Wound inhibition biofilms. Medical search. Frequent questions

Effectiveness of honey on Staphylococcus aureus and Pseudomonas aeruginosa biofilms. (microbiologyresearch.org)
In the example shown in Table 1, we determined the non-cytotoxic, safe concentration of several important and widely used skin/wound cleansers using cytotoxicity assay with L929 mouse fibroblasts and compared the microbicidal activity of these cleansers at their non-cytotoxic concentration against Methicillin-Resistant Staphylococcus aureus (MRSA) ATCC 33591. (emerypharma.com)

How do hard-to-heal wounds contribute to antimicrobial resistance? (news-medical.net)
If we were to do nothing to address the current gaps in managing hard to heal wounds, the problem of antimicrobial resistance would continue to get worse, and the ability to heal wounds would become 10 times more difficult. (news-medical.net)
The work covered in our poster addresses the gaps in current understanding and clinical management of hard-to-heal wounds. (news-medical.net)
Background - The presence of chronic hard-to-heal wounds significantly affects patients' quality of life causing pain, discomfort, decrease of mobility and consequently leads to social isolation and depression. (romj.org)
The treatment of hard-to-heal wounds is expensive and long-term process, and, stresses healthcare systems of every country. (romj.org)
Therefore, several reports of doctors from different regions of Kazakhstan were referring to the number of patients accepted annually in local hospitals to describe the prevalence of hard-to-heal wounds. (romj.org)
Managing chronic or hard-to-heal wounds such as diabetic or venous ulcers, or pressure ulcers is difficult as it diverges from its normal healing process. (woundsasia.com)

PW-HAM wound dressings that had been processed, decellularized, and dehydrated had a thinner average thickness of 30 µm and lacked nuclear-cellular structures. (dspacedirect.org)
Both wet and dry HAM wound dressings are durable, portable, have a shelf life of 3-5 years, and are available all year. (dspacedirect.org)
Successful treatment of wounds to the cornea of the eye was achieved with the application of the HAM wound dressings. (dspacedirect.org)
HAMP-ZnO Nanoparticles HAM Wound Dressing Wet and dry wound dressings were produced. (dspacedirect.org)
Wounds to the cornea of the eye healed easily when treated with HAM wound dressings. (dspacedirect.org)
The flow chart depicts the methods for processing, and preparation of wet (PWHAM) and dry (PD-HAM) wound healing dressings. (dspacedirect.org)
The wound dressings are ready to be applied. (dspacedirect.org)
Natural wound dressings composed of gelatin (GEL) and chitosan (CH) impregnated with bioactive compounds (Nigella sativa oil) were prepared and characterized to evaluate their potential application. (europeanreview.org)
The production of wound dressings takes place in a highly controlled environment (clean room). (vivamel-medicalhoney.com)
2016). Hydro-Responsive Wound Dressings simplify T.I.M.E. wound management framework. (hydrotherapy.info)
Advanced therapies have emerged to address chronic wounds, such as extracellular matrices, growth factors, chitosan-based wound care dressings and collagen-based dressings. (woundsasia.com)
Paul W, Sharma C, Tirunal C. Chitosan and alginate wound dressings: a short review. (jhsmr.org)

