Loading...
  • Nude
  • In addition, when neural progenitor cells were used as delivery vectors for toTK1 in intracranial GBM xenografts in nude rats, substantial attenuation of tumor growth was achieved in animals exposed to AZT, and survival of the animals was significantly improved compared with controls. (curehunter.com)
  • progression
  • Here, we have generated everolimus resistance in ER+ breast cancer cells and in long-term estrogen deprived (LTED) models that mimic progression on anti-estrogens. (nih.gov)
  • cell
  • Neurosphere assays revealed that the combination of radiation and LBW242 led to a pro-apoptotic effect in these glioma-initiating cell-enriched assays, with a corresponding inhibition of primary tumor cell growth. (biomedsearch.com)
  • To evaluate the role of chromatin condensation for radiation cell survival, tumor cells grown in three-dimensional (3D) cell cultures as xenografts and monolayer cell cultures were compared. (biomedsearch.com)
  • Notably, clotrimazole treatment inhibited OSCC tumor growth and cell proliferation in CAL27 xenograft model. (nih.gov)
  • The process of self-assembly of the mitotic spindle remains a major unsolved question in cell biology, and a robust model awaits further details of the regulation and behavior of various microtubule motors and structural elements that compose this machinery. (wikipedia.org)
  • targets
  • The miR-21-mediated program is modified by 5-fluorouracil and pirarubicin treatment in HCC cellsA: The correlation between miR-21 and its targets was validated in Hep3b cells via luciferase reporter assay (i) and immunoblots (ii) analysis. (nih.gov)
  • agents
  • PURPOSE: ART and its derivatives, clinically used antimalarial agents, have recently shown antitumor activities. (isharonline.org)
  • A consistent mechanism of resistance to EGFR targeting agents has not yet been identified in HNSCC likely due, in part, to the paucity of preclinical models. (biomedsearch.com)
  • resistance
  • These data suggest that MYC plays an important role in mediating resistance to everolimus in ER+ and ER+/LTED models. (nih.gov)
  • Results
  • The work presented here shows that in the breast cancer models examined, the combination of dovitinib + NVP-BEZ235 or dovitinib + AEE788 results in strong inhibition of tumor growth and a block in metastatic spread. (nih.gov)
  • breast cancer
  • Combinatorial targeting of FGF and ErbB receptors blocks growth and metastatic spread of breast cancer models. (nih.gov)