TripletsFetal MortalityQuintupletsMultiple Birth OffspringGestational AgeMaternal AgeInfant, NewbornPregnancyLoop of HenleMolecular Sequence DataModels, MolecularAmino Acid SequenceProtein Structure, SecondaryFeedback, PhysiologicalProtein Structure, TertiaryNucleic Acid ConformationBinding SitesMutagenesis, Site-DirectedProtein BindingCrystallography, X-RayBase SequenceBlind Loop SyndromeMutationSequence Homology, Amino AcidStructure-Activity RelationshipKineticsEscherichia coliAmino Acid SubstitutionSequence AlignmentFeedbackCatalytic Domain