Whole blood platelet aggregation blood platelets. Medical search. Frequent questions

Savage, B., Almus-Jacobs, F. & Ruggeri, Z.M. Specific synergy of multiple substrate-receptor interactions in platelet thrombus formation under flow. (nature.com)
An antiplatelet is a medication that decreases platelet aggregation and inhibits thrombus formation. (cdc.gov)
describes a novel signaling pathway involving Notch1 and its ligand, Δ-like ligand-4 (DLL4) in driving platelet activation and thrombus formation. (elifesciences.org)
Human atheromatous plaques stimulate thrombus formation by activating platelet glycoprotein VI. (thieme-connect.com)

In contrast, the strong inhibition of platelet adhesion by GPVI-Fc in combination with GPIIb/IIIa inhibitors could be harmful. (thieme-connect.com)

The inhibition of platelet aggregation and blood coagulation by Micropechis ikaheka venom. (ox.ac.uk)
The aim of this study was to compare the platelet effects of a novel S-nitrosated glyco-amino acid, RIG200, with an established S-nitrosothiol, S-nitrosoglutathione (GSNO) in PRP, and to investigate the effects of cell-free haemoglobin and red blood cells on S-nitrosothiol-mediated inhibition of platelet aggregation. (uhi.ac.uk)

GPS is characterized by "thrombocytopenia, abnormally large agranular platelets in peripheral blood smears, and almost total absence of platelet alpha-granules and their constituents. (wikipedia.org)
Epistaxis has been controlled by the use of porcine strip packing in patients with thrombocytopenia prior to and with platelet transfusion. (nebraska.edu)
The workup of a patient with a platelet-type bleeding pattern typically includes correlation with platelet count ( thrombocytopenia ), evaluation of platelet morphology on peripheral smear, exclusion of acquired causes of platelet dysfunction, and testing for von Willebrand disease (VWD) . (arupconsult.com)
Blood count reveals thrombocytopenia, in some cases anemia, and very rarely neutropenia. (orpha.net)
Thrombocytopenia related manifestations can be treated with platelet transfusions. (orpha.net)

Transcripts/peptides of Notch1 and Delta-like ligand (DLL)-4 were detected in platelets isolated from human blood by RT-qPCR, Western analysis and flow cytometry. (elifesciences.org)
Platelet aggregation, granule secretion and platelet-leukocyte interaction were analyzed by lumi-aggregometry and flow cytometry. (elifesciences.org)
further testing may include platelet aggregation tests, platelet flow cytometry, and in some cases, genetic testing. (arupconsult.com)
Platelets were analyzed by flow cytometry for relative size, shape, aggregation, fibrinogen binding, P-selectin, and lysosomal-associated membrane protein-1 (LAMP-1) expression. (cdc.gov)

Savage, B., Saldivar, E. & Ruggeri, Z.M. Initiation of platelet adhesion by arrest onto fibrinogen or translocation on von Willebrand factor. (nature.com)
Distinct glycoprotein Ib/V/IX and integrin αIIbβ3-dependent calcium signals cooperatively regulate platelet adhesion under flow. (nature.com)
These proteins are vital to normal platelet adhesion and hemostatic function. (nottingham.ac.uk)
We also observed host-dependent differences for interaction of platelets with C. albicans , showing enhanced platelet aggregation, adhesion and activation in murine blood. (frontiersin.org)
Functional platelet disorders affect the adhesion, activation, or aggregation of platelets and are frequently associated with excessive bleeding, often following trauma or surgery. (arupconsult.com)
Bernard-Soulier syndrome (an adhesion disorder) and Glanzmann thrombasthenia (an aggregation disorder) are among the most well-recognized inherited disorders of platelet function and are severe clinical conditions. (arupconsult.com)
GPVI-Fc added on top of abciximab, a clinically used anti-fibrinogen receptor antibody which blocks platelet aggregation, strongly inhibited total (81%) and stable (89%) platelet adhesion. (thieme-connect.com)
It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. (bvsalud.org)

