AlbinoMethodsAdultDiabetic ratsFortyBiochemical parametersGavageGroupsRattusHyperglycemiaStrainMaleToxicologyDoseTwentySusceptibilityChloral hydrateStudyFemaleConcentrationsExposureCollagenSpeciesDiabetesModelSpatial memoryLaboratoryGroupGlucoseEnzymeMelatoninVivo2002InjectionIndividuallyWeightAcuteEthanolMRNAWeeksVeinCagesSupplementationEffectResultsSignificantlyHigherDays
Albino4
- The effects of the aqueous leaf extract of Basella alba on haematological and biochemical parameters were studied in Wistar strain albino rats. (researchgate.net)
- Twenty four (24) Wistar strain albino rats were randomly distributed into four groups of six (6) rats each. (researchgate.net)
- were studied in Wistar st rain albino rats. (researchgate.net)
- Study assessed the hypoglycemic effect of C. schweinfurthii aqueous and total crude leaf and pulp extracts on blood glucose levels in Wistar albino rats. (academicjournals.org)
Methods2
- Methods- The present study made use of 300 Wistar rats randomly allocated into controls and rats receiving a 16-week high-fat, high-caloric diet (HCD). (sun.ac.za)
- The day following the previous anxiety methods (at eight a.m.), the rats were anaesthetized with 8% chloral-hydrate and, adhering to the transcardial perfusion with chilly saline solution, the cerebral hemispheres have been divided and the hippocampus and frontal cortex have been dissected on an ice-cold tile. (dna-alkylating.com)
Adult6
- 28 adult female Wistar rats with regular estrous cycles were randomly divided into four groups. (nel.edu)
- A total of 60 adult male Wistar rats weighing 300?500 g were used in the study. (tubitak.gov.tr)
- PURPOSE: To analyze the effects of chronic ethanol intake on the optic nerve in an adult rat model. (unifesp.br)
- Adult male Wistar rats (twenty 00 g n = six? (dna-alkylating.com)
- Adult Wistar rats were randomly allocated in control and diabetic group. (ac.ir)
- Thirty adult male Wistar rats were used in this study. (bvsalud.org)
Diabetic rats6
- To investigate the effect of simvastatin on glucose homeostasis in streptozotocin induced type 2 diabetic rats. (hindawi.com)
- Diabetic rats were induced by a single intraperitoneal injection of STZ. (hindawi.com)
- the simvastatin intervention rats had a higher FPG compared to the diabetic rats and were more easily be induced to diabetes at the end of 4 weeks, FPG level of simvastatin treatment rats was increased compared with diabetic model rats after 12 weeks. (hindawi.com)
- The target of the present study is to investigate the effect of simvastatin on FPG in STZ-induced diabetic rats. (hindawi.com)
- The conclusion is that prescription of stevia in the doses of 250 and 500 mg/kg/d decreases the omentin level indirectly via activating insulin sensitivity and lowering blood glucose in STZ-induced diabetic rats. (researchgate.net)
- 1.Golalipour MJ, Ghafari S, Farsi M. Effect of urtica dioica L extract on quantitative morphometric alterations of liver parenchymal cells in STZ diabetic rats. (ac.ir)
Forty4
- Forty male Wistar rats were randomly divided into four groups. (hindawi.com)
- Forty male wistar rats weighing 180-250 g were induced with diabetes by intraperitoneal injection of streptozotocin (STZ). (researchgate.net)
- Forty five aged male wistar rats were divided randomly into three equal number groups (n = 15). (scialert.net)
- Forty-two Wistar rats (21 obese, 21 non-obese) were anesthetized and tracheotomized, and laparotomy was performed with standardized bowel manipulation. (tropmedres.ac)
Biochemical parameters1
Gavage2
- Single application of the test item to Wistar rats by gavage resulted in an LD50 of 8252 mg/kg bw. (europa.eu)
- A Combined Repeated Dose Toxicity Study with the Reproduction/Developmental Toxicity Screening Test (OECD Guideline 422) in Wistar rats administered by oral gavage was to determine the possible health hazards likely to arise from repeated exposure to AP 729 over a relatively limited period of time. (europa.eu)
Groups14
- 0.05).Immunohistochemical analysis revealed that the expression of LC3 and Beclin 1 in rat ameloblasts in the experimental groups was positive compared to control group. (fluoridealert.org)
- Rats in group 1 (non-diabetic control) and group 2 (diabetic control) were treated with distilled water, and the rats in the treated groups, group 3 (T250), group 4 (T500), and group 5 (T750) were treated with stevia, gavaged every day at 9 a.m. in doses of 250, 500, and 750 mg/kg, respectively. (researchgate.net)
- One hundred and eight female Wistar rats were randomly divided in nine groups. (nih.gov)