We are working with a novel mechanism, which is quorum sensing inhibition and is essentially the way that the bacteria communicate. (news-medical.net)
We can affect biofilms when they're made up of mixed populations of bacteria, which is clinically relevant as this mirrors the environment you would see in the wound or in a respiratory infection. (news-medical.net)
One of the things that many of my clinical colleagues believe is that the only infected wound is either a wound that has grown bacteria, which is incorrect, or a patient who has evidence of spreading infection cellulitis or sepsis, which is also incorrect. (news-medical.net)
A wide range of antibacterial activity was observed after treatment with 75 µg/ml zinc oxide nanoparticles derived from human amniotic membrane proteins (HAMP-ZnO NP), including dose-dependent biofilm inhibition and inhibition of Gram-positive (S. aureus, S. mutans, E. faecalis, and L. fusiformis) and Gram-negative bacteria (S. sonnei, P. aeruginosa, P. vulgaris, and C. freundii). (dspacedirect.org)
We propose making a bandage that contains our engineered bacteria behind a semipermeable membrane, allowing only small peptides such as ''RIP'' to pass through, into the wound. (igem.org)
We have [https://2009.igem.org/Team:SDU-Denmark/Background#Quorum-quenching_using_RIP reason to hope] that this will weaken the biofilm formation, thereby making multiresistant bacteria easier to treat with conventional antibiotics. (igem.org)
LxA 4 increased ciprofloxacin inhibition on biofilm formation but did not affect ciprofloxacin's action on non-adherent bacteria. (researchwithrowan.com)
Among lactic acid bacteria with antifungal activity, the strain LAB 58 presented the highest emulsification ability by releasing biosurfactants with anionic charge, with anti-biofilm effect. (rjas.ro)
Sugar uses the osmotic principle to dehydrate bacteria and simultaneously triggers a local immune response in the wound. (vivamel-medicalhoney.com)
Medical chestnut honey creates an acidic environment in the wound that triggers the healing process, prevents the growth of bacteria, and regulates the level of matrix metalloproteinases (MMPs). (vivamel-medicalhoney.com)
The innovative Rinsing-Absorption Mechanism cleanses, debrides, desloughs wounds, absorbs exudates and binds bacteria. (hydrotherapy.info)
[13] The biofilm bacteria can share nutrients and are sheltered from harmful factors in the environment, such as desiccation, antibiotics, and a host body's immune system. (wikipedia.org)
They can be found very early in Earth's fossil records (about 3.25 billion years ago) as both Archaea and Bacteria, and commonly protect prokaryotic cells by providing them with homeostasis, encouraging the development of complex interactions between the cells in the biofilm. (wikipedia.org)
[8] [5] The first colonist bacteria of a biofilm may adhere to the surface initially by the weak van der Waals forces and hydrophobic effects. (wikipedia.org)
Emory University suggested, in a recent study published in Nature, that traditional plant-based remedies used during the American Civil War to treat soldiers' wounds could represent a source of modern-day antibiotics for some of the most dangerous multidrug-resistant bacteria. (connersclinic.com)
Our findings suggest that the use of these topical therapies may have saved some limbs, and maybe even lives, during the Civil War," said ethnobotanist Cassandra Quave, PhD. The extracts of the common plants were tested for growth inhibition of S. aureus , A. baumannii , K. pneumoniae , and P. aeruginosa, three common, often drug-resistant bacteria. (connersclinic.com)
All plants also inhibited bacterial biofilm formation and it is thought that the biofilm is what protects the bacteria from drug induced death. (connersclinic.com)

Cotton cellulose-CdTe quantum dots composite films with inhibition of biofilm-forming S. aureus . (ttu.edu)

Results: Eighty percent of the isolated samples (16/20) could form a biofilm, and most of these were isolated from wound infections. (ac.ir)
Microbes form a biofilm in response to a number of different factors, [9] which may include cellular recognition of specific or non-specific attachment sites on a surface, nutritional cues, or in some cases, by exposure of planktonic cells to sub-inhibitory concentrations of antibiotics . (wikipedia.org)

Chestnut honey is the only type of honey that contains kynurenic acid, which prevents the formation of biofilm or destabilizes it. (vivamel-medicalhoney.com)

A dose-response relationship was observed between the concentrations of Manuka honey and zones of inhibition formed by the C . difficile strains, in which increasing concentrations of Manuka honey resulted in increasing size of zone of inhibition formed. (biomedcentral.com)
Wounded apples treated experimentally with strains LAB 58 and LAB13 and exposed to Penicillium expansum spore suspension developed smaller infection spots comparatively with non treated control. (rjas.ro)
Antibacterial activity and anti-biofilm effect of chitosan against strains of Streptococcus mutans isolated in dental plaque. (jhsmr.org)
We demonstrated that both peptides are endowed with a significant antimicrobial activity towards Gram-negative and Gram-positive strains, and are able to prevent biofilm formation in several strains at concentrations lower than those required to directly kill planktonic bacterial cells. (unina.it)

2016). Introducing HydroClean® plus for wound-bed preparation: a case series. (hydrotherapy.info)
2016). HydroClean® plus: a new perspective to wound cleansing and debridement. (hydrotherapy.info)
2016). A multi-centre 15 patient evaluation of a Hydro-Responsive Wound Dressing (HRWD) - HydroClean® plus. (hydrotherapy.info)
2016). HydroTherapy® wound healing of a post amputation site. (hydrotherapy.info)

Our interest is in addressing a new and challenging aspect of wound infection in terms of quorum sensing and biofilm formation. (news-medical.net)
The inhibition of quorum sensing, called quorum quenching, may disrupt oral biofilm formation, which is the main etiological factor of oral diseases, including periodontitis. (mdpi.com)

