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  • Survival
  • Also, antiapoptotic molecules regulated by these kinases and thereby regulating proapoptotic proteins have been studied to elucidate protective mechanisms by survival factors. (aacrjournals.org)
  • Our data indicate that the PARP inhibitor PJ34 has, apparently, opposing effects on the mitochondrial structure and cell survival. (bioportfolio.com)
  • This implies that TNF-α promotes macrophage survival and suggests that TNF-α may protect against MTX-induced apoptosis. (springer.com)
  • Macrophage colony stimulating factor, the primary macrophage survival and differentiation factor, does not activate NF-κB or protect macrophages from MTX-induced apoptosis. (springer.com)
  • Mammary gland development goes through different stages that depend on proper regulation of proliferation and programmed cell death (apoptosis) ( Fig. 1 A). Sex hormone-dependent cyclic organization of growth and survival provides the plasticity of the mammary gland that is needed for its function. (biologists.org)
  • mitochondrial
  • Mitochondrial-Shaping Proteins in Cardiac Health and Disease - the Long and the Short of It! (springer.com)
  • Mitochondrial health is critically dependent on the ability of mitochondria to undergo changes in mitochondrial morphology, a process which is regulated by mitochondrial shaping proteins. (springer.com)
  • Mitochondria undergo fission to generate fragmented discrete organelles, a process which is mediated by the mitochondrial fission proteins (Drp1, hFIS1, Mff and MiD49/51), and is required for cell division, and to remove damaged mitochondria by mitophagy. (springer.com)
  • Mitochondria undergo fusion to form elongated interconnected networks, a process which is orchestrated by the mitochondrial fusion proteins (Mfn1, Mfn2 and OPA1), and which enables the replenishment of damaged mitochondrial DNA. (springer.com)
  • Although the mitochondria are arranged differently, emerging data supports a role for the mitochondrial shaping proteins in cardiac health and disease. (springer.com)
  • In this review article, we provide an overview of the mitochondrial fusion and fission proteins in the adult heart, and highlight their roles as novel therapeutic targets for treating cardiac disease. (springer.com)
  • By undergoing fission they generate fragmented discrete mitochondria, a process which is regulated by the mitochondrial fission proteins, dynamic-related peptide-1 (Drp1), human fission protein-1 (hFis1), mitochondrial fission factor (Mff) and mitochondrial dynamics proteins 49 and 51 (MiD49 and 51). (springer.com)
  • reactive oxygen
  • In this study, the level of PTL-induced generation of reactive oxygen species (ROS) and apoptosis was significantly higher in the MPO-high leukemia cell lines compared with the MPO-low leukemia cell lines. (aspetjournals.org)
  • small-molecule
  • ErbB2 targeting is clinically relevant using trastuzumab (anti-ErbB2 antibody) and lapatinib (small-molecule ErbB1/2 inhibitor). (duke.edu)
  • 2X-121 is a small molecule targeted inhibitor of Poly ADP ribose polymerase (PARP), a key enzyme involved in DNA damage repair in cancer cells. (bioportfolio.com)
  • inflammatory
  • Although this chronic inflammation has been now linked with most chronic illnesses, including cancer, cardiovascular diseases, diabetes, obesity, pulmonary diseases, and neurologic diseases ( 7 ), the current review focuses on the role of inflammatory pathways in tumorigenesis. (aacrjournals.org)
  • histone
  • It is possible to interfere with epigenetic modifications, such as histone acetylation, using relatively specific and reversible inhibitors. (hindawi.com)
  • The expression of ATP4B was restored in GC cell lines by treatment with the DNA methyltransferase inhibitor, 5-aza-2ʹ-deoxycytidine (5-AZA), or histone deacetylase inhibitor, trichostatin A (TSA), with further enhancement by combined treatment with both drugs. (cognizantcommunication.com)
  • elicit
  • This paper aims to critically discuss how the anticancer potential of HDAC inhibitors may elicit a response to human cancers through different cell pathways leading to cell death. (hindawi.com)
  • tumour
  • Levels of this protein were also significantly higher in tumour tissue, compared to matched normal tissue in highly resistant tissue. (biomedcentral.com)
  • clinical
  • Indeed, the potential of HDAC inhibitors for cancer therapy has been explored in preclinical models, and some agents approved for hematologic malignancies have reached the clinical setting. (hindawi.com)
  • cancers
  • Only 5% to 10% of all cancers are caused by inheritance of mutated genes and somatic mutations, whereas the remaining 90% to 95% has been linked to lifestyle factors and environment ( 1 ). (aacrjournals.org)
  • cancer
  • On the other hand, consumption of low-fat diet along with high intake of dark green leafy vegetables, fruits, and soy products has been linked to the low rate of prostate cancer. (aspetjournals.org)
  • All these risk factors are linked to cancer through inflammation. (aacrjournals.org)