Wherein proteinaceous residues protein residues. Medical search. Frequent questions

The invention relates generally to antibodies engineered with reactive cysteine residues and more specifically to antibodies with therapeutic or diagnostic applications. (justia.com)
2-Cys Prx enzymes are homodimeric and contain two conserved (C P and C R ) cysteine residues per subunit. (molcells.org)
All of the cysteine residues are found as disulfides in ESM. (udel.edu)

In the last four decades, toxinologists around the world have elucidated a wealth of information on the various classes of constituent proteins and peptides that provide each cone with its own distinctive, complex, and sophisticated bioarmamentarium. (medscape.com)
An increasing number of three-dimensional virus structures known to atomic resolution paved the way for derivatization of VBNPs with dyes, metals, peptides, proteins, and small molecules and is being explored for generating novel nanomaterials. (biomedcentral.com)
While we could place a number of these peptides within proteins that had already been identified, there were many cysteine-rich peptides that traced to fragments of avian nucleic acid sequences that have yet to find their proper place in the chicken genome. (udel.edu)

The framework of ～12nm MSP1E2 was modeled predicated on Rutaecarpine (Rutecarpine) crystal framework … If fusion skin pores can't be lipidic as concluded from the tiny nanodisc size they might be formed by proteins transmembrane domains as an ion route or space junction pore. (biotech2012.org)
Two v-SNAREs are too few to form a proteinaceous pore lined by Syb2 TM domains (which would require at least 3 TM domains) and the query arises how can a fusion pore become formed that is neither lipidic nor created by a protein transmembrane channel. (biotech2012.org)
A recent cryo-EM study involving four individuals with FTLD-TDP types A-D in the absence of ALS did not find amyloid filaments of TDP-43 and reported that filaments of transmembrane protein 106B (TMEM106B) characterize FTLD-TDP instead21. (lafurnitura.com)
A large pore is formed by transmembrane proteins. (tcdb.org)
however, the hydrophobic nature of the transmembrane domain (TMD) of the protein has resulted in difficulties in crystallization. (uky.edu)
Although initially thought to be solely a membrane anchor, the transmembrane domains of several viruses have been shown to be important for the functionality of fusion proteins. (uky.edu)

The carboxy-terminal part comprises an intrinsically disordered low-complexity domain (LCD), which contains regions enriched in glycine, hydrophobic residues, and glutamine and asparagine (Q/N). The DIX domain, RRMs and LCD all contribute to the association of TDP-43 with ribonucleoprotein granules and RNA10,11. (lafurnitura.com)

2011) addresses two of these aspects, the translocation of soluble proteins into the peroxisomal matrix and the biogenesis of the peroxisomal membrane. (tcdb.org)

Further, we identified a single pore-lining residue mutation that confers the same phenotype as substitution of the full EutM protein, indicating that small molecule diffusion through the shell is the cause of growth enhancement. (northwestern.edu)
This study highlights the use of two strategies to engineer microcompartments to control metabolite transport: altering the existing shell protein pore via mutation of the pore-lining residues, and generating chimeras using shell proteins with the desired pores. (northwestern.edu)
of neurotransmitters occurs by starting of the fusion pore thought be formed by action of SNARE protein if the fusion pore is a lipidic or proteinaceous structure is controversial. (biotech2012.org)
When reconstituted into liposomes these protein represent a minor equipment that promotes fusion 2-4 which includes resulted in the hypothesis how the SNARE proteins open up the fusion pore which allows vesicular material to become released into extracellular space. (biotech2012.org)
It isn't known just how many SNARE complexes take part in fusion pore development 6 and if the fusion pore route can be lipidic 7 proteinaceous 8 or of proteolipid structure 9. (biotech2012.org)
Residue locations that are labeled are accessible from your aqueous phase and collection the ion channel pore. (biotech2012.org)
Rutaecarpine (Rutecarpine) They find that Syb2 TM website mutants V101C I105C and I109C are labeled in the presence of t-SNARE liposomes but not in their absence and conclude that during fusion these residues are accessible and therefore collection the fusion pore. (biotech2012.org)
The likely solution is that the fusion pore must be of a hybrid composition incorporating protein as well as lipids and that both SNARE TM domains Rutaecarpine (Rutecarpine) and lipids collection the pore. (biotech2012.org)
Intrinsically disordered regions in Pex13 and Pex5 resemble those found in nuclear pore complex proteins. (tcdb.org)

These proteins are unstable when submitted to heat, and can be removed by treatment using bentonite, a process that contributes to the clarification and stabilization of wine. (wikipedia.org)

