Wild type mice mice knockout. Medical search. Frequent questions

T6080The Stable Bcl-x Knockout Mouse Embryonic Fibroblast Cell Line was generated from embryos of a pregnant mouse heterozygous for. (topsan.org)
Here we show that Cul3 is essential to regulate neuronal migration and, therefore, constitutive Cul3 heterozygous mutant mice display cortical lamination abnormalities. (nature.com)
Intriguingly, LTP was normal in TEC slices from heterozygous knockouts of the alternate VPS26a subunit, whereas homozygous VPS26a knockouts died in utero. (alzforum.org)
This produces offspring that are either white and heterozygous for the knocked out gene or grey and wildtype. (wikipedia.org)
White heterozygous mice can subsequently be crossed to produce mice that are homozygous for the knocked out gene. (wikipedia.org)

Recent work with transgenic mice demonstrated that disruption of the production of granulocyte-macrophage colony-stimulating factor (GM-CSF) or the common beta-subunit of the GM-CSF receptor caused alveolar proteinosis that was histologically similar to that seen in human patients. (nih.gov)
Here, we explored the role of NPC1L1 in colorectal tumorigenesis in vivo by using transgenic mice. (biomedcentral.com)
5' noncoding region] and significantly lower neurovirulence supplementary immunization activity (SIA) to sample collection of fecally shed vaccine virus in transgenic mice) ( 3 - 5 ). (cdc.gov)

By recording neuronal activity in vivo , Yizhar found that neurons in the medial prefrontal cortex of Cntnap2 homozygous mice have enhanced activity compared with wild-type littermates. (sfari.org)

2017. Dibenzo[def,p]chrysene transplacental carcinogenesis in wild-type, Cyp1b1 knockout, and CYP1B1 humanized mice. . (oregonstate.edu)
2015. Cytochrome P450 1b1 in polycyclic aromatic hydrocarbon (PAH)-induced skin carcinogenesis: Tumorigenicity of individual PAHs and coal-tar extract, DNA adduction and expression of select genes in the Cyp1b1 knockout mouse. . (oregonstate.edu)

Whereas wild-type littermates all exhibited LH surges and c-FOS in ∼50% of their GnRH neurons, none of the mutant mice from either line showed an LH surge or any GnRH neurons with c-FOS. (jneurosci.org)
In the mutant mice, which are characterized by social deficits, these elevated levels of activity were also associated with a reduced capacity to learn and distinguish between social and nonsocial stimuli, thus suggesting a role of E/I imbalance in forming representations in behavioral domains relevant to ASD. (sfari.org)
In the new mutant mice, a planted bacterial phage enzyme turns on with Wnt1, which excises a gene necessary for cells to respond to the hedgehog signal. (harvard.edu)
2002. Response of Apc(min) and A33 (delta N beta-cat) mutant mice to treatment with tea, sulindac, and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). . (oregonstate.edu)

CRISPR/Cas9-mediated NHEJ in mouse embryos will be used to generate founder animals harboring insertion/deletion (indel) or interval deletion knockout alleles. (bcm.edu)
Fmr1, Cntnap2 and Tsc2 knockout and 16p11.2 deletion mice showed increased feed-forward excitatory and inhibitory currents in neurons of layers 2-3 of the somatosensory cortex relative to the wild-type. (sfari.org)
In one of the most comprehensive tests of the E/I hypothesis to date, SFARI investigator Dan Feldman discussed findings from a recent study in which he examined E/I ratios in four well-validated mouse models ( Cntnap2 , Fmr1 and Tsc2 knockout, and 16p11.2 deletion mice) 3 . (sfari.org)
Mice with a heart-specific deletion of cdc42 developed greater levels of hypertrophy than wild-type controls under neuroendocrine stress, and also transitioned more quickly into heart failure. (bmj.com)

