Wilms tumors tumor cell nuclei. Medical search. Frequent questions

In its initial from, stellate cells with amphiphilic cytoplasm and ovular central nuclei are observed. (wikipedia.org)
Commonly referred to as rhabdoid features, the maturing rhabdomyoblast will likely exhibit low levels of eosinophilic cytoplasm in proximal distances to the nucleus. (wikipedia.org)
In the concluding phase of differentiation, the white blood cell rich cytoplasm appears bright and exhibits cross-striation. (wikipedia.org)
These tumors are morphologically identical to infantile fibrosarcoma and are characterized by a spindle-shaped tumor cells with scanty cytoplasm, vesicular and bland appearing nuclei, and may demonstrate a high mitotic count. (cap.org)
The tumors are characterized by interlacing fascicles of fibroblasticappearing cells with thin, tapered, bland-appearing nuclei and minimal eosinophilic cytoplasm. (cap.org)
Characteristic histopathologic ﬁndings include round to polygonal cells that have strongly eosinophilic cytoplasm and round nuclei, and which are arranged in nests, acini, tubules, and microcysts. (pediagenosis.com)
The cells are usually large and polygonal, containing abundant eosinophilic cytoplasm, a large nucleus with open chromatin, a prominent eosinophilic nucleolus, and an occasional intracellular lumina containing red blood cells 1,4-7 . (bvsalud.org)
These tumors are histologically confirmed by having large cells with eccentrically located nuclei and abundant eosinophilic cytoplasm (Beckwith and Palmer 1978). (preventiongenetics.com)
characterized by 3 or more of the following: necrosis, sheetlike growth, prominent nuclei, increased cellularity, and high nucleus/cytoplasm ratio. (medscape.com)

While most tumors metastatic to the serous membranes are of epithelial origin, cytologists should be aware that non-epithelial neoplasms can also cause malignant effusions including sarcomas, melanomas, germ cell tumors, and, more rarely, brain tumors. (cytojournal.com)
Diagnosing non-epithelial malignancies in effusion specimens based entirely upon their cytomorphologic features is difficult because these neoplasms often exhibit considerable morphological overlap and their cytomorphology can differ from the original tumor. (cytojournal.com)
As malignant cells have a tendency to round up in body fluids these non-epithelial neoplasms can therefore mimic reactive mesothelial cells and metastatic adenocarcinoma. (cytojournal.com)
Common non-epithelial neoplasms that may cause malignant effusions include malignant melanoma, sarcomas, and other neoplasms including germ cell tumors [ Figure 1 ]. (cytojournal.com)
CD56 is a sensitive marker of ovarian sex cord-stromal tumors and may also be useful in the diagnosis of this group of neoplasms, especially in cases that are inhibin or calretinin negative, and the differential diagnosis includes neoplasms that are CD56 negative. (medscape.com)

Other rare non-epithelial malignancies that may be encountered in effusion cytology include neuroblastoma, Wilms tumor, and metastatic brain tumors. (cytojournal.com)
1 - 3 Intracranial brain tumors, most commonly medulloblastoma [ Figure 2 ], can metastasize to the peritoneal cavity via ventriculo-peritoneal shunts used to divert excess cerebrospinal fluid. (cytojournal.com)
Approximately 10-15% of patients with malignant rhabdoid tumors have synchronous or metachronous brain tumors. (preventiongenetics.com)

Sex cord-stromal tumors are groups of tumors composed of granulosa cells, theca cells, Sertoli cells, Leydig cells, and fibroblasts of stromal origin, singly or in various combinations. (medscape.com)
[ 1 ] sex cord-stromal tumors are classified into the following categories. (medscape.com)
Sex cord-stromal tumors account for approximately 8% of all ovarian tumors. (medscape.com)
Although various markers have been reported to stain sex cord-stromal tumors (eg, CD99, CD56, A103, müllerian inhibiting factor, vimentin), inhibin and calretinin have proven to be the most helpful to date. (medscape.com)
A worldwide database analysis revealed that younger age, smaller tumor size, early stage, and granulosa cell tumor histologic type appear to be independent prognostic factors for improved survival in patients with malignant sex cord-stromal tumors who undergo lymph node dissection. (medscape.com)
Carcinoma of cervix is classified as per the WHO classification into primary tumors which are predominantly epithelial tumors, mesenchymal tumors and tumor like lesions, mixed epithelial stromal tumors, melanocytic, germ cell, and lymphoid tumors. (cytojournal.com)