Those proteins have been identified by mass spectrometry and originate from grape, yeast, bacteria and fungi. (wikipedia.org)
To solubilize aggregates comprised of a diverse range of amyloid and amyloid-like species, we have developed engineered variants of Hsp104, a hexameric AAA+ protein disaggregase from yeast. (wustl.edu)
However, production of VLPs in adequate quantities has been achieved by expression of virus capsid proteins in heterologous systems (insect cells, yeast, and bacteria). (biomedcentral.com)
In the budding yeast Saccharomyces cerevisiae , the minimal transport machinery includes the membrane proteins Pex13 and Pex14 and the cargo-protein-binding transport receptor, Pex5. (tcdb.org)

Most peroxisomal membrane proteins do not have PTS1 or PTS2, and insertion requires several peroxins distinct from those required for import of soluble matrix proteins. (tcdb.org)
The matrix proteins of many enveloped viruses have been shown to associate in high order oligomers to form a grid- like array underneath the plasma membrane, where they can induce membrane curvature to allow for the budding of viral particles. (uky.edu)
One of these newly uncovered roles for viral matrix proteins involves the regulation of viral RNA synthesis. (uky.edu)

Their unique hourglass-shaped architecture is highly conserved among different bacterial membrane proteins and other biological channels. (ibecbarcelona.eu)
2011 ) have reviewed the processes by which matrix and membrane proteins are incorporated into the peroxysome. (tcdb.org)

Indeed, within the pyrenoids of eukaryotic algae, the functional homologues of carboxysomes, Rubisco adopts a liquid-like state by interacting with the intrinsically disordered protein EPYC1 14 . (nature.com)

Hsp40/DNAJ proteins interact differently with Hsp70 chaperones [ 13 ] . (encyclopedia.pub)

Interestingly, these variable regions determine the differential effects of Hsp70 isoforms on the aggregation or degradation of the Alzheimer's-disease-related protein tau [ 16 ] . (encyclopedia.pub)
Using this system, we probed the molecular drivers of PSMα aggregation to delineate key similarities and differences among the PSMs and identified a crucial residue that drives PSM features. (wustl.edu)
It is a chronic neurodegenerative disease caused by defected folding and aggregation of amyloid beta (Aβ) protein. (biomedcentral.com)
The major pathological hallmarks of AD include widespread neuronal and synaptic loss, excessive presence of astrocytes, and aggregation of multiple proteinaceous deposits for instance β-amyloid plaques and neurofibrillary tangles (NFT) [ 2 ]. (biomedcentral.com)

Bacteriocins are ribosomally synthesized proteinaceous compounds produced by bacteria to protect themselves as well as to competitively colonize in the gut through elimination of undesirable organisms. (researchsquare.com)
Lanthipeptides are a group of therapeutically relevant proteinaceous compounds predominantly produced by Gram-positive bacteria at the ribosomal level, containing thioether cross-linked amino acids called lanthionine as a characteristic structural element. (tu-berlin.de)

C-terminal PTS1 [(SAC)-(KRH)-(LM)] and N-terminal PTS2 [(RK)-(LIV)-X 5 -(HQ)-(LA)] targeting sequences are recognized by Pex5p and Pex7p, respectively, which may shuttle with the substrate protein to the peroxisomal lumen. (tcdb.org)

Biopolymers, such as proteins, DNA, and polysaccharides, which are available in almost unlimited quantity in nature, as well as many synthetic polymers, which are industrially produced on a large scale, belong to this fascinating class of polymers. (mdpi.com)
Using cryo-histochemistry as well as infrared and sum frequency generation spectroscopy on the mucus of two arboreal ( H. cinerea and Osteopilus septentrionalis ) and of two terrestrial, non-climbing frog species ( Pyxicephalus adspersus and Ceratophrys cranwelli ), we find neutral and acidic polysaccharides, and indications for proteinaceous and lipid-like mucus components. (biomedcentral.com)

Hsp70, Hsp90, and their co-chaperones are crucial members of the proteostasis network that are able to recognize misfolded proteins, aberrant condensates and protein aggregates, triaging proteins for refolding or degradation. (encyclopedia.pub)
Indeed, Hsp70, Hsp90 and their co-chaperones are increasingly recognized as therapeutic targets for the development of treatments against prevalent protein misfolding diseases. (encyclopedia.pub)
Hop (Hsp-organizing protein) promotes the transfer of the substrate from the Hsp70 machinery to Hsp90. (encyclopedia.pub)

The in vitro starch digestion (hydrolytic index, HI) of pea (Pisum sativum) and mixtures of pea starch with different pea protein isolates and fiber has been investigated to learn about the involvement of anti-nutrients for the digestibility of legume starches. (dtu.dk)

