It is very similar to the human roundworm parasite Trichuris trichiura due to its immunological reactivity when crossed, and so is often used in related studies. (wikipedia.org)
The parasite in this case is the whipworm , aka Trichuris trichiura . (medscape.com)
The human whipworm Trichuris trichiura infects 289 million people worldwide, resulting in substantial morbidity. (ui.ac.id)
Here, we used a combined 16S rRNA gene OTU analysis approach (QIIME2) for samples from humans and mice infected with whipworm (T. trichiura and T. muris, respectively) to identify for the first time, bacterial taxa that were consistently associated with whipworm infection spanning host species and infection status using four independent comparisons (baseline infected vs uninfected and before vs after deworming for both humans and mice). (ui.ac.id)
Infection7
This study aims to examine the ability of SOCS3 to regulate IEC turnover in an in vivo murine model of T. muris infection. (lancs.ac.uk)
Mice with and without IEC SOCS3 conditional knockdown were infected with T. muris and intestinal tissue examined at 3, 14, 21 and 35 days after infection. (lancs.ac.uk)
Results: SOCS3 mRNA was increased in the intestine of mice susceptible to T. muris infection compared to resistant mice both prior to infection and at 14 days following infection. (lancs.ac.uk)
Lack of IEC SOCS3 may promote resistance to T. muris infection. (lancs.ac.uk)
We will identify the in vivo function of the intestinal macrophage by analysing (1) the reparative processes in the gut post T. muris infection, (2) the response to second infection and (3) the response to an inflammatory driver (DSS), in the presence of absence of the intestinal macrophage. (ukri.org)
Interactions between whipworm and its host's intestinal microbiome present a potential novel target for infection control or prevention but are very complicated and are identified using inconsistent methodology and sample types across the literature, limiting their potential usefulness. (ui.ac.id)
Overall, the novel cross-species analysis approach utilized here provides a valuable research tool for studies of the interaction between whipworm infection and the host intestinal microbiome. (ui.ac.id)
Parasite2
T. muris has a direct life cycle and nonmobile free stage: if these traits constrain the parasite to an intimate association with its host we expect a geographic break in the parasite genetic structure across the HMHZ. (nih.gov)
Trichuris muris is a nematode parasite of mice. (wikipedia.org)
Intestinal4
Trichuris muris relies on direct contact with intestinal bacteria to promote hatching of the embryonated eggs. (wikipedia.org)
The activation of type 2 helper cells (Th2) is decreased in the presence of antibiotics because fewer whipworms bind to the intestinal walls. (wikipedia.org)
Background: Intestinal epithelial cell (IEC) turnover has been implicated in the expulsion of and resistance to intestinal pathogens, including the murine whipworm Trichuris muris. (lancs.ac.uk)
We demonstrate the applicability of a mouse animal model for comparison to human whipworm infections with respect to whipworm-induced intestinal microbiome disruption and subsequent restoration following deworming. (ui.ac.id)
Nematode1
Here we systematically compare the in vitro efficacy of all major anthelmintic classes currently used in human therapy (benzimidazoles, nicotinic acetylcholine receptor agonists, macrocyclic lactones, nitazoxanide) against species closely related to human parasitic nematodes-Ancylostoma ceylanicum, Trichurismuris, and Ascarissuum--- as well as a rodent parasitic nematode used in veterinary drug discovery, Heligmosomoidesbakeri, and the free-living nematode Caenorhabditis elegans. (nih.gov)
Necator1
These parasites, which include two hookworm species, Ancylostomaduodenale and Necator americanus, the whipworm Trichuristrichiura, and the large roundworm Ascarislumbricoides, infect upwards of two billion people and are a major cause of disease burden in children and pregnant women. (nih.gov)
Species1
And, as with almost everything else, the researchers turned to mice, which were introduced to a closely related species, Trichuris muris . (medscape.com)
Mice1
Methods: SOCS3 expression was examined in the intestine of T. muris resistant or susceptible mice by immunohistochemistry and real-time PCR. (lancs.ac.uk)
Taxa3
To test whether the whipworm, Trichuris muris, is intimately associated with its house mouse host, we studied its population genetics across the European house mouse hybrid zone (HMHZ) which has a strong central barrier to gene flow between mouse taxa. (nih.gov)
Using these four comparisons, we identified significant positive associations for seven taxa including Escherichia, which has been identified to induce whipworm egg hatching, and Bacteroides, which has previously been identified as a major component of the whipworm internal microbiome. (ui.ac.id)
We additionally identified significant negative associations for five taxa including four members of the order Clostridiales, two from the family Lachnospiraceae, including Blautia which was previously identified as positively associated with whipworm in independent human and mouse studies. (ui.ac.id)
Vivo1
We use Trichuris muris in the mouse, as an in vivo model of resolving gut inflammation. (ukri.org)
Significant1
The relationship between T. muris and bacteria also has a significant effect on the host's immune response. (wikipedia.org)