• The obesity epidemic has resulted in more overweight/obese women before and during pregnancy. (karger.com)
  • Many pregnancies in overweight/obese women are uncomplicated and result in offspring of normal weight, leaving the main determinants of later adverse outcomes to be clarified. (karger.com)
  • The current obesity epidemic has resulted in an increasing number of overweight and obese women entering pregnancy [ 1 ]. (karger.com)
  • Dietary restriction is an effective strategy for weight loss in obese individuals. (researchgate.net)
  • Accordingly, this review examines the effects of daily CR versus intermittent CR on weight loss, fat mass loss and lean mass retention in overweight and obese adults. (researchgate.net)
  • We aimed to compare the effects of IER with those of CER on blood pressure control and weight loss in overweight and obese patients with hypertension during a 6-month period. (researchgate.net)
  • These data further our understanding of the role of endocannabinoid signaling to promote not only diet-induced, but also, hormonal-mediated obesity and support the argument that peripheral blockade of endocannabinoid signaling could be a potential treatment for obese conditions. (iasvn.org)
  • Objective Indole‐3‐carbinol (I3C), a naturally occurring compound found in cruciferous vegetables, and its metabolite 3,3′‐diindolylmethane (DIM) reduce body mass and serum glucose levels in high‐fat‐diet‐induced obese mice. (researchgate.net)
  • Moreover, I3C exerts anti-obesity effects by reducing body weight and fat accumulation in epididymal adipose tissue in HFD-induced obese mice and thereby improves hyperglycemia and hyperinsulinemia [126]. (researchgate.net)
  • The increased 11β-HSD1 activity in adipose tissue in obese rats and in some but not all studies of obese humans causes visceral obesity and its metabolic consequences [ 3 ]. (biomedcentral.com)
  • In this study, we investigated the ameliorative effect of LYPs on metabolic syndrome using a high-fat diet (HFD)-induced obese mouse model. (bvsalud.org)
  • Sugar is one of the leading contributors to obesity and people that consume more sugar are more likely to be overweight or obese. (loweringbloodsugar.com)
  • This review summarizes the major pathological factors linking obesity to diabetes, focussing on current epidemiological data related to obese diabetic patients in the Arab world, the etiology of the disease and the genetic determinants of diabetes and obesity. (who.int)
  • Promising results of fecal transplantation have also emerged from clinical trials including obese individuals with metabolic disturbances [ 9 ]. (biomedcentral.com)
  • An excess of adipose visceral fat is known as central obesity, the "pot belly" or "beer belly" effect, in which the abdomen protrudes excessively. (wikipedia.org)
  • And it is waistline adipose tissue (central obesity) which seems to be the foremost type of fat deposits contributing to rising levels of serum resistin. (wikipedia.org)
  • In recent years, the mechanism(s) by which excess body weight produces adverse cardiovascular outcomes has attracted interest, with one potential pathway being the dysfunction of adipose tissue. (nature.com)
  • Reduction of PPAR-γ expression and generation of a pro-inflammatory environment by increased lipocalin-2 expression in white adipose tissue may contribute to stress-induced glucose intolerance. (biomedcentral.com)
  • This study aims to unveil biological markers that establish the molecular basis of stress-induced glucose intolerance, with a special emphasis on the visceral white adipose tissue (vWAT). (biomedcentral.com)
  • report on studies with male mice indicating that the metabolic benefits of intermittent fasting result in part from promotion of histone acetylation in lipid oxidation genes of muscle and adipose tissue. (tomwademd.net)
  • Obesity (OB) is a metabolic disorder characterized by adipose tissue dysfunction that has emerged as a health problem of epidemic proportions in recent decades. (bvsalud.org)
  • Particularly, a specialized adipose tissue (AT) depot known as periprostatic adipose tissue (PPAT) has gained increasing attention over the last few years as it could be a key player in the pathophysiological interaction between PCa and OB. (bvsalud.org)
  • Obesity-induced metabolic syndrome is strongly associated with infiltrated adipose tissue macrophages (ATMs). (bvsalud.org)
  • After the menopause, when progesterone synthesis has ceased altogether, excess weight may continue increasing risk through elevated plasma levels of androgen precursors, increasing estrogen levels through the aromatization of the androgens in adipose tissue. (scienceopen.com)
  • Abdominal obesity has been strongly linked to cardiovascular disease, Alzheimer's disease, and other metabolic and vascular diseases. (wikipedia.org)
  • Researchers first started to focus on abdominal obesity in the 1980s when they realized it had an important connection to cardiovascular disease, diabetes, and dyslipidemia. (wikipedia.org)
