Whole genome databases genetic. Medical search. Frequent questions

Analysis of high coverage sequencing data (more than 30x) from 10,000 individuals showed that each newly analyzed genome added roughly 0.7MB of new sequences to the human reference genome and contributed an average of 8,579 new SNVs to the existing human variation data set 13 . (nature.com)
Genome sequences and population genetic parameters can give insight into the potential for population- or species-level drug resistance. (biomedcentral.com)
We assembled and aligned the S. haematobium sequences to the genomes of S. mansoni and S. japonicum , identifying microsatellite DNA loci across all three species and designing primers to amplify the loci in S. haematobium . (biomedcentral.com)
We show that although point mutations and structural variants that drive cancer are less frequent in non-coding genes and regulatory sequences than in protein-coding genes, additional examples of these drivers will be found as more cancer genomes become available. (lu.se)
mVISTA can be used to align and compare your sequences to those of multiple other species rVISTA (regulatory VISTA) combines transcription factor binding sites database search with a comparative sequence analysis, the discovery of possible regulatory transcription factor binding sites in regions of their genes of interest. (wikipedia.org)
GenomeVISTA allows the comparison of sequences with whole genome assemblies. (wikipedia.org)
wgVISTA allows the alignment of sequences up to 10Mb long (finished or draft) including microbial whole-genome assemblies. (wikipedia.org)
Researchers can use the VISTA Browser: to examine pre-computed alignments among a variety of species to submit sequences of their own (not limited by the species collection already in the database) There are more than 28 searchable genomes, including vertebrate, non-vertebrate, plants, fungi, algae, bacteria, and others. (wikipedia.org)
CDC contributes gene sequences to public databases, such as GenBank and the Global Initiative on Sharing Avian Influenza Data (GISAID) , for use by researchers and public health scientists. (cdc.gov)
The sequences deposited into these databases allow CDC and other researchers to compare the genes of currently circulating influenza viruses with the genes of older influenza viruses and those used in vaccines. (cdc.gov)
data are preliminary and based on broth microdilution susceptibility testing and/or presence of resistance genes and mutations found in whole genome sequences of bacterial DNA. (cdc.gov)
To this scope, genome sequences of both strains were obtained and subjected to in silico analyses. (frontiersin.org)
Here we report genome sequences and analyses of 44 diploid potatoes, as well as 2 species in the Etuberosum section. (nature.com)
The researchers began by exploring a genome database to compare the genetic sequences of avian and human TRPV1. (phys.org)
While Dr. Jarvik celebrates these milestones, she thinks the databases are missing genomic sequences from underrepresented people around the world. (ashg.org)
In 2022, the project announced that 100,000 highly diverse genome sequences have been completed, with 50% from racial or ethnic groups that have been historically underrepresented. (ashg.org)
These full-length genome sequences will be used to investigate the epidemiology, ecology, and evolution of the virus to understand why this VSIV strain caused a widespread outbreak in 2019. (usda.gov)
The paucity of full-length vesicular stomatitis virus (VSV) sequences, and particularly vesicular stomatitis virus - Indiana (VSIV) sequences, currently available in public databases limits understanding of the genetic basis associated with the emergence of epidemic lineages. (usda.gov)
In spite of their broad abundance, viruses, in particular bacteriophages, remain largely unknown since only about 20% of sequences obtained from viral community DNA surveys could be annotated by comparison with public databases. (mdpi.com)
A genome-wide survey for N-terminal signal sequences using bioinformatic tools (Psortb 2.0 and SignalP 3.0) combined with a strategy of the subtraction of lipoproteins and proteins containing multiple transmembrane domains yielded 116 secretory proteins. (cdc.gov)
Accordingly, we present hereby the tool called TRS-omix, which comprises a new engine for searching information on genomes and enables generation of sets of sequences and their number, providing the basis for making comparisons between genomes . (bvsalud.org)
In contrast to metagenomic detection of unknown pathogens which sequences all available genetic material, 16S sequencing specifically targets the small ribosomal subunit. (folkhalsomyndigheten.se)
In epidemiological contact tracing, this technology enables the mapping of infection spread and identification of sources of infection through the comparison of genetic sequences. (folkhalsomyndigheten.se)