In this study, we evaluated the effect of C. nobile against Pseudomonas aeruginosa biofilm formation. (ac.ir)
Pseudomonas aeruginosa (P. aeruginosa) is an opportunistic bacterium commonly found in wound infections and airways of cystic fibrosis patients. (researchwithrowan.com)

Chronic non-healing wounds, such as venous ulcers, diabetic ulcers, and pressure ulcers cause tremendous patient suffering. (emerypharma.com)
human being chronic wounds [16]. (cahrr.org)
We hypothesize that manipulating specific redox parameters immediately after wounding will lead to development of chronic wounds in db/db mice and that repairing the antioxidant status will reverse chronicity and lead to proper healing. (cahrr.org)
Here we display that inhibition of the activity of GPx and catalase, two antioxidant enzymes, immediately after wounding produces chronic wounds comprising spontaneously created antibiotic-resistant polymicrobic bacterial biofilms. (cahrr.org)
The wounds were fully chronic 20 days after wounding and remained open sometimes for more than 3 weeks, depending on the experiment.Control db/db micewere treated exactly the same way but instead of inhibitors of the antioxidant enzymes they were treated with the vehicle (PBS). (cahrr.org)
This led us to hypothesize that high oxidative stress levels in the wound cells critically contribute to impaired healing and that exacerbated oxidative stress contributes to chronic wound development. (cahrr.org)
Manipulating the Redox Microenvironment Prospects to Chronicity A chronic wound is definitely one that offers failed to proceed through an orderly and timely reparative process to produce anatomic and practical integrity or that has proceeded through the restoration process without creating a sustained anatomic and practical result [24, 25]. (cahrr.org)
In humans these wounds stay nonhealing for at least 3 months [24] whereas in animals it has been difficult to establish how long wounds need to be impaired to be considered chronic. (cahrr.org)
Biofilm is present in most chronic wounds. (vivamel-medicalhoney.com)
HydroClean® plus can be used on a variety of acute and chronic wounds where moist wound healing is needed. (hydrotherapy.info)
Unfortunately, limited information is available about the situation with chronic wounds in Kazakhstan as the statistical data on such patients is not monitored and not registered in this country. (romj.org)
Akhmetova A, Saliev T, Kulsharova G, Nurgozhin T, Mikhalovsky S. Current state of chronic wound care in Kazakhstan: focus on topical treatments. (romj.org)
Although there is no agreed definition of chronic wounds, they have been usually described as wounds that were not able to heal within a certain period of time [1, 2]. (romj.org)
The major types of chronic wounds are venous leg ulcer, diabetic foot, and pressure ulcer [1]. (romj.org)
For Kazakhstan, no collection of data for statistical analysis on the prevalence of chronic wounds has been conducted for the whole country. (romj.org)
For example, Negemedjanov [5] wrote that around 17-19 patients with chronic wounds were treated annually in Petropavlovsk hospital. (romj.org)
This is the first review article that is written with the purpose of increasing public awareness and describing the current situation of chronic wound care in Kazakhstan. (romj.org)
Results: We have recruited 5 patients with chronic wounds. (woundsasia.com)
The primary goal for healthcare providers when managing chronic wounds is to effectively address wound care, control exudate and provide pain relief. (woundsasia.com)
Chronic wounds that struggle to undergo complete re-epithelisation share common characteristics. (woundsasia.com)
Contemporary approaches to managing chronic wounds align with the TIME framework, which encompasses tissue management, infection and inflammation control, moisture balance, and edge-of-the-wound considerations. (woundsasia.com)

Osmotic pull of fluids from the tissues activates autolytic debridement, so the necrotic tissue in the wound softens and is easier to detach. (vivamel-medicalhoney.com)

Methods: The P. aeruginosa samples were isolated from patients with different types of infection, including wound infection, septicemia, and urinary tract infection. (ac.ir)
The microdilution method was used to evaluate the minimum inhibitory concentration (MIC) of this extract on P. aeruginosa, and biofilm inhibition was assayed. (ac.ir)
P. aeruginosa readily forms biofilms which can reduce the efficacy of antibiotics used to eradicate the pathogen. (researchwithrowan.com)
In this study, we examined the direct actions of LxA 4 and RvD 2 on P. aeruginosa biofilm formation and virulence gene expression. (researchwithrowan.com)
LxA 4 and RvD 2 reduced P. aeruginosa biofilm formation and virulence gene expression. (researchwithrowan.com)
Together these results suggest that LxA 4 has direct effects on P. aeruginosa biofilm formation and can increase antibiotic efficacy directly. (researchwithrowan.com)
LxA4 and RvD2 reduced P. aeruginosa biofilm formation and virulence gene expression. (researchwithrowan.com)

