Whereas snare complexes n ethylmaleimide sensitive proteins. Medical search. Frequent questions

To achieve this, the neuronal SNARE (i.e., soluble N -ethylmaleimide-sensitive factor attachment protein receptor) complex brings the vesicle and presynaptic membranes in close proximity, thereby, mediating the fusion of the two membranes resulting in exocytosis of neurotransmitters. (nature.com)
is compatible with a role in regulating Ca 2+ channel activity or SNARE [soluble N -ethylmaleimide-sensitive factor attachment protein (SNAP) receptor] complex function in vesicle fusion. (jneurosci.org)
The essential membrane fusion apparatus in mammalian cells, the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex, consists of four alpha-helices formed by three proteins: SNAP-25, syntaxin 1, and synaptobrevin 2. (nih.gov)
Both the CAPS and UNC-13 docking pathways converge on syntaxin, a component of the SNARE (soluble N -ethyl-maleimide-sensitive fusion protein attachment receptor) complex. (rupress.org)
Another fundamental question underlying the mechanism of vesicle fusion at these synapses is the role of SNARE (Soluble N-ethylmaleimide sensitive factor Attachment Protein Receptor) proteins. (tmc.edu)
Biphasic glucose-stimulated insulin secretion (GSIS) from pancreatic β-cells involves soluble N-ethylmaleimide-sensitive fusion protein-attachment protein receptor (SNARE) proteinregulated exocytosis. (ttu.edu)
2011) The Dsl1 Tethering Complex Actively Participates in Soluble NSF (N-Ethylmaleimide-sensitive Factor) Attachment Protein Receptor (SNARE) Complex Assembly at the Endoplasmic Reticulum in Saccharomyces cerevisiae. (columbiabiosciences.com)
Complexins (CPXs I-IV) presumably act as regulators of the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) complex, but their function in the intact mammalian nervous system is not well established. (le.ac.uk)
This crucial function was ascribed to a minimal Munc13 region called the MUN domain, which likely participates in soluble N-ethylmaleimide sensitive factor attachment protein receptor complex (SNARE) assembly and is also found in Ca 2+ -dependent activator protein for secretion. (elsevierpure.com)
These findings further unify the mechanism of neurotransmitter release with those of other types of intracellular membrane traffic and, in turn, support a role for tethering complexes in soluble N-ethylmaleimide sensitive factor attachment protein receptor complex assembly. (elsevierpure.com)
750 kDa), conserved macromolecular machines that are essential for soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE)-mediated membrane fusion in all eukaryotes.MTCs are thought to organizemembrane trafficking by mediating the initial long-range interaction between a vesicle and its target membrane and promoting the formation of membrane-bridging SNARE complexes. (princeton.edu)
Les SNARE orchestrent la fusion membranaire lors du trafic vésiculaire Dans le cas du trafic vésiculaire intra-cellulaire, la fusion membranaire est orchestrée par les protéines SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor), dont les plus étudiées et les mieux caractérisées sont les SNARE neuronales plexe t-SNARE, situé dans la membrane cible, permet de rapprocher, déformer et ainsi mélanger les deux membranes. (hal.science)
Membrane mix inside endomembrane technique comes after a detailed purchase associated with events: membrane tethering, mediated by Rabs and also tethers, assemblage regarding disolveable N-ethylmaleimide-sensitive factor (NSF) attachment health proteins receptor (SNARE) buildings, and also lipid bilayer combining. (notes.io)
Research over the years have established SNARE (soluble-N-ethylmaleimide-sensitive factor attachment receptor) complex as the core synaptic vesicle fusion machinery. (uic.edu)
Moreover, hydrosol obtained from the branch substantially inhibited a lipopolysaccharide (LPS) induced overproduction of intracellular active oxygen (ROS) and nitric oxide (NO). Consistently, the soluble N-ethylmaleimide-sensitive factor-attachment protein receptor (SNARE) proteins of SNAP23, syntaxin4, VAMP7, and VAMP8 were remarkably decreased through hydrosol treatment. (ncsu.edu)
The complex process by which tick salivary gland proteins exit the glands and enter the host has been extensively studied, in what is called the SNARE hypothesis, soluble N-ethylmaleimide-sensitive factor attachment proteins (SNAPs) and their receptor proteins (SNAREs) interact to move vesicles rich in tick salivary gland proteins out of the salivary gland cells. (usm.edu)
Using this framework to analyze the SM (Sec1/Munc18)-SNARE ( N -ethylmaleimide-sensitive factor activating protein receptor) system in exocytic membrane fusion in yeast and neurons, we find that the SM-SNARE network motifs of yeast and neurons show distinct dynamical behaviors. (biomedcentral.com)
SNARE (soluble N- ethylmaleimide-sensitive factor attachment protein receptor) assembly is the central event that may drive membrane fusion. (grantome.com)
The M-type phospholipase A2 receptor (PLA2R), thrombospondin type 1 domain-containing 7A (TSHD7A), and neural epidermal growth factor-like 1 protein (NELL-1) are major autoantigens against podocyte antigens in idiopathic membranous nephropathy (IMN) [ 1 ]. (biomedcentral.com)
The first layer of immunity, known as pathogen-associated molecular pattern- (PAMP-) triggered immunity (PTI), is activated following recognition of the fungal pattern molecule chitin, by four lysin motif- (LysM-) containing protein (LYP) receptors, i.e., chitin elicitor binding protein (CEBiP), chitin elicitor receptor kinase (CERK1), LYP4 and LYP6 (Shimizu et al. (biomedcentral.com)