High-coverage whole-genome sequencing data of a single ethnicity can provide a useful catalogue of population-specific genetic variations, and provides a critical resource that can be used to more accurately identify pathogenic genetic variants. (nature.com)
We also discovered selective enrichment of 3.8M SNVs and 0.5M indels in Korean individuals, which were used to filter out 1,271 coding-SNVs not originally removed from the 1,000 Genomes Project when prioritizing disease-causing variants. (nature.com)
KoVariome health records were used to identify novel disease-causing variants in the Korean population, demonstrating the value of high-quality ethnic variation databases for the accurate interpretation of individual genomes and the precise characterization of genetic variations. (nature.com)
More recently, the Exome Aggregation Consortium (ExAC) released ten million human genetic variants from 60,706 individuals with a resolution of one exonic variant for every eight base-pairs 12 . (nature.com)
Here we present analyses of driver point mutations and structural variants in non-coding regions across 2,658 genomes from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium5 of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). (lu.se)
By the 1990s, OMIM was adding more than 150 disease-related genetic variants per year, nearly all of them rare mutations discovered in families ( 1 ). (cdc.gov)
Recently, NCBI embraced these efforts by allowing users to search, annotate, and submit human genome sequence variants to the dbSNP database by using HGVS standard nomenclature ( 11 ). (cdc.gov)
Now that it seems clear that common genetic variants have only small effects on disease risk, the field has shifted toward studies of rare variants with large effects. (cdc.gov)
Many inherited disorders and phenotypes are genetically heterogeneous - that is, pathogenic variants in more than one gene can cause one phenotype (e.g., dilated cardiomyopathy, ataxia, hereditary hearing loss and deafness) or one genetic disorder (e.g. (nih.gov)
Comprising only 1%-2% of the human genome, the exome nonetheless contains the majority of currently recognized disease-causing variants. (nih.gov)
Now, in a series of recent studies, scientists at the University of Missouri are using whole genome sequencing through the 99 Lives Cat Genome Sequencing Consortium to identify genetic variants that cause rare diseases, such as progressive retinal atrophy and Niemann-Pick type 1, a fatal disorder in domestic cats. (sciencedaily.com)
When sequencing DNA, we are looking for the high priority variants, or genetic mutations that result in disease. (sciencedaily.com)
A) Venn diagram identifying 5 missense TRPV1 variants that intersect when examining the human TRPV1 missense variants from the gnomAD and avian genetic divergence from the human TRPV1 sequence. (phys.org)
The database lists all genetic variants that have been identified in any of the patients' exomes. (lu.se)
Variants have been annotated with a wide range of bioinformatical and database information, in an attempt to make the database useful for many MultiPark researchers. (lu.se)
The added information includes various standardized nomenclatures for variant designation, the variant's frequency in large international databases as well as within the MultiPark NGS database, locus conservation between species, and predictions of the variants' biological effect on the protein level from a large number of prediction tools. (lu.se)

As a part of the Korean Personal Genome Project (KPGP), we constructed the KoVariome database using 5.5 terabases of whole genome sequence data from 50 healthy Korean individuals in order to characterize the benign ethnicity-relevant genetic variation present in the Korean population. (nature.com)
Sankar A, Moore G. Evaluation of inter-simple sequence repeat analysis for mapping in Citrus and extension of the genetic linkage map. (citrusgenomedb.org)
Thus, the rebound could be attributed to host immune response to yellow fever virus Comparative Analysis of rather than to another pathogen or to direct effects of the vi- Whole-Genome Sequence of rus itself. (cdc.gov)
Screening test for neutralizing antibodies against yellow fever virus, based on a We analyzed the whole-genome sequence of African swine flavivirus pseudotype. (cdc.gov)
NCBI has become a central repository for genomic sequence data in humans and other species and has developed many other public databases, such as dbSNP (for single nucleotide polymorphisms, or SNPs) and Entrez Gene (for genes) ( 5 , 6 ). (cdc.gov)
For example, the UCSC Human Genome Browser , launched in 2002, created a framework for displaying multiply annotated sequence data at any scale throughout the genome ( 7 ). (cdc.gov)
Genome sequencing is a process that determines the order, or sequence, of the nucleotides (i.e. (cdc.gov)
Full genome sequencing can reveal the approximately 13,500-letter sequence of all the genes of the influenza virus' genome. (cdc.gov)
Genome sequencing reveals the sequence of the nucleotides in a gene, like alphabet letters in words. (cdc.gov)
Since the first draft of the human genome sequence was announced in 2001, PubMed has added more than one million articles on human genetics and genomics. (cdc.gov)
They also analyzed the exome (the sequence of all exons), reflecting the protein-coding portion of the genomes concerned. (indiatimes.com)
This is due to a paucity of functional annotation from sequence homology, which is compounded by low genetic tractability compared with many model organisms. (portlandpress.com)
Exome sequencing is a laboratory test designed to identify and analyze the sequence of all protein-coding nuclear genes in the genome. (nih.gov)
Chen L, Gu W, Xu H, Yang G, Shan X, Chen G, Wang CF, Qian AD (2018) Complete genome sequence of Bacillus velezensis 157 isolated from Eucommia ulmoides with pathogenic bacteria inhibiting and lignocellulolytic enzymes production by SSF. (springer.com)
Whole genome sequencing (WGS), which is the process of determining an organism's complete DNA sequence, can be used to identify DNA anomalies that cause disease. (sciencedaily.com)
Here we present the whole genome sequence analysis of an individual from the Kashmir region of India who is from the pandit community (IHGP04). (ijpsonline.com)
The Indian male's genome was sequenced at 38.6 X coverage with a total of 110 Gb of sequence data generated using the Illumina HiSeq 2000 platform. (ijpsonline.com)
This thematic series of companion papers constitutes the initial exploration of the genome biology of the waterflea (Daphnia) building on the first complete crustacean genome sequence. (biomedcentral.com)
Sequence analysis of the Daphnia pulex genome holds some surprises that could not have been anticipated from what was learned so far from other arthropod genomes. (biomedcentral.com)
Simple sequence repeats (SSRs) are highly variable features of all genomes. (biomedcentral.com)
Sometimes only a single DNA mutation (change in the DNA sequence) can cause a person to have a devastating genetic disease , and researchers have been able to identify mutations responsible for causing thousands of different genetic diseases and conditions. (sciencebuddies.org)
Through this activity, it will analyze and sequence the genetic codes of 500,000 volunteers. (globenewswire.com)
A homology search against the M. tuberculosis database identified nine additional secretory protein homologs that lacked a secretory signal sequence. (cdc.gov)
Entrez is NCBI's (the National Center for Biotechnology Information) database system that integrates the PubMed database of biomedical literature with 38 other literature and molecular databases including DNA and protein sequence, structure, gene, genome, genetic variation and gene expression. (lu.se)

