• In the 1980s the research group of Marguerite Vergnes at Institut National de la Santé et de la Recherche Médicale (INSERM) in Strasbourg (France) reported the spontaneous occurrence of spike-and-wave discharges (SWD) evocative of absence seizures in Wistar rats during cortical electroencephalographic (EE]) recordings. (wikipedia.org)
  • Mice (around 280 strains which include inbred, out bred and genetically engineered lines), Rats (out bred stocks like Wistar, Sprague Dawley, Long Evans and several transgenic rat strains), Xenopus laevis and Zebra fish . (ncbs.res.in)
  • Forty naïve Wistar rats were trained to orally self-administer ethanol during a nine day training period. (5dok.org)
  • RHODIXAN A-1 was tested for acute oral toxicity in Wistar rats, according to O.E.C.D. guideline N° 423/EEC method B.1ter, and in compliance with Good Laboratory Practice. (europa.eu)
  • An outbred strain of rats developed in 1915 by crossing several Wistar Institute white females with a wild gray male. (lookformedical.com)
  • Inbred strains have been derived from this original outbred strain, including Long-Evans cinnamon rats (RATS, INBRED LEC) and Otsuka-Long-Evans-Tokushima Fatty rats (RATS, INBRED OLETF), which are models for Wilson's disease and non-insulin dependent diabetes mellitus, respectively. (lookformedical.com)
  • After mouzes and rats Guinea pigs are easy in maintained laboratory animals. (heat-shock.com)
  • In the rats of the "0" strain, the levels of cytokines in the dorsal striatum after the action of sound (which did not induce AE seizures) were not different from those of the background, while in the brain stem of the "0" strain the levels of IL-1ß were lower than in the background (40.28%, p (bvsalud.org)
  • Female Wistar rats were exposed orally to 200 and 400 ppm propineb (Zn-containing dithiocarbamate) and 250 ppm maneb (Mn-containing dithiocarbamate), from the 6th day of gestation up to birth. (go.jp)
  • Two inbred mouse strains (BALB/c and A/J) and one outbred strain (ICR) were subcutaneously injected with saline solutions containing penicillin G (1.25, 2.5 and 5 mg/mouse), D-penicillamine (0.5, 1 and 2 mg/mouse), or barbital (2 mg/mouse) into one hind footpad and saline only was injected into the contralateral footpad. (go.jp)
  • Reproductive performance consisting of mean litter size, number of pups that wean (wean: born ratio) and mean reproductive index of three inbred mice strains, which are BALB/cMlac, C57BL/6Mlac and DBA/2Mlac, were investigated to provide some basic information on the breeding and maintaining of a foundation colony. (mahidol.ac.th)
  • These mice have both BALB/c inbred and NIH(S) outbred stock in their genetic background. (vivobio.com)
  • Recent investigations in patients and animal models suggest that absence seizures could originate from restricted regions of the cerebral cortex. (moam.info)
  • Atomoxetine affected the performance in a puzzle-box cognitive test in a complicated way-the large brain mice were less successful at task solutions (presumably because they were not afraid of the brightly lit test box), while the small brain strain of atomoxetine treated mice solved the task more successfully. (bvsalud.org)
  • The behavior of all atomoxetine treated animals was more active in an aversive situation (an unescapable slippery funnel, (analogous to the Porsolt test) and the time of immobility decreased significantly in all atomoxetine treated mice. (bvsalud.org)
  • After inbreeding for 20 generations, a surprisingly high incidence of hydronephrosis was encountered and we finally obtained a strain of mice with a very high incidence of severe hydronephrosis affected on both sides of kidney and in both sexes as the process of inbreeding has been increased. (mahidol.ac.th)
  • Health monitoring of the SPF animal colonies is done every quarter. (ncbs.res.in)
  • Clinical signs and mortality: Observations were made within 1 hour and within 4 hours after dosing, and subsequently in surviving animals at least once daily throughout an observation period of 14 days. (europa.eu)
  • In 1958, at F31 to Silvers, who distributed this strain subsequently. (inotivco.com)
  • Subsequently experimental animal models employing cholinergic agonists like carbamylcholine (carbachol), CCK and its analogues as well as scorpion venom were shown to induce pancreatic injury in a time- and dose-dependent manner [9, 10, 11, 12, 13]. (pancreapedia.org)
  • Examination at autopsy of the males and females or of animals that had died did not reveal distinct treatment-related gross alterations. (europa.eu)
  • The development of two inbred strains from the same initial colony has appeared as a very powerful tool to study the possible mutations involved in a genetically complex idiopathic epilepsy. (wikipedia.org)
  • This study established a low incidence hydronephrosis Wistar rat (Mlac:WR) colony at the National Laboratory Animal Center, Mahidol University, Thailand. (mahidol.ac.th)
  • Twenty Mlac:WR breeding pairs were randomized to determine the percentage of hydronephrosis in the original National Laboratory Animal Center colony. (mahidol.ac.th)
  • To Central Institute for Laboratory Animal Breeding, Hannover, in 1973 at F58. (inotivco.com)
  • In 1994, to Harlan Netherlands through acquisition of Central Institute for Laboratory Animal Breeding. (inotivco.com)
  • To Scientific Products Farm, Ltd. [predecessor of Charles River United Kingdom (CRUK)] in 1947 from Wistar Institute. (animalab.eu)
  • In this paper, the data are presented concerning different reactions to seven daily injections of atomoxetine in two mouse strains differing in relative brain weight. (bvsalud.org)