Nile tilapia was enzymatically hydrolyzed by several commercially available proteases (Alcalase 2.4 L, Neutrase and Flavourzyme), with protein recovery of 89.86, 81.92 and 73.12%, respectively. (scialert.net)

Bacterial microcompartments are a class of proteinaceous organelles comprising a characteristic protein shell enclosing a set of enzymes. (northwestern.edu)
The C P residue is conserved in all Prx enzymes. (molcells.org)

High alkaline low-foaming detergent for challenging residues, adherent sticky waxes and oils, insoluble complexes. (saintifikpertama.com.my)
The peroxisomal protein import machinery, which shares similarities with chloroplasts, is unique in transporting folded and large (up to 10 nm in diameter) protein complexes into peroxisomes. (tcdb.org)

TAR DNA-binding protein 43 (TDP-43) is a ubiquitously expressed RNA-binding protein with diverse roles in RNA processing. (lafurnitura.com)
We found that the (L/I) zipper plays important roles in functionality of the PIV5 F protein, but not surface expression of the protein. (uky.edu)
In the life cycle of NNS viruses, viral proteins assume multi-functional roles to optimize their replication and spread. (uky.edu)
One of the key players during the course of infection is the matrix protein (M). The matrix protein has been identified as a master regulator of viral infection with most studies focusing on its roles in late-stage infection, during assembly and budding of viral progeny. (uky.edu)
Interestingly, some recent studies show that the matrix protein has other critical roles in viral infection such as immune modulation and host cell translation antagonism. (uky.edu)

More than half of world s population depends on fish as a principal source of animal protein ( Jhingram, 1987 ). (scialert.net)
Researchers have reported that protein solubility has a close relationship with emulsifying properties ( Quaglia and Orban, 1990 ) and foaming properties ( Quaglia and Orban, 1987 , 1990 ). (scialert.net)

Agglomeration, loss, unwanted residues affect the quality and clarity of particle imaging with obvious repercussions on the reliability and reproducibility of the morphological analysis. (billilab.info)
TSEs are caused by a transmissible proteinaceous particle, which is yet to be fully characterized. (medscape.com)

Tilapia fish is nutritious and forms a healthy part of a balanced diet that is high in protein (16-25%), low in fat (0.5-3.0%) and substitutes well in any seafood recipe. (scialert.net)
In terms of its structure, chitin is associated with proteins and, therefore, high in protein contents. (ukessays.com)

Drug moieties used in antibody drug conjugates include bacterial protein toxins such as diphtheria toxin, plant protein toxins such as ricin, small molecules such as auristatins, geldanamycin (Mandler et al (2000) J. of the Nat. (justia.com)
Towards this goal, CPV virus-like particles (VLPs) produced by expression of the CPV-VP2 capsid protein in a baculovirus expression system were examined for attachment of small molecules and delivery to tumor cells. (biomedcentral.com)

We found that the ethanolamine utilization (Eut) protein EutM properly incorporates into the 1,2-propanediol utilization (Pdu) microcompartment, altering native metabolite accumulation and the resulting growth on 1,2-propanediol as the sole carbon source. (northwestern.edu)
Utilization of Food and Agricultural Residues for a Flexible Biogas Production: Process Stability and Effects on Needed Biogas Storage Capacities. (boku.ac.at)

For example, an inefficient and/or incomplete digestion of the proteinaceous content can lead to agglomeration or loss of particles. (billilab.info)
Incomplete cleaning of proteinaceous organic substances contaminated on medical devices has a protective effect on microorganisms and may easily cause sterilization failure. (sodium-hypochloritegenerator.com)

99% reduction in soil parameters (i.e., protein, carbohydrate, hemoglobin) in the ported and nonported laparoscopic devices. (cdc.gov)
Following observations in endoscopy units, we evaluated some factors influencing protein adsorption inside luminal endoscope channels and the action of current initial cleaning techniques using a proteinaceous test soil and very sensitive fluorescence epimicroscopy. (soton.ac.uk)
Findings: Disposable endoscope accessories appeared likely to contribute to the contamination of lumens and were useful indicators of the amount of proteinaceous soil transiting through the channels of luminal endoscopes. (soton.ac.uk)
Heavily soiled items, especially if the soil is of a proteinaceous nature, should be autoclaved longer because soil may protect the microorganism from the lethal effects of wet heat. (missouri.edu)