Several presentations discussed to what extent this formulation still holds and considered novel findings on E/I dynamics in mice harboring mutations in genes known to be strong risk factors for ASD and related neurodevelopmental disorders. (sfari.org)
For example, SFARI investigator Ofer Yizhar showed that, consistent with the E/I hypothesis, mice with mutations in Cntnap2 , a high-confidence autism risk gene, show increased cortical 'noise' 2 . (sfari.org)
Limb-girdle muscular dystrophy type 2A is an autosomal recessive disorder generated by inactivating mutations in the gene coding for the muscle specific protease calpain-3. (lu.se)
Based on the favorable preclinical and clinical strain (GenBank ID MZ245455), and isolates were classified into data, and the public health emergency of international concern one of nine categories, based on their risk profile and loss of key generated by ongoing endemic wild poliovirus transmission attenuating nOPV2 mutations (Figure 1). (cdc.gov)

In the January 18 issue, Small, Beth Stevens at Boston Children's Hospital, and colleagues reported that knocking out a different retromer protein, VPS35, in hippocampal neurons in mice not only jammed neuronal endosome traffic but also caused microglia to assume shapes resembling those seen in AD. (alzforum.org)
To see which brain cells carried which VPS26, Simoes cultured primary mouse neurons, astrocytes, microglia, and endothelial cells separately. (alzforum.org)

Remarkably, nucleoside reverse-transcriptase inhibitors (NRTIs), which inhibit L1 retrotransposition, significantly improved health and lifespan of SIRT6 knockout mice and completely rescued type I interferon response. (genengnews.com)
NPC1L1 −/− mice significantly had fewer tumors than wild-type. (biomedcentral.com)
The ratio of malignant/tumor in NPC1L1 −/− mice was significantly lower than in wild-type 20 weeks after AOM-DSS treatment. (biomedcentral.com)
SV40 immortalized mouse embryonic fibroblasts derived from Bax-Bak double-knockout mice were significantly more resistant to GL-induced cell killing compared with wild-type cells. (aspetjournals.org)
In p22phox -/- mice, HPV was significantly impaired. (ersjournals.com)
However, the post-synaptic potentials (PSPs) of those neurons were not significantly increased in these mouse models relative to wild-type (lighter colors). (sfari.org)

Calbindin D(9k) knockout mice are indistinguishable from wild-type mice in phenotype and serum calcium level. (qiagen.com)

Using mouse models, the present study addressed whether kisspeptin and GPR54 have a key role in the activation of GnRH neurons to generate the luteinizing hormone (LH) surge responsible for ovulation. (jneurosci.org)
Using an ovariectomized, gonadal steroid-replacement regimen, which reliably generates an LH surge, ∼30% of RP3V kisspeptin neurons were found to express c-FOS in surging mice compared with 0% in nonsurging controls. (jneurosci.org)
First, we set out to determine whether kisspeptin neurons in mice expressed the appropriate receptors required for gonadal steroid positive feedback, and whether they were activated at the time of the LH surge, as had been found previously in the rat. (jneurosci.org)
In cultured primary neurons from mice, fluorescent antibodies to VPS26a (blue) and 26b (red) detected two distinct retromer complexes. (alzforum.org)
In situ hybridization and immunohistochemical studies have shown that Purkinje cells (PCs), the output neurons of the cerebellar cortex, are the neuron type with the highest levels of GABA B receptors (Bowery et al. (springer.com)
In paper №2, I describe how mesDA neurons transplanted in the adult SN of a PD mouse model, extended axons across millimetres into the striatum, functionally reforming the nigrostriatal pathway. (lu.se)

Knocking it out in mice slowed glutamate receptor recycling and weakened synaptic transmission, but only in the transentorhinal cortex, hinting at why this region is so vulnerable to AD pathology in people. (alzforum.org)
Given the metabolic decline in the 12-month-old VPS26b knockouts, did synaptic signaling wane as well? (alzforum.org)
Lack of increased synaptic firing in the somatosensory cortex of four mouse models of ASD. (sfari.org)

88 TAg Stable Y-LIZ DNA Polymerase-β Knockout Mouse Embryonic Fibroblast Cell Line carries the lambda-LIZ transgene (Y-LIZ), a shuttle vector which enables for mutation analysis. (topsan.org)
T316992 TAg Stable Y-LIZ Wildtype Mouse Embryonic Fibroblast Cell Line carry the lambda-LIZ transgene (Y-LIZ), a shuttle. (topsan.org)
T6081The Stable Bcl-xL Mouse Embryonic Fibroblast Cell Line was derived from primary embryonic cells from an 11-d-pregnant Bcl-x. (topsan.org)
T6304To generate the Rieske ISP Stable Knockout Mouse Fibroblast Cell Line, primary lung fibroblast culture was established from a. (topsan.org)
T6303To generate the COX10 Stable Knockout Mouse Fibroblast Cell Line, a primary skin fibroblast culture was established from a knockin mouse. (topsan.org)