- Pushchino Laboratory, Pushchino, Russia) and assigned the animals randomly into experimental and control groups (Table 1 ). (frontiersin.org)
- distributed in to fo ur groups of six (6) rats each. (researchgate.net)
- METHOD: We conducted a prospective longitudinal study with 174 participants randomly assigned to two groups: SUS Group and Streamline Group. (scielo.br)
- The rats were randomly divided into 2 groups named A (uncoated/control) and B (biocomposite coated). (tubitak.gov.tr)
- The classical three-point bending and impact tests were carried out for three rat bone groups: control (SHO), the humerus of animals under the conditions of established osteopenia (OVX), and bones of rats receiving nesfatin-1 after ovariectomy (NES). (mdpi.com)
- Initially the animals are divided randomly into three groups to receive standard diet + water (n = 12 animals), fructose diet + 25% fructose in water (n = 36 animals) or fructose diet with ³-oryzanol + 25% fructose in water (n = 12 animals). (fapesp.br)
- At 21 days after modeling, the rats in oxygen group were given an injection of oxygen in the knee joint weekly for 3 weeks, and the rats in O3 groups were injected the concentration of O3 as they marked weekly for 3 weeks. (houstonsportsdoctor.com)
- All rats in groups (2-9) were infected with 3x10 6 of Trypanosoma brucei per ml of blood. (veterinarypaper.com)
- Three groups of 5 week old female Wistar-rats were exposed to SO vapor at 0, 100, or 300 parts per million (ppm) for 7 hours/day, 5 days/week for 3 weeks prior to mating. (cdc.gov)
- The 6 rats were randomly assigned to 2 groups, injected intravenously with 500 µL of an HEV sample suspension through the tail vein, and monitored for 3 months. (cdc.gov)
- Healthy children aged 1-3 years were randomly assigned to one of the three groups: bivalent OPV (bOPV)-alone, OCV-alone, or combined bOPV+OCV and received vaccines on the day of enrollment and 28 days later. (cdc.gov)
Rattus1
- For example, anti-HEV IgG has been detected in various rat species, including Norway ( Rattus norvegicus ), black ( Rattus rattus ), and cotton ( Sigmodon hispidus ) rats, by using ELISA with antigens derived from G1 HEV. (cdc.gov)
Hyperglycemia1
- These data indicate that simvastatin intervention rats may cause hyperglycemia by impairing the function of islet β cells and have an adverse effect on glucose homeostasis, especially on FPG level. (hindawi.com)
Strain1
- The Wistar rat was selected due to the large amount of background data available for this strain. (europa.eu)
Male5
- Effects of LPS injection on the hypothalamic and testicular mRNA expression levels of reproductive factors in male rats. (nel.edu)
- The present study demonstrated that the hypothalamic mRNA expression level of the kisspeptin receptor was decreased by the injection of lipopolysaccharide (LPS) (500 μg/kg) in male rats, and it was suggested that such changes might contribute to reductions in serum luteinizing hormone levels. (nel.edu)
- Iwasa T, Matsuzaki T, Tungalagsuvd A, Munkhzaya M, Kuwahara A, Yasui T, Irahara M. Effects of LPS injection on the hypothalamic and testicular mRNA expression levels of reproductive factors in male rats. (nel.edu)
- It will be used male Wistar rats (n = 60), 30 days old, from the Universidade Estadual Paulista (UNESP). (fapesp.br)
- During mating, two rats (one male and one female) were housed in standard polysulfone cages with a stainless-steel top grill having facilities for pelleted food and drinking water in polycarbonate bottles. (europa.eu)
Toxicology2
Dose3
- Acute toxicity of the test item has been investigated in female SPF-Wistar rats (10 animals per dose group). (europa.eu)
- C: rats in control group received neither radiation nor melatonin, M: rats received only 100 mg/kg melatonin intraperitoneally, R: rats' right legs were exposed to 30 Gy single dose gamma radiation, and MR: rats received 100 mg/kg melatonin 30 min before irradiating their right legs with 30 Gy single dose gamma radiation. (aapm.org)
- The dose formulations were administered once daily to a specific group of rats for two weeks prior to mating, during mating and post-mating periods for males, during pregnancy and up to Lactation Day (LD) 13 for females. (europa.eu)
Twenty1
- Twenty four (24) wistar rats weighing between 125-180g were randomly grouped into four (4) of six animals each. (ajol.info)
Susceptibility2
Chloral hydrate1
- Rats were deeply anesthetized with an intraperitoneal injection of chloral hydrate (80 mg/ml, 0.4 ml per 100 g, Sigma). (frontiersin.org)
Study18
- In vivo and in vitro experimental study on the effect of fluoride-induced autophagy in rat HAT-7 cell line]. (fluoridealert.org)