Airway epithelial loss, patchy alveolar damage, proteinaceous exudates, and inflammatory cells within alveolar walls were observed in animals exposed to 800 ppm Cl2. (cdc.gov)
The immune tolerance to such citrullinated protein can be lost, leading to inflammatory and autoimmune diseases. (usf.edu)

Wine chemistry Protein adsorption in the food industry Pocock, K. F. (wikipedia.org)

Upon being signaled, the fusion protein undergoes dramatic essentially irreversible conformational changes for membrane mixing. (uky.edu)

The molecular approach of using Geneious Prime software and protein prediction data base for characterization of bacteriocin is novel and predicts " KSSAYSLQMGATAIKQVKKLFKKWGW " as peptide responsible for antimicrobial activity. (researchsquare.com)
Our results show that RumM catalyzed the introduction of dehydroamino acids into the core peptide of preRumA and subsequently conjugated the dehydrated residues with cysteine to generate thioether bridges. (tu-berlin.de)
Results here demonstrate that fusing a larger protein carrier to the N-terminus of the leader peptide does not necessarily obstruct in vivo processivity of the lanthionine-generating enzyme in modifying its substrate. (tu-berlin.de)
Thus, the principle of protein or peptide haptenation could be used in in vitro assays to predict the sensitization potential of a new chemical entity. (cdc.gov)

Moreover particles of small dimension (few nanometers) can easily bind to proteins, stick to the wall of tubes or flushed away through the pores of filters. (billilab.info)

The production of amyloid beta (Aβ) takes place by the proteolytic cleavage of beta-secretase protein on amyloid precursor protein (APP) whereas in AD, a pathogenic mutations affects the protease cleavage sites in APP and aid its cleavage [ 5 ]. (biomedcentral.com)

Anschließend erfolgte die heterologe Expression und rekombinante Produktion des Proteins und einiger davon abgeleiteten Varianten in E. coli. (uni-bayreuth.de)
As a start, we have expressed four consecutive abab modules in Escherichia coli and find that the resulting 8-disulfide protein is well behaved and highly structured. (udel.edu)
Known hypersensitivity to E coli -derived proteins, Kineret, or to any component of the product. (drugs.com)

The basis of hapten- molecular mechanisms of the sensitization pro- protein binding work is the hypothesis that upon cess will result in novel opportunities for the skin absorption, only protein-reactive chemicals development of alternative methods for assessing (or those that can be metabolically or chemically skin sensitization hazard and relative potency of converted to protein-reactive species) are able to chemicals. (cdc.gov)

In a quantitative analysis of residual protein contamination of reprocessed surgical instruments, median levels of residual protein contamination per instrument for five trays were 267, 260, 163, 456, and 756 µg 458 . (cdc.gov)
Aim: We intended to evaluate the potential protein deposition and removal in the channels of flexible luminal endoscopes during a simple contamination/ cleaning cycle. (soton.ac.uk)
Enzymatic cleaning according to the manufacturer's recommendations and brushing of the channels were ineffective at removing all proteinaceous residues from new endoscope channels after a single contamination. (soton.ac.uk)

The long term goal of our research is to elucidate the molecular mechanisms by which proteins are targeted to specific and distinct compartments. (stanford.edu)

The substrate binding cleft of AMY1 is composed of two aglycone and seven glycone binding subsites, of which subsite -6 (key residue: Y105) is characterized by having the highest binding affinity and being situated at the opposite end of the enzyme molecule of SBS2 at a distance of 60 Å. (dtu.dk)

In this article, we analyze some of the currently available data on the structural properties of human PADs, the mechanisms of their calcium-induced activation, and show that these proteins contain functionally important regions of intrinsic disorder. (usf.edu)
In this review, we consider some of the theoretical aspects of protein haptenation, how mechanisms of protein haptenation can be investigated experimentally and how we can use such knowledge in the development of novel, alternative approaches for predicting skin sensitization potential in the future. (cdc.gov)

Some cytotoxic drugs tend to be inactive or less active when conjugated to large antibodies or protein receptor ligands. (justia.com)

The CDRs of V H and V L are held in close proximity by the FRs, and amino acid residues within the CDRs bind the antigen. (justia.com)
Here we define the precise Rab29 binding region of the LRRK2 Armadillo domain between residues 360-450 and show that this domain, termed 'Site #1', can also bind additional LRRK2 substrates, Rab8A and Rab10. (stanford.edu)

All the estimated nutritional parameters based on amino acids composition suggested that Nile tilapia protein hydrolysates and concentrates have good nutritional quality and could be used as protein ingredient in food industries. (scialert.net)
The Aβ are mainly divided into two isoforms, based upon the length of amino acids, Aβ of 40 amino acid residues (Aβ40) and Aβ of 42 amino acid residues (Aβ42) are the two isoforms. (biomedcentral.com)

