• Some patients receive total body irradiation (TBI) in addition to chemotherapy. (ucsfhealth.org)
  • About 50 percent of [BMT] transplant patients overall receive total body irradiation, including a higher proportion of those patients who are younger," Bhatia said. (greenhealthlive.com)
  • Treosulfan, fludarabine, and 2-Gy total body irradiation followed by allogeneic hematopoietic cell transplantation in patients with myelodysplastic syndrome and acute myeloid leukemia. (bvsalud.org)
  • In this prospective phase II trial, we assessed the efficacy and toxicity of treosulfan, fludarabine, and 2 Gy total body irradiation (TBI) as conditioning for allogeneic HCT in patients with MDS or AML. (bvsalud.org)
  • A conditioning regimen consisting of fludarabine, total body radiation 450 cGy and alemtuzumab (CD52 mAb) was used for 15 patients. (nih.gov)
  • 2 1 The most frequently used protocol, spear-headed by investigators from the Fred Hutchinson Cancer Research Center, was based on a single dose of 200 cGy of total-body irradiation (TBI) and a few doses of fludarabine followed by pharmacological immunosuppression. (haematologica.org)
  • OBJECTIVES: I. Determine whether mixed or full donor chimerism can be safely established in older patients with acute myeloid leukemia (AML) treated with nonmyeloablative conditioning comprised of low dose total body irradiation, followed by allogeneic peripheral blood stem cell transplantation, followed by unrelated donor lymphocyte infusion (DLI). (knowcancer.com)
  • OUTLINE: Conditioning: Patients undergo low dose total body irradiation followed by infusion of allogeneic peripheral blood stem cells (PBSC) on day 0. (knowcancer.com)
  • The radiation therapist may use shielding blocks to keep some parts of the body from getting full dose radiation during TBI. (stjude.org)
  • As a reference point, we can note that the so-called maximum permissible dose for exposure of the whole body to x, gamma, and beta radiation was 0.3 R per week, as recommended by the International Commission on Radiological Protection. (ratical.org)
  • Dr. Jerry Cuttler provided a copy of an open letter signed by 23 members or affiliate members of SARI - Scientists for Accurate Radiation Information that describes important information about the use of a specific regimen of whole (or half) body low dose radiation as a treatment in the continuing battle against cancer. (atomicinsights.com)
  • Purpose: We have developed a megavoltage CT (MVCT) based dose reconstruction strategy for total body irradiation (TBI) with Helical TomoTherapy (HT, TomoTherapy, Inc, Madison, WI) using a deformable registration model to retrospectively account for interfraction changes in the region of interest (ROI). (elsevierpure.com)
  • TBI provided a uniform dose of radiation to the entire body, penetrating areas such as the central nervous system (CNS) and testes. (sumathipublications.com)
  • Low-dose cranial irradiation has an effect on GH secretion affecting predominantly frequency modulation leading to fast frequency, normal amplitude GH pulsatility. (ox.ac.uk)
  • nausea and vomiting associated with radiotherapy in patients receiving either total body irradiation, single high-dose fraction to the abdomen, or daily fractions to the abdomen. (nih.gov)
  • radiotherapy in patients receiving either total body irradiation, single high-dose fraction to the abdomen, or daily fractions to the abdomen. (nih.gov)
  • This study investigated hematopoietic recovery and immune function in rhesus macaques Cross-sectionally (at a single time point) 2 to 5 years after exposure to a single large dose (6.5 to 8.4 Gray) of total body radiation (TBI) derived from linear accelerator-derived photons (2 MeV, 80 cGy/minute) or Cobalt 60-derived gamma irradiation (60 cGy/min). (cdc.gov)
  • Taken together, these data show that dose-related changes in peripheral blood cells and immune responses to both novel and recall antigens can be detected 2 to 5 years after exposure to whole body radiation. (cdc.gov)
  • A new study examining long-term outcomes of blood or marrow transplantation (BMT) found that patients who received total body irradiation (TBI) at age 30 or younger had a 4.5-fold increase in their risk of developing breast cancer later in life compared with the general population. (greenhealthlive.com)
  • Background: The use of total body radiation (TBI) before hematopoietic stem cell transplantation (HSCT) would increase the engraftment without transplant-related morbidity or mortality among Thalassemia major (TM) cases. (sumathipublications.com)
  • Food irradiation is a food safety process that uses radiation to kill germs that can cause food poisoning (foodborne illness). (cdc.gov)
  • Food irradiation is safe, and its safety and efficacy have been endorsed by various federal agencies and intergovernmental organizations. (cdc.gov)
  • Food irradiation is also used to extend the shelf life of foods and control for insects. (cdc.gov)
  • This page contains questions and answers you may have about food irradiation for food safety. (cdc.gov)
  • How does food irradiation work? (cdc.gov)
  • Food irradiation works by exposing food products to ionizing radiation . (cdc.gov)
  • Food irradiation is considered a "cold" method, meaning it does not use heat to kill germs. (cdc.gov)
  • What are the benefits of food irradiation? (cdc.gov)
  • Think of food irradiation as an added layer of protection against harmful germs that can make you sick. (cdc.gov)
  • During the food irradiation process, beams of radiation pass through the food in the same way that X-ray beams pass through you when you get a medical X-ray. (cdc.gov)