Mutations in the CTNNB1 gene can cause a type of aggressive but noncancerous (benign) growth called a desmoid tumor. (medlineplus.gov)
CTNNB1 gene mutations are found in about 85 percent of all noninherited (sporadic) desmoid tumors. (medlineplus.gov)
The CTNNB1 gene mutations that cause desmoid tumors are somatic, which means they are acquired during a person's lifetime and are present only in tumor cells. (medlineplus.gov)
The CTNNB1 gene mutations that cause desmoid tumors usually occur in a region of the gene called exon 3. (medlineplus.gov)
Somatic mutations in the CTNNB1 gene are found in almost all pilomatricomas, a type of benign skin tumor associated with hair follicles. (medlineplus.gov)
Mutations in the CTNNB1 gene have been found in Wilms tumor, a rare form of kidney cancer that occurs almost exclusively in children. (medlineplus.gov)
These mutations are somatic and occur only in kidney cells that give rise to the tumor. (medlineplus.gov)
CTNNB1 gene mutations in Wilms tumor result in an overly active protein. (medlineplus.gov)
The development of Wilms tumor has been linked to mutations of the WT1 and WT2 genes located on chromosome 11 at 11p13 and 11p15.5, respectively ( 8 , 9 ). (abdominalkey.com)
Cancer cells acquire genetic heterogeneity to escape from immune surveillance during tumor evolution, but a systematic approach to distinguish driver from passenger mutations is lacking. (nature.com)
Genetic inactivation of the machinery or re-introduction of ANKRD52 frequent patient mutations dampens the JAK-STAT-interferon-γ signaling and antigen presentation in cancer cells, largely by abolishing miR-155-targeted silencing of suppressor of cytokine signaling 1 (SOCS1). (nature.com)
This test is specifically designed for heritable germline mutations and is not appropriate for the detection of somatic mutations in tumor tissue. (preventiongenetics.com)
Mutations in the DROSHA/DGCR8 microprocessor complex in high-risk blastemal Wilms tumor (Doctoral dissertation, Universität Würzburg). (axonmedchem.com)

however, occasional tumors composed entirely of rhabdoid cells have been described in which no RCC component is detected despite extensive sampling. (medscape.com)
RR CC was named for its morphologic resemblance to pediatric malignant rhabdoid tumor (MRT) of the kidney, which is a highly aggressive tumor characterized by cells that resemble rhabdomyoblasts and by genetic alterations involving chromosome 22, particularly the hSNF5/INI1 gene on 22q11.2. (medscape.com)
[ 13 , 14 ] MRT usually arises in children younger than 3 years, and the occasional cases previously reported as adult MRT are now considered more likely to be RRCC in which rhabdoid components have overgrown the original histologic tumor type. (medscape.com)
Individuals who are clinically suspected or diagnosed with SCCOHT, individuals with rhabdoid tumor predisposition syndrome who have been found to be negative for pathogenic variants in the SMARCB1 gene, and individuals with a family history of a pathogenic variant in SMARCA4 may be tested. (preventiongenetics.com)
2014). SCCOHT can often be difficult to distinguish from other primary and metastatic ovarian cancers, and morphologically, clinically and molecularly resemble atypical teratoid/rhabdoid tumors (ATRTs) and malignant rhabdoid tumors (MRTs) (Foulkes et al. (preventiongenetics.com)
2014). Rhabdoid tumors are rare aggressive tumors found in children and can be involved in rhabdoid tumor predisposition syndrome, especially when a family history is present. (preventiongenetics.com)
Originally, rhabdoid tumors were found in the kidney, but have since been found in the liver, soft tissue, lung, skin, heart and the central nervous system (CNS). (preventiongenetics.com)
In the CNS, where rhabdoid tumors are termed ATRT (atypical teratoid, rhabdoid tumor), the most affected area is in the cerebellum (Bourdeaut et al. (preventiongenetics.com)
2014). Pathogenic variants in this gene also cause autosomal dominant rhabdoid tumor predisposition syndrome (Schneppenheim et al. (preventiongenetics.com)
Missense pathogenic variants appear to be responsible for Coffin-Siris syndrome whereas nonsense, splicing, indels, small insertions and deletion variants are reportedly responsible for SCCOHT and rhabdoid tumor predisposition syndrome (Human Gene Mutation Database). (preventiongenetics.com)

Sarcomatoid renal cell carcinoma (SRCC) is currently defined in the 2004 World Health Organization (WHO) classification of renal tumors as any histologic type of renal cell carcinoma (RCC) containing foci of high-grade malignant spindle cells. (medscape.com)
Currently, the 2004 WHO classification of renal tumors recognizes this transformation as "sarcomatoid change" or "sarcomatoid features" arising within RCC, rather than as a separate histologic entity. (medscape.com)

Most tumors metastatic to the serous membranes are of epithelial origin. (cytojournal.com)
Local recurrence and metastatic tumors may occur in up to 10% of cases. (cap.org)

The tumor is usually circumscribed by a pseudocapsule formed of compressed renal and perirenal tissues. (abdominalkey.com)

The differential diagnosis of a malignant effusion is accordingly broad, especially for the small round blue cell tumors that includes not only mesenchymal tumors, but also non-mesenchymal tumors, such as neuroblastoma and Wilms tumor. (cytojournal.com)