Taken together, our results suggest that SNARE complex-mediated exocytosis of serially-organized vesicle pools at ribbon-style active zones is important in the neurotransmission of vision. (tmc.edu)
The primed SNARE-complexin-synaptotagmin complex for neuronal exocytosis. (uchicago.edu)
Syntaxins are membrane integrated Q-SNARE proteins known to participate in exocytosis. (ommegaonline.org)
Soluble N-ethylmaleimide-sensitive-factor attachment protein receptors (SNARE) are membrane proteins responsible for the intercellular trafficking of signals through endocytosis and exocytosis of vesicles. (scielo.org)
Vesicle-associated membrane proteins 721 and 722 (VAMP721/722) are secretory vesicle-localized arginine-conserved soluble N -ethylmaleimide-sensitive factor attachment protein receptors (R-SNAREs) to drive exocytosis in plants. (molcells.org)
The SYP121-SNAP33-VAMP721/722 ternary SNARE complex drives an immune exocytosis. (molcells.org)

FcεRI), physical injury through pattern recognition receptors for damage-associated molecular patterns (DAMPs), microbial pathogens through pattern recognition receptors for pathogen-associated molecular patterns (PAMPs), and various compounds through their associated G-protein coupled receptors (e.g., morphine through opioid receptors) or ligand-gated ion channels. (wikipedia.org)
Complement proteins can activate membrane receptors on mast cells to exert various functions as well. (wikipedia.org)
The clustering of the intracellular domains of the cell-bound Fc receptors, which are associated with the cross-linked IgE molecules, causes a complex sequence of reactions inside the mast cell that lead to its activation. (wikipedia.org)
2009) Transforming Growth Factor beta can stimulate Smad1 phosphorylation independently of Bone Morphogenic Protein receptors. (columbiabiosciences.com)
SNAREs (N-ethylmaleimide-sensitive factor adaptor protein receptors) are small polypeptides characterized by a particular domain, the SNARE motif, that can form a coiled-coil structure. (unisalento.it)
Proteins of the SNARE family (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) are necessary to bring the membranes of a small vesicle and a cell membrane into close contact to promote fusion. (uni-goettingen.de)

However a recent study has suggested that ribbon synapses involved in hearing can operate independently of neuronal SNAREs. (tmc.edu)
To mimic the natural fusion process for e.g. in neuronal cells, different model systems with artificial membranes containing the SNARE core complex were investigated. (uni-goettingen.de)
There are several other neuronal proteins that regulate SV fusion by directly or indirectly affecting SNARE complex assembly and its function. (uic.edu)
My thesis focuses on understanding the role of three such neuronal proteins: UNC-13 (Uncoordinated), SAX-7 (Sensory Axon Guidance), and VPS-39 (Vacuolar Protein Sorting). (uic.edu)
We identify the closed binding mode of neuronal SM (Munc18-1) and SNARE (syntaxin-1) as the key factor leading to mechanistic divergence of membrane fusion systems in yeast and neurons. (biomedcentral.com)
Neuronal loss of the serine-threonine protein kinase Tao , a regulator of the Hippo signaling pathway, results in supernumerary boutons, each of which contain a normal number of active zones. (sdbonline.org)

