The cells of the pronephric duct migrate caudally whilst inducing adjacent mesenchyme to form the tubules of the initial kidney-like structure called the pronephros. (wikipedia.org)
In mammals however, the pronephric tubules and the anterior portion of the pronephric duct degenerates in 3.5 weeks to be succeeded by the mesonephros, the embryonic kidney. (wikipedia.org)
The permanent kidney of amniotes, the metanephros, develops during the 10th week in human embryos and is formed by the reciprocal interactions of the metanephrogenic blastema (or metaneophrogenic mesenchyme) and the ureteric bud. (wikipedia.org)
In this research, we generate differentiated kidney cells (DKCs) from mouse pluripotent stem cells (mPSCs) analyzing their morphological, genetic, phenotypic, and spectroscopic characteristics along differentiation, highlighting that there are no reports of the use of Fourier transform infrared (FTIR) spectroscopy to characterize the directed differentiation of mPSCs to DKCs. (biomedcentral.com)
The genetic and protein experiments proved the obtention of DKCs that passed through the chronological stages of embryonic kidney development. (biomedcentral.com)
Our results indicated that we obtained DKCs from mPSCs, which passed through the chronological stages of embryonic kidney development. (biomedcentral.com)
ESCs are obtained from inner cell mass, characterized by unlimited self-renewal and pluripotentiality, which allow them to differentiate into various specialized cells types in a morphologically and functionally way, characteristics that make them attractive for developing differentiated kidney cells (DKCs) [ 9 ]. (biomedcentral.com)
The kidney is a complex organ composed of several cell types, and it is conformed approximately by 11,000 nephrons. (biomedcentral.com)
Non-Wilms' renal tumors, rhabdoid tumors, and clear cell sarcoma of the kidney (CCSK) are uncommon. (bvsalud.org)
Herein, we report a case of bilateral Wilms tumor (BWT) in a patient with a concurrent horseshoe kidney and left duplex kidney, which had not been previously reported. (bvsalud.org)
Stages3
Regarding vibrational spectroscopy analysis by FTIR, bands related with biomolecules were shown on mPSCs and DKCs spectra, observing distinct differences between cell lineages and maturation stages. (biomedcentral.com)
Moreover, FTIR spectroscopy resulted in a non-invasive, rapid and precise technic that together with principal component analysis allows to characterize chemical and structurally both kind of cells and also discriminate and determine different stages along the cell differentiation process. (biomedcentral.com)
RESULTS: Most (42.2%, n = 35) of the cases were in advanced tumor stages (III-V), and almost one-quarter (21.7%, n = 18) of the cases were in high-risk group. (bvsalud.org)
Types5
We aimed to determine the risk of embryonic and other types of tumors in patients with PROS in order to evaluate surveillance relevance. (bvsalud.org)
Long-term follow-up studies are needed to evaluate the risk of other cancer types, as well as the relationship with the extent of tissue mosaicism and the presence or not of the variant in the tumor samples. (bvsalud.org)
An improved ontological representation of dendritic cells as a paradigm for all cell types. (philarchive.org)
The Cell Ontology (CL) is designed to provide a standardized representation of cell types for data annotation. (philarchive.org)
Currently, the CL employs multiple is_a relations, defining cell types in terms of histological, functional, and lineage properties, and the majority of definitions are written with sufficient generality to hold across multiple species. (philarchive.org)
Initial1
In this report, we present a child presenting with a huge renal mass consistent with Wilms' tumor on computed tomography and initial biopsy. (bvsalud.org)
Approximately1
CCSK constitutes approximately 3% of all malignant renal tumors in childhood. (bvsalud.org)
Renal tumors8
This study was aimed at evaluating the usefulness of PAX-2 in the diagnosis of renal tumors and comparing it with that of RCCM and KSC. (medscape.com)
Immunostaining for PAX-2, RCCM, and KSC was performed on consecutive tissue sections of 130 renal tumors. (medscape.com)
Renal cell carcinoma (RCC) is the most common malignancy among primary renal tumors. (medscape.com)
PAX-2 expression by renal tumors has been described in only a few reports. (medscape.com)
In the present study, we wanted to comprehensively evaluate PAX-2 expression in renal tumors and compare its expression with RCCM and KSC expression to gain insight into the diagnostic usefulness and the biologic implications of this transcription factor in renal neogenesis. (medscape.com)
Pediatric renal tumors account for 3%-11% of childhood cancers, the most common of which is Wilms tumor or nephroblastoma. (bvsalud.org)
Large pediatric research consortium trials have led to a clearer understanding of pediatric renal tumors, identification of risk factors, and development of more risk-adapted therapies. (bvsalud.org)
In this article, we review the global epidemiology of pediatric renal tumors, including key consortium and global studies. (bvsalud.org)
Metanephrogenic blastema3