Here, we report that aquaporin 3 (AQP3), a channel protein that mediates the transport of water/glycerol, was highly expressed in the epidermis and CD4+ T cells of both rosacea patients and experimental mice. (bvsalud.org)
This protein is present in many types of cells and tissues, where it is primarily found at junctions that connect neighboring cells (adherens junctions). (medlineplus.gov)
The beta-catenin protein is also involved in cell signaling as an essential part of the Wnt signaling pathway. (medlineplus.gov)
Certain proteins in this pathway attach (bind) to beta-catenin, which triggers a multistep process that allows the protein to move into the cell nucleus. (medlineplus.gov)
This protein is active in cells that make up a part of the hair follicle known as the matrix. (medlineplus.gov)
As a result, the protein accumulates within cells. (medlineplus.gov)
This active beta-catenin protein promotes Wnt signaling longer than normal, which leads to the unchecked proliferation of kidney cells and tumor development. (medlineplus.gov)
Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA-4) is a receptor on T helper cells that functions as an immune checkpoint and downregulator of immune responses. (attogene.com)
2 Protein interactions are critical to the stability, localization and activity of b-catenin, and we recently performed the first proteomic analyses of the b-catenin interactome in myeloid cells. (haematologica.org)
3 This study identified Wilms tumor protein (WT1) as a putative novel interaction partner in myeloid cells. (haematologica.org)
In order to idenitfy appropriate cell lines in which to study b-catenin:WT1 interplay we first performed a screen of myeloid cell lines to examine b-catenin and WT1 protein expression. (haematologica.org)
WT1 is an RNA-binding protein, 6 and β-catenin has also been shown to bind RNA, 7 so to confirm this interaction was not indirect via RNA binding we repeated WT1 Co-IP (with or without CHIR99021) after first confirming complete digestion of RNA through RNase A pre-treatment of cell lysates ( Figure 1E ). (haematologica.org)
A) Immunoblot of myeloid leukemia cell lines showing the relative level of b-catenin (~92 kDa) and WT1 (~50 kDa) protein, with b-actin (42 kDa) used to assess protein loading. (haematologica.org)
Insulin receptor substrate 1 (IRS-1) is an adaptor protein that integrates multiple transmembrane signals from growth factors and hormones, to regulate cell growth, survival, differentiation and metabolism ( 4 ). (spandidos-publications.com)
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Wilms Tumor Protein (WT1) in tissue homogenates, cell lysates and other biological fluids. (kits-elisa.com)
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Wilms Tumor Protein (WT1) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (kits-elisa.com)
Description: A sandwich ELISA kit for detection of Wilms Tumor Protein from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (kits-elisa.com)
Description: Quantitative sandwich ELISA for measuring Human Wilms tumor protein (WT1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. (kits-elisa.com)
[ 1 ] His prediction was subsequently supported by the cloning of the retinoblastoma tumor suppressor gene ( RB1 ) and by functional studies of the retinoblastoma protein, Rb. (medscape.com)
Like Rb protein, many of the proteins encoded by tumor suppressor genes act at specific points in the cell cycle. (medscape.com)
For example, the TP53 gene, located on chromosome 17, encodes a 53-kd nuclear protein that functions as a cell cycle checkpoint. (medscape.com)
The CDK4-cyclinD complex normally phosphorylates the retinoblastoma protein (Rb protein), leading to release of the E2F transcription factor and cell cycle progression. (medscape.com)
The p19ARF protein, which is encoded by the same locus as p16, also leads to cell cycle arrest by inhibiting the ability of MDM2 to inactivate TP53. (medscape.com)
The p16INK4A protein is a cell-cycle inhibitor that acts by inhibiting activated cyclin D:CDK4/6 complexes, which play a crucial role in the control of the cell cycle by phosphorylating Rb protein. (medscape.com)
Nucleus accumbens-associated protein-1 promotes glycolysis and survival of hypoxic tumor cells via the HDAC4-HIF-1 axis. (tamu.edu)
C-erbB-2/ HER-2 upregulates fascin, an actin-bundling protein associated with cell motility, in human breast cancer cell lines. (tamu.edu)
Binding of cellular proteins to a conformational domain of tumor suppressor protein p53. (tamu.edu)
Genes whose protein products stimulate or enhance the division and viability of cells. (cancerquest.org)
Genes whose protein products can directly or indirectly prevent cell division or lead to cell death. (cancerquest.org)
GCNA is a histone binding protein required for spermatogonial stem cell maintenance. (axonmedchem.com)