Fusion of synaptic vesicles with the presynaptic membrane occurs in the presence of the NSF (N-ethylmaleimide-sensitive-factor) / α-SNAP (α-soluble NSF attachment protein) disassembly machinery. (nature.com)
Vesicles at conventional neurons undergo SNARE complex-mediated fusion. (tmc.edu)
The SNARE peptides blocked fusion of reserve vesicles but not vesicles in the rapid and releasable pools, possibly because both rapid and releasable vesicles were associated with preformed SNARE complexes. (tmc.edu)
However, an activity-dependent block in refilling of the releasable pool was seen, suggesting that new SNARE complexes must be formed before vesicles can join a fusion-competent pool. (tmc.edu)

Following membrane fusion SNARE complexes are dissociated by the NSFs (N-ETHYLMALEIMIDE-SENSITIVE FACTORS), in conjunction with SOLUBLE NSF ATTACHMENT PROTEIN, i.e. (uchicago.edu)
and the cytosolic proteins N-ethylmalemide sensitive factor (NSF), a trimeric ATPase required for membrane fusion, and the α-β-Y-SNAPs (soluble NSF attachment proteins), which function in binding NSF to the membrane [10,14] . (ommegaonline.org)

Major histocompatibility complex class I (MHC I) molecules present antigenic peptides to cytotoxic T cells to eliminate infected or cancerous cells. (researchgate.net)
To assess the functional role of SNARE proteins at retinal ribbon synapses, we used peptides derived from SNARE proteins that compete with endogenous proteins for SNARE complex formation. (tmc.edu)
Bioactive peptides are small protein fragments that promote metabolic health by exerting a positive influence on biological responses within the body. (psyclopeptide.com)
These bacteria or yeast secrete their proteolytic enzymes in due course to release peptides from the proteins. (psyclopeptide.com)
This process, termed cross-presentation, involves loading tumour-derived peptides onto major histocompatibility complex I (MHC-I) molecules. (biomedcentral.com)

SNARE complex assembly further requires the regulatory proteinsMunc18c,Munc18-1 and Doc2b. (ttu.edu)
These distinct Munc18-1 and Munc18c roles are related to their transient high-affinity binding with their cognate target (t-)SNAREs, Syntaxin 1A and Syntaxin 4 respectively. (ttu.edu)
Towards this, macromolecular complexes composed of Munc18c, Doc2b and Munc18-1 were detected in β-cells. (ttu.edu)
Hence these data support a working model wherein Doc2b functions as a docking platform/scaffold for transient interactions with the multiple Munc18 isoforms operative in insulin release, promoting SNARE assembly. (ttu.edu)
Furthermore, many of us noticed which Vps16, Vps18, as well as the Sec1/Munc18 proteins Vps33, which part of the HOPS complex, hole towards the Q-SNARE complicated. (notes.io)
In plants, three groups of regulatory proteins such as Sec1/Munc18 (SM), small GTPase and synaptotagmin (SYT) have been studied for modulating the trafficking functionality of SNAREs. (molcells.org)

We, therefore, follow the stepwise assembly of the SNARE complex and target individual SNAREs, binary sub-complexes, the ternary SNARE complex as well as interactions with Complexin-1. (nature.com)
Importantly, we find that interactions with Complexin-1 reduce multimerisation of the ternary SNARE complex. (nature.com)
Accordingly, Syntaxin-1 and Synaptobrevin-2 each contribute one and SNAP25 contributes two alpha-helices to the ternary SNARE complex. (nature.com)

By combining lipidomics and molecular dynamic simulations the authors show that oxidatively truncated (ox-tr) triacylglycerides accumulate in large lipid droplets of tumour-associated mouse DCs, and that these highly electrophilic species are predicted to preferentially occupy the droplet surface where they can directly access cytosolic proteins. (biomedcentral.com)
The cargo transport pathways are facilitated with the help of four multi subunit cytosolic protein complexes, BLOC‑1, ‑2, ‑3 and adaptor protein (AP)-3 complex. (indiabioscience.org)