Here, we employed MPO knockout genotoxic effects [7] possibly associated with carcinogenesis (e.g. (cdc.gov)

Nicotine responses in hypersensitive and knockout alpha 4 mice account for tolerance to both hypothermia and locomotor suppression in wild-type mice. (umassmed.edu)
Cytoplasmic "guardians" (types of DNA sensors) detect invaders and trigger immune responses such as inflammation. (genengnews.com)
Given the expression of IRAP in areas of the brain associated with oxytocin modulated maternal behavior, we also investigated whether the IRAP global knockout mice had improved maternal responses. (monash.edu)
We found that ACE knockout mice have increased startle responses but no differences in baseline PPI compared to wildtype controls. (unboundmedicine.com)

The present study explores the possible involvement of a purinergic mechanism in mechanosensory transduction in the bladder using P2X 3 receptor knock-out (P2X 3 − /− ) and wild-type control (P2X 3 +/+ ) mice. (jneurosci.org)
Likewise, transplantation of wild-type bone marrow cells expressing the common beta-chain of the GM-CSF receptor restores surfactant homeostasis in the GM-CSF receptor knockout mouse. (nih.gov)
In addition, we analyzed single-cell RNA sequencing data and determined the expression of IL6 and IL6 receptor in specific cell types of the murine hypothalamus. (nih.gov)
Proapoptotic (Panels A - B ) and antiapoptotic (Panels C - D ) in control, β2-adrenergic receptor knockout mice+49b, and β2-adrenergic receptor knockout mice. (molvis.org)
0.05 versus β2-adrenergic receptor knockout (KO) mice. (molvis.org)
Treatment with the dopamine receptor agonist, apomorphine, or the dopamine-releasing drug, amphetamine, produced significant disruption of PPI in control mice but not in ACE knockout mice. (unboundmedicine.com)

If the guide RNAs were (i) tested in mouse embryos by the core and the core approved their use based on the genotyping results and (ii) the core conducted the founder genotyping, the core can review results, redesign the approach and reagents if needed, and the electroporation can be repeated. (bcm.edu)
If the guide RNAs were not tested in mouse embryos or the investigator conducts their own genotyping, there will be no reduced costs for additional work. (bcm.edu)
At the molecular level, Cul3 regulates cytoskeletal and adhesion protein abundance in mouse embryos. (nature.com)

WIKIMEDIA, TIIA MONTO Mice lacking a subunit of a G protein-gated inwardly rectifying potassium (GIRK) channel drank more ethanol than their wild-type counterparts when given access to the beverage for only two hours a day during a time when they would be most likely to drink-a test intended to mirror a bar's happy hour. (the-scientist.com)
GIRK3 knockout mice did not drink to the point of intoxication when given continuous access to alcohol, however, suggesting this subunit specifically affects the tendency to binge drink, according to a study published this week (May 11) in PNAS . (the-scientist.com)
Leukocyte adhesion deficiency type I (LAD I) is a failure to express CD18, which composes the common ß 2 subunit of LFA1 family (ß2 integrins). (medscape.com)

On the other hand, mechanisms that impair the circadian clock genes, such as circadian locomotor output cycles kaput ( CLOCK ), brain and muscle Arnt-like protein 1 ( BMAL1 ), and period genes ( PER1 , PER2 , and PER3 ), contribute to defective beta-cell function and development of type 2 diabetes [ 7 - 12 ]. (hindawi.com)
During embryogenesis, most structures in the face in fact come from one cell type, called neural crest cells," says graduate student Juhee Jeong, first author of the paper in the April 15 Genes & Development . (harvard.edu)
Humans share many genes with mice. (wikipedia.org)

Knockout cell lysate achieved by CRISPR/Cas9. (abcam.com)
Knockout achieved by using CRISPR/Cas9, 1 bp insertion in exon7. (abcam.com)