The epithelial-mesenchymal transition (EMT) plays important roles in tumor metastasis. (spandidos-publications.com)
Cells undergoing EMT lose their epithelial characteristics and phenotype, acquire mesenchymal properties, and thus gain enhanced motility ( 12 ). (spandidos-publications.com)
Squamous cell carcinoma (SCC) in various morphological forms needs to be separated from other epithelial tumors for treatment modality selection. (cytojournal.com)
Mixed mesenchymal and epithelial tumors are of Mullerian origin. (cytojournal.com)
The classification of epithelial tumors of the kidney has in particular undergone substantial progress in the last two decades with major contributions from genetic typing of renal cell carcinomas (RCCs). (abdominalkey.com)
[ 7 ] Tumors with pure sarcomatoid morphology due to overgrowth of the RCC components are classified as SRCC if evidence of epithelial differentiation can be demonstrated through immunohistochemical or ultrastructural analysis. (medscape.com)
Histone deacetylases, Mbd3/NuRD, and Tet2 hydroxylase are crucial regulators of epithelial-mesenchymal plasticity and tumor metastasis. (tamu.edu)

Outlier case reports have been presented, including the aggressive prognosis of embryonal rhabdomyosarcoma and the simultaneous development adipocyte-like cells. (wikipedia.org)
Purpose: More effective approaches are needed to improve the prognosis of non-small-cell lung cancer (NSCLC) patients. (bvsalud.org)
Patients with congenital mesoblastic nephroma almost always have an excellent prognosis when the tumor has been completely excised. (cap.org)
Upregulation of AKR1C1 and AKR1C3 expression in OPSCC with integrated HPV16 and HPV-negative tumors is an indicator of poor prognosis. (cancerindex.org)

The Wnt signaling pathway promotes the growth and division (proliferation) of cells and helps determine the specialized functions a cell will have (differentiation). (medlineplus.gov)
Excess beta-catenin promotes the uncontrolled proliferation of cells, allowing the formation of desmoid tumors. (medlineplus.gov)
These genes increase the proliferation and differentiation of cells associated with the hair follicle matrix. (medlineplus.gov)
Endothelial cell lineage tracing showed that BNP directly stimulated the proliferation of resident endothelial cells via NPR-A binding and p38 MAP kinase activation. (elifesciences.org)
BNP also stimulated the proliferation of WT1 + epicardium-derived cells but only in the hypoxic area of infarcted hearts. (elifesciences.org)
The origin of new endothelial cells (i.e. resident or infiltrating) as well as the underlying mechanism leading to their proliferation (partial endothelial-to-mesenchymal transition [EndMT] or not) have long been debated. (elifesciences.org)
However, recently Houghton et al ( 7 ) showed increased cell proliferation after silencing of IRS1 gene expression in A549 cells suggesting tumor suppression potential. (spandidos-publications.com)
Inactivation of tumor suppressor genes, whose products normally provide negative control of cell proliferation, contributes to malignant transformation in various cell types. (medscape.com)
MTT colorimetric assays, colony formation assays and 5‑ethynyl‑20‑deoxyuridine incorporation assays were also conducted to evaluate ACC cell proliferation. (cancerindex.org)

While the standard workup did not identify the primary tumor, genomic profiling analysis was useful in therapeutic management. (spandidos-publications.com)
Phosphorylation of serine 367 of FOXC2 by p38 regulates ZEB1 and breast cancer metastasis, without impacting primary tumor growth. (tamu.edu)

The former includes adenocarcinoma of the axillary lymph nodes, papillary serous carcinoma of the peritoneum (redefined as peritoneal cancer), squamous cell carcinoma of the cervical lymph nodes and extragonadal germ cell tumors in young men, which are derived from the middle of the body ( 4 ). (spandidos-publications.com)

The malignant version of this tumor is known as a pilomatrix carcinoma. (medlineplus.gov)
Lymph node metastasis is responsible for the high morbidity of head and neck squamous cell carcinoma (HNSCC). (spandidos-publications.com)
The role of genotyping and ancillary tools, in particular immunohistochemistry, in correctly classifying these tumors is highlighted in the section on Renal Cell Carcinoma. (abdominalkey.com)
Pathological diagnosis based on a biopsy sample of the para‑aortic lymph nodes indicated that the tumor was a high‑grade serous carcinoma of possible gynecological organ origin. (spandidos-publications.com)
On the other hand, the unfavorable subset (majority of patients) includes patients with adenocarcinoma metastasis to the liver or other organs, poorly differentiated carcinoma and squamous cell carcinoma of the abdominal cavity ( 1 ). (spandidos-publications.com)
Thus even a suspected oncocytoma is generally treated like a renal cell carcinoma, with the deﬁnitive diagnosis established only after surgical resection of the entire mass. (pediagenosis.com)
Fat-poor tumors that cannot be conﬁdently distinguished from renal cell carcinoma should also be removed. (pediagenosis.com)
Go to Renal Cell Carcinoma and Clear Cell Renal Cell Carcinoma for more complete information on these topics. (medscape.com)
Renal oncocytoma, a benign tumour of the kidney, may pose a differential diagnostic problem due to overlapping phenotype with chromophobe renal cell carcinoma or other types of renal cell tumours. (biomedcentral.com)
Altered expression of the p50 subunit of the NF-kappa B transcription factor complex in non-small cell lung carcinoma. (tamu.edu)
Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is a rare aggressive form of ovarian cancer found in young women (i.e. (preventiongenetics.com)