The SNARE complex assembles from vesicular Synaptobrevin-2 as well as Syntaxin-1 and SNAP25 both anchored to the presynaptic membrane. (nature.com)
Based on the presence of glutamine or arginine residues in the zero layer, the SNAREs are classified as Qa- (Syntaxin-1), Qb- and Qc- (SNAP25) or R-SNAREs (Synaptobrevin-2) resulting in the formation of the ternary QabcR (3Q:1R) SNARE complex 8 . (nature.com)
During this process, Rab7 promotes the assembly of HOPS, which mediates lysosomal tethering with endosomes by pairing an R-SNARE on a lysosome (VAMP7 or VAMP8) with three Q-SNAREs on an endosome (syntaxin-7, VTI1b, syntaxin-8). (biomedcentral.com)
4) Lysosomal fusion with autophagosomes also requires SNAREs, including VAMP8, syntaxin-17 and SNAP29. (biomedcentral.com)
In fact, few SNARE proteins are known to interact with ion channels, notably mammalian Syntaxin 1A, which binds several different Ca2+ and K+ channels in nerves. (unisalento.it)
VAMP (Vesicle-associated membrane protein), SNAP-25 (Synaptosome associated protein of 25 kDa) and Syntaxin constitute the basic SNARE complex. (biomedcentral.com)
Synaptobrevin2/Vesicle associated membrane protein-2 (v-SNARE) and Syntaxin (t-SNARE) form a vesicular docking complex during endocytosis. (scielo.org)
Part of synaptobrevin 2-SNAP-25-syntaxin-1a complex. (nih.gov)

In this project, conformational changes of SNARE complexes induced by SytI, complexins, and Ca++ are determined using SDSL EPR to gain insights into the structural basis of the synchronized release. (grantome.com)

To overcome energetically unfavorable lipid fusion, they form a SNARE complex in which four α-helices are bundled. (molcells.org)

SNAP-25 contributes two helices to the complex and is targeted to the plasma membrane by palmitoylation of four cysteines in the linker region. (nih.gov)
Gabrilovich's team begins to answer this with an astonishing observation that either inhibiting or depleting HSP70 leads to a re-routing of pMHC-I complexes, which rather than reaching the plasma membrane, are sent to lysosomes instead. (biomedcentral.com)
It was also shown that plasma membrane SNAREs can be phosphorylated as part of the signaling cascade elicited by interaction with microorganisms or hormonal stimulation and that they influence turnover of channels. (unisalento.it)
It is proposed that membrane fusion is induced by, the formation of SNARE complexes, at the active zones in the plasma membrane that are composed many of different lipids and proteins. (uni-goettingen.de)
Following the acrosome reaction the fused hybrid membrane complex remains adherent to the zona surface, [4] and the newly exposed inner acrosomal membrane of the spermatozoon functions as the limiting membrane or plasma membrane equivalent [1] . (ommegaonline.org)
Key interacting proteins of the plasma membrane, the cytosol and the vesicle membrane which function in the membrane fusion pathway, have been identified in a variety of cell types and characterized at the molecular level [10-14] . (ommegaonline.org)

NSF-mediated disassembly of on- and off-pathway SNARE complexes and inhibition by complexin. (uchicago.edu)

Zippering of the SNAREs is proposed to provide the required energy to initiate membrane fusion 6 , 7 and proceeds from the N-terminus towards the membrane-proximal C-terminus through interactions of their complementary SNARE motifs. (nature.com)
the latter contains two SNARE motifs. (nature.com)
The observed binding modes appear to anchor the Dsl1 complex to the ER target membrane while simultaneously ensuring that both SNAREs are in open conformations, with their SNARE motifs available for assembly. (princeton.edu)
The proximity of the two SNARE motifs, and therefore their ability to enter the same SNARE complex, will depend on the relative orientation of the two Dsl1 legs. (princeton.edu)
We present a comparative network motif experimental approach, which helps to explain complex biological phenomena and increases the understanding of biological functions at the molecular level by exploring evolutionary design principles of network motifs. (biomedcentral.com)

A superfamily of small proteins which are involved in the MEMBRANE FUSION events, intracellular protein trafficking and secretory processes. (uchicago.edu)
Intracellular bacteria encode inhibitory SNARE-like proteins. (uchicago.edu)
Although 271 genes linked to hereditary retinal diseases have already been identified, these genes encode diverse functions, including phototransduction, retinol metabolism, and intracellular protein transport. (oist.jp)
As for many essential biological processes, intracellular membrane fusion is mediated by interactions among a series of evolutionarily conserved proteins. (biomedcentral.com)