The international Human Genome Project's early commitment to data sharing helped stimulate the construction of other, online genomic data repositories and tools for use by researchers and the public. (cdc.gov)
Human genome epidemiology is the basic science for translating genomic research, relating genetic variation with variability in health status among well-defined groups of people. (cdc.gov)
WIKIMEDIA, GEORGE GASTIN Amid much talk about how to secure individuals' genomic information from prying eyes, a British group is working to do the opposite-allow for people to put their genomic and health information in an open-access database for anyone to use. (the-scientist.com)
We are also analyzing whole-genome structure, identifying gene networks and understanding gene expression and its regulation, constructing computational models from genomic data so that function and dysfunction can be predicted based on established patterns, and more. (jax.org)
Staying true to its vision of comprehensive data provision, AquaMine v1.2 also introduces new genomic variant data from the Ensembl Variation Archive and extends its resources to include RNA-seq-based gene expression levels for selected species, offering a deeper understanding of genetic function and regulation. (washington.edu)
A focus on the molecular and genomic biology associated with forensic science, including genome structure, genotyping, genetic analysis of DNA fingerprints, DNA data bases and CODIS, Y STRs. (sfu.ca)
That's precisely the technology researchers at Human Longevity , a San-Diego based company with the world's largest genomic database, claim to have developed. (bigthink.com)
You are able to load genomic, genetic or radiation hybrid maps. (animalgenome.org)
In the current version of VCMap, if you wish to load genetic or radiation hybrid comparative map, the genomic version of that map must be loaded before the genetic or radiation hybrid comparative map. (animalgenome.org)
Genomic information from the 49 TLR exons that are annotated in the genome Sscrofa10.2.69 database. (figshare.com)
Here, we report a comprehensive secretome (600 proteins) of this species, which was identified using a multipronged strategy based on genetic/genomic, proteomic, and bioinformatic approaches. (cdc.gov)
The increasingly expanding genomic databases generate the need for new tools for their processing and further use. (bvsalud.org)

Full genome-sequencing of additional species and specimens of S. haematobium, S. japonicum, and S. mansoni is desirable to better characterize differences within and among these species, to develop additional genetic markers, and to examine genes as well as conserved non-coding elements associated with drug resistance. (biomedcentral.com)
The HUGO Gene Nomenclature Committee maintains a database of approved, unique gene names and symbols, which currently includes more than 28,000 genes ( https://www.genenames.org ) ( 9 ). (cdc.gov)
An influenza virus' genome consists of all genes that make up the virus. (cdc.gov)
A, C, G and T/U) in each of the genes present in the virus's genome. (cdc.gov)
The ∼30 Mb genomes of the Plasmodium parasites that cause malaria each encode ∼5000 genes, but the functions of the majority remain unknown. (portlandpress.com)
We find that the potato genome substantially expanded its repertoire of disease-resistance genes when compared with closely related seed-propagated solanaceous crops, indicative of the effect of tuber-based propagation strategies on the evolution of the potato genome. (nature.com)
These are designed by a laboratory to include genes commonly associated with a broad phenotype (e.g., cardiomyopathy, ataxia, intellectual disability) or a recognizable syndrome with genetic heterogeneity (e.g. (nih.gov)
Many proteins, and the genes that make them, aren't well understood, and there's still much to learn from the human genetic instruction book. (sciencenews.org)
After the exclusion of type II collagen and vitamin D receptor genes and the recessive loci for HSPs, a genome wide search was performed with about 500 fluorescent markers. (bmj.com)
It is noteworthy that type II collagen and vitamin D receptor genes map in the same region on chromosome 12q13.11, according to the UCSC Genome Browser database. (bmj.com)
Resistance-conferring genes in the 7,658 sequenced genomes were identified using genetic databases. (medicalxpress.com)
From Genes to Genetic Diseases: What Kinds of Mutations Matter? (sciencebuddies.org)
Our genes are made up of hundreds to millions of building blocks, called DNA nucleotides, and if just a single nucleotide of DNA becomes mutated it might cause a devastating genetic disease. (sciencebuddies.org)
The Human Genome Project has estimated that the human genome contains around 20,000 to 25,000 genes . (sciencebuddies.org)
Whole genome sequencing can also provide insights into the specific genes or mutations that may be linked to antibiotic resistance. (folkhalsomyndigheten.se)