- PURPOSE: To study the effect of fluoride on autophagy in rat ameloblasts both in vitro and in vivo. (fluoridealert.org)
- This study investigates the effect of stevia on serum omentin and visfatin levels as novel adipocytokines in diabetic induced rats to find potential mechanisms for the anti hyperglycemic effect of stevia. (researchgate.net)
- This study aimed to evaluate the effects of TQ on spatial memory and hippocampal long-term potentiation (LTP) in rats with thioacetamide (TAA)-induced liver injury and hepatic encephalopathy. (magiran.com)
- The study was carried out with an aqueous extract of the roots of Asparagus racemosus utilizing three doses viz 800 mg/kg, 1600 mg/kg and 3200 mg/kg for its diuretic activity in comparison with standard drug (furosemide) and control (normal saline) rats after doing acute toxicity study. (raysahelian.com)
- In this study, it was aimed to investigate the effects of a novel biocomposite consisting of hydroxyapatite (HA), hexagonal boron nitride (h-BN), chitosan (Cs), and type 1 collagen (Ct1) on biocompatibility and fracture healing in rats. (tubitak.gov.tr)
- Aim of this study was to investigate the effects of Grape Seed Extract (GSE), as a potent antioxidant on spatial memory in rats with Alzheimer's Disease (AD). (scialert.net)
- 1999). In the earlier study we examined whether long-term feeding with grape seed extract (100 mg kg -1 for 30 days) would forestall the improvement effects of spatial memory in healthy aged rats. (scialert.net)
- This study compared the long-term consequences of two common forms of bariatric surgery: one-anastomosis gastric bypass (OAGB) and Roux-en-Y Gastric Bypass (RYGB) in a preclinical rat model. (nature.com)
- This study aimed to investigate the protective mechanism of a GLP-1R agonist E4 against early DR in Goto-Kakizaki (GK) rats. (molvis.org)
- In this study, proteomics and metabonomics techniques were used to analyze the tissue and plasma of DOX-induced heart failure (HF) in rats and to clarify the molecular mechanism of the harmful effects of DOX on cardiac metabolism and function in rats from a new point of view. (frontiersin.org)
- Here, we used ultra-high performance liquid chromatography-tandem quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS) to analyze DOX-induced HF in rats, to explain the toxicological pathways of DOX to the heart, especially the combined proteomic technology, to provide more information for the study of its pathogenesis. (frontiersin.org)
- Effects of Protective Mechanical Ventilation With Different PEEP Levels on Alveolar Damage and Inflammation in a Model of Open Abdominal Surgery: A Randomized Study in Obese Versus Non-obese Rats. (tropmedres.ac)
- The objectives of this study were to observe the therapeutic effect of ozone (O3) of different concentrations on rat with rheumatoid arthritis (RA), and to investigate the role of O3 in regulating the level of TNF-α (tumor necrosis factor), TNF-R1 (tumor necrosis factor receptor 1), and TNF-R2. (houstonsportsdoctor.com)
- Acclimation period: After detailed clinical examination for good health and the suitability for the study, the rats were acclimatized for five days before the pre-treatment period. (europa.eu)
- This study evaluated radiographically the effects of 1% hyaluronan in bone healing using a critical size rat-calvaria defect model. (bvsalud.org)
- recently reported that G1, G2, and G3 do not infect laboratory rats ( 7 ), and we found in a previous study that laboratory rats are not susceptible to G1, G3, or G4 HEV ( 8 ). (cdc.gov)
- This study examined the reinforcement omission effects on behavioral repertoire of rats with lesions in the central nucleus and basolateral complex of the amygdala, using classical conditioning and non-contingent reinforcement schemes. (bvsalud.org)
Female2
- The architecture of the neurons in the hippocampus histopathological studies was seen when the combined treatment with estrogen and AMEE was given confirming that our given combination has the potential to improve memory in female rats, particularly those who were estrogen-deficient as in our experimental design. (ijpsr.com)
- The behavioural, cognitive and neuropathological changes observed in AD can be induced by intraperitoneal (i.p) administration of scopolamine in female rats. (ijpsr.com)
Concentrations4
- On the contrary, BA concentrations were the highest in the residual gastric pouch of OAGB-15 rats. (nature.com)
- To test this hypothesis, basal extracellular concentrations of dopamine (DA) and serotonin (5-HT) in the nucleus accumbens as well as the effects of repeated ethanol pretreatment on the basal release of these transmitters were examined in alcohol-preferring (P), alcohol-nonpreferring (NP), and genetically heterogeneous Wistar rats. (aspetjournals.org)