It has long been assumed that platelet aggregation and thrombus growth are initiated by soluble agonists generated at sites of vascular injury. (nature.com)
By using high-resolution intravital imaging techniques and hydrodynamic analyses, we show that platelet aggregation is primarily driven by changes in blood flow parameters (rheology), with soluble agonists having a secondary role, stabilizing formed aggregates. (nature.com)
Platelet aggregation was measured in 55 patients undergoing elective PCI at 16-24 hours after 600 mg clopidogrel loading dose by light transmittance aggregometry using ADP 20 μM and thrombin receptor agonist peptide (TRAP) at 15 μM and 25 μM as agonists. (nih.gov)
Platelets exhibit diverse responses in a variety of agonists. (edu.pk)
In vivo, most of the agonists act in synergism, causing aggregation of platelets. (edu.pk)
Results: The combinations of these agonists in subthreshold levels showed the synergistic responses in causing platelet aggregation. (edu.pk)
Conclusion: These findings indicate that the optimal platelet aggregation does occur between the above mentioned pairs of agonists even when each of the agonist is added to the other in subthreshold doses. (edu.pk)
Characteristics of the synergistic actions of platelet agonists. (edu.pk)
Our study presents compelling evidence in support of non-canonical juxtacrine Notch signaling within platelet aggregates that synergizes with physiological agonists to generate occlusive intramural thrombi. (elifesciences.org)
A modification of standard light transmission aggregometry was used to assess platelet function, with light absorbance measured following addition of 5 different agonists at maximal and sub-maximal concentrations. (bmj.com)
Since platelets have multiple receptors it is necessary to study more than one receptor with the various agonists. (bmj.com)
This pattern of platelet aggregation was not repeated for the agonists TRAP and ADP. (bmj.com)
Platelets often have functional abnormalities, shown by a defect in the aggregation response to agonists. (orpha.net)

The venom inhibited platelet aggregation in response to ADP and collagen, and also delayed clotting dependent on platelet activation or endothelial cell tissue factor expression. (ox.ac.uk)
The key finding is under electron microscopy, EDTA-exposed platelets showed extensive activation, with loss of storage granule contents and pseudopod formation. (wikipedia.org)
The mechanism by which platelet activation occurs remains unknown. (wikipedia.org)
1. S-Nitrosothiols are nitric oxide (NO) donor drugs that have been shown to inhibit platelet aggregation in platelet rich plasma (PRP) in vitro and to inhibit platelet activation in vivo. (uhi.ac.uk)
Addition of platelets at different times after leukocyte activation resulted in progressively reduced cytoplasmic Ca2+ increase. (nih.gov)
Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system. (nih.gov)
Inhibition of Notch signaling, too, restrained agonist-induced platelet activation, and significantly impaired arterial thrombosis in mice. (elifesciences.org)
We investigated, whether GPVI-Fc added in vitro on top of acetylsalicylic acid (ASA), the P2Y 12 antagonist ticagrelor, and the fibrinogen receptor antagonist abciximab alone or in combination would increase inhibition of platelet activation by atherosclerotic plaque. (thieme-connect.com)
Exposure of mice to concentrated ambient particulate matter results in platelet and systemic cytokine activation. (cdc.gov)
The authors evaluated blood cell parameters and markers of platelet activation in mice exposed to concentrated ambient particulate matter (CAPs) from the San Joaquin Valley of California, a region with severe particulate matter (PM) pollution episodes. (cdc.gov)
These findings demonstrate a systemic proinflammatory and procoagulant response to inhalation of environmentally derived fine and ultrafine PM and suggests a role for platelet activation in the cardiovascular and respiratory effects of particulate air pollution. (cdc.gov)

AF acted synergistically with nonaggregating amounts of either adenosine diphosphate or collagen to cause aggregation. (nebraska.edu)
2. The effects of GSNO and RIG200 in collagen (2.5 microg ml(-1))-induced platelet aggregation in PRP and whole blood were investigated in vitro. (uhi.ac.uk)
Methods: In this study, the synergism between ADP - Epinephrine and Epinephrine - Collagen has been determined by means of turbidometric method, which measures changes in optical density of platelet suspension. (edu.pk)
Cytosolic calcium as a second messenger for collagen-induced platelet responses. (edu.pk)
Platelet thrombus on immobilized collagen was quantified using microfluidics platform. (elifesciences.org)
GPVI-Fc, a recombinant dimeric fusion protein binding to plaque collagen and concealing binding sites for platelet GPVI, acts as a lesion-focused antiplatelet drug, and does not increase bleeding in vivo. (thieme-connect.com)
The collagen-induced platelet aggregation of platelet-rich plasma samples from 14 healthy rabbits was measured turbidometrically using a platelet aggregometer, before and 1 hour after intravenous injection of alum. (who.int)
Collagen-induced platelet aggregation was significantly reduced after alum injection. (who.int)
contradiction in the mechanism of action of alum, we evaluated the in vivo effect of Alum (aluminium potassium sulfate) is a alum in terms of collagen-induced platelet food additive and traditional remedy used to aggregation and bleeding time. (who.int)