These tests evaluate large numbers of individual variations (single nucleotide polymorphisms or SNPs) across a person's entire genome. (medlineplus.gov)
In 2010, researchers at the J. Craig Venter Institute in La Jolla, Calif., had stitched together a copy of the entire genome of the bacterium Mycoplasma mycoides and popped it into the cell of another bacterium whose genome had been removed. (sciencenews.org)
By sequencing the entire genome, a comprehensive understanding of the genetic composition is obtained. (folkhalsomyndigheten.se)

For the first five years, a complex PubMed query was used to identify studies of genotype prevalence, gene-disease association, gene-environment interaction, and the performance characteristics of genetic tests. (cdc.gov)
The HuGE published literature database will continue to be updated weekly with automatic indexing of gene symbols, study type (meta-analysis, GWAS), and category (pharmacogenomics, genetic testing). (cdc.gov)
No virulence factors were detected for any strain and only the non-transferable erm(49) gene, which confers resistance to erythromycin and clindamycin, was identified in the genome of B. longum KABP042. (frontiersin.org)
Pathogens' inhibition was mostly mediated by the production of organic acids, but neutralization experiments strongly suggested the presence of additional antimicrobial compounds in probiotic culture supernatants such as the bacteriocin Lantibiotic B, whose gene was detected in the genome of B. longum KABP042. (frontiersin.org)
Here, we review the arrival of genetic screens in malaria parasites to analyse parasite gene function at a genome-scale and their impact on understanding parasite biology. (portlandpress.com)
The database is manually curated by experts and can be searched by OMIM ID, gene, disease, or phenotype. (go.jp)
The genetic mutation identified was located the IQCB1 gene and is associated with progressive retinal atrophy, an inherited degenerative retinal disorder that leads to blindness. (sciencedaily.com)
We evaluated each gene of the African black-footed cat, one at a time, to look for the genetic mutation that is associated with vision loss. (sciencedaily.com)
Enter AquaMine -a cutting-edge data mining system poised to revolutionize aquatic eumetazoan research by integrating genome assemblies and gene annotation data. (washington.edu)
In this science project, you will explore online genetic databases to identify how a mutation in a gene can result in a dysfunctional protein, and how other mutations may have no effect at all. (sciencebuddies.org)
Determine why some gene mutations cause genetic diseases, but others do not. (sciencebuddies.org)
The variations in the progesterone receptor gene - consisting of single nucleotide polymorphisms, or one-letter changes in the genetic code - were found in regions of the gene that regulate when it is switched on and off. (stanford.edu)

Microsatellite DNA loci are genetic markers in wide use by Schistosoma researchers, but there are few primers available for S. haematobium . (biomedcentral.com)
WASHINGTON: Two recent papers by Brazilian researchers have added to the scientific understanding of the genetic factors that protect people from SARS-CoV-2 infection or prevent progression to severe Covid-19. (indiatimes.com)
Using new tricks of genetic engineering, researchers could make adjustments to the DNA in the human cell so it matches the code of the Neanderthal. (nationalgeographic.com)
MSSNG provides autism researchers with free access to thousands of sequenced genomes from families affected by autism. (autismspeaks.org)
The researchers hope this resource will help to further understanding of the sheep's genetic make-up. (ed.ac.uk)
Researchers at Human Longevity have developed technology that can generate images of individuals face using only their genetic information. (bigthink.com)
A core belief from the HLI researchers is that there is now no such thing as true deidentification and full privacy in publicly accessible databases," HLI said in a statement. (bigthink.com)
With GWAS studies, researchers are looking at the impact of small genetic variations on the genome. (ashg.org)
MultiPark NGS database is completed and available to interested MultiPark researchers. (lu.se)