A rhabdomyoblast is a cell type which is found in some rhabdomyosarcomas. (wikipedia.org)
Myogenin is found strictly in cells of skeletal muscle origin, and is therefore used as a biomarker for tumors of the muscle lineage, including alveolar rhabdomyosarcomas. (attogene.com)

Cell detection in pathology and microscopy images with multi-scale fully convolutional neural networks. (tissuegnostics.com)

The TP53 gene is also capable of stimulating apoptosis of cells containing damaged DNA. (medscape.com)
The other approach is to screen CRISPR-Cas9-based guide RNA (gRNA) libraries that target either the whole genome using cancer cell and immune cell co-culture systems 9 , 10 , or focused gene sets using immunocompetent murine tumors 11 , 12 . (nature.com)
The new isoform is specifically upregulated in renal oncocytoma, whereas the known DLG2 gene is downregulated in this type of kidney tumour. (biomedcentral.com)
We used the Affymetrix Human Genome U133 A and B GeneChip sets [ 16 ] to establish the gene expression in normal kidney tissues and distinct types of renal cell tumours. (biomedcentral.com)
MicroRNA-21 promotes cell transformation by targeting the programmed cell death 4 gene. (tamu.edu)
Estrogen regulation of vascular endothelial growth factor gene expression in ZR-75 breast cancer cells through interaction of estrogen receptor alpha and SP proteins. (tamu.edu)
We have two copies of each gene and for oncogenes, a single defective copy is enough to cause a cell to divide. (cancerquest.org)

In this study, we found a negative correlation of IRS-1 expression with tumor metastasis both in human tissue samples and in cell lines. (spandidos-publications.com)
Furthermore studies in tumor metastasis are quite limited and controversial. (spandidos-publications.com)
While in lung cancer, IRS-1 has been confirmed to suppress tumor metastasis ( 11 ). (spandidos-publications.com)
β-catenin, when translocating to and accumulating in the nucleus, induces transcription of other oncogenes involved in tumor progression, malignancy and metastasis ( 15 ). (spandidos-publications.com)

Medulloblastoma is an embryonal neoplasm and accounts for 1% of all adult intracranial tumors. (surgicalneurologyint.com)
In the pediatric group, MB is the most common malignant brain tumor, but accounts for less than 1% of all adult intracranial tumors,[ 11 5 ] with an annual incidence of approximately only 0.5 per million individuals. (surgicalneurologyint.com)
Meningiomas are the most commonly reported intracranial tumor. (medscape.com)

The first section will cover those tumors that characteristically are associated with the pediatric population. (abdominalkey.com)
This study shows that a single receptor may play various roles depending on whether its site of action is in the nucleus or on the cell membrane," states Dr. Jean-Sï¿½bastien Joyal, MD, PhD, a pediatric intensivist at the Sainte-Justine UHC and an assistant professor at the Universitï¿½ de Montrï¿½al. (cancerlive.net)

In addition, these alterations affect 3 principal categories of genes, as follows: proto-oncogenes, tumor suppressor genes, and DNA repair genes. (medscape.com)
This article briefly discusses tumor suppressor genes and then focuses on the role of proto-oncogenes in childhood cancer. (medscape.com)
Another important class of tumor suppressor genes involved in cell cycle control and in the generation of human cancers is the cyclin-dependent kinase (CDK) inhibitors. (medscape.com)
This is in contrast with tumor suppressor genes which must BOTH be defective to lead to abnormal cell division. (cancerquest.org)

Once in the nucleus, beta-catenin interacts with other proteins to control the activity (expression) of particular genes. (medlineplus.gov)
The review highlights the discovery of oncogenes and suppressor tumor genes, underlining the crucial role of these achievements in cancer diagnosis and therapies. (jcancer.org)
TP53 activates the expression of genes involved in apoptosis, cell cycle regulation (p21), and MDM2. (medscape.com)
Although carcinogenic roles for the INK4B, INK4C, INK4D, CIP1, KIP1, and KIP2 genes appear to be limited, INK4A is among the most commonly mutated genes in human tumors. (medscape.com)
The genes that have been identified to date have been categorized into two broad categories, depending on their normal functions in the cell. (cancerquest.org)
This first category also includes genes that contribute to tumor growth by inhibiting cell death. (cancerquest.org)
The genes in the second group are called tumor suppressors. (cancerquest.org)
Many of these genes are responsible for providing the positive signals that lead to cell division. (cancerquest.org)
As stated in the introduction to this section, the defective versions of these genes, known as oncogenes, can cause a cell to divide in an unregulated manner. (cancerquest.org)
Despite the differences in their normal roles, these genes all contribute to unregulated cell division if they are present in a mutant (oncogenic) form. (cancerquest.org)
The identified DEGs included 20 downregulated genes and 51 upregulated genes, which were highly associated with the cell cycle, organelle fission, chromosome segregation, cell division and spindle stability. (cancerindex.org)