- In addition, ethanol pretreatment increased extracellular DA concentrations in Wistar and P rats, but not in NP rats. (aspetjournals.org)
- Wistar rats were exposed for 30 min to a range of concentrations (10 to 300 mg/m3) of the well-known respiratory allergen trimellitic anhydride (TMA). (cdc.gov)
Exposure3
- The rats exposed to 0 and 100ppm SO were mated and then randomly divided into two subgroups for gestational exposure to 0 or 100ppm (7 hours/day, 7 days/week) SO continuing through 18 days of gestation (dg). (cdc.gov)
- In both rats and rabbits, exposure to SO resulted in a statistically significant increase in mortality, and statistically significant reductions in mean body weight and mean food consumption. (cdc.gov)
- Gestational exposure resulted in reduced fetal weights and crown/rump lengths in rats and rabbits, and increased the incidence of ossification defects of the sternebrae and occipital bones in rats. (cdc.gov)
Collagen2
- Therefore, we determined whether the regulation of lung microbiota by YS would alleviate lung injury, ventilatory function, inflammatory reactions, and collagen deposition in a rat model of COPD. (researchsquare.com)
- RA was induced in all rats by hypodermic injection of collagen II and complete Freund\'s adjuvant except that in the control group. (houstonsportsdoctor.com)
Species1
- Rat is the standard laboratory rodent species used for toxicity assessment and also recommended by various regulatory authorities. (europa.eu)
Diabetes3
- The simvastatin intervention rats were fed with simvastatin during the experiment process, and the simvastatin treatment rats were fed with simvastatin after diabetes rats were induced. (hindawi.com)
- Intrauterine growth retardation leads to the development of type 2 diabetes in the rat. (ac.ir)
- Gestational diabetes leads to the development of diabetes in adulthood in the rat. (ac.ir)
Model7
- The efficacy of vascular endothelial growth factor (VEGF), COX-2, calcium and aromatase inhibitors in an ovarian hyperstimulation syndrome (OHSS) rat model was tested. (nih.gov)
- Distinct hallmarks of cancer were examined using in silico analysis, various in vitro cell culture assays, and ex vivo organotypic rat brain slice culture model. (hindawi.com)
- We investigated the impact on tumor malignancy in F98 glioma cells using in silico analysis, in vitro cell culture assays, and ex vivo vascular organotypic glioma impact model (VOGIM) [ 35 ] by implanting F98 cells into rat brain slices. (hindawi.com)
- The rat model of Alzheimer's disease was induced by local injection of Ibotenic acid (Ibo) into brain Nucleus Basalis Magnocellularis (NBM) or meynert bilaterally (Ibo, 6 μg μL -1 each site) under stereotaxic surgery. (scialert.net)
- In conclusion, RYGB results in a better long-term outcome than OAGB, as chronic signs of biliary reflux or reactional gastritis were reported post-OAGB even after reducing the BPL length in a preclinical rat model. (nature.com)
- YS improved animal behaviors, prevented declines in pulmonary ventilatory function and lung injury in a rat model of COPD. (researchsquare.com)
- YS changed the relative abundance of specific pulmonary microbiota and modulated bacterial flora in the rat model. (researchsquare.com)
Spatial memory1
- The results show that injection of Ibo into NBM of rats could impair spatial memory capacity. (scialert.net)
Laboratory3
- Rats were housed in wire-floored cages under a 12 h light-dark cycle for at least 7 days prior to treatment and were fed with standard laboratory chow and tap water ad libitum. (hindawi.com)
- According to the "Guidelines for the Care and Use of Laboratory Animals" published by the National Institutes of Health, all rats experiments were approved by the Animal Ethics Experiment Committee of Yunnan University of Traditional Chinese Medicine and were conducted by the guidelines of the committee. (researchsquare.com)
- also reported that human HEV (presumably G1) was transmissible to Wistar laboratory rats ( 6 ). (cdc.gov)
Group3
- Group I rats served as control and received 10 ml/kg of normal saline, while group II, III and IV received 60, 80 and 100 mg/kg of aqueous leaf extract of B. alba, respectively, for two weeks. (researchgate.net)
- At the commencement of the treatment, the weight variation of rats used did not exceed ± 20% of the mean body weight in each sex and group. (europa.eu)
- the 3 rats in group 2 were injected with the cell culture supernatant sample, which contained 4 × 10 6 copies of G3 HEV. (cdc.gov)