  • Is food irradiation safe? (cdc.gov)
  • The U.S. Food and Drug Administration has approved food irradiation as a safe and effective process. (cdc.gov)
  • FDA has also evaluated food irradiation for safety for over 30 years. (cdc.gov)
  • For more detailed information on labeling, please visit the FDA food irradiation page . (cdc.gov)
  • Food irradiation can prevent food borne illness caused by microorganisms like eColi. (atomicinsights.com)
  • Therefore, the aim of this study was to assess risk of CNS recurrence in ALL patients treated with TBI, to identify subsets of these high-risk patients at an increased or decreased risk of CNS recurrence after TBI, and to investigate whether regimens with higher doses of cranial irradiation further reduce the risk of CNS recurrence. (johnshopkins.edu)
  • Additionally, high doses of total body irradiation can eradicate residual cancer cells in the transplant recipient, increasing the likelihood that the transplant will be successful. (wikipedia.org)
  • Ciliary body melanomas can push the iris diaphragm anteriorly, or they can infiltrate the trabecular meshwork, producing acute angle closure. (medscape.com)
  • Purpose: Total body irradiation (TBI) as part of a conditioning regimen before hematopoietic stem cell transplant (HSCT) is an important component in the management of acute lymphoblastic leukemia (ALL) that has relapsed or has other certain high-risk features. (johnshopkins.edu)
  • Since approximately 30% of leukemia patients relapse after allogeneic BMT using total body irradiation (TBI)-based preparative regimens, treatment intensity may be suboptimal. (nature.com)
  • Patients who die from ciliary body melanoma die because of distant metastasis rather than local spread. (medscape.com)
  • Graft failure was seen in 17 patients with an overall cumulative incidence of 17% in patients receiving conditioning with or without total body irradiation: 9 of these 17 patients survive in the long-term. (unicatt.it)
  • Forty-one (61%) patients did not receive an extracranial boost of irradiation with TBI. (johnshopkins.edu)
  • The body feels the effects of the chemotherapy or radiation about a week after a BMT. (ucsfhealth.org)
  • Before a stem cell transplant, a conditioning or preparative treatment gets the body ready for the new and healthy stem cells. (stjude.org)
  • To determine the possible effects that irradiation of the body might have on neuronal function and cognitive performance, rats were given head-only, body-only or whole-body exposures to 56Fe particles. (usda.gov)
  • Total body irradiation (TBI) is radiation therapy given to the whole body using high-energy x-rays. (stjude.org)
  • Total body irradiation and chemotherapeutic exposures such as alkylating agents and anthracyclines are used to prepare the patient for BMT. (greenhealthlive.com)
  • To determine whether irradiation of the body (apart from the head) can impact brain function, rats were given head-only, body-only or whole-body exposures to radiation. (usda.gov)
  • Uveal melanomas are the most common primary intraocular malignancies and the second most common type of primary malignant melanoma in the body. (medscape.com)
  • Until now, there is no unified theory about the effect of UVR on the human body, along with this, scientists have proved that under the influence of UVR, the bactericidal activity of blood and inactivated toxic substances and enzymes is sharply increased by their oxidation. (kalinka-store.com)
  • To the diseased body more oxygen and nutrients are supplied, and harmful substances (including "extra" sugar and cholesterol) are excreted faster. (kalinka-store.com)
  • There were no effects of irradiation on these measures of oxidative damage. (elsevierpure.com)
  • Thus, the novel object recognition test is particularly sensitive to detect early cognitive effects of 56 Fe irradiation through a mechanism unlikely involving ROS or oxidative damage. (elsevierpure.com)
  • Although the evidence presented here is based on in vitro using isolated DNA, the results clearly demonstrate that the hot-water extract of Ganoderma lucidum shows good radioprotective ability, as well as protection against DNA damage induced by metal-catalyzed Fenton reactions and UV irradiation. (nih.gov)
  • Exposure to radiation from any radioactive material or radiation exposure device can damage cells in your body. (cdc.gov)
  • Some examples include cancers of the extremities, cranio-spinal treatment for medulloblastoma, whole brain irradiation for leukemia and certain diseases that affect tissues throughout a section of the lungs, abdomen or pelvis. (chla.org)
  • Conclusion: Total Body Irradiation with the SAD technique is the most effective way of treatment. (sumathipublications.com)
  • The purpose of a Phase 2 trial is to learn if a new treatment works in treating a specific type of cancer and how it affects the body. (childrensoncologygroup.org)
  • The fruit bodies of Ganoderma lucidum have been used for the prevention and treatment of various diseases in the Orient. (nih.gov)
  • The amount of extractable antioxidant from the stabilised polymers was determined chromatographically and a gradual diminution in the total extractable levels of each antioxidant was observed as irradiation progressed, the extent depending on the nature of both the antioxidant and the polymer 2,6-Di-t-butyl-1,4-benzoquinone was shown to be an extractable degradation product, arising from the effects of gamma-irradiation on the phenolic antioxidants. (bl.uk)