Wild-type SGK1 improves the learning abilities of rats. (wikipedia.org)
Gene knockout in rats is much harder and has only been possible since 2003. (wikipedia.org)
Carcinogenicity and chronic toxicity in rats and mice exposed to chloroform by inhalation. (who.int)

Labial ulceration from which Escherichia coli was cultured in an 8-month-old girl with leukocyte adhesion deficiency type 1 (LAD I). Note the thin bluish scar at the superior aspect of the labia from an earlier cellulitis. (medscape.com)
This 3-year-old girl had leukocyte adhesion deficiency type I (LAD I) with complete absence of CD18 expression. (medscape.com)
This 10-month-old patient with severe leukocyte adhesion deficiency type I (LAD I) developed a cervical adenitis caused by Klebsiella pneumoniae. (medscape.com)
Currently, 18 subtypes have been reported: 12 are type I (dysfunctional lipid-linked oligosaccharide precursor synthesis), and 6 are type II (dysfunctional trimming/processing of the protein-bound oligosaccharide), including leukocyte adhesion deficiency II (CDG-IIc). (medscape.com)
Another reported type of leukocyte adhesion deficiency involves dysfunction in platelet aggregation in addition to a defect in leukocyte adhesion. (medscape.com)
Thus, patients with this type of leukocyte adhesion deficiency manifest both severe bacterial infections and bleeding disorder. (medscape.com)

Embryonic stem cells are isolated from a mouse blastocyst (a very young embryo ) and grown in vitro . (wikipedia.org)

At all times, the level of HDL in ABC1 -/- recipient mice remained low relative to WT recipient mice irrespective of the genotype of the donor macrophage ABCA1 or high-fat feeding. (jci.org)

Here, to confirm that cPKC activity is required for contraction-stimulated glucose uptake in mouse muscles, contraction-stimulated glucose uptake ex vivo was first evaluated in the presence of three commonly used cPKC inhibitors (calphostin C, G{\'o}-6976, and G{\'o}-6983) in incubated mouse soleus and extensor digitorum longus (EDL) muscles. (ku.dk)
However, in muscles from PKCalpha knockout (KO) mice, neither contraction- nor phorbol ester-stimulated glucose uptake ex vivo differed compared with the wild type. (ku.dk)

Mice are currently the laboratory animal species most closely related to humans for which the knockout technique can easily be applied. (wikipedia.org)
Consequently, observing the characteristics of knockout mice gives researchers information that can be used to better understand how a similar gene may cause or contribute to disease in humans. (wikipedia.org)

B6.129X1-MPO (MPO k/o) vs wild-type C57Bl/6 mice (w/t) and induction of mesotheliomas) [8,9]. (cdc.gov)

Using standard tests to assess maternal behavior, including pup retrieval, feeding and nurturing, no differences between knock out and wild type dams were observed. (monash.edu)
Notably, using a viral vector to reintroduce GIRK3 in the VTA of knockout mice rescued normal alcohol consumption behavior. (the-scientist.com)

We could identify 16 proteins which differed in knockout and wild type mice. (lu.se)

However, the damage caused by these genomic parasites reaches much further than researchers had at first thought, according to a paper (" LINE1 Derepression in Aged Wild-Type and SIRT6-Deficient Mice Drives Inflammation ") in Cell Metabolism . (genengnews.com)
In this case, the researchers used a neat genetic trick called a conditional knockout to shut down the signaling of sonic hedgehog only in the neural crest cells. (harvard.edu)
A knockout mouse , or knock-out mouse , is a genetically modified mouse ( Mus musculus ) in which researchers have inactivated, or " knocked out ", an existing gene by replacing it or disrupting it with an artificial piece of DNA . (wikipedia.org)
By causing a specific gene to be inactive in the mouse, and observing any differences from normal behaviour or physiology, researchers can infer its probable function. (wikipedia.org)

FGF21 is dispensable for hypothermia induced by fasting in mice. (nel.edu)
We examined whether FGF21 is essential for fasting-induced hypothermia using FGF21 knockout (KO) mice. (nel.edu)

We assessed the reproductive and maternal profile of global IRAP knock out mice. (monash.edu)

However, western blot analysis of pregnant mouse serum, failed to detect IRAP, a result which was confirmed by fluorimetric IRAP enzyme assay. (monash.edu)