There are several different kinds of benign renal tumors, which may originate from a wide range of cell types. (pediagenosis.com)
Although certain benign tumors have characteristic radiologic ﬁndings, most cannot be distinguished from malignant tumors using imaging alone. (pediagenosis.com)
Some of the more common and well-documented benign renal tumors are presented here. (pediagenosis.com)
Renal oncocytoma (RO) is a benign tumour of the kidney accounting for approximately 5% of renal cell tumours. (biomedcentral.com)

Mayo researchers studied three patients - two women and a man - who were treated for inflammatory disease and developed melanoma tumors in one eye within a year to two of taking TNF inhibitors. (cancerlive.net)
My research interests comprise cutaneous tumors with emphasis in lymphomas and melanoma. (mdanderson.org)

While most children with Wilms tumor are thankfully cured, those with more aggressive tumors do poorly, and we are increasingly concerned about the long-term adverse side effects of chemotherapy in Wilms tumor patients. (cancerlive.net)
In lymphomas I have conducted studies in rare aggressive primary cutaneous tumors such as gamma/delta T cell lymphoma (expanding the description of the epidermotropic variant) as well as more indolent entities such as lymphomatoid papulosis (type D) and CD4-positive small to medium size T cell lymphoproliferative disorders. (mdanderson.org)

Loss of E-cadherin, not only results in loss of adherens junctions between neighbor cells resulting in dissemination of cells from the original tumor, but also results in releasing its cytoplasmic binding with β-catenin. (spandidos-publications.com)

In adult tissues, this pathway plays a role in the maintenance and renewal of stem cells, which are cells that help repair tissue damage and can give rise to other types of cells. (medlineplus.gov)
These rare tumors arise from connective tissue, which provides strength and flexibility to structures such as bones, ligaments, and muscles. (medlineplus.gov)
Anti-Myogenin staining may occur in Wilms' tumor, and labels the nuclei of myoblasts in developing muscle tissue. (attogene.com)
Description: tissue homogenates, cell lysates and other biological fluids. (kits-elisa.com)
Peritoneum is defined as gliding membrane, composed of mesothelial cells maintained by basement membrane and thin layer of connective tissue. (ukessays.com)
Tissue samples were collected from patients underwent tumour nephrectomy. (biomedcentral.com)
A piece of tumour and corresponding normal kidney were snap-frozen immediately after nephrectomy in liquid nitrogen and stored at -80°C. The remaining tissue was fixed in 4% buffered formaldehyde for histological report. (biomedcentral.com)
Transfection of tissue transglutaminase into a highly malignant hamster fibrosarcoma leads to a reduced incidence of primary tumour growth. (tamu.edu)
However, owing to recent advances, deep learning is frequently used in biomedical image analysis to detect nuclei, phenotypes or morphological substructues in stained tissue sections. (tissuegnostics.com)
Another innovative approach to using AI in medicine is tissue cytometry, used specifically for the segmentation of cells and other morphological tissue structures. (tissuegnostics.com)
Artificial intelligence plays an essential role in cell segmentation as scientists use machine learning to identify cells in tissue section s 3 . (tissuegnostics.com)
TissueGnostics, recognized expert in image analysis, offers a deep learning-based nuclei segmentation algorithm which needs no or only limited user input to identify nuclei in stained tissue sections, be it IHC or IF based. (tissuegnostics.com)
Doctors look at tissue samples under a microscope to determine if cells have mutated and formed into mesothelioma . (mesotheliomaguide.com)
Histopathology" is the inspection of tissue for diseased cells. (mesotheliomaguide.com)
MRI spectroscopy can be used to detect malignant meningiomas by comparing the metabolic and chemical contents of the healthy tissue with malignant tumor. (medscape.com)

As a transcription factor whose expression is increased by DNA damage, p53 blocks cell division at the G1 phase of the cell cycle to allow DNA repair. (medscape.com)

One complementary therapy could be 're-activating' vasculogenesis (i.e. the differentiation of precursor cells into mature endothelial cells), a mechanism that occurs in the heart during development but is quiescent in adult hearts. (elifesciences.org)
In this experiment we have pooled 3-5 RNAs each from normal healthy fetal and adult kidneys, Wilms' tumours, conventional, chromophobe and papillary RCCs and ROs. (biomedcentral.com)

A useful analogy to consider when thinking about tumor suppressors and oncogenes is an automobile. (cancerquest.org)
In normal cells, both internal and external signals control the activity of the oncogenes. (cancerquest.org)
Some proto-oncogenes work to regulate cell death. (cancerquest.org)
The proto-oncogenes that have been identified so far have many different functions in the cell. (cancerquest.org)