The lower neutrophil number in murine blood only partially explains insufficient infection and filamentation control, as spiking with murine neutrophils had only limited effects on fungal killing. (frontiersin.org)

Figure 2: Platelet aggregation induced shear microgradients occurs independently of ADP, TXA 2 and thrombin. (nature.com)
Thrombin induces platelet aggregation by binding to protease activated receptor-1 (PAR-1), and inhibition of PAR-1 has been evaluated in patients treated with clopidogrel to reduce ischemic events after acute coronary syndromes. (nih.gov)
Strikingly, prevention of DLL-4-Notch1 interaction by a blocking antibody abolished platelet aggregation and extracellular vesicle shedding induced by thrombin. (elifesciences.org)
Disseminated Intravascular Coagulation (DIC) Disseminated intravascular coagulation (DIC) involves abnormal, excessive generation of thrombin and fibrin in the circulating blood. (msdmanuals.com)
Stimulation of platelets by thrombin resulted in up-regulation of LAMP-1 expression in CAPs-exposed animals and an increased microparticle population relative to control animals. (cdc.gov)

Clopidogrel inhibits ADP mediated platelet aggregation through inhibition of the P2Y12 receptor by its active metabolite. (nih.gov)
ii) Determination of the platelet receptor glycoprotein Ib extracellular domain and von Willebrand factor A1 domain structures (iii) determination of the coagulation factor xi structure. (nottingham.ac.uk)
Synergistic responses and receptor occupancy in rabbit blood platelets. (edu.pk)
DLL-4, in turn, instigated neighbouring platelets to switch to 'activated' phenotype through cleavage of Notch receptor and release of its intracellular domain (NICD), which was averted by inhibition of γ-secretase and phosphatidylinositol-3-kinase (PI3K). (elifesciences.org)

We find that in response to vascular injury, thrombi initially develop through the progressive stabilization of discoid platelet aggregates. (nature.com)
Analysis of blood flow dynamics revealed that discoid platelets preferentially adhere in low-shear zones at the downstream face of forming thrombi, with stabilization of aggregates dependent on the dynamic restructuring of membrane tethers. (nature.com)
and the number of platelet-neutrophil aggregates increased significantly at 12 hours. (tamu.edu)
CONCLUSIONS AND CLINICAL RELEVANCE: In horses, concurrent increases in venous blood ET-1 immunoreactivity, insulin and glucose concentrations, and platelet-neutrophil aggregates support a role of endothelial dysfunction in the pathogenesis of CHO-induced laminitis. (tamu.edu)

The primary endpoint was assessment of platelet aggregation after stimulation with adenosine diphosphate 20 μM at 12-month follow-up. (revespcardiol.org)
Michal F, Motamed M. Shape change and aggregation of blood platelets: interaction between the effects of adenosine diphosphate, 5-hydroxytryptamine and adrenaline. (edu.pk)

Human platelets were loaded with aequorin, a Ca2(+)-sensitive photoprotein, and tested in the platelet-ionized calcium aggregometer for simultaneous recording of platelet aggregation and intraplatelet Ca2+ levels both in the presence and in the absence of autologous polymorphonuclear leukocytes. (nih.gov)
Hypersensitivity of diabetic human platelets to platelet activating factor. (edu.pk)
We demonstrate expression of Notch1, its ligand DLL-4 and their respective transcripts in human platelets. (elifesciences.org)

Pharmacologists, clinical laboratories, blood transfusion centres, manufacturing firms producing diagnostic instruments, and the pharmaceutical industry will also benefit. (iospress.com)
The key factors driving the market include growing prevalence of blood-related disorders, extensive usage of its components in several surgical procedures, rising number of transfusion procedures. (grandviewresearch.com)
In IgA-immunized patients, blood collected from IgA-deficient donors may be preferable for transfusion. (msdmanuals.com)
for exchange transfusions, for patients who require cytomegalovirus-negative blood that is unavailable, and possibly for the prevention of human leukocyte antigen (HLA) alloimmunization to help prevent refractoriness to platelet transfusion (failure to achieve the target level of blood platelets after platelet transfusion). (msdmanuals.com)
FFP can supplement RBCs when whole blood is unavailable for neonatal exchange transfusion. (msdmanuals.com)