We generated mice expressing ABCA1 in macrophages and mice with selected inactivation of ABCA1 in macrophages by bone marrow transplantation in ABCA1-deficient ( ABC1 -/- ) and wild-type (WT) mice. (jci.org)
We have previously showed that OB are attracted to DC-STAMP+ OC proximity at bone fracture sites in wild-type mice, a phenomena which was not detected in DC-STAMP KO mice. (rochester.edu)

They are widely used in knockout experiments, especially those investigating genetic questions that relate to human physiology . (wikipedia.org)
Approximately 111 million doses of nOPV2 were administered vaccine (nOPV2), produced by genetic modification of the type worldwide during the initial use phase (March-October 2021). (cdc.gov)
stool specimens collected as part of routine AFP surveillance nOPV2 was demonstrated to be safe and well-tolerated, have from six countries, and 123 nOPV2 isolates corresponding to 39 noninferior immunogenicity, and have superior genetic stabil- distinct environmental surveillance samples were detected from ity compared with Sabin monovalent type 2 (as measured by seven countries. (cdc.gov)

Pulmonary OPN relative mRNA expression (peaked at 7 d) and protein levels were induced in wild-type mice following MWCNT exposure. (cdc.gov)
2012) Impaired Clearance and Enhanced Pulmonary Inflammatory/Fibrotic Response to Carbon Nanotubes in Myeloperoxidase-Deficient Mice. (cdc.gov)
CNT in biochemical models and in cells yielding the products engineered CNT represent a possible health risk due to their that did not cause pulmonary inflammation in mice [14]. (cdc.gov)

Dawn phenomenon mostly affects children and youth with type 1 diabetes, although it is not rare in subjects with type 2 diabetes (as high as 40%, reported by Monnier et al. (hindawi.com)
In the present study, we investigated the role of TLR2 during the development of experimental deep dermatophytosis in normal mice and mice with alloxan-induced diabetes mellitus, an experimental model of diabetes that exhibits a delay in the clearance of the dermatophyte, Trichophyton mentagrophytes (Tm). (frontiersin.org)
Regarding Type 1 diabetes(T1D), animal/islet-cell studies found that GABA promotes insulin secretion, inhibits α-cell glucagon and dampens immune inflammation, while GAD immunization may also preserve β-cells. (nature.com)
Examples of research in which knockout mice have been useful include studying and modeling different kinds of cancer , obesity , heart disease , diabetes , arthritis , substance abuse , anxiety , aging and Parkinson's disease . (wikipedia.org)

And boosting expression of the protein in wild-type mice resulted in even less binge drinking. (the-scientist.com)
For example, the p53 knockout mouse is named after the p53 gene which codes for a protein that normally suppresses the growth of tumours by arresting cell division and/or inducing apoptosis. (wikipedia.org)

There was not detectable change of p53 by NPC1L1 knockout. (biomedcentral.com)
No detectable levels of OPN were found in the OPN-/- mice, verifying the knockout model. (cdc.gov)

To understand the role of TLR2 during the development of murine experimental deep dermatophytosis, we employed TLR2 knockout mice. (frontiersin.org)
Here, we use Ac-deficient mice with ubiquitously increased ceramide levels to elucidate the role of endogenous Ac activity in a murine malaria model. (elifesciences.org)

NPC1L1 was highly expressed in the small intestine of wild-type mice but its expression was undetectable in colorectal mucous membranes or tumors in either group. (biomedcentral.com)
NPC1L1 knockout in mice decreased β-catenin in tumors and regulated TGF-β and p-gp in adjacent colons or tumors. (biomedcentral.com)

0.6 mg/ml mouse serum albumin and 0.01 mg/ml DPPC) or 40 microg of MWCNT, a dose known to induce granulomas, and sacrificed 1, 7, and 28 d post-exposure. (cdc.gov)

