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  • cleavage
  • WIDER IMPLICATIONS OF THE FINDINGS: Our results provide functional data that can help explain the high aneuploidy rates seen in human cleavage-stage embryos and suggest that this is due to their unusual cell cycle control. (vub.be)
  • time-lapse
  • PARTICIPANT/MATERIALS, SETTING, METHODS: We cultured human preimplantation embryos overnight in a time-lapse imaging system, in control or in a nocodazole-containing medium that prevents the formation of a proper mitotic spindle. (vub.be)
  • cells
  • The FISH data suggest that in compacted Day-4 embryos, approximately one in six cells started a polyploid new cell cycle rather than to go in apoptosis after the failure to maintain the SAC-mediated M-phase arrest. (vub.be)
  • placenta
  • 1 ] is that on further study, it became evident that one of the X-linked genes, Rhox5 / Pem (reproductive homeobox 5/placenta and embryos gene), was apparently being expressed in females preferentially from their paternal X chromosome, which is preferentially inactivated in the preimplantation embryo. (biomedcentral.com)
  • It is proposed that human decidua contains a population of stem cells that are responsible for the proliferation ability during the process of embryo implantation and placenta formation and that factors in the crosstalk between the decidua and chorion may mediate decidual stem cell. (ebscohost.com)
  • However, Ms van den Berg and her colleagues have now found the first evidence that XCI does occur in pre-implantation embryos, indicating that this mechanism of compensating for gene dosages has remained basically unchanged throughout evolution and is probably the same in all mammals that have their young attached to a placenta in the womb "" from mice to humans. (redorbit.com)
  • stem cell res
  • Ms Ilse van den Berg told the 25th annual meeting of the European Society of Human Reproduction and Embryology in Amsterdam today (Monday) that her findings may have implications for the laboratory cultures that embryos are grown in before transfer to a woman's womb during fertility treatment, as well as for embryo stem cell research. (redorbit.com)
  • modulate
  • To this end naturally fertilized embryos were cultured in vitro to blastocyst in the presence or absence of myo-Ins and analyzed for activation of the PKB/Akt pathway, known to modulate proliferation/survival cellular processes. (hindawi.com)
  • bovine
  • In vitro production of embryos alters levels of insulin-like growth factor-II messenger ribonucleic acid in bovine fetuses 63 days after transfer. (publish.csiro.au)
  • survival
  • As a result of our finding that XCI occurs at the pre-implantation stage, further research should be able to clarify whether culture conditions in the laboratory influence the growth rate and survival of female embryos and whether this can be improved. (redorbit.com)
  • mechanisms
  • Using wildtype or engineered stem cell lines, researchers may use this technique to uncover the various mechanisms or treatments that may affect early brain infection and resulting microcephaly in Zika virus-infected embryos. (jove.com)
  • mice
  • MICRO-ePORE™ was designed for a range of applications including generation of CRISPR/Cas9 mediated knock-in mice with large insertions by microinjection into two-cell stage embryos with high viability.7 The MICRO-ePORE™ has delivered accurate microinjection of morpholino oligomers (anti-sense "knockdown") in zebrafish tails. (wpiinc.com)
  • If preimplantation XCI in mice fails for any reason, it results in cell and embryo death. (redorbit.com)
  • human
  • We now have an experimental system that provides us with routine access to stages of the human life cycle that were previously out of reach to experimentation. (biologists.org)
  • Focuses on private research concerning the cloning of human embryos, and resulting pressure on the United States Congress from medical and religious interest groups. (ebscohost.com)
  • Discusses the controversy over research on stem cells taken from human embryos in the United States. (ebscohost.com)
  • These data further identify myo-Ins as a possibly important supplement for human preimplantation embryo culture in assisted reproduction technology. (hindawi.com)
  • The researchers looked at human embryos that had been donated for scientific research by couples undergoing fertility treatment. (redorbit.com)
  • nutrient
  • The inner cell mass is extracted from the embryo and cultured in a nutrient rich environment in a Petri dish in order to create stem cell lines. (spusa.org)
  • females
  • By breeding X GFP Y transgenic males to non-transgenic (XX) females, female progeny could be distinguished at preimplantation stages from male littermates by their green fluorescence, which results from the zygotic expression of the paternally inherited GFP transgene. (biomedcentral.com)
  • findings
  • On the whole these findings suggest that reverse transcription is strictly required in early embryos as a key component of a novel RT-dependent mechanism that regulated the proper unfolding of the developmental program. (mdpi.com)