Advances in X-ray free electron laser (XFEL) diffraction data processing applied to the crystal structure of the synaptotagmin-1 / SNARE complex. (uchicago.edu)
Synaptotagmin 1 and SNAREs form a complex that is structurally heterogeneous. (uchicago.edu)
A Ca++-sensor synaptotagmin I (SytI) and complexins impinge upon SNARE assembly to control the timing and the size of the release. (grantome.com)

Previous studies suggest that the vesicular cysteine-string protein (CSP) may modulate presynaptic Ca 2+ channel activity in fast neurotransmitter release. (jneurosci.org)
These two proteins appear to play different roles in vesicular trafficking and exhibit distinct localization. (usm.edu)

Here, we used X-ray crystallography to investigate these Dsl1-SNARE interactions in greater detail. (princeton.edu)
These results underscore the critical roles of SNARE N-terminal domains in mediating interactions with other elements of the vesicle docking and fusion machinery. (princeton.edu)
Via hetero-oligomeric interactions, these proteins form highly stable protein-protein interactions, the so called SNARE-complex, that allow membrane fusion. (unisalento.it)
Take a look at Ibrutinib chemical structure existing evidence how the vacuolar Jumps tethering complicated handles mix by means of particular interactions with the vacuolar Pitfall complex (made up of Vam3, Vam7, Vti1, and also Nyv1) as well as the N-terminal domains of Vam7 and Vam3. (notes.io)
Cellular processes are governed by complex molecular interaction networks where the molecular components and the interactions between them are represented by nodes and edges, respectively. (biomedcentral.com)
By capturing the evolutionary dynamics of target biological systems, the comparative modeling framework is empowered to (i) identify the functional roles of poorly characterized proteins and interactions and (ii) further decipher the underlying regulatory mechanisms of complicated cellular processes. (biomedcentral.com)
The team intends to further work on uncovering the details of the intramolecular interactions between the SNAREs, BLOC‑1/-2 complexes and other key players involved in the transport pathway. (indiabioscience.org)
This remarkable process is controlled by an exquisitely orchestrated array of protein-protein interactions. (grantome.com)

Ces complexes v-SNARE/t-SNARE, qui créent un pont transitoire entre les deux membranes destinées à fusionner et au sein desquels chaque SNARE est ancrée dans une bicouche distincte, sont appelés SNAREpins (ou complexes trans-SNARE). (hal.science)

We applied the framework to study SM-SNARE-mediated exocytic membrane fusion processes in yeast and neurons. (biomedcentral.com)

Biochemical and molecular dynamic simulation experiments revealed that the two substitutions do not regulate secretion by affecting the property of SNARE complex itself, but rather make the SNAP-25b-containing SNARE complex more available for the interaction with accessory factor(s). (nih.gov)
synaptophysin is thought to regulate the formation of this complex. (ommegaonline.org)
These diverse functions performed by the acrosomal segment during fertilization reveal the importance of identifying the specific signaling events and protein constituents which initiate and regulate the membrane fusion process of the acrosome reaction and prepare spermatozoa to fuse with the egg. (ommegaonline.org)
Several anterograde and retrograde signaling pathways, including the canonical Bone Morphogenic Protein (BMP) pathway , regulate synaptic development in vertebrates and invertebrates. (sdbonline.org)
The RanBP2/RanGAP1-SUMO complex gates β-arrestin2 nuclear entry to regulate the Mdm2-p53 signaling axis. (u-paris.fr)

Such an evolutionary relationship allows structure prediction of the MUN domain and suggests functional similarities between MUN domain-containing proteins and multisubunit tethering complexes such as exocyst, conserved oligomeric Golgi complex, Golgi-associated retrograde protein complex, and Dsl1p. (elsevierpure.com)

Recent Advances in Deciphering the Structure and Molecular Mechanism of the AAA+ ATPase N-Ethylmaleimide-Sensitive Factor (NSF). (uchicago.edu)
The present project uses the newly developed single fusion assay based on total internal reflection (TIRF) microscopy to investigate the mechanism by which SNARE-dependent fusion is regulated by SytI, complexins, and Ca++. (grantome.com)

Using native mass spectrometry, we identify the stoichiometry of sub-complexes and monitor oligomerisation of various assemblies. (nature.com)
In summary, we unravel the stoichiometry of intermediates and off-pathway complexes and compile a road map of SNARE complex assembly including regulation by Complexin-1. (nature.com)
Stoichiometry of these proteins reveals that they are more abundant than required for membrane traffic. (unisalento.it)