The completion of the human genome marked the beginning of our concerted efforts to understand and catalogue genetic variation across human populations. (nature.com)
The Human Genome Variation Society (HGVS) has begun a grass-roots effort to compile a list of locus-specific databases (LSDBs), which are curated collections of mutations, often reported with associated phenotypic information ( 10 ). (cdc.gov)
Certain patterns of genetic variation are often shared among people of particular backgrounds. (medlineplus.gov)
In ethnic groups with a smaller range of genetic variation due to the group's size and history, most members share many SNPs, and it may be difficult to distinguish people who have a relatively recent common ancestor, such as fourth cousins, from the group as a whole. (medlineplus.gov)
Human genome epidemiology has grown, too, but studies of genetic variation and disease in populations-i.e., groups of people not defined by family relationships-still accounts for only a small fraction of the total (Figure 1). (cdc.gov)
The HuGE Navigator will remain online as a freely accessible resource for all who are interested in human genetic variation and population health. (cdc.gov)
An extensive literature documenting physiological and ecological diversity make Daphnia an ideal model to study the genetic architecture of phenotypic variation in natural populations and the evolution of genome structure/function relationships in aquatic environments. (biomedcentral.com)
Humans have unexpectedly high genetic variation in the receptor for a key pregnancy-maintaining hormone, according to research led by scientists at the Stanford University School of Medicine . (stanford.edu)

International Cancer Genome Consortium. (cancerindex.org)

The International HapMap project resolved human haplotypes into more than one million common single nucleotide polymorphisms (SNPs) in an effort to catalogue genetic variations associated with diseases 3 . (nature.com)
Recently, genome-wide association studies have identified seven germline single-nucleotide polymorphisms (SNP) that are associated with risk of Barrett's esophagus and esophageal adenocarcinoma. (who.int)

The authors of the new study performed whole- genome sequencing on 3,489 S. typhi isolates obtained from blood samples collected between 2014 and 2019 from people in Bangladesh, India, Nepal, and Pakistan with confirmed cases of typhoid fever. (medicalxpress.com)
We report herein 86 near-full-length genomes obtained from VSIV isolates collected from naturally infected horses in 27 counties of Colorado during 2019. (usda.gov)
For contact tracing or inquiries related to antibiotic resistance, whole genome sequencing (WGS) of bacterial isolates is offered. (folkhalsomyndigheten.se)

The information CDC collects from studying genetic changes (also known as "substitutions" or "mutations") in influenza viruses plays an important public health role by helping to determine whether vaccines and antiviral drugs will work against currently circulating influenza viruses, as well as helping to determine the potential for influenza viruses in animals to infect humans. (cdc.gov)
As S. typhi genomes only cover a fraction of all typhoid fever cases, estimates of resistance -causing mutations and international spread are likely underestimated. (medicalxpress.com)
What kinds of mutations have to occur to cause a genetic disease? (sciencebuddies.org)
In modern genetic studies , we developed efficient methods for identifying predictors in large data bases, with the specific emphasis on identifying causal mutations and building predictive models based on Genome Wide Association Studies. (lu.se)

The largest genome analysis of Salmonella enterica serovar typhi (S. typhi) also reveals that resistant strains-almost all originating in South Asia-have spread to other countries nearly 200 times since 1990. (medicalxpress.com)
In an interview with Nature, Piper said that Human Longevity has a vested interest in restricting access to DNA databases because it's a for-profit company that's trying to build the largest genome database in the world. (bigthink.com)

Furthermore, it seems clear from the interstrain crosses not only that the onset of tumors depends on the presence of susceptibility alleles from the EAC-prone BDII strain, but also that tumor development is affected by the contribution of a genetic component derived from the nonsusceptible strains. (mcw.edu)

13,790 primer pairs to amplify unique microsatellite loci in S. haematobium , (available at http://www.cebio.org/projetos/schistosoma-haematobium-genome ). (biomedcentral.com)
About half of the primers in the database of Schistosoma haematobium microsatellite DNA loci should yield amplifiable and easily scored polymorphic markers, thus providing thousands of potential markers. (biomedcentral.com)
From a genetic point of view, little information has so far been available on possible susceptibility loci. (bmj.com)
Whether these genetic susceptibility loci modify previously identified exposure-disease associations is unclear. (who.int)

It is a matter of concern that the Human reference genome originally developed in 2003[ 1 ] is derived from about 200 anonymous individuals from six countries: China, France, Germany, Great Britain, Japan and the United States, but did not have Deoxyribonucleic Acid (DNA) from any Indian. (ijpsonline.com)
With affordable technology and accessible reference genome database, analyzing individual genome has become feasible to understand one's health and associated health related risk factors. (ijpsonline.com)

In his 2012 book Regenesis , Harvard geneticist George Church proposes a different approach for cloning extinct animals whose genome has been sequenced. (nationalgeographic.com)

