ribosomes, thereby uncoupling early development from the de novo ribosome biosynthesis required for cell growth. (silverchair.com)
  • Silencing at mating locus HMR requires silencers, and one of the roles of the silencer is to recruit Sir proteins. (sdbonline.org)
  • Brix domain-containing proteins, such as Peter Pan (PPan), are essential for eukaryotic ribosome biogenesis. (silverchair.com)
  • TEAD proteins are found in many organisms under different names, assuming different functions. (wikipedia.org)
  • The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH) E-protein family that recognizes the consensus binding site (E-box) CANNTG. (novusbio.com)
  • We found that PPan protein is localized in the nucleoli and mitochondria and that loss of PPan results in increased apoptosis. (silverchair.com)
  • Proteins found in the nucleus of a cell. (lookformedical.com)
  • The function of specific proteins from this organism are the subject of intense scientific interest and have been used to derive basic understanding of the functioning similar proteins in higher eukaryotes. (lookformedical.com)