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  • Wnts
  • Thus, for generating other Wnts, we recommend the PGK promoter driving the native Wnt gene, and selection of highest expressing clones of c ells. (stanford.edu)
  • We demonstrate that exosomes carry Wnts on their surface to induce Wnt signalling activity in target cells. (uni-hd.de)
  • transmembrane protein
  • By analyzing gene expression and chromatin dynamics during directed differentiation of human embryonic stem cells (hESCs), we identified a suppressor of Wnt/β-catenin signaling, transmembrane protein 88 (TMEM88), as a potential regulator of cardiovascular progenitor cell (CVP) specification. (biologists.org)
  • hydrophobic
  • in the absence of serum, the protein tends to precipitate due to its hydrophobic nature. (stanford.edu)
  • Here we show that purified Wnt3a protein is ineffective because it rapidly loses activity in culture media due to its hydrophobic nature, and its solubilization requires a detergent, CHAPS (3-[(3-cholamidopropyl) dimethylammonio]-1-propanesulfonate), that interferes with stem cell self-renewal. (eur.nl)
  • As morphogens, hydrophobic Wnt proteins exert their function over a distance to induce patterning and cell differentiation decisions. (uni-hd.de)
  • modulator
  • It acts as a biphasic modulator of Wnt signaling, counteracting Wnt-induced effects at high concentrations and promoting them at lower concentrations. (wikipedia.org)
  • mammary gland
  • Wnt signalling has been implicated in tumourigenesis, early mesodermal patterning of the embryo, morphogenesis of the brain and kidneys, regulation of mammary gland proliferation and Alzheimer's disease. (wikipedia.org)
  • Nusse
  • As the 2019 Gordon Research Conference "Wnt Signaling Networks in Development, Disease and Regeneration" approaches , Stanford developmental biology professor Roeland Nusse is continuing more than 30 years of work with the protein Wnt. (stanforddaily.com)
  • To Nusse and Varmus's surprise, the gene showed similarities among different species, demonstrating the significance of Wnt both evolutionarily and functionally. (stanforddaily.com)
  • At the time, Nusse was studying how breast cancer in mice was regulated, and his work with Varmus demonstrated that a hyperactive Wnt gene caused the cancer. (stanforddaily.com)
  • Even though the full processes involving Wnt signaling are unknown, Nusse said the effects of the signal pathway are profound. (stanforddaily.com)
  • Besides understanding liver damage and regeneration, Nusse is also interested in how Wnt plays a role in hepatoblastoma, a liver cancer that affects children. (stanforddaily.com)