Structural basis of the leukocyte integrin Mac-1 I-domain interactions with the platelet glycoprotein Ib. (nottingham.ac.uk)

or = 2.5 microM), significantly reduced their inhibitory effects on platelets. (uhi.ac.uk)
Platelet-leukocyte interaction could have physiopathological relevance and constitutes a new model for studying old and new platelet inhibitory drugs. (nih.gov)
Synergistic interaction and platelet inhibitory agents. (edu.pk)

Whole blood coagulation was studied by thromboelastography. (elifesciences.org)
During the process, increased platelet aggregation and coagulation. (msdmanuals.com)

Figure 1: Shear microgradients promote platelet aggregate formation in vivo . (nature.com)
Our results reveal substantial differences between murine and human whole-blood models infected with C. albicans and thereby demonstrate limitations in the translatability of this ex vivo model between hosts. (frontiersin.org)
In mice, as the most commonly used laboratory animal for in vivo experiments, the blood volume that can be withdrawn repeatedly is very limited and thereby hampers in depth analysis of interactions within blood. (frontiersin.org)
Therefore, we previously established an ex vivo human whole-blood infection model that allowed us to define which immune cells interact with the human fungal pathogen Candida albicans ( 4 ), to identify cross-talk between different components of the host response ( 5 ), and to detect substantial differences between related fungal pathogens ( 6 ). (frontiersin.org)
This study investigated the in vivo effect of alum on platelet aggregation and bleeding time in rabbits. (who.int)

The percentage aggregation response for each concentration of each agonist was calculated. (bmj.com)
Platelet reactivity differed significantly between the two groups of patients for each agonist. (bmj.com)

C-reactive protein is an antibody found in the blood in certain acute and chronic conditions including infections and cancers. (cdc.gov)

Bone marrow biopsy can reveal dyserythropoiesis, dysmorphic erythroblasts, and dysplastic platelets and megakaryocytes. (orpha.net)

The present study has extended previous observations about the probable mode of action of porcine tissue, to show that the addition of an aqueous fraction (AF) of homogenized porcine tissue to platelets causes prompt aggregation in vitro. (nebraska.edu)

Initial laboratory testing for a functional platelet disorder includes a CBC with platelet count and a peripheral smear. (arupconsult.com)
Peripheral blood smear shows abnormal erythrocyte size and shape as well as paucity of platelets. (orpha.net)
Platelets were the only peripheral blood cells that were significantly elevated in number in CAPs-exposed mice. (cdc.gov)

SjR,-Cold storage of platelet-rich plasma, platelet concen- platelet aggregation and reduced platelet viability.1-6 Nevertheless, although many centres now advise short-term storage of platelet concentrates and platelet-rich plasma at room temperature, whole blood is still stored refrigerated, partly because of the unknown effects of long term (up to 35 days) storage at room temperature and also to inhibit bacterial multiplication. (docksci.com)
citation needed] The abnormal platelet reaction following EDTA exposure is thought to be caused by a plasma factor, although not an immunoglobulin. (wikipedia.org)
Human platelet rich plasma was aggregated by the AF using standard turbidimetric techniques. (nebraska.edu)
When blood vessels are damaged by a cut or by other types of vascular injury, VWF in blood plasma binds to the site of damage and unravels to form long protein strings that specifically capture specialised blood cells (platelets) to the site of injury. (nottingham.ac.uk)
However, our understanding of how pathogens interact with cellular and humoral host factors in blood is limited, mainly due to technical issues: While it is relatively easy to study the interaction of pathogens with isolated blood cells, or their survival in serum or plasma, such approaches lack the complexity of interactions between different types of immune cells and additional factors, e.g., complement, present in blood. (frontiersin.org)
Butt IF, Aslam M, Khan FA, Ayub M. Plasma insulin and platelet functions in diabetes mellitus. (edu.pk)
Vanags DM, Rodgers SE, Duncan EM, Lloyd JV, Bochner F. Potentiation of ADP induced aggregation in human platelet-rich plasma by 5-hydroxytryptamine and adrenaline. (edu.pk)
Moreover, the increasing usage of plasma as life-saving therapeutics for numerous chronic and acute life-threatening diseases such as Hemophilia and Hereditary Angioedema in the biopharmaceutical and pharmaceutical industries is likely to boost the blood preparation market. (grandviewresearch.com)
L'agrégation plaquettaire induite par le collagène dans des échantillons de plasma riche en plaquettes de 14 lapins sains a été mesurée par turbidimétrie en utilisant un agrégomètre, avant et une heure après une injection intra- veineuse d'alun. (who.int)
Washed RBCs are free of almost all traces of plasma, most white blood cells, and platelets. (msdmanuals.com)
Fresh frozen plasma (FFP) is an unconcentrated source of all clotting factors without platelets. (msdmanuals.com)