Altered expression of SNARE proteins in cellular communication is the major hallmark of cancer phenotypes as indicated in recent studies. (scielo.org)
Integrating the dynamics across species is particularly important in modeling cellular processes through protein interaction networks. (biomedcentral.com)
In addition to these key proteins, other cellular machineries are also known to be responsible for membrane fusion and cargo delivery. (indiabioscience.org)

Several patients with clinical features of chronic myeloid leukemia (CML) have fusion of the TEL (ETV6) gene on 12p13 with ABL on 9q34 and express a chimeric Tel-Abl protein that contains the same portion of the Abl tyrosine kinase fused to Tel, an Ets family transcription factor, rather than Bcr. (shengsci.com)
These proteins are called S oluble N SF ( N -ethylmaleimide-sensitive factor) A ttachment Protein RE ceptor (SNARE). (indiabioscience.org)

The Tel-Abl (ETV6-Abl) tyrosine kinase, product of complex (9;12) translocations in human leukemia, induces distinct myeloproliferative disease in mice. (shengsci.com)
Complexin induces a conformational change at the membrane-proximal C-terminal end of the SNARE complex. (uchicago.edu)

For the first time , the researchers have identified two members from the SNARE family that are involved in the protein transport pathways to melanosomes. (indiabioscience.org)

4) provided direct evidence that SYP121 is part of a scaffold of proteins associated, by direct interaction with channel KAT1, with the membrane transport of K+. (unisalento.it)
4) Grefen C, Chen Z, Honsbein A, Donald N, Hills A, Blatt MR. (2010) A novel motif essential for SNARE interaction with the K(+) channel KC1 and channel gating in Arabidopsis. (unisalento.it)
Many of the biological processes mediated by protein interaction networks are highly evolutionarily conserved or related across species. (biomedcentral.com)
Mutations of a gene sequence can modify the interfaces or domains of its protein product and lead to the emergence of new or loss of existing protein interaction patterns [ 11 ]. (biomedcentral.com)
The cytoHubba plug-in were used to identify hub genes from the protein-protein interaction network. (biomedcentral.com)

Protein is hydrolyzed by culturing bacteria or yeast on the protein substrates. (psyclopeptide.com)

We have found that the calcium-activated protein for secretion (CAPS) protein is required for dense core vesicle docking but not synaptic vesicle docking. (rupress.org)

Camphor and estragole are the main chemical components of hydrosol and downregulate the LPS-induced phosphorylation of the SNARE proteins. (ncsu.edu)

Here we show that AtSYP51 interacts directly with a non-SNARE protein, AtNLM1, probably regulating autophagocytosis processes. (unisalento.it)

We used the well-characterized goldfish bipolar neuron to investigate the organization of vesicle pools and the role of SNARE proteins at a retinal ribbon synapse. (tmc.edu)

A beta-hairpin comprising the nuclear localization sequence sustains the self-associated states of nucleosome assembly protein 1. (colorado.edu)

We focus on zebrafish mutants, in which photoreceptor degeneration is caused by defects in protein synthesis in ER, protein transport from ER to the apical photoreceptive membrane region, and phototransduction. (oist.jp)

Secondly, they find that HSP70 in turn regulates the trafficking of peptide-loaded major histocompatibility complex class I (pMHC-I) molecules, a complex that triggers the proliferation of cancer-killing T cells. (biomedcentral.com)
These peptide-MHC-I complexes (pMHC-I) then traffic to the cell surface, where together with co-stimulatory molecules they trigger the proliferation and differentiation CD8 + T cells into cancer-specific cytotoxic T cells. (biomedcentral.com)

Seeking ovarian cancer related SNAP proteins may help to reveal new mechanisms of invasion and metastasis of ovarian cancer, and provide new ideas for clinical diagnosis and treatment. (biomedcentral.com)

CAPS function in dense core vesicle docking parallels UNC-13 in synaptic vesicle docking, which suggests that these related proteins act similarly to promote docking of independent vesicle populations. (rupress.org)
This structure suggests how theDsl1 complex might tether a vesicle to its target membrane by binding at one end to the COPI coat and at the other to ER-associated SNAREs. (princeton.edu)
The impaired proliferation and reduced invasive capacity observed in cells as a consequence of inhibiting SNAP23 function suggests an important role for SNARE mediated pathway in OC progression. (biomedcentral.com)
strongly suggests that at least one regulatory protein should control the SNARE complex formation of VAMP721/722 with a specific Qa-SNARE in a particular biological process in plants. (molcells.org)
Previous research suggests that Vti1B, or other identified SNARE partners, may be able to partially compensate for the loss of Vti1A. (usm.edu)

