• The effects of hepatic uptake and efflux transporters on metabolism of digoxin were examined in isolated rat hepatocytes versus microsomes. (aspetjournals.org)
  • In the present study the hepatoprotective efficacy of two edible macrofungi Dacryopinax spathularia and Schizophyllum commune has been assessed against CCl4-induced hepatotoxicity in albino wistar rats. (ansfoundation.org)
  • Uppercott: Implication in nephrotoxicity in male albino wistar rats. (livedna.net)
  • Exposure to uppercott induces hepatotoxicity in male albino wistar rats. (livedna.net)
  • Protective effect of vitamins C and E against Nitrocellulose thinner induced nephrotoxicity in albino Wistar rats. (livedna.net)
  • Hypoglycemic and hypolipidemic potentials of extract of Vernonia calvoana on alloxan-induced diabetic albino wistar rats. (livedna.net)
  • Hepatotoxicity effect of oral exposure to nitrocellulose thinner in albino Wistar rats. (livedna.net)
  • A total of 80 albino Wistar male rats were randomly divided into 4 groups. (lifenscience.org)
  • METHODS@#Fifty-four male Wistar rats were randomly divided into normal control (NC, n=14) and high-fat diet (HFD) groups (n=40). (bvsalud.org)
  • According to the current study, Erythromycin-induced oxidative stress and hepatocyte damage were markedly reduced by aqueous neem leaf extract, which is a powerful antioxidant. (lifenscience.org)
  • PGJ abrogates liver fibrosis instigated by NDEA in Wistar rats by declining oxidative stress via regulation of Nrf2 and NFκB. (nature.com)
  • This age-dependent HPGL profile will be instrumental for hepatic drug clearance prediction when designing juvenile toxicity studies in Wistar rats. (aspetjournals.org)
  • The latest advances include the use of human hepatocytes to evaluate hepatic uptake, metabolism, efflux and toxicity. (eurekaselect.com)
  • This review summarizes the latest findings on human hepatocytes isolation, cryopreservation, culturing, as well as application in the evaluation of metabolic stability, metabolite profiling, hepatic uptake and efflux, metabolic drug-drug interactions, and drug toxicity. (eurekaselect.com)
  • The use of hepatocyte to evaluate the role of metabolism in drug toxicity represents a major advance in drug toxicity evaluation. (eurekaselect.com)
  • These results strongly suggest that the hepatic uptake and efflux transporters that are found in hepatocytes, but not in microsomes, modulate intracellular concentration of digoxin and thus affect metabolism. (aspetjournals.org)
  • Efficient hepatoprotective activity of Cranberry extract against CCl4-induced hepatotoxicity in wistar albino rat model: Down regulation of liver enzymes and strong antioxidant activity. (ansfoundation.org)
  • T4 in both experiments in vivo and in vitro increased lipogenesis in liver cells of young rats, while old hepatocytes were resistant to the hormone action. (webmedcentral.com)
  • The liver is a major site of metabolism of many endogenous compounds and xenobiotics since hepatocytes (which comprise 80% of the liver cells) contain large amounts of smooth endoplasmic reticulum, where many metabolizing enzymes reside. (aspetjournals.org)
  • He reported the first demonstration of killing of infected hepatocytes (liver cells) by malaria sporozoite specific T cells, the first demonstration of human cytotoxic T lymphocytes against any parasite, and the complexity of protective immunity at this stage of the parasite life cycle. (wikipedia.org)
  • EMD, E. Merck, Darmstadt) and substrates of endogenous transport systems of liver cells were studied in isolated rat hepatocytes. (nih.gov)
  • Caspase-3 levels were assessed from the blood sample, while the apoptosis of hepatocytes was evaluated using histopathologic examination of the liver. (bsmiab.org)
  • Similarly, the apoptosis of hepatocyte was significantly lower in the combination group compared to the UDCA or HuMSC-S alone. (bsmiab.org)
  • Because of this, we aimed to study the effect of human mesenchymal stem cell secretome (HuMSC-S) administration on caspase 3 levels and apoptosis of hepatocytes in a rat model with cholestasis after choledochal duct ligation receiving standard UDCA therapy. (bsmiab.org)
  • however, revealed some hepatocyte morphological lesions including mild microvesicular steatosis, kupffer cell hyperplasia, shrinkage of glomeruli, glomerular distortion, necrotic renal tubules, severe congestion and atrophy of renal tubules in rats fed 8.13mL/kg of the nut oil. (njbas-udus.com)
  • Animals receiving the NASH-inducing diet gained more body weight, got glucose intolerant and developed a liver pathology with steatosis, hepatocyte hypertrophy, inflammation and fibrosis typical of NAFLD or NASH. (uni-bayreuth.de)
  • We studied morphological and immunological features of system inflammation response (SIR) one day after intraperitoneal injection of 15 mg/kg of Escherichia coli lipopolysaccharide (LPS) to female Wistar rats. (morfolhum.ru)
  • Twelve male Wistar rats were randomly assigned to four groups labeled I, II, III and IV (3 rats per group). (njbas-udus.com)
  • We studied proliferation and cell death in hepatocytes after subtotal resection of the rat liver. (morfolhum.ru)
  • Hepatocyte proliferation proceeded rapidly as indicated by two peaks of the mitotic index. (morfolhum.ru)
  • As compared with newborn and adult females, injection of LPS to prepubertal rats induced more pronounced changes in hepatocytes, increased endotoxin level, lowered corticosterone and estradiol blood concentration. (morfolhum.ru)