A. Tumor grossly limited to the true pelvis with negative nodes but with histologically confirmed microscopic seeding of abdominal peritoneal surfaces. (medscape.com)
B. Tumor of one or both ovaries with histologically confirmed implants of abdominal peritoneal surfaces, none exceeding 2 cm in diameter. (medscape.com)

Moreover, we show that AQP3 was upregulated during T cell differentiation and promotes helper T (Th) 17 differentiation possibly via the activation of STAT3 signaling. (bvsalud.org)
It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. (cancerindex.org)
Focal spindling due to noncohesion of tumor cells is not considered to represent sarcomatoid differentiation. (medscape.com)
In cases in which the histologic subtype of the RCC component is not recognizable, the tumor is designated as unclassified RCC with sarcomatoid differentiation. (medscape.com)
Stability of Imprinting and Differentiation Capacity in Naïve Human Cells Induced by Chemical Inhibition of CDK8 and CDK19. (axonmedchem.com)

Wiedemann-Beckwith syndrome is related to abnormalities on chromosome 11p15 and characterized by multiple craniofacial anomalies, abdominal wall defects, and tumors of the genitourinary tract, liver, adrenal gland, and central nervous system among other abnormalities. (abdominalkey.com)
Wilms tumor is the most common childhood genitourinary tract cancer and the third most common solid tumor of childhood. (cancerlive.net)

Genetic testing revealed a high loss of heterozygosity score and high tumor mutational burden (TMB). (spandidos-publications.com)
An important development in cancer research over the past 2 decades has been the recognition that genetic changes drive the pathogenesis of tumors of both adulthood and childhood. (medscape.com)
Two complementary approaches have been adopted to identify genetic elements that control cancer cell sensitivity to T cell-mediated cytotoxicity. (nature.com)
It is therefore imperative to uncover novel immune evasion mechanisms in the dynamic tumor-immune microenvironment by untangling the genetic heterogeneity of cancer cells. (nature.com)

Biopsies, however, are also unreliable because oncocytoma-like areas can be found in chromophobe renal cell carcinomas. (pediagenosis.com)

Ninety percent of these tumors occur within the first year of life and nearly all cases have been reported in children less than 30 months of age. (cap.org)
When this process does not occur properly, unregulated cell growth may be the end result. (cancerquest.org)

A diverse array of tumors can arise in the human kidney. (abdominalkey.com)
These tumors oftentimes have a highly irregular interface with the kidney parenchyma and have fascicles of tumor cells interlacing with renal parenchyma. (cap.org)

Samples of adrenal tumors were collected from patients undergoing adrenalectomy at the Department of Urology, the First Hospital of China Medical University. (cancerindex.org)

Medulloblastoma (MB) is an embryonal tumor. (surgicalneurologyint.com)

The histologic hallmark of AE is represented by the presence of sheets and groups of atypical endothelial cells with prominent epithelioid morphologies. (bvsalud.org)
Neuroradiologists and neurosurgeons must be aware of both the typical and the atypical imaging appearances of meningiomas, as there is some correlation with different histologic types of tumor. (medscape.com)
Significant factors contributing to recurrence include atypical and malignant histologic types and heterogeneous tumor contrast enhancement on CT scans. (medscape.com)

Cancer encompasses the group of diseases classified by abnormal cell growth. (wikipedia.org)
Cancer has been in existence on Earth even before the appearance of man, as evidenced by paleontological findings of tumors in animals ( 1 , 2 ). (jcancer.org)
We find that the core microRNA (miRNA) biogenesis and targeting machinery maintains the sensitivity of cancer cells to PD-1-independent T cell-mediated cytotoxicity. (nature.com)
Expression of each miRNA machinery component strongly correlates with intratumoral T cell infiltration in nearly all human cancer types. (nature.com)
Our data indicate that the evolutionarily conserved miRNA pathway can be exploited by cancer cells to escape from T cell-mediated elimination and immunotherapy. (nature.com)
Cancer immunotherapies such as immune checkpoint blockade (ICB) unleash T cell cytotoxicity against cancer cells and have significantly improved the perspective of cancer patients. (nature.com)
Combined, these approaches have led to the discovery of a myriad of mechanisms underlying cancer susceptibility to or evasion from T cell attack. (nature.com)
Correction to: The androgen receptor-lncRNASAT1-AKT-p15 axis mediates androgen-induced cellular senescence in prostate cancer cells. (tamu.edu)
The androgen receptor-lncRNASAT1-AKT-p15 axis mediates androgen-induced cellular senescence in prostate cancer cells. (tamu.edu)
Hyperactivated FRS2-mediated signaling in prostate cancer cells promotes tumor angiogenesis and predicts poor clinical outcome of patients. (tamu.edu)
The nuclear receptor TR3 regulates mTORC1 signaling in lung cancer cells expressing wild-type p53. (tamu.edu)
PKG inhibits TCF signaling in colon cancer cells by blocking beta-catenin expression and activating FOXO4. (tamu.edu)