These drugs, which were originally developed to fight HIV, have been shown to help cells maintain the suppression of inflammation-promoting LINE1 retrotransposons in mice. (genengnews.com)
Using these drugs to reduce LINE1s improves health in mice and reduces inflammation, in addition to improving lifespan, notes Seluanov, who adds that "sterile inflammation triggered by LINE1 elements is a new mechanism of aging. (genengnews.com)
NPC1L1 −/− mice had significant lower intestinal inflammation scores and expressed inflammatory markers p-c-Jun, p-ERK and Caspase-1 p20 lower than wild-type. (biomedcentral.com)
NPC1L1 knockout also reduced lymphadenectasis what may be caused by inflammation. (biomedcentral.com)
NPC1L1 knockout decreasing plasma lipid, especially cholesterol, to reduce inflammation and decreasing β-catenin, p-c-Jun and p-ERK may be involved in the mechanism. (biomedcentral.com)

Pretreatment with the ACE inhibitor, captopril, which itself did not affect PPI, caused a reduction in the effect of apomorphine on PPI, similar to that seen in the ACE knockout mice. (unboundmedicine.com)

In the late 1960s, neurophysiologic testing allowed the classification of CMT into 2 groups, one with slow nerve conduction velocities and histologic features of a hypertrophic demyelinating neuropathy (hereditary motor and sensory neuropathy type 1 or CMT1) and another with relatively normal velocities and axonal and neuronal degeneration (hereditary motor and sensory neuropathy type 2 or CMT2). (medscape.com)

Our results provide the first evidence that NPC1L1 knockout protects against colitis-associated tumorigenesis. (biomedcentral.com)

Access thousands of knockout cell lysates, generated from commonly used cancer cell lines. (abcam.com)

While AND-34 is widely expressed in wild type mice, histologic analysis of multiple organs in AND-34 −/− mice is unremarkable and analyses of lymphocyte development show no overt changes. (molvis.org)

See here for more information on knockout cell lysates. (abcam.com)
The story begins with the neural crest cells, a type of precursor cell unique to vertebrates. (harvard.edu)
I also describe the development of a novel behavioural task that is predictive of mesDA neuron cell loss in mice. (lu.se)

Expression of WT macrophage ABCA1 in ABC1 -/- mice resulted in a small but significant increase in apoA-I levels starting 2 weeks after transplantation. (jci.org)
In outbred mice, obesity-resistance is accompanied by increased expression of IL6 in the hypothalamus. (nih.gov)
IL6 induces neurogenesis-related gene expression in the hypothalamus and in neuroprogenitor cells, both from WT as well as from KO mice. (nih.gov)
IL6 induces neurogenesis-related gene expression in the hypothalamus of WT mice. (nih.gov)
Our results demonstrated that inoculation of Tm into the footpads of normal mice increases the expression of TLR2 in CD115 + Ly6C high blood monocytes and, in hypoinsulinemic-hyperglycemic (HH) mice infected with Tm, the increased expression of TLR2 was exacerbated. (frontiersin.org)
2005. Alpha-tocopherol modulates Cyp3a expression, increases gamma-CEHC production, and limits tissue gamma-tocopherol accumulation in mice fed high gamma-tocopherol diets. . (oregonstate.edu)
Acute fasting decreased body temperature late at night accompanied by the induction of hepatic FGF21 and hypothalamic NPY expression in wild-type mice. (nel.edu)

however, TLR2 −/− mice showed a noteworthy increase in production of IFN-γ, IL-10, and IL-17, and an increased percentage of splenic CD25 + Foxp3 + Treg cells. (frontiersin.org)

Accordingly, the volume of SR tubules localized around the myofibrils is strongly reduced in skeletal muscle fibers of 4- and 10-month-old sAnk1 knockout (KO) mice, while additional structural alterations only develop with aging. (mdpi.com)
To verify whether the lack of sAnk1 also alters intracellular Ca 2+ handling, cytosolic Ca 2+ levels were analyzed in stimulated skeletal muscle fibers from 4- and 10-month-old sAnk1 KO mice. (mdpi.com)

More recently, studies in mice with targeted inactivation of ABCA1 ( 11 ) have demonstrated a critical role of ABCA1 in lipid metabolism and confirmed its role in the biogenesis of HDL. (jci.org)

SGK1 knockout mice show seemingly normal development. (wikipedia.org)
Mice lacking AND-34 are fertile and have normal longevity. (molvis.org)
A laboratory mouse in which a gene affecting hair growth has been knocked out (left) is shown next to a normal lab mouse. (wikipedia.org)
The chimera mice are crossed with a normal wildtype mouse (grey). (wikipedia.org)
Usually, the new sequence is also given a marker gene , a gene that normal mice don't have and that confers resistance to a certain toxic agent (e.g., neomycin) or that produces an observable change (e.g. colour or fluorescence). (wikipedia.org)