The risk of complications is higher in elderly patients, rheumatoid arthritis sufferers, patients taking blood thinning medications ( anticoagulants such as Coumadin and heparin ) or prednisone (cortisone medication), and patients with heart disease or a prior history of bleeding ulcers. (medicinenet.com)

A study in the December 2003 Diabetes Care found that eating one to six grams of cinnamon daily significantly reduced blood sugar levels in people with type 2 diabetes. (sikhnet.com)
Apc Min/+ mice with the deletion of platelet COX-1 showed a significantly reduced number (67%) and size (32%) of tumors in the small intestine. (bvsalud.org)

Clinical Hemorheology and Microcirculation , a peer-reviewed international scientific journal, serves as an aid to understanding the flow properties of blood and the relationship to normal and abnormal physiology. (iospress.com)
aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs) are common causes of abnormal platelet function, and platelet function testing may need to be deferred if patients have been taking these medications. (arupconsult.com)

Cells were exposed to one of three chemotactic stimuli: platelet-activating factor (PAF), N-formyl-methionyl-leucyl-phenylalanine (FMLP), or leukotriene B4 (LTB4). (nih.gov)
The findings show how a crucial enzyme in our blood, known as ADAMTS13, works like a pair of molecular scissors to carefully cut back the clotting effects of a key protein, von Willebrand factor (VWF). (nottingham.ac.uk)
Production of platelet derived growth factor-like mitogen by smooth muscle cells from human atheroma. (edu.pk)
Functional platelet disorders are generally associated with immediate bleeding in response to surgery or trauma, whereas factor deficiencies are associated with delayed bleeding. (arupconsult.com)

Intercellular calcium communication regulates platelet aggregation and thrombus growth. (nature.com)
Ishii, Umeda F, Hashimoto T, Nawata H. Increased intracellular calcium mobilization in platelets from patients with type 2 (non-insulin dependent) diabetes mellitus. (edu.pk)

These results suggest that, by inhibiting procoagulant activities of platelets and endothelial cells, a 17 kDa PLA2 plays an important role in the anticoagulant action of M. ikaheka venom. (ox.ac.uk)
4. Experiments involving measurement of cyclic GMP levels, electrochemical detection of NO and electron paramagnetic resonance of haemoglobin in red blood cells, indicated that scavenging of NO generated from S-nitrosothiols by haemoglobin was responsible for the lack of effect of S-nitrosothiols on platelets in whole blood. (uhi.ac.uk)
It produces hormones that play a crucial role in the maturation of T-cells, which are a type of white blood cell involved in immune responses. (proprofs.com)
WBC-depleted RBCs (leukoreduced) are prepared with special filters that remove ≥ 99.99% of white blood cells. (msdmanuals.com)

1 Istituto di Ricerche Farmacologiche Mario Negri, Giulio Bizzozero Laboratory of Platelet and Leucocyte Pharmacology, Consorzio Mario Negri Sud, Santa Maria Imbaro, Italy. (nih.gov)
The Platelets : physiology and pharmacology / edited by Gesina L. Longenecker. (who.int)

Therefore, the present study explored the effects of M. ikaheka venom on platelets and endothelium, which are important components of the haemostatic mechanism. (ox.ac.uk)

Thus, Notch pathway can be a potential anti-platelet/anti-thrombotic therapeutic target. (elifesciences.org)