  • It was demonstrated using 14C-labelled Irganox 1076 that degradation products formed during gamma-irradiation are becoming covalently bound to the polymer, as a result of radical coupling processes. (bl.uk)
  • Finally, the effects of gamma-irradiation on the extent of migration of antioxidants from polyolefins into food simulants was studied. (bl.uk)
  • As the name implies, TBI involves irradiation of the entire body, though in modern practice the lungs are often partially shielded to lower the risk of radiation-induced lung injury. (wikipedia.org)
  • Local growth of ciliary body melanoma produces signs and symptoms as it pathologically involves adjacent structures. (medscape.com)
  • The conventional external beam, with either photons or electrons, can be employed when the diseased tissue is either very superficial or involves an entire region of the body. (chla.org)
  • It was found that irradiation leads to a decrease in the extent to which hindered phenolic antioxidants migrate from polyolefins into fatty media, consistent with the reduction in extractable antioxidant levels and the increase in the extent of antioxidant-polymer binding. (bl.uk)
  • As 56 Fe irradiation can increase reactive oxygen species (ROS) levels, which may contribute to the impairments in novel object recognition, the effects of the antioxidant alpha-lipoic acid (ALA) on cognition following sham irradiation and irradiation were also assessed. (elsevierpure.com)
  • Irradiation can make foods safer that are typically eaten raw, like some produce. (cdc.gov)
  • Workers at nuclear facilities, irradiation facilities, or nuclear waste storage sites may be exposed to small amounts of radioactive cobalt and its radiation. (cdc.gov)
  • The National Toxicology program under U.S. Department of Health and Human Services (DHHS) has classified cobalt and cobalt compounds that release ions inside the body as reasonably anticipated to be a human carcinogen based o n evidence from human and animal studies. (cdc.gov)
  • These results suggest that radiation to the body can impact the brain, therefore it may be necessary to re-evaluate the estimates of the risk of HZE particle-induced changes in neuronal function and cognitive performance. (usda.gov)
  • Total body irradiation results in infertility in most cases, with recovery of gonadal function occurring in 10−14% of females. (wikipedia.org)
  • Custom body molds help position the patient for Total Body Irradiation (TBI). (stjude.org)
  • Cumulative total body irradiation caused subtle but significant changes in serum lipids, electrolytes and protein which may be due to non-specific stress reactions. (uwi.edu)
  • The aim of this research is to sequentially document the effect of total body radiation on body function utilizing the sequential changes in liver function enzymes and proteins in rats. (uwi.edu)
  • 1. Enhances intracellular and intercellular metabolism, restores cell parameters, thanks to which it contributes to the restoration of protective (immune) properties and impaired functions of the body. (kalinka-store.com)
  • There were no effects of irradiation on contextual fear conditioning or spatial memory retention in the water maze. (elsevierpure.com)
  • Relatively little is known about early irradiation effects on hippocampal function in wild-type mice. (elsevierpure.com)
  • In this study, the effects of 56 Fe irradiation on hippocampal function were assessed starting 2 weeks after whole-body irradiation. (elsevierpure.com)
  • shows the radiation intensity of a black-body heat source (i.e.emissivity = 1) as a function of wavelength and temperature. (eurotherm.com)
  • In addition, bulk samples of irradiated mail and mail that had not gone through the irradiation process were analyzed for anions, metals, and pH. (cdc.gov)
  • Radiation in the implant can send high-energy rays outside the patient's body. (kidshealth.org)
  • We can presume that the measure being obtained is that of whole-body radiation, and that hence the breasts would have received some radiation from anterior, lateral, and posterior entry of x-rays. (ratical.org)
  • 3. It has a pronounced anti-inflammatory and immunomodulatory effect, positively affects the overall resistance (protection from diseases) of the body, contributes to the cure or prevention of a specific disease, improves blood quality and markedly improves general condition of the body. (kalinka-store.com)
  • Irradiation is one more protective step, but it does not replace other food safety measures. (cdc.gov)
  • We also found that the water-soluble polysaccharide isolated from the fruit body of Ganoderma lucidum was as effective as the hot-water extract in protecting against hydroxyl radical-induced DNA strand breaks, indicating that the polysaccharide compound is associated with the protective properties. (nih.gov)
  • Nutrient loss during irradiation is similar to the amount of nutrients lost during cooking, freezing, canning and other food safety methods. (cdc.gov)
  • The added dryness of the mail from the irradiation process can lead to dryness and skin irritation from repeated handling of the mail. (cdc.gov)
  • Ciliary body melanomas are mostly found in Whites, particularly in those with light-colored irides. (medscape.com)
  • When solid tumors are much smaller than the body part in which they are found, radiation can be delivered in a way that conforms to the shape of the tumor, sparing nearby normal tissues. (chla.org)
  • For the inner planet (-e), we found a mass and density of Me = 9.0 ± 0.5 M⊕ and ρe = 8.1 ± 0.5 g cm−3, suggesting an Earth-like composition close to other ultra-hot planets at similar irradiation levels. (lu.se)