A database of tissue-specific human enhancers is available through VISTA Enhancer Browser. (wikipedia.org)
HGVS standard nomenclature Human Genome Epidemiology (2nd ed. (cdc.gov)
The Human Genome Organization (HUGO) was founded in 1988 to foster coordination among large-scale human genome mapping and sequencing projects around the world. (cdc.gov)
During the past several years, the Human Genome Epidemiology Network (HuGENet™) has laid out a process for knowledge synthesis and evaluation in human genome epidemiology. (cdc.gov)
Also, because most human populations have migrated many times throughout their history and mixed with nearby groups, ethnicity estimates based on genetic testing may differ from an individual's expectations. (medlineplus.gov)
The National Human Genome Research Institute discusses human origins and ancestry . (medlineplus.gov)
Human genome epidemiology must evolve to help meet this challenge. (cdc.gov)
Human genome epidemiology is a global enterprise. (cdc.gov)
OMIM is a database of human disease and genetic information and the online representation of Mendelian Inheritance in Man, a project initiated in the 1960s. (go.jp)
Our computational biology work investigates the precise makeup of both mouse and human genomes and the similarities (and important differences) important for translating preclinical research to clinical benefit. (jax.org)
The "unknome" database ranks human proteins by how little we know about them. (sciencenews.org)
Subsequently, significant work has been done on Indian genomes but not much variant data from the Indian population has been added to the human genome variant database[ 2 - 7 ]. (ijpsonline.com)
This leaves the reference human genome not an ideal representative of the human race. (ijpsonline.com)
The reference Human Genome and related variant databases need to be enriched with data from underrepresented populations. (ijpsonline.com)
Collectively the database has also revealed important aspects of the development of the human race. (ijpsonline.com)
Interesting as the applications may be, Human Longevity is more concerned with the implications its findings has on privacy in genomics research, namely that technologies like this could be used to match people's thought-to-be anonymous genetic information to their online photos. (bigthink.com)
They all share a common passion: delving deeper into the human genome to better understand the link between genetic sequencing and clinical care. (ashg.org)
Since then, the human genome has been sequenced, opening the doors to understanding risk factors for diseases based on genetic profiles, which are stored in large databases open to the scientific community. (ashg.org)
The new study used data from the 1,000 Genomes Project, a publicly accessible database of complete human genomes from people of different ancestral backgrounds. (stanford.edu)

The project is a major contribution to the global Functional Annotation of ANimal Genomes (FAANG) initiative. (ed.ac.uk)
The introduction of new JBrowse genome browsers equipped with Apollo manual genome annotation tools for aquaculture species is on the horizon. (washington.edu)

Gail Jarvik, MD, PhD, the Arno G. Motulsky Endowed Chair in Medicine, Joint Professor of Medicine and Genome Sciences, and Head of the Division of Medical Genetics (only the third since the founding of the division in 1957), an Adjunct Professor of Epidemiology at the UW Medical Center (UWMC) and an Affiliate Member of the Fred Hutchinson Cancer Research Center. (ashg.org)
Online databases including PubMed, Google Scholar and Web of Science were searched to obtain relevant publications on the epidemiology, treatment, vaccines and the economic impacts of the current monkeypox (Mpox) outbreak. (bvsalud.org)

So far, relatively few studies have examined the genome evolution and diversity of wild and cultivated landrace potatoes, which limits the application of their diversity in potato breeding. (nature.com)
Hongoh Y (2010) Diversity and genomes of uncultured microbial symbionts in the termite gut. (springer.com)
With greater diversity in the database, the resource will become indispensable for health-related research. (ashg.org)
To do this, we examine the non-redundant viral diversity stored in public databases, predict proteins in genomes lacking such information, and used all annotated and predicted proteins to identify potential protein domains. (mdpi.com)

VISTA is a collection of databases, tools, and servers that permit extensive comparative genomics analyses. (wikipedia.org)
The Office of Public Health Genomics has compiled this database since 2001 via weekly systematic sweeps of PubMed performed by a single curator. (cdc.gov)
Reinventing potato from a clonally propagated tetraploid to a true seed-propagated diploid has the potential to considerably accelerate genetic improvement, and would enable the genome design of a crop that has been highly recalcitrant to the use of molecular breeding and genomics approaches 3 , 6 , 7 . (nature.com)

Among them, it has usually been suggested that a genetic factor or a familial predisposition may be of relevance to the development of disc herniation. (bmj.com)

In a typical year, CDC performs whole genome sequencing on about 7,000 influenza viruses from original clinical samples collected through virologic surveillance. (cdc.gov)
The result is a comprehensive technical report, including a detailed list of database matches and an interpretation of potential clinical relevance following consultation with a clinical microbiologist. (folkhalsomyndigheten.se)
Metagenomic sequencing engables a thorough mapping of the genetic material in the clinical sample, providing a broader understanding of the microbiological profile. (folkhalsomyndigheten.se)

Arabidopsis-rice-sorghum E. coli-mycoplasma-nitrosomonas Pre-computed full scaffold alignments for microbial genomes are available as the VISTA component of IMG (Integrated Microbial Genomes System) developed in the DOE (Department of Energy's) Joint Genome Institute. (wikipedia.org)

We conducted a combined genome-wide association study (GWAS) of 7,481 individuals with bipolar disorder (cases) and 9,250 controls as part of the Psychiatric GWAS Consortium. (nih.gov)
Another project, called genome-wide association studies (GWAS), is making use of an established database called the eMERGE consortium. (ashg.org)

The team, led by genome-sequencing pioneer Craig Venter, reported their findings in a controversial paper published in the journal Proceedings of the National Academy of Sciences. (bigthink.com)

