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  • humans
  • Bordetella pertussis is a gram-negative bacterium that can cause the respiratory disease known as pertussis or whooping cough in humans. (beds.ac.uk)
  • Humans, other animals , and plants are all susceptible to diseases of some sort. (britannica.com)
  • In humans, for example, the lack of an enzyme known as phenylalanine hydroxylase, which is necessary for the metabolism of the common amino acid phenylalanine , leads to the disease phenylketonuria (PKU), which appears at a few weeks of age and, if not treated, is often associated with the onset of intellectual disability . (britannica.com)
  • In humans, particular autoimmune diseases occur more frequently in certain races and are often familial in nature. (vin.com)
  • Leishmaniases are cutaneous, mucocutanous and visceral diseases affecting humans and domesticated animals mostly in the tropical and subtropical areas of the planet. (compgen.org)
  • apparent
  • Nevertheless, a sharp demarcation between disease and health is not always apparent. (britannica.com)
  • 3 Such genetic influence might also underlie the apparent geographical prevalence of some immune-mediated diseases, for example canine autoimmunity appears to arise more commonly in Australia than in the UK which may reflect a 'founder effect' in some breeds. (vin.com)
  • genetic basis
  • Despite these observations, relatively little is understood of the precise genetic basis for immune-mediated disease with the exception of the characterisation of specific molecular defects underlying certain canine immunodeficiency diseases. (vin.com)
  • This information, together with modern genomic technology, has led to a reawakening of interest in comparative genomics and there is likely to be an explosion in knowledge of the genetic basis of canine disease in the near future. (vin.com)
  • species
  • For example, several felid species developed prion disease (feline spongiform encephalopathy or FSE) during the bovine spongiform encephalopathy (BSE) epidemic in the United Kingdom, whereas no canine BSE cases were detected. (bibsys.no)
  • Whether either of these or other groups of carnivore species can contract other prion diseases (e.g. chronic wasting disease or CWD) remains an open question. (bibsys.no)
  • Among other carnivores studied, wolverine (Gulo gulo) and pine marten (Martes martes) were the only non-canid species to also express PrP-Asp163, which may impact on their prion diseases susceptibility. (bibsys.no)
  • tetracycline
  • Susceptibility testing on the isolated bacteria to routine antibiotics (including: bacitracin, chloramphenicol, gentamicin, kanamycin, neomycin, oxytetracycline, penicillin G, sulfadiazine, tetracycline and tylosin) indicated that the most potent of these compounds was tylosin and the less one was bacitracin. (priory.com)
  • The antimicrobial susceptibility to levofloxacin, moxifloxacin, erythromycin, clindamycin and tetracycline were determined at various breakpoints. (biomedcentral.com)
  • toxic
  • Finally, the disease may be caused by some agent external to the organism, such as a chemical that is a toxic agent. (britannica.com)
  • commonly
  • Knowledge of the most commonly isolated microorganisms in the canine eye in a geographic area and their antibiotic susceptibility is important to provide the most efficacious antimicrobial treatment (Gerding et al. (priory.com)
  • Examples
  • Examples of inherited disease include cystic fibrosis , Down syndrome , and inborn errors of metabolism , which are present at birth. (britannica.com)
  • organism
  • Disease , any harmful deviation from the normal structural or functional state of an organism, generally associated with certain signs and symptoms and differing in nature from physical injury . (britannica.com)
  • Thus, the normal condition of an organism must be understood in order to recognize the hallmarks of disease. (britannica.com)
  • The initial cause of the diseased state may lie within the individual organism itself, and the disease is then said to be idiopathic, innate, primary, or "essential. (britannica.com)
  • largely
  • Although largely preventable, cardiovascular diseases (CVDs) are the biggest cause of death worldwide. (frontiersin.org)
  • Despite the fact that cardiovascular diseases (CVDs) are largely preventable they are the biggest cause of death worldwide, responsible for almost one-third of all global deaths ( 1 ). (frontiersin.org)
  • clinically
  • The various immune-mediated disorders are linked together and immunological disturbance may be manifest clinically as more than a single type of disease occurring concurrently in any one individual (e.g., concurrent IgA deficiency and autoimmunity). (vin.com)
  • efficacy
  • In addition to disease susceptibility, genetic variations that influence the efficacy and toxicity of anti-RA agents have also been identified. (mdpi.com)
  • The issue of data information management systems was highlighted as a lesson to be learned from the official inquiry into the UK 2007 foot-and-mouth outbreak: results here suggest that the efficacy of disease control measures could be markedly improved through an accurate livestock database incorporating flock/herd size and location, which would enable tactical as well as strategic modelling. (pubmedcentralcanada.ca)
  • protein
  • In the laboratory it is widely used to inhibit protein synthesis but there are recent reports indicating that emetine has anti-viral effects that are independent of protein synthesis inhibition. (princeton.edu)
  • study
  • In this study we determined whether specific immunosuppressants impair the serological response to the standard 23-valent pneumococcal polysaccharide vaccine (PPSV23) in a large cohort of patients with Crohn's disease (CD). (jove.com)
  • Thus the purpose of the study reported here was to determine the antimicrobial susceptibility of most bacteria isolated from the normal flora of dogs that were presented for check up examination and vaccination to Veterinary Clinic of Shiraz University. (priory.com)
  • found
  • In my investigations regarding the types of individuals who develop rheumatic group lesions as a result of dental focal infections, (1) I found that individuals could be divided into very definite groups in which 15.05 per cent with severe lesions belonged to families in which similar disease symptoms had occurred. (journeytoforever.org)
  • marker
  • Moreover, undetected population admixture or poor choice of control populations probably explain part of the difficulties in reproducing significant marker disease associations. (aspetjournals.org)
  • Although
  • Although an abundance of autoantibodies can be detected in sera from SLE patients, only a limited number of autoantibodies are associated with specific disease manifestations such as anti-dsDNA and LN [ 1 ]. (hindawi.com)
  • insight
  • Metabolic defects offer useful insight into understanding the impact of noncommunicable disease on the function of the human body . (britannica.com)
  • estimates
  • WHO estimates that, combined, these four groups of conditions account for 82 percent of all deaths from noncommunicable disease. (britannica.com)
  • explain
  • Here we examine what risk factors older adults are prone to and explain how they contribute to higher rates of oral disease, in particular root caries. (hindawi.com)
  • findings
  • Immune complexes containing autoantibodies and nuclear antigens (IC) play a central role in renal inflammation, and depending on their interaction with activating and/or inhibitory FCgR can lead to complement activation, cytokine release, and attraction of neutrophils in Lupus Nephritis (LN), similar to findings in anti-GBM disease [ 4 - 6 ]. (hindawi.com)
  • However
  • It should be noted, however, that speed is essential if accurate prediction of airborne transmission is to contribute to the control and prevention of transmission and successful eradication of disease. (pubmedcentralcanada.ca)