The first recorded knockout mouse was created by Mario R. Capecchi , Martin Evans , and Oliver Smithies in 1989, for which they were awarded the 2007 Nobel Prize in Physiology or Medicine . (wikipedia.org)

Morquio syndrome (mucopolysaccharidosis type IV [MPS IV]) is a rare lysosomal storage disease (LSD) that is inherited in an autosomal-recessive fashion. (medscape.com)

To probe VPS26b's role in brain function, the scientists turned to VPS26b knockout mice. (alzforum.org)

We report that SIRT6-deficient cells and tissues accumulate abundant cytoplasmic L1 cDNA, which triggers strong type I interferon response via activation of cGAS. (genengnews.com)
Here, we analysed the distribution of GABA B receptors using highly sensitive SDS-digested freeze-fracture replica labelling in mouse cerebellar Purkinje cells. (springer.com)
Our investigation indicates that most of these studies examined endothelial progenitor cells, hematopoietic stem cells, mesenchymal stem cells, adipose-derived stem cells, and a few others were about less-discussed types of stem cells such as cardiac stem cells, myeloblasts, and induced pluripotent stem cells. (magiran.com)
Mechanistically, we identified dysregulated erythropoiesis with reduced numbers of reticulocytes, the preferred host cells of P. yoelii , in Ac-deficient mice. (elifesciences.org)
Blastocysts containing cells, that are both wildtype and knockout cells, are injected into the uterus of a foster mother. (wikipedia.org)
For this example, we will take stem cells from a white mouse. (wikipedia.org)

very recently reported that GPR54 was not critical for this mechanism, because one of the GPR54 mutant mouse lines was found to exhibit an LH surge. (jneurosci.org)
Simoes found VPS26a co-localized with markers of all three types of endosomes-early, late, and recycling-while VPS26b associated primarily with early and recycling endosomes. (alzforum.org)
Using high-resolution functional MRI, the authors found the tiny transentorhinal cortex lit up more in 3-month-old knockouts than it did in age-matched wild-type controls (see image below). (alzforum.org)

Immunohistochemistry revealed abundant nerve fibers in a suburothelial plexus in the mouse bladder that are immunoreactive to anti-P2X 3 . (jneurosci.org)

These results indicate that L1 activation contributes to the pathologies of SIRT6 knockout mice. (genengnews.com)

In contrast, 12-month-old knockouts had less metabolic activity than controls in the same region. (alzforum.org)

2008. Characterization of mouse flavin-containing monooxygenase transcript levels in lung and liver, and activity of expressed isoforms. . (oregonstate.edu)

In paper №1, I detail the neurodegenerative and behavioural outcomes in a mouse lesion model of PD, which can be used as a platform for the development of novel therapeutic strategies. (lu.se)

Anatomy18

Organisms9

Diseases2

Chemicals and Drugs19

Analytical, Diagnostic and Therapeutic Techniques and Equipment15

Psychiatry and Psychology2

Phenomena and Processes33

Disciplines and Occupations1

Information Science3

Health Care1

Heterozygous5

Transgenic mice3

Homozygous1

CYP1B12

Mutant mice4

Deletion4

Mutations4

Microglia2

Significantly6

Phenotype1

Neurons6

Synaptic3

Fibroblast5

Carcinogenesis1

Responses4

Receptor6

Embryos3

Subunit3

Genes3

CRISPR2

Rats3

Deficiency6

Embryonic1

Genotype1

Vivo2

Humans2

C57BL1

Behavior2

Proteins1

Researchers4

Hypothermia2

Knock out1

Western blot1

Bone2

Genetic3

Pulmonary3

Diabetes4

Protein2

Detectable2

Murine2

Tumors2

Serum1

Inflammation5

Inhibitor1

Neuronal1

Protects1

Cancer1

Widely1

Cell3

Expression7

Splenic1

Muscle2

Metabolism1

Normal5

Physiology1

Autosomal recessive1

Scientists1

Cells6

Found3

Abundant1

Results1

Metabolic1

Lung1

Neurodegenerative1