This results in the production of virulence factors, of which biofilm production is a good example. (news-medical.net)
We have shown that we can affect these virulence factors, particularly the biofilm. (news-medical.net)

The microbial cells growing in a biofilm are physiologically distinct from planktonic cells of the same organism, which, by contrast, are single cells that may float or swim in a liquid medium. (wikipedia.org)
Drinking water pipe biofilms control microbial regrowth and are a possible source of pathogens. (who.int)
A deeper understanding of drinking water biofilms microbial ecology must be achieved before this issue can be adequately assessed. (who.int)

A biofilm usually begins to form when a free-swimming bacterium attaches to a surface. (wikipedia.org)
The water samples were di- of inhibition of each antimicrobial agent bacterium survives in water systems as rectly placed in ice, for transportation was measured and recorded as resistant, a parasite of protozoa [4], which are and examination within the same day. (who.int)

Now scientists know that onions and garlic contain antimicrobial agents that impact bacterial growth and biofilm formation. (connersclinic.com)

Amongst many other effects this causes Extracellular matrix (ECM) degradation and inhibition of re-epithelialisation. (emerypharma.com)
[2] [3] The cells within the biofilm produce the EPS components, which are typically a polymeric conglomeration of extracellular polysaccharides , proteins , lipids and DNA . (wikipedia.org)

It was great to see that the Royal College of Physicians, a well-established organization, are very interested in wound infection. (news-medical.net)
It discusses the issue that many of the existing therapies that we use for infection, such as systemic antibiotics or topical antimicrobials, have limited effect when clinicians believe there may be a biofilm present. (news-medical.net)
GAS) is always of clinical significance in wounds where it can initiate infection, destroy skin grafts and persist as a biofilm. (microbiologyresearch.org)
Conclusion: The use of chitosan-based dressing increased granulation, and aided in the management of pain, exudates, and infection, all of which promotes quicker wound healing. (woundsasia.com)

Therapeutic failures of antibiotics used to treat macrolide-susceptible Streptococcus pyogenes infections may be due to biofilm formation. (microbiologyresearch.org)
these infections include UTIs, most intra-abdominal infections, and uncomplicated wound infections. (medscape.com)

Therefore, LL-37 can inhibit the formation of bacterial biofilms. (wikipedia.org)
Bactericidal effects were found in both planktonic cultures and biofilms, although higher concentrations of manuka honey were needed to inhibit biofilms. (microbiologyresearch.org)
A practical approach utilized in this study involves the preparation of an antibacterial thin film on the surfaces, which can effectively inhibit and reduce biofilm formation and bacterial adherence. (nature.com)

The biofilm inhibitory concentration of the C. nobile extract was 6.25-25mg/ml, whereas the MIC was 12.5-50mg/ml. (ac.ir)

2014). Protease-modulating polyacrylate-based hydrogel stimulates wound bed preparation in venous leg ulcers - a randomized controlled trial. (hydrotherapy.info)

In this study, the effect of manuka honey on S. pyogenes (M28) was investigated in vitro with planktonic and biofilm cultures using MIC, MBC, microscopy and aggregation efficiency. (microbiologyresearch.org)

The isolate showed several genes that are associated with resistance to environmental stresses, such as genes encoding heat/cold shock proteins, antioxidant enzymes, carbon starvation proteins, proteins that control osmotic balance and biofilm formation. (biomedcentral.com)