The diagnostic utility of exome sequencing has consistently been 20%-30% (i.e., a diagnosis is identified in 20%-30% of individuals who were previously undiagnosed but had features suggestive of a genetic condition) [ Gahl et al 2012 , Lazaridis et al 2016 ]. (nih.gov)
To date, more than 9,000 people (with autism or in families affected by autism) have contributed genetic material for sequencing. (autismspeaks.org)
Remarkable advancement in next generation sequencing technology has made personal genome analysis feasible and affordable. (ijpsonline.com)

MSSNG has grown into one of the world's largest open-access genome databases. (autismspeaks.org)

The UCSC Genome Browser Database has continued to evolve, adding many web-based applications for viewing, manipulating, and analyzing the data ( 8 ). (cdc.gov)
Other methods are needed to integrate genetic data into ways of thinking that can help us understand, prevent and treat disease. (cdc.gov)
After clicking the 'Search' button, VCMap will begin searching the currently loaded maps and the data from its database. (animalgenome.org)
Pipelines are series-connected data processes that utilise software tools to structure, process, and interpret genetic information. (folkhalsomyndigheten.se)

That's more difficult than it sounds, as there are millions of spots in the genome that are different in modern humans and Neanderthals. (nationalgeographic.com)
In conclusion, this study adds information on genetic factors involved in individual vulnerability to acute hypoxia and supports the critical role of the ≪ O 2 sensor ≫ - heme oxygenase-2 - in the chemosensitivity of carotid bodies in Humans. (frontiersin.org)

These efforts laid the groundwork for approximately 1,800 genome-wide association (GWA) studies that investigated the genetic basis of complex diseases such as diabetes, cancer, and heart disease 6 . (nature.com)

Genetic analysis of susceptibility to endometrial adenocarcinoma in the BDII rat model. (mcw.edu)
An analysis of all 11,974 bipolar disorder cases and 51,792 controls confirmed genome-wide significant evidence of association for CACNA1C and identified a new intronic variant in ODZ4. (nih.gov)
The Applied Biosystems CytoScan Dx microarray platform is an in vitro diagnostic solution that offers a reliable genome-wide approach for high-resolution DNA copy number analysis to study gains, losses, loss of heterozygosity (LOH)/absence of heterozygosity (AOH), copy-neutral loss of heterozygosity (cnLOH), regions identical-by-descent, and mosaicism. (thermofisher.com)
Designed for cytogenetic analysis, ChAS Dx Software is a stand-alone application for analysis and visualization of chromosomal aberrations across the genome that may include CN gain or loss or LOH. (thermofisher.com)
This genome-based analysis will facilitate our understanding of the mechanism underlying the biodegradation of lignocellulose and the biotechnological application of this novel lignocellulolytic bacteria or related enzymes. (springer.com)
With individual genome analysis, we are now able to ascertain the ethnic affiliation of the ancestors and develop a migratory pattern for that particular group and develop a health profile of the individual. (ijpsonline.com)
New Genetic Markers Differentiating IPEC and ExPEC Pathotypes-A New Approach to Genome-Wide Analysis Using a New Bioinformatics Tool. (bvsalud.org)

The three Schistosoma genomes contained similar overall frequencies of microsatellites, but the frequency and length distributions of specific motifs differed among species. (biomedcentral.com)
In the first study, Lyons and her team used the 99 Lives consortium to identify a genetic mutation that causes blindness in the African black-footed cat, an endangered species often found in U.S. zoos. (sciencedaily.com)
AquaMine-Ortho, a precomputed orthology dataset within AquaMine v1.2, spans all included species and fills gaps not covered by databases like OrthoDB or Ensembl. (washington.edu)
Everyone has a different genome, but we are all tied together as one group of species. (ashg.org)

This database contains records of people with a range of diseases and conditions, including colorectal cancer, susceptibility to infection, metabolic disorders, and carotid artery disease. (ashg.org)

For now, the Neanderthal genome is an abstract string of billions of DNA letters stored in computer databases. (nationalgeographic.com)

This type of testing identifies genetic variations in mitochondrial DNA. (medlineplus.gov)
Genetic variations are important because they can change amino acids that make up the influenza virus' proteins, resulting in structural changes to the proteins, and thereby altering properties of the virus. (cdc.gov)
Genetic variations are important because they affect the structure of an influenza virus' surface proteins. (cdc.gov)
It will help participants understand the genetic variations that affect them. (autismspeaks.org)

We therefore introduce the reader to CRISPR-based screens in the related apicomplexan Toxoplasma gondii and discuss how these approaches could be adapted to develop CRISPR/Cas9 based genome-scale genetic screens in malaria parasites. (portlandpress.com)
The main purpose of a bioinformatics platform within SWEGENE should be to provide com- putational facilities and logistical support [databases & infrastructure] for scientists whose primary research in biology and medicine benefit from computational approaches. (lu.se)