  • Erythropoietic Effects of Eremomastax polysperma Leaf Extracts on Female Prepubertal and Pubertal Wistar Rats. (livedna.net)
  • Successful cryopreservation of human hepatocytes to retain high viability, metabolic capacity, as well as the ability to be cultured allow routine application of this relevant experimental system. (eurekaselect.com)
  • The present work profiles the hepatocellularity number in male Wistar rats as a function of age. (aspetjournals.org)
  • 1963). Oleic, linoleic, and linolenic acids, and their triglycerides, were chlorinated with 36 Cl-chlorine and administered orally to male Wistar rats. (inchem.org)
  • The aim of this study was to evaluate the biosafety of Anacardium occidentale (cashew) nut oil using male Wistar rats as model. (njbas-udus.com)
  • Twenty-four male Wistar rats were subjected to a choledochal duct ligation and were included in this randomized experimental study. (bsmiab.org)
  • Male Wistar rats received control chow or a NASH-inducing diet rich in fat, cholesterol, and fructose. (uni-bayreuth.de)
  • 1989) and 20-month-old Wistar rats (Nogalska and Swierczynski, 2001). (webmedcentral.com)
  • Methods: Pharmacokinetic parameters of riluzole were determined in Wistar rats after single-dose co-administration with ciprofloxacin and grapefruit juice. (researchgate.net)
  • In this model, the chronic administration of DEN+2-AAF induces characteristic alterations of hepatocellular carcinoma in Wistar rats without AFP gene expression changes, highlighting different signatures in hepatocellular carcinoma heterogeneity. (bvsalud.org)
  • Hepatocyte-restricted constitutive activation of PPAR alpha induces hepatoproliferation but not heatocarcinogenesis. (who.int)
  • Whereas both inhibitors exerted minimal effects on metabolism in microsomes, rifampin and GG918 significantly decreased and increased digoxin metabolism in hepatocytes, respectively. (aspetjournals.org)
  • Hepatocyte invasion of mutant sporozoites was significantly decreased (~8% of that of wildtype). (pberghei.eu)
  • Pre-treatment of CDEE to CCl4 treated rats prevented hepatocyte damage as evidenced by estimating various biochemical parameters and histopathological observations. (phcogcommn.org)
  • As a result, UVA + B exposure has toxic effects, especially on the liver and the heart of Wistar albino rats. (nih.gov)
  • In conclusion, the cashew nut oil was responsible for hepatic parenchymal and matrix alteration in wistar rats administered 8.13 mL/kg of cashew nut oil. (njbas-udus.com)
  • 2011). Over-expression of the FAS, ACC, ACL and SREBP-1 was determined in both the senescent immortalized normal human hepatocytes (Chang cells) and liver of 24-month-old Fisher 344 rats (Kim et al. (webmedcentral.com)
  • however, Group A and Group D observed normal hepatocyte architecture. (lifenscience.org)
  • Furthermore, a histological analysis showed the loss of normal liver architecture with nuclear pleomorphism in the hepatocytes, atypical mitosis, and fibrous septa that were distributed between the portal triads and collagen fibers through the hepatic sinusoids. (bvsalud.org)
  • The haematological result showed slight deviation from the normal in packed cell volume (52%), total white blood cell count (9.38 x 10³/mm³) and lymphocyte count (58.17%) in Wistar rats administered 4 to 8.13 mL/kg of the cashew nut oil, respectively yet no visible compromise of the immune system was observed. (njbas-udus.com)
  • To investigate the possible free radical-scavenging activity of an extract of Cineraria maritima on selenite-induced cataractous lenses in Wistar rat pups. (molvis.org)
  • cMOAT-deficient (TR-) Wistar rats are mutated in the gene encoding MRP2, resulting in defective hepatobiliary transportation of a complete selection of substrates, including bilirubin glucuronide. (healthanddietblog.info)
  • This study was designed to assess the ameliorative effects of eugenol and to propose the possible mechanisms of action of eugenol in diethylnitrosamine (DENA)/acetylaminofluorene (AAF)-caused lung cancer in Wistar rats. (bvsalud.org)
  • In the present study, Wistar rat pups were divided into three experimental groups. (molvis.org)
  • This study was undertaken to determine the influences of various doses of peppermint oil on the hepatic en-zymes, alanine transaminase, apartate tranaminase, alkaline phosphotase and gamma glutamyl transferase and the level of malondialdehyde in the serum of mice with and without immobility stress. (openbiochemistryjournal.com)
  • Female Wistar Albino rats, whose hair of the dorsal skin was shaved, were exposed to a combined UVA + B radiation for 2 h/day, for 4 weeks in order to be compared with the control group. (nih.gov)
  • Since levels of MRP2 are already high in the hepatocytes, this may clarify why only marginal raises of MRP2 was seen in the livers of CDDP-treated animals [24]. (healthanddietblog.info)
  • CDEE significantly prevented CCl4 induced elevation of aspartate aminotransferase (AST), alanine aminotransaminase (ALT), alkaline phosphatase (ALP), total bilirubin (TB) and CCl4 induced decrease in total protein (TP) level in Wistar rats. (phcogcommn.org)
  • We hypothesize that hepatic transporters present in hepatocytes, but not in microsomes, are often the missing link explaining such discrepancies between microsome data and in vivo profiles. (aspetjournals.org)
  • Hepatocyte traversal activity in vitro (HepG2) was higher than of wild type sporooites (~5 times higher). (pberghei.eu)