The permanent kidney of amniotes, the metanephros, develops during the 10th week in human embryos and is formed by the reciprocal interactions of the metanephrogenic blastema (or metaneophrogenic mesenchyme) and the ureteric bud. (wikipedia.org)
Gonadal derived neurotrophic factor (GDNF) secreted by the metanephrogenic blastema activates the receptor tyrosine kinase RET, via the co-receptor GFRα1 and triggers outgrowth of Ret positive cells from the nephric duct towards the GDNF signal, promoting ureteric bud outgrowth and invasion. (wikipedia.org)
Bone morphogenetic protein ( BMP ) signaling in the surrounding mesoderm is also inhibitory to outgrowth of the ureteric bud, but within the metanephrogenic blastema its action is counteracted by the BMP-inhibitory actions of gremlin , which is produced within the blastema itself. (clinicalgate.com)
Carcinoma9
The diagnosis of renal cell carcinoma (RCC) remains problematic, especially in the context of metastasis or small needle biopsy specimens. (medscape.com)
The renal cell carcinoma marker (RCCM) and kidney-specific cadherin (KSC) are considered specific markers for RCC but are expressed preferentially in specific subtypes of RCC of lower grades. (medscape.com)
However, overlapping morphologic features can create diagnostic problems, including differentiation among chromophobe RCC, oncocytoma, and the granular variant of clear cell RCC and among poorly differentiated clear cell RCC, collecting duct RCC, and high-grade transitional cell carcinoma. (medscape.com)
[ 1-6 ] Other markers, including the renal cell carcinoma marker antigen (RCCM) and kida classney-specific cadherin (KSC), are more "kidney-specific" and have helped improve diagnostic accuracy. (medscape.com)
They are, however, usually negative in poorly differentiated tumors or tumors differentiating along an unrelated tubular cell line such as collecting duct carcinoma and, thus, are not significantly helpful when immunomarkers are most needed. (medscape.com)
Such is the case for colonic carcinoma (CDX-2), Wilms tumor (WT-1), and lung tumor (thyroid transcription factor-1). (medscape.com)
Acinic Cell Carcinoma A malignant glandular epithelial neoplasm consisting of secretory cells forming acinar patterns. (nih.gov)
Representative examples include the acinar cell carcinoma of the pancreas and the acinar adenocarcinoma of the prostate gland. (nih.gov)
Malignant C40367 Acinic Cell Breast Carcinoma A breast adenocarcinoma characterized by the presence of serous (acinic cell) differentiation. (nih.gov)
Differentiation1
Differentiation of embryonic tissue into mature organs is directed by orderly expression of molecules under the control of organ-specific transcription factors, which cease to express when differentiation is completed and, thus, are not present in normal mature tissue. (medscape.com)
Transcription factors4
Because neoplastic transformation often recapitulates organogenesis in reverse, tumors may express these organ-specific transcription factors, which can serve as sensitive and specific diagnostic markers. (medscape.com)
Because these transcription factors are nuclear protein, as opposed to the cytoplasmic nature of other more traditional immunomarkers, they add an additional morphologic advantage to tumor immunodiagnosis. (medscape.com)
[ 11-28 ] PAX-2 is a member of the paired box family of transcription factors, which is required for development and proliferation of renal tubules from blastema. (medscape.com)
A link has been established between Vg1/Nodal signalling and BMP signalling, whereby Vg1/Nodal signalling regulates intermediate mesoderm formation by modulating the growth-inducing effects of BMP signalling. (wikipedia.org)
Lim-1 is required for the aggregation of the mesenchymal cells of the intermediate mesoderm into the primary nephric ducts. (clinicalgate.com)
Tissue1
Pathologies, as atherosclerosis, cardiac fibrosis, and cardiomyopathy, are often linked to the failure of cardiovascular tissue cells to reenter the cell cycle, namely, senescence, due to endogenous or exogenous causes. (hindawi.com)
Collecting duct1
[ 7-10 ] However, these markers represent terminally differentiated molecules, ie, RCCM is a component of the brush border of normal proximal tubular cells, whereas KSC is found in the basolateral infolding membrane of normal distal tubular and collecting duct cells. (medscape.com)
Development1
While it is commonly accepted as an aging-related phenomenon, senescence might happen also during the embryonic development with the biological meaning of replacing transient structures or specific cell types with other ones [ 3 - 5 ]. (hindawi.com)
Primary1
The pronephros is active in adult forms of some primitive fish and acts as the primary excretory system in amphibious larvae and embryonic forms of more advanced fish. (wikipedia.org)
Growth2
Activation of the cellular senescence genetic program prompts a series of molecular changes, mostly affecting cell cycle, extracellular matrix (ECM), secretion of growth factors, and inflammatory mediators. (hindawi.com)
WHO, 2001) Malignant C45929 Acidophil Stem Cell Pituitary Gland Adenoma Acidophil Stem Cell Adenoma An infrequent pituitary gland adenoma composed of cells showing immunoreactivity for prolactin and less often growth hormone. (nih.gov)