One of the big problems that we've had for years is to get recognition that wounds and problems associated with wound healing are an important clinical issue. (news-medical.net)
What was the importance of presenting Neem's wound healing research findings? (news-medical.net)
Previously we have been active in cystic fibrosis, which is another focus of our research efforts, but through involvement with Keith and further reviews of strategy, we've now additionally focused on wound healing. (news-medical.net)
We've shown that our approach works well in synergy with either antibiotics and/or antiseptics, which can be used as standard of care in treatment of wounds, and it has no negative impact on wound healing. (news-medical.net)
Strategies that optimize the tissue repair have evolved with advances in understanding of the wound healing process (1). (emerypharma.com)
Recently, there had been increased interest in the role of biofilms in impaired healing. (emerypharma.com)
Epithelial advancement, another critical component of wound healing, requires activity of fibroblasts and keratinocytes which may be hampered by aggressive and toxic wound cleansers. (emerypharma.com)
An ideal wound cleanser provides periodic reduction of bacterial contamination and removal of debris without adversely impacting cellular activities vital to the wound healing process. (emerypharma.com)
Surface engineering of spongy bacterial cellulose via constructing crossed groove/column micropattern by low-energy CO 2 laser photolithography toward scar-free wound healing. (ttu.edu)
Open in a separate window Number 1 db/db mouse wounds have increased oxidative stress and delayed healing: time course NCRW0005-F05 of wound closure in C57BL/6 mice (a) and in db/db mice (b). (cahrr.org)
In vivo, the tissue wound-healing process was studied by applying GEL-CH-Nigella in dorsal skin rabbit tissue. (europeanreview.org)
throughout the wound healing process. (vivamel-medicalhoney.com)
Specific properties of chestnut honey provide a complex mechanism of various effects in the wound healing process. (vivamel-medicalhoney.com)
An oxidative balance is established in the tissue, which shortens the inflammatory phase and promotes wound healing. (vivamel-medicalhoney.com)
Honey with a high content of sugars has a low water content and is ideal for wound healing . (vivamel-medicalhoney.com)
HydroTherapy Symposium: A New Perspective on Wound Cleansing, Debridement and Healing. (hydrotherapy.info)
Conclusions - The review highlights the mechanisms of wound healing process, methods for wound care, and encompasses the information available on wound healing in Republic of Kazakhstan. (romj.org)
Wound healing is a complicated process that needs a comprehensive environment for proper healing. (woundsasia.com)
It aids wound healing by protecting the skin in blocking the matrix metalloproteinase-2 expression. (woundsasia.com)
This research aimedto evaluate the effects of chitosan and poloxamer 407 on in vitro cytotoxicity, anti-inflammatory, wound healing, and antimicrobial activities of 0.3% w/v benzydamine hydrochloride (HCl) oromucosal solutions. (jhsmr.org)
The formulation containing 0.5% w/v chitosan exhibited the highest wound healing activity on the fibroblast cells among all tested products, and showed anti-inflammatory activity on macrophage cells, which is comparable to benzydamine HCl. (jhsmr.org)
The alcohol-free benzydamine HCl solution containing 0.5% w/v chitosan as a mucoadhesive polymer is a promising oral care candidate, which is safe to be used, and has wound healing, anti-inflammatory, and antimicrobial activities. (jhsmr.org)
HDPs are seen as true multifunctional peptides with activities as diverse as chemotaxis, inhibition of LPS-induced inflammation, modulation of leukocyte differentiation and promotion of wound healing. (unina.it)
Moreover, ApoB-derived peptides were found to be endowed with anti-inflammatory properties as well as the ability to promote wound healing in keratinocytes. (unina.it)
Studies also show benefits in wound healing and photoprotection. (jcadonline.com)

These studies are useful to clinicians developing wound care strategies and to those wishing to develop and expand in vitro methods to evaluate the potential cytotoxic and bactericidal effects of agents used for wound care. (emerypharma.com)
Biofilm production was quantified using methods explained previously [17] with small modifications. (cahrr.org)
Methods: After a basic wound cleaning, Maxiocel was applied to the wound bed and dressed according to the standard of care. (woundsasia.com)

Fibrinogen induces biofilm formation by Streptococcus suis and enhances its antibiotic resistance. (microbiologyresearch.org)

Hydrogen peroxide is released slowly and in low concentrations, the pH in the wound is further lowered, proteases are activated, and they stimulate proteolytic debridement. (vivamel-medicalhoney.com)

Wound areas were traced and analyzed using Image J and display delayed NCRW0005-F05 closure as compared to C57BL/6. (cahrr.org)

The comprehensive profiling and characterization of absorbed components in mice blood following oral administration of XHP were identified by HPLC/Q-TOF-MS techniques, and the absorbed components in blood were combined with proteomics to reveal the mechanism of enteritis inhibition by XHP. (bvsalud.org)
Biofilms are thought to have arisen during primitive Earth as a defense mechanism for prokaryotes, as the conditions at that time were too harsh for their survival. (wikipedia.org)

In cases where wounds produce excessive exudate, patients may experience distress and pain, compounded by concerns about dressing leakage, malodour, and staining of personal belongings like clothing, bedding etc. (woundsasia.com)