Intensive glucose control with insulin in patients with an acute coronary syndrome reduces platelet reactivity during hospitalization, compared to conventional control. (revespcardiol.org)
However, the effect of strict, long-term glucose control on platelet reactivity in these patients remains uncertain. (revespcardiol.org)
180 mg/dL), on platelet reactivity after hospital discharge in patients with an acute coronary syndrome and hyperglycemia. (revespcardiol.org)
We have demonstrated a significant reduction in platelet reactivity in patients with both pre-eclampsia and gestational hypertension compared to patients with uncomplicated pregnancies in the third trimester. (bmj.com)

These volunteers came to the laboratory once a week to consume pork prepared in various ways and to have their blood examined before and after eating it. (westonaprice.org)
Refer to the table, Laboratory Findings in Selected Inherited Functional Platelet Disorders , for additional information and a more comprehensive list of inherited functional platelet disorders. (arupconsult.com)
Laboratory testing for functional platelet disorders is appropriate in individuals with bleeding manifestations that suggest a functional platelet disorder (eg, easy bruising, prolonged bleeding following dental work or surgery, menorrhagia), particularly those with a family history of a bleeding disorder and in whom VWD has been previously excluded. (arupconsult.com)

Platelet-derived extracellular vesicles were documented with Nanoparticle Tracking Analyzer. (elifesciences.org)

Pseudo gray platelet syndrome was described by Cockbill, Burmester, and Heptinstall (1988) who reported a 25-year-old woman with a history of mild bruising and bleeding. (wikipedia.org)

We thus determine whether traditional preparation methods of pork affect the blood differently than the modern method of simply cooking fresh pork. (westonaprice.org)

Platelet aggregation at sites of vascular injury is essential for hemostasis and arterial thrombosis. (nature.com)

5. These studies suggest that scavenging of NO by haemoglobin in blood might limit the therapeutic application of S-nitrosothiols as anti-platelet agents. (uhi.ac.uk)

GPVI-Fc alone or in combination with ASA or ticagrelor did not increase closure time measured by the platelet function analyzer (PFA)-200. (thieme-connect.com)

Platelets alone aggregated and showed intracellular Ca2+ movement only when exposed to PAF. (nih.gov)

If a patient is thought to have carcinoid syndrome, blood and urine tests must be performed to determine levels of bioactive substances secreted by carcinoid tumors. (medscape.com)

platelet-neutrophil aggregation, and concentrations of nitric oxide, insulin, and glucose in blood obtained from horses following carbohydrate overload. (tamu.edu)
PROCEDURES: Digital and jugular venous blood samples were collected at 1-hour intervals (for assessment of endothelin-1 [ET-1] immunoreactivity and measurement of glucose, insulin, and nitric oxide [NO] concentrations) or 4-hour intervals (CBC and platelet-neutrophil aggregate assessment) for 8 hours or 16 hours after induction of CHO-associated laminitis in horses treated with an ET-1 antagonist. (tamu.edu)
This process is important in maintaining blood glucose levels during periods of fasting or stress. (proprofs.com)

Uncoagulable blood and life-threatening bleeding can result from the action of some snake venom toxins on haemostatic components of blood and vessel walls. (ox.ac.uk)
NSAIDs can close the fetal ductus arteriosus, a vital blood vessel that supports blood flow to the placenta. (medicalnewstoday.com)

These findings provide insight into the prothrombotic effects of disturbed blood flow parameters and suggest a fundamental reinterpretation of the mechanisms driving platelet aggregation and thrombus growth. (nature.com)

Cell-free supernatants prepared from FMLP-stimulated leukocytes were able to induce platelet aggregation, thromboxane B2 generation, and Ca2+ mobilization, although at a reduced degree as compared with intact leukocyte addition. (nih.gov)

3. Neither compound inhibited aggregation in whole blood, even at concentrations of 100 microM. (uhi.ac.uk)

Flow cytometric analysis of unstimulated platelets from CAPs-exposed mice indicated size and shape changes, and platelets from CAPs-exposed animals had a 54% increase in fibrinogen binding indicative of platelet priming. (cdc.gov)

Addition of PAR-1 antiplatelet drugs may be most effective in patients with reduced clopidogrel response and high residual TRAP mediated platelet aggregation. (nih.gov)

We aimed to elucidate the role of platelet COX-1 (the target of low-dose aspirin in humans) in intestinal tumorigenesis of Apc Min/+ mice, considered a clinically relevant model. (bvsalud.org)