Background: The presence and potential build up of patient material such as proteins in endoscope lumens can have significant implications, including toxic reactions, device damage, inadequate disinfection/sterilisation, increased risk of biofilm development and potential transmission of pathogens. (soton.ac.uk)

Generally, the shell of selected crustacean was reported by Knorr (1984) to consist of 30-40% protein, 30-50% calcium carbonate and calcium phosphate, and 20-30% chitin. (ukessays.com)
Chitin fibrils are embedded in a matrix of calcium carbonate and protein. (ukessays.com)

The experts at Alconox formulate all cleaners to be biodegradable, readily disposable, and free rinsing to leave no interfering residues. (saintifikpertama.com.my)

For most NNS RNA viruses, the attachment protein is important for the tethering of a viral membrane to host cells, while the fusion protein is responsible for the membrane merger of the virus and host. (uky.edu)
The fusion protein of paramyxo-and pneumovirus proteins are class I proteins that are folded into trimers, must be proteolytically cleaved to be functional, and are held in a metastable prefusion conformation until the signal for fusion occurs. (uky.edu)
The L/I zipper was found to be present in 140 paramyxo- and pneumovirus fusion protein TMDs. (uky.edu)
This was achieved with preRumA expressed as a chimeric fusion protein together with GFP. (tu-berlin.de)

The high amount of anti-nutritional factors (phytate, proteinaceous inhibitors, tannins, and lectins) in legumes has been associated with the slow starch digestion. (dtu.dk)

Increased inducible nitric oxide synthase expression and oxidation of lung proteins were observed. (cdc.gov)
Mutations to this L/I zipper motif in the context of the full protein resulted in reduced surface expression, and a loss of functionality. (uky.edu)

Many species of tilapia have been cultured in developing countries, where animal protein is lacking. (scialert.net)

So it is particularly striking that the protein composition of these fibers is still unknown! (udel.edu)

Guided by these determinations, the antibody is accordingly modified (altered) to improve upon, e.g., antibody/antigen binding by modifying at least one amino acid residue to decrease the binding free energy between the antibody and antigen when bound in a solvent. (justia.com)

Protein functional properties are determined to a large extent by a protein s physicochemical and structural properties ( Diniz and Martin, 1997 ). (scialert.net)

Yet, some RNA strands can also fold to form ribozymes, 3D structures that could have guided life's chemical processes the way proteins do now. (elifesciences.org)

Y105A/Y380A and Y105A/Y380M showed decreased activity (kcat) on amylose, reminiscent of single SBS2 mutant proteins, Y380A and Y380M, and KM increased approx. (dtu.dk)

One of the key molecular events in skin sensitization is protein haptenation, i.e. the chemical modification of self-skin protein(s) thus forming macromolecular immunogens. (cdc.gov)

Deciphering protein–protein interactions. (crossref.org)

SBS1 (key residues: W278 and W279) and SBS2 (key residues: Y380 and H395) along with the high affinity subsite -6 have been studied individually by site-directed mutagenesis the joint role, however, of SBS1, SBS2 and subsite -6 is still unknown. (dtu.dk)

Phenol-soluble modulins (PSMs) are the primary proteinaceous component of Staphylococcus aureus biofilms. (wustl.edu)

Anatomy10

Organisms11

Chemicals and Drugs105

Analytical, Diagnostic and Therapeutic Techniques and Equipment47

Phenomena and Processes81

Disciplines and Occupations3

Technology, Industry, Agriculture1

Information Science10

Health Care4

Cysteine residues3

Peptides3

Transmembrane6

Hydrophobic1

Soluble Proteins1

Pore9

Stabilization1

Yeast4

Matrix proteins3

Membrane proteins2

Intrinsically disordered protein1

DNAJ1

Aggregation4

Compounds2

Sequences1

Polysaccharides2

Hsp703

Isolates1

Proteases1

Enzymes2

Complexes2

Roles5

19872

Particle2

High in protein2

Small molecules2

Utilization2

Incomplete2

Soil4

Inflammatory2

Adsorption1

Conformational1

Peptide4

Pores1

Amyloid1

Coli3

Hypothesis1

Contamination3

Molecular mechanisms1

Substrate1

Mechanisms2

Receptor1

Bind2

Amino acids2

Toxic1

Chitin2

Disposable1

Fusion protein4

Starch1

Expression2

Species1

Composition1

Decrease1

Structural1

Processes1

Single1

Chemical1

Interactions1

Affinity1

Component1