Grade III anaplastic tumors are distinguished by their agressiveness, with invasion into surrounding areas and lack of demarcation between the tumor and parenchyma. (medscape.com)

It was identified that the nuclear division cycle 80, cyclin B2 and topoisomerase 2‑α may serve important roles in adrenocortical tumor development. (cancerindex.org)

Although there were no primary sites in the gynecological organs, marked lymphovascular invasion was found around the left ovary, suggesting a left ovary‑derived tumor. (spandidos-publications.com)

Gross pathologic findings of congenital mesoblastic nephroma typically include tumor, which may measure up to or greater than 10.0 cm. (cap.org)
Classical congenital mesoblastic nephroma represents approximately 20% of all congenital mesoblastic nephromas and these tumors are morphologically similar to infantile fibromatosis. (cap.org)
Another 20% of cases include mixed-type congenital mesoblastic nephroma, those tumors containing histologic features of both cellular and classical congenital mesoblastic nephroma. (cap.org)
The cells of congenital mesoblastic nephroma are positive for markers of myofibroblasts including actin and vimentin. (cap.org)

1 Wnt/b-catenin is also known to drive the emergence and maintenance of leukemia stem cells in AML. (haematologica.org)
Efficient generation of embryonic stem cells from single blastomeres of cryopreserved mouse embryos in the presence of signalling modulators. (axonmedchem.com)
Chemical conversion of human conventional Pluripotent Stem Cells to Trophoblast Stem Cells. (axonmedchem.com)
Revealing cell populations catching the early stages of the human embryo development in naïve pluripotent stem cells. (axonmedchem.com)

irregular growth in the primitive form of these skeletal muscle cells, rhabdomyoblasts, are commonly associated with Rhabdomyosarcoma. (wikipedia.org)
Less commonly, the tumors may cause ﬂank pain, hematuria, and a palpable abdominal mass. (pediagenosis.com)

Vimentin is a component of intermediate filament in mesenchymal cells, such as endothelial cells, fibroblasts, lymphocytes, and melanocytes. (attogene.com)
BNP treatment increased vascularisation and the number of endothelial cells in all areas of infarcted hearts. (elifesciences.org)
Our results demonstrated that these immature cells have a natural capacity to differentiate into endothelial cells in infarcted hearts. (elifesciences.org)
Peritoneal cavity is rich in number of cells like mesothelial cells, fibroblasts, endothelial cells, adipocytes and immune cells like macrophages, T cells, B cells, mast cells. (ukessays.com)
Epithelioid angiosarcoma is a rare malignant neoplasm found in vascular endothelial cells. (bvsalud.org)

Neoplasia, the formation of a neoplasm, can result in the expression of tumors and ultimately progress into cancers. (wikipedia.org)

Our findings reveal that AQP3-mediated activation of NF-κB in keratinocytes and activation of STAT3 in CD4+ T cells acted synergistically and contributed to the inflammation in rosacea. (bvsalud.org)

An overlapping cytological and growth pattern may also be seen in other malignant renal cell tumours such as conventional RCC (cRCC) and papillary RCC (pRCC). (biomedcentral.com)

More than 80% of renal tumors of childhood are Wilms tumor (nephroblastoma) ( 1 , 2 ). (abdominalkey.com)

The unique course of the disappearance of the effusion and the absence of tumor in the adnexa might be associated with the high immunogenicity of the tumor characterized by the high TMB. (spandidos-publications.com)

Anatomy29

Organisms9

Diseases72

Chemicals and Drugs44

Analytical, Diagnostic and Therapeutic Techniques and Equipment46

Phenomena and Processes57

Disciplines and Occupations1

Information Science4

Health Care6

Cytoplasm9

Neoplasms5

Brain tumors3

Stromal6

Mutations13

Rhabdoid10

Classification of renal tumors2

Metastatic2

Compressed renal1

Neuroblastoma1

Protein30

Epithelial7

Prognosis4

Proliferation9

Primary tumor2

Germ cell t1

Carcinoma11

Rhabdomyosarcomas2

Pathology1

Gene7

Metastasis4

Intracranial3

Pediatric2

Suppressor genes4

Genes11

Benign4

Melanoma2

Aggressive2

Original tumor1

Tissue15

Transcription1

Adult2

Oncogenes4

Histologically confirmed2

Differentiation5

Genitourinary tract2

Genetic4

Oncocytoma1

Occur2

Kidney2

Adrenal1

Embryonal1

Atypical3

Cancer12

Anaplastic1

Adrenocortical1

Ovary1

Congenital4

Stem cells4

Commonly2

Endothelial cells5

Cancers1

Findings1

Papillary1

Childhood1

Effusion1