Glucose1
- Similar results were found in primary rat Müller cells under high glucose culture in vitro. (molvis.org)
Enzyme1
- 2013. Green asparagus (Asparagus officinalis) prevented hypertension by an inhibitory effect on angiotensin-converting enzyme activity in the kidney of spontaneously hypertensive rats. (raysahelian.com)
Melatonin4
- Effects of melatonin and oxytetracycline in autologous intraperitoneal ovary transplantation in rats. (nel.edu)
- To comparatively investigate the effects melatonin and oxytetracycline as antioxidants on autologous intraperitoneal ovary transplantation in rats. (nel.edu)
- Although both melatonin and oxytetracycline were found to be effective in autologous intraperitoneal pelvic ovary transplantation, melatonin is more effective against both the ovarian necrosis and tissue MDA level in rats. (nel.edu)
- Sapmaz E, Ayar A, Celik H, Sapmaz T, Kilic N, Yasar M. Effects of melatonin and oxytetracycline in autologous intraperitoneal ovary transplantation in rats. (nel.edu)
Vivo2
- The expression of LC3 and Beclin 1 in rats was investigated by immunohistochemical staining in vivo. (fluoridealert.org)
- First, to date, evidence on monoaminergic differences between high and low P rats is based largely on ex vivo, whole-tissue measures of DA and 5-HT rather than extracellular measures of transmitter release. (aspetjournals.org)
20021
- 2002) showed that grape seed extracts are non-toxic to rats. (scialert.net)
Injection1
- Diabetic GK rats and control animals were randomly assigned to receive E4 or vehicle by intravitreal injection. (molvis.org)
Individually1
- Rats were housed individually in biosafety level 2 facilities. (cdc.gov)
Weight1
- OAGB-35 rats also revealed the greatest weight loss and malabsorption. (nature.com)
Acute2
- Acute toxicity and diuretic studies of the roots of Asparagus racemosus in rats. (raysahelian.com)
- The highest level at which no acute airway irritation as based on both breathing pattern and frequency was observed in both rat strains was 14 mg/m3. (cdc.gov)
Ethanol1
- In ethanol-naive rats, significant line differences were observed with high basal 5-HT release in P rats, low 5-HT release in NP rats, and intermediate 5-HT levels in Wistar rats. (aspetjournals.org)
MRNA1
- The exact same animals ended up utilized to evaluate mRNA and protein ranges, but they ended up chosen randomly to remove the adjustments induced by laterality. (dna-alkylating.com)
Weeks2
- After 30 weeks of follow-up, Wistar rats operated on RYGB, OAGB with a short BPL (15 cm, OAGB-15), or a long BPL (35 cm, OAGB-35), and unoperated rats exhibit no cases of esogastric cancer, metaplasia, dysplasia, or Barrett's esophagus. (nature.com)
- Four weeks after irradiation, all rats were sacrificed. (aapm.org)
Vein1
- At the end of each week, blood sample (2ml) was drawn from the median cantus vein of the eyes of the rats with the aid of a capillary tube and the plasma samples prepared for the biochemical tests. (ajol.info)
Cages3
- Rats were housed in clear plastic cages (12 h/12 h light/dark cycle) with food and water available ad libitum . (frontiersin.org)
- Housing: Two rats of same sex were housed per cage in sterilized standard polysulfone cages (Size: L 425 x B 266 x H 185 mm), with stainless steel top grill having facilities for pelleted food and drinking water in polycarbonate bottles with stainless steel sipper tubes. (europa.eu)
- Polycarbonate rat huts were provided to the animals as environmental enrichment objects in the cages that either provide shelter or exercising opportunities to minimize animal stress and promote overall well-being. (europa.eu)
Supplementation1
- Various reports have also shown that long term dietary supplementation of polyphenols improved the cognitive performance in aged rats (Balu et al . (scialert.net)
Effect1
- Toward this goal, we observed the different effect between simvastatin intervention rats and simvastatin treatment rats, especially on FPG levels of various periods. (hindawi.com)
Results1
- These results suggest that HEV or HEV-like virus infections occur in wild rats. (cdc.gov)
Significantly1
- E4 significantly prevented the reduction of the b-wave and oscillatory potential amplitudes and retinal cell loss and maintained the Bcl-2/Bax and Bcl-xL/Bax ratio balances in GK rats. (molvis.org)
Higher1
- Compared to RYGB, OAGB-35 rats presented higher rate of esophagitis, fundic gastritis and perianastomotic foveolar hyperplasia. (nature.com)
Days1
- After surgery, rats had a daily intramuscular administration of gentamicin (25 mg/kg, Omela, Russia) for seven consecutive days. (frontiersin.org)