To reverse chronicity, at 20 days, the antioxidant NAC (Aldrich Chemistry (St. Louis, MO)) was topically applied to the wound at 200?mg/kg and the tegaderm replaced. (cahrr.org)
In the wound, proline acts as a potent antioxidant and is crucial in collagen synthesis. (vivamel-medicalhoney.com)
Antioxidant activity and, by extent, anti-inflammatory action are based on the inhibition of free radicals. (vivamel-medicalhoney.com)

Research has demonstrated a variety of types of treatments utilized in the country, particularly the treatment of the diabetic foot.It also indicates the lack of statistics on wound care. (romj.org)

Therefore important steps in a comprehensive strategy for evaluating wound care products are studying their antimicrobial activity and potential cytotoxicity for relevant cell types. (emerypharma.com)

Manuka honey permeated 24 h established biofilms of S. pyogenes, resulting in significant cell death and dissociation of cells from the biofilm. (microbiologyresearch.org)
This study demonstrates that many wound and skin cleansers (Fig. 5) may be toxic to fibroblasts, one of the key cells in wound repair, and suggests that these cleansers might also be toxic to other cells. (emerypharma.com)
A biofilm comprises any syntrophic consortium of microorganisms in which cells stick to each other and often also to a surface. (wikipedia.org)
Subpopulations of cells within the biofilm differentiate to perform various activities for motility, matrix production, and sporulation, supporting the overall success of the biofilm. (wikipedia.org)

Therefore, it is able to remove impurities and foreign matter from the wound. (vivamel-medicalhoney.com)

The influence of LxA 4 on antibiotic efficacy and the combined effects on biofilm formation were also investigated. (researchwithrowan.com)

A biofilm may also be considered a hydrogel , which is a complex polymer that contains many times its dry weight in water. (wikipedia.org)

The observed inhibition of fibronectin binding was confirmed by a reduction in the expression of genes encoding two major fibronectin-binding streptococcal surface proteins, Sof and SfbI. (microbiologyresearch.org)
[10] [11] A cell that switches to the biofilm mode of growth undergoes a phenotypic shift in behavior in which large suites of genes are differentially regulated . (wikipedia.org)

LL-37 plays a role in the activation of cell proliferation and migration, contributing to the wound closure process. (wikipedia.org)
A histological analysis revealed that GEL-CH-Nigella accelerated wound closure and improved collagenisation and enhanced epidermal tissue thickness. (europeanreview.org)

Chitosan also has haemostatic properties to absorb blood which allows accumulation of erythrocytes and platelets at the wound site which then causes activation of the coagulation process. (woundsasia.com)
Anti-biofilm properties of chitosan-coated surfaces. (jhsmr.org)

[8] Biofilms can form on the teeth of most animals as dental plaque , where they may cause tooth decay and gum disease . (wikipedia.org)

These results indicate that GEL-CH-Nigella wound dressing is a promising biomaterial for engineered tissue. (europeanreview.org)
Results - We have identified and analyzed current situation with wound care in the Republic of Kazakhstan. (romj.org)

Treatment of such wounds presents a serious unmet medical need. (emerypharma.com)

Maximum zone of inhibition was observed at 50% (v/v) Manuka honey and the growth inhibition persisted over 7 days. (biomedcentral.com)

Anatomy6

Organisms13

Diseases13

Chemicals and Drugs30

Analytical, Diagnostic and Therapeutic Techniques and Equipment15

Phenomena and Processes17

Disciplines and Occupations1

Technology, Industry, Agriculture7

Health Care5

Staphylococcus2

Hard-to-heal wounds7

Dressings12

Bacteria17

Aureus1

Form a biofilm2

Formation of biofilm1

Strains4

20164

Quorum2

Pseudomonas2

Chronic21

Necrotic tissue1

Aeruginosa7

Virulence factors2

Microbial3

Bacterium2

Bacterial growth1

Extracellular2

Infection4

Infections2

Inhibit3

Inhibitory1

Venous leg1

Planktonic1

Osmotic1

Healing25

Methods3

Streptococcus1

Debridement1

Traced and analyzed1

Mechanism2

Exudate1

Antioxidant3

Diabetic1

Cytotoxicity1

Cells4

Impurities1

Antibiotic1

Hydrogel1

Genes2

Closure2

Chitosan2

Disease1

Results2

Treatment1

Growth1