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  • genetic
  • The human genetic material consists of 46 chromosomes of which two are sex chromosomes. (clinicaltrials.gov)
  • The understanding achieved so far as to the interplay between our genetic material and disease has arisen from genetic syndromes which as the X-chromosome syndromes are relatively frequent and show clear manifestations of disease giving the researcher a possibility to identify genetic material linked to the disease. (clinicaltrials.gov)
  • X-chromosome genetic association test accounting for X-inactivation, skewed X-inactivation, and escape from X-inactivation. (semanticscholar.org)
  • Her subsequent research helped elucidate the genetic control mechanisms of the X chromosome and helped explain why female 'carriers' of X-linked genetic disorders can display mild symptoms. (wikipedia.org)
  • For an individual cell or lineage the inactivation is therefore skewed or 'non-random', and this can give rise to mild symptoms in female 'carriers' of X-linked genetic disorders. (wikipedia.org)
  • locus
  • This finding demonstrates that the combination of Xist, Tsix and Xite acts as a cis-acting master-switch locus that is not involved in determining the number of X chromosomes silenced, and also indicates that this counting process is regulated by other factors that are encoded by genes located elsewhere in the genome. (biologists.org)
  • Orange is a locus on the X chromosome. (blogspot.com)
  • patterns
  • Deng X, Berletch JB, Nguyen DK et al (2014) X chromosome regulation: diverse patterns in development, tissues and disease. (springer.com)
  • These findings suggest that the contribution of X-linked genes to the etiology of ASD is still likely but it is not supported by X-inactivation patterns on peripheral blood cells. (scirp.org)