How do functional platelet disorders manifest clinically? (arupconsult.com)
The clinical features of functional platelet disorders vary. (arupconsult.com)
rarely, it may be observed in functional platelet disorders). (arupconsult.com)
What are some causes of acquired functional platelet disorders? (arupconsult.com)
Which functional platelet disorders are inherited? (arupconsult.com)

For human blood, opsonization was shown to decrease platelet interaction suggesting that complement factors interfere with fungus-to-platelet binding. (frontiersin.org)

Figure 4: The magnitude and spatial distribution of the shear microgradient directly affects platelet aggregate size. (nature.com)

The study will involve one additional blood test to determine the pharmacogenomic profile for clopidogrel metabolism. (who.int)

Existence of functional Notch signaling in enucleate platelets remains elusive. (elifesciences.org)
It is important to rule out acquired conditions during an evaluation for a functional platelet disorder. (arupconsult.com)

Figure 5: Stabilized discoid platelet aggregation occurs via restructuring of membrane tethers. (nature.com)
Angina is chest pain or discomfort that occurs if an area of your heart muscle doesn't get enough oxygen-rich blood. (cdc.gov)
Furthermore, if bacteremia or fungemia occurs transiently or intermittingly, pathogens might not be detectable in every blood sample during hematogenous dissemination ( 3 ). (frontiersin.org)

Acute myocardial infarction results from a blockage in one or more of the blood vessels leading to the heart. (cdc.gov)
Arteries are blood vessels that carry oxygen-rich blood to your heart and other parts of your body. (cdc.gov)
Blood Pressure is the force of blood on the inside walls of blood vessels, measured by analyzing both the systolic blood pressure, the pressure when the heart pushes blood out into the arteries (systole), and the diastolic blood pressure, when the heart is at rest (diastole). (cdc.gov)
Diseases relating to the heart and the blood vessels or the circulation. (cdc.gov)
The active ingredient in ginger is gingerol, a compound that's thought to relax blood vessels, stimulate blood flow and relieve pain. (sikhnet.com)
The rapidly expanding science of hemorheology concerns blood, its components and the blood vessels with which blood interacts. (iospress.com)
Bleeding time is a medical test that measures how fast small blood vessels in the skin stop bleeding. (medlineplus.gov)
Dissemination of pathogens from a primary site of colonization or infection can occur via different routes, including lymphatic vessels and the blood stream ( 1 ). (frontiersin.org)
The hypophyseal portal system consists of a network of blood vessels that connect the hypothalamus and the anterior pituitary gland, enabling the hormones to reach their target organ more efficiently. (proprofs.com)

Increasing quartiles of 20 μM ADP induced platelet aggregation after clopidogrel loading were associated with increasing levels of TRAP mediated platelet aggregation. (nih.gov)
Non-responders to clopidogrel show increased residual platelet aggregation induced by TRAP, whereas clopidogrel responders exhibit attenuated response to TRAP. (nih.gov)

Aggregation and intraplatelet Ca2+ mobilization were also observed in the presence of leukocytes activated by either FMLP or LTB4. (nih.gov)

Platelet-dependent neutrophil function is dysregulated by M protein from Streptococcus pyogenes. (lu.se)

Anatomy2

Organisms1

Diseases3

Chemicals and Drugs23

Analytical, Diagnostic and Therapeutic Techniques and Equipment5

Phenomena and Processes9

Thrombus formation4

Inhibitors1

Inhibition of platelet aggregation2

Thrombocytopenia5

Flow cytometry4

Adhesion8

Agonists13

Activation11

Collagen9

Neutrophils1

Thrombin5

Receptor4

Aggregates4

Adenosine Diphosphate2

Human platelets3

Transfusion5

Glycoprotein1

Inhibitory3

Coagulation2

Vivo5

Agonist2

Antibody1

Megakaryocytes1

Vitro1

Peripheral3

Plasma11

Anticoagulants1

Significantly reduced2

Abnormal2

Factor4

Calcium2

Cells4

Pharmacology2

Mechanism1

Anti-thrombotic1

Reactivity4

Laboratory3

Extracellular1

19881

Methods1

Arterial thrombosis1

Therapeutic1

Analyzer1

Intracellular1

Substances1

Glucose3

Vessel2

Findings1

Leukocyte1

Concentrations1

Fibrinogen1

Drugs1

Humans1

Disorders5

Interaction1

Aggregate1

Metabolism1

Functional2

Occurs3

Vessels9

TRAP2

Mobilization1

Neutrophil1