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  • proline-rich
  • These domains are followed by a proline-rich region containing several serine/threonine/tyrosine residues that are targets for different kinases and an SH3 (Src homology 3) domain at the C terminus through which cortactin can bind to a plethora of different proteins ( Cosen-Binker and Kapus, 2006 ). (rupress.org)
  • induces
  • Integrin signaling also induces formation of a complex of p130Cas, the adapter protein Crk, and a third molecule, DOCK 180, that is required for membrane ruffling, a component of cell migration ( 13 , 14 ). (jimmunol.org)
  • scaffold
  • Several Ras and Rho subfamily GEFs associate with scaffold proteins that may serve to colocalize molecules or more directly catalyze activation of signaling by physical arrangement of components ( 8 , 9 ). (jimmunol.org)
  • peptide
  • Here we report the crystal structure of tetrameric rabbit muscle aldolase in complex with a C-terminal peptide of Wiskott-Aldrich syndrome protein. (uniprot.org)
  • However, characterization of increasing numbers of protein sequences and structures has suggested that the interacting modules of multidomain proteins can be distinguished as globular domains, as short peptide functional sites, and as long peptides that interact with their partners over extensive regions. (hindawi.com)
  • homology
  • Protein interaction domains can be classified based on sequence homology, ligand-binding properties, or structural similarity [ 11 ]. (hindawi.com)
  • Thus, a typical class of ligand binding proteins may contain a variety of protein interaction domains that recognize a common ligand, whereas a family classified based on sequence homology contains a single fold that may recognize a variety of ligands. (hindawi.com)
  • motor proteins
  • whereas actin and its motor proteins are best known for generating the protrusive and contractile forces that control cell shape, motility, and cytokinesis ( Pollard and Cooper, 2009 ). (rupress.org)
  • pathways
  • Therefore, the identification of tyrosine phosphorylated proteins and the investigation into their involvement in signaling pathways are important. (mcponline.org)
  • peptides
  • The latter is often an issue as typically several milligrams of (stable isotope-labeled) starting protein material are required to enable the detection of low abundance phosphotyrosine peptides. (mcponline.org)
  • Enrichment of tyrosine phosphorylated proteins or peptides prior to mass spectrometric detection is therefore essential. (mcponline.org)
  • UniProt
  • p>When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later. (uniprot.org)
  • WASH
  • We recently showed that WASH localizes to early endosomal subdomains, where it is associated with vesicular F-actin, and regulates retromer-mediated vesicle trafficking through an interaction with the protein FAM21 ( 8 ). (pnas.org)
  • Human
  • The current version of the human immunome network consists of nearly 1400 interactions involving approximately 600 proteins. (hindawi.com)
  • abundant
  • Profilin is one of the most abundant actin monomer binders, but proteins such as CAP and (in mammals) thymosin β4 have some functional overlaps with profilin. (thefullwiki.org)