  • In the three strains tested, the penicillin G and D-penicillamine injections resulted in approximately dose-dependent responses. (go.jp)
  • In the present collaborative study, popliteal lymph node (PLN) responses to penicillin G (an allergenic chemical), D-penicillamine (an autoimmunity-inducing chemical), and barbital (a negative reference chemical) were investigated in three different mouse strains by ten pharmaceutical companies. (go.jp)
  • All the Rodent animal rooms have a controlled environment with 20-22'c temperature, 50-60 relative humidity, 0.3 micron HEPA filtered air supply at 15-20 ACPH and 14/10 light/dark cycle maintained. (ncbs.res.in)
  • Possible role of intravenous administration of mesenchymal stem cells to alleviate interstitial cystitis/bladder pain syndrome in a Toll-like receptor-7 agonist-induced experimental animal model in rat. (kyoto-u.ac.jp)
  • This includes, but is not limited to, the acquisition and housing of laboratory animals, training researchers regarding proper animal care and use, providing state-of-the art facilities, and monitoring the safety of all personnel with laboratory animal contact. (ncbs.res.in)
  • The ACRC is dedicated to provide quality (healthy and non-stressed) laboratory animals for research and 24X7 caring of animals. (ncbs.res.in)
  • The ACRC handles breeding, maintenance and supply of healthy laboratory animals to support the ongoing research at the center. (ncbs.res.in)
  • National Laboratory Animal Center. (mahidol.ac.th)
  • Importantly, the ACRC is dedicated to ensuring the humane and ethical usage of animals for research pursuits by strictly complying with the CPCSEA and in-house animal care principles, rules, regulations and guidelines. (ncbs.res.in)
  • The levels of a number of pro-inflammatory cytokines were examined in the Krushinsky-Molodkina (KM) rat strain with high audiogenic epilepsy (AE) proneness (intense tonic seizure fit in response to loud sound) and in the control strain "0" (not predisposed to AE) using multiplex immunofluorescence magnetic assay (MILLIPLEX map Kit). (bvsalud.org)
  • It also provides veterinary assistance including anaesthesia of animals, surgical procedures on animals, peri-operative care of animals, collection of biological samples, administration of medications and treatments, and record keeping as per Govt. (ncbs.res.in)
  • Good surgical small animal model. (animalab.eu)
  • Fasting period before study: Prior to dosing, the animals had fasted overnight. (europa.eu)
  • For timed mated animals fulfilled from Envigo Affiliates in Europe, in general, animals are mated overnight from 16.00 until 08.00 hours. (inotivco.com)
  • Inbreeding of the Lewis rat is begun by Dr. Margaret Lewis from a Wistar stock. (inotivco.com)
  • Envigo does not guarantee that late term animals will not deliver in transit. (inotivco.com)
  • The GAERS or Genetic Absence Epilepsy Rat from Strasbourg is a recognized animal model of absence epilepsy, a typical childhood form of epilepsy characterized by recurrent loss of contact and concomitant pattern on the electroencephalogram called "spike-and-wave" discharges. (wikipedia.org)
  • Further analysis of the noradrenergic system in these strains is needed (and further analysis of the effects of drugs which affect noradrenergic receptors). (bvsalud.org)
  • In addition, the ACRC provides orientation and training to all authorized animal facility users to assure high standards of humane, ethical and responsible use of animals in their research. (ncbs.res.in)
  • The advantages of animal models are the possibility to isolate specific aspects of a complex and varying disease course, the high degree of standardization and reproducibility, and the reduction of the required sample size eliminating variability in the study population. (pancreapedia.org)
  • The general patterns of behavioral reactions to atomoxetine in the cognitive test and other interstrain differences demonstrated in these experiments made it possible to suggest that differences in ascending noradrenergic projections between the two strains used exist. (bvsalud.org)
  • These seizures were recorded on both sides of the brain, lasted about 20 sec and occurred when the animals were quiet. (wikipedia.org)
  • Much of our current knowledge regarding the onset of pancreatitis was not gained from studies involving the human pancreas or patients with pancreatitis but from animal or isolated cell models. (pancreapedia.org)
  • The ACRC provides services and resources for investigators to accomplish animal research objectives. (ncbs.res.in)
  • Depending on the requirements of the approved research protocol, the ACRC imports new strains of animals from commercial suppliers and/or collaborators from abroad. (ncbs.res.in)
  • Body weight: The body weight of each animal was recorded immediately before dosing on day 0, and of the surviving animals on days 3, 7 and 14 of the study. (europa.eu)
  • When animals are sourced from the UK, the minimum age of the litter must be at least 7 days at packing. (inotivco.com)
  • If problems regarding gestational age or pregnancy are encountered, customers should immediately contact Envigo's customer service department and provide detailed information regarding the animals involved. (inotivco.com)
  • Instinctual patterns of activity related to a specific area including ability of certain animals to return to a given place when displaced from it, often over great distances using navigational clues such as those used in migration (ANIMAL MIGRATION). (lookformedical.com)