One goal of the SCORE program is to understand and document whether changes in drug tolerance arise during different drug administration programs, and specific genetic assays are needed to better monitor population structure and potential changes in Schistosoma populations under praziquantel treatment. (biomedcentral.com)
On a larger scale, combined genetic ancestry test results from many people can be used by scientists to explore the history of populations as they arose, migrated, and mixed with other groups. (medlineplus.gov)
Recent natural selection took the genetic code in different directions as different populations adapted to their local environments, the scientists found. (stanford.edu)
The findings also predict that the genetic forms of the progesterone receptor seen in East Asians would not necessarily protect against premature birth in other populations. (stanford.edu)

The HuGE published literature database now contains more than 100,000 citations, a milestone reached at the end of 2014. (cdc.gov)
The first 100,000 articles in the database included authors from 151 countries (Fig 2). (cdc.gov)

Perhaps the most prominent and widely used NCBI database is PubMed , a continuously updated, public database of more than 18 million citations for biomedical literature. (cdc.gov)
Entrez is the search engine that allows searching across all NCBI databases. (cdc.gov)

Influenza viruses are constantly changing, in fact all influenza viruses undergo genetic changes over time (for more information, see How Flu Viruses Can Change: "Drift" and "Shift" ). (cdc.gov)
CDC conducts year-round surveillance of circulating influenza viruses to monitor changes in the genome of these viruses. (cdc.gov)

Finally, they fed the photos and genetic information to an algorithm that taught itself how small differences in DNA relate to facial features, like cheekbone height or protrusion of the brow. (bigthink.com)
There are differences in genomes but not in humanity. (ashg.org)

Various software resources are also required to enable users to conveniently connect their experimental results with publicly, and application specific, bioinformatics databases and tools. (lu.se)

The study was supported by FAPESP via HUG-CELL, the National Science and Technology Institute on Aging and Genetic Disorders, and four other projects (19/19998-8, 20/09702-1, 13/17084-2 and 17/19223-0). (indiatimes.com)
We went from zero full genomes two years ago to over 200 now, said Maria Nieves-Col n, an anthropological geneticist at the University of Minnesota who was not involved in the new study. (artdaily.com)
I don t think we re as close as we thought we d be to an answer, said Nieves-Col n, an author of another large-scale genetic study in July. (artdaily.com)

The potential applications of this technology are especially intriguing for fields like forensic science - what if investigators were able to use genetic information left at a crime scene to "see" the perpetrator? (bigthink.com)

The U.K.'s newly launched Personal Genome Project seeks volunteers. (the-scientist.com)
The new British Personal Genome Project (PGP-UK) follows the lead of other groups in various countries around the world that have had success recruiting volunteers to submit their personal information. (the-scientist.com)
The goal of this project was to produce a collection of VSIV genomes representing an epidemic lineage circulating in the US. (usda.gov)
In September 2019, the UK announced that it has invested a huge sum in a new database for the Genome Decoding Research Project. (globenewswire.com)

Our findings provide insights into the alteration of potato genomes during the evolution of tuberization, and will enable genome design for new diploid hybrids. (nature.com)

Furthermore, the effects of the evolution of a clonal reproduction strategy on potato genomes and the evolutionary mechanisms of tuberization are largely unexplored. (nature.com)
However, the minor portion of biodiversity in the Petota section that is captured by these genomes is insufficient to obtain a comprehensive understanding of the potato genome and tuber evolution. (nature.com)

It is not intended to be used for standalone diagnostic purposes, pre-implantation or prenatal testing or screening, population screening, or detection of or screening for acquired or somatic genetic aberrations. (thermofisher.com)

AquaMine v1.2 is more than a mere database-it's a beacon for aquaculture and fisheries research, guiding the way towards a more informed and sustainable management of aquatic resources. (washington.edu)

To identify genetic changes that affect the virus' properties. (cdc.gov)

Anatomy8

Organisms29

Diseases7

Chemicals and Drugs26

Analytical, Diagnostic and Therapeutic Techniques and Equipment45

Phenomena and Processes122

Disciplines and Occupations9

Anthropology, Education, Sociology and Social Phenomena2

Technology, Industry, Agriculture4

Information Science33

Health Care11

Geographicals1

Sequences23

Variants16

Sequence24

Genomic12

Genes15

Entire genome3

Gene12

Researchers9

Variation8

International Cancer Gen1

Single nucleotide po2

Isolates3

Mutations4

Largest genome2

Strains1

Loci4

Reference genome2

Whose genome1

Human19

Annotation2

Epidemiology2

Diversity4

Genomics3

Predisposition1

Clinical3

Microbial1

GWAS2

Sciences1

Sequencing3

World's largest1

Data4

Humans2

Investigated the genetic basis1

Analysis7

Species4

Susceptibility1

Abstract1

Variations4

Approaches2

Populations4

100,0002

NCBI2

Influenza2

Differences2

Publicly1

Study3

Forensic science1

Project4

Findings1

Evolution2

Somatic1

Aquatic1

Identify genetic1