Researchers from IISc identify and shed light on the role of protein complexes that play key roles in transporting synthesizing enzymes that aid melanin production in cells. (indiabioscience.org)

We found that two nonconservative substitutions in the N-terminal SNARE domain and not the different localization of one palmitoylated cysteine cause the functional difference between the isoforms. (nih.gov)
Therefore this study provides a new method to solve the discrepancies and to generalize the functional role of SM proteins. (biomedcentral.com)

Ovarian cancer (OC) was the primary malignant gynecological cancer and SNARE protein is closely related with tumor progression. (biomedcentral.com)

The expression of Insulin and Pancreatic and duodenal homeobox-1 mRNA was significantly reduced in MIPβ1KO islets, along with reductions in insulin exocytotic proteins. (oncotarget.com)

Here, we identified SNAP23, a member of SNARE complex, as a potential oncogene in OC. (biomedcentral.com)

While the general sequence of SNARE complex formation is well-established, our knowledge on possible intermediates and stable off-pathway complexes is incomplete. (nature.com)
While the general sequence of SNARE complex formation is well-established, our knowledge on. (researchgate.net)
SNAREs also interact with several proteins acting as regulators of SNARE-complex formation. (unisalento.it)
The formation of a SNARE complex (composed of one each of the four different types SNARE domains (Qa, Qb, Qc, and R)) mediates MEMBRANE FUSION. (uchicago.edu)

We found weak yet significant sequence similarities between the MUN domain and a set of protein subunits from several related vesicle tethering complexes, such as Sec6 from the exocyst complex and Vps53 from the Golgi-associated retrograde protein complex. (elsevierpure.com)

A pure form of proteolytic enzyme is used to hydrolyze the protein to produce short peptide sequences. (psyclopeptide.com)
The Dsl1 complex comprises three subunits that together form a two-legged structure with a central hinge. (princeton.edu)
It was shown (1) that they may assemble to form non-fusogenic complexes acting as interfering-SNAREs or iSNARE (2) as in the case of AtSYP51 and SYP52. (unisalento.it)
The team demonstrated that higher expression of a mutant form of SNARE increased cell pigmentation. (indiabioscience.org)

BLOC‑1 consists of 8 subunits, functioning in the initial step of transport pathway, while BLOC‑2, a 3‑subunit protein complex, functions towards the end of the pathway. (indiabioscience.org)

In this study, we tested the hypothesis that VTI family of SNARE proteins, VTI1A and VTI1B, are required for the salivary vesicle transport and success of tick to gain an uninterrupted access to blood-meal for several days. (usm.edu)

SNAREs play an important role in maintaining cell growth and epithelial membrane permeability of the bladder and are not only involved in cancer progression but also metastatic cell invasion through SNARE-mediated trafficking. (scielo.org)
Some earlier studies have shown a critical role of SNARE in colon, lungs, and breast cancer progression and metastasis. (scielo.org)
Our results demonstrate an important role of VTI protein family in uninterrupted prolonged tick feeding on the host. (usm.edu)
SNARE proteins, a family of about 38 proteins has been known for their role in membrane fusion during the delivery of cargo. (indiabioscience.org)

We show homotypic fusion and necessary protein sorting (HOPS) binds Vam7 by means of it's subunits Vps16 as well as Vps18. (notes.io)

Chemicals and Drugs13

Phenomena and Processes2

Receptor20

Exocytosis6

Receptors6

Neuronal6

Vesicles4

Soluble2

Peptides5

Munc186

Ternary SNARE complex3

Cytosolic2

Syntaxin8

Conformational changes1

Lipid1

Plasma membrane6

Disassembly1

Motifs5

Intracellular4

Synaptotagmin3

Vesicular2

Interactions8

Membranes1

Neurons1

Regulate5

Multisubunit1

Mechanism2

Stoichiometry3

Cellular3

Factor2

Induces2

Pathways1

Interaction5

Bacteria1

Secretion1

Phosphorylation1

Processes1

Synapse1

Assembly1

Apical1

Molecules2

SNAP1

Suggests5

Roles1

Functional2

Tumor1

Exocytotic1

SNAP231

Formation4

Sequence1

Form4

Pathway1

VTI1b1

Role4

Binds1