  • Abdominal obesity was more closely related with metabolic dysfunctions connected with cardiovascular disease than was general obesity. (wikipedia.org)
  • Obesity can induce type 2 diabetes mellitus, dyslipidemia, cardiovascular disease and other chronic disorders with high social and health costs. (benthamscience.com)
  • Obesity and associated metabolic disorders (e.g., cardiovascular disease and type 2 diabetes) are major public health concerns. (iasvn.org)
  • MS is closely related to lifestyle and central obesity, serving as a risk factor for metabolic diseases, such as type 2 diabetes and cardiovascular disease. (biomedcentral.com)
  • This includes obesity-related factors that increase the likelihood of cardiovascular disease. (medicalnewstoday.com)
  • Dietary supplementation with complex carbohydrates is known to alter the composition of gut microbiota, and optimal implementation of the use of these so called "prebiotics" could be of great potential in prevention and possibly treatment of obesity and associated cardiometabolic and inflammatory diseases via changes in the gut microbiota. (frontiersin.org)
  • However, the consumers still associate dietary FA with fat deposition and increased occurrence of metabolic diseases such as obesity and atherosclerosis. (nature.com)
  • Previous studies already demonstrated that some fatty acids are linked with inflammatory response, preventing metabolic diseases. (nature.com)
  • To better understand the role of dietary FA on metabolic diseases, for the first time, a study to identify key transcription factors (TF) involved in lipid metabolism and inflammatory response by transcriptome analysis from liver samples of animal models was performed. (nature.com)
  • An increased proportion of omega (n)-6:n-3 PUFA, which is observed typically in Western diets, leads to a wide range of pathologies, such as cardiovascular, inflammatory, autoimmune, and diabetic diseases. (nature.com)
  • Social-ecological environment, dietary pattern, metabolic state and lifestyle including exercise, are mutually interacting and form a global burden of non-communicable diseases. (heraldopenaccess.us)
  • Manipulation of the gut microbiota through the administration of prebiotics or probiotics may assist in weight loss and reduce plasma glucose and serum lipid levels, decreasing the incidence of cardiovascular diseases and type 2 diabetes mellitus. (biomedcentral.com)
  • Thus, preventative and therapeutic strategies to reduce the morbidity and mortality caused by metabolic diseases are significant. (biomedcentral.com)
  • Identifying and treating these diseases could reverse weight gain. (dibesity.com)
  • Gaining this type of fat is extremely detrimental as this leads to several health disorders like cardiovascular diseases, type 2 diabetes, and fatty liver. (dibesity.com)
  • Animal studies indicate that BPC157 may significantly improve gastrointestinal healing from ulcers, colitis, irritable bowel syndrome, and other inflammatory bowel diseases. (buypeptidesonlineusa.com)
  • Therefore, it has been suggested that the modulation of gut microbiota could be a reliable tool to prevent metabolic and inflammatory diseases. (springer.com)
  • Added sugars are the worst ingredient in our diet, it has no nutritional value and can have harmful effects on your metabolism and of course can contribute to weight gain and other diseases. (loweringbloodsugar.com)
  • We also study how these pathways go awry in human diseases such as cancer, neurodegeneration and metabolic syndrome, in order to engineer new therapeutic modalities. (stanford.edu)
  • Lysosomal function is critical for organismal homeostasis-mutations in genes encoding lysosomal proteins cause severe human disorders known as lysosomal storage diseases, and lysosome dysfunction is implicated in age-associated diseases including cancer, neurodegeneration and metabolic syndrome. (stanford.edu)
  • By developing novel tools and harnessing the power of metabolomics, proteomics and functional genomics, our lab will define 1) how the lysosome communicates with other cellular compartments to fulfill the metabolic demands of the cell under various metabolic states, 2) and how its dysfunction leads to rare and common human diseases. (stanford.edu)
  • We apply this knowledge to understand how lysosomal dysfunction leads to human diseases including neurodegeneration, cancer and metabolic syndrome. (stanford.edu)
  • Hyperlipidemia, characterized by the abnormal blood lipid profiles, is one of the dominant factors of many chronic diseases such as diabetes, obesity, and cardiovascular diseases (CVD). (hindawi.com)
  • We then reviewed whether the reported changes in gut bacterial members found to be established by complex carbohydrates would benefit or harm the cardiometabolic and immunological health of the host taking into account the alterations in the microbiome composition and abundance known to be associated with obesity and its associated disorders. (frontiersin.org)
  • Therefore, effective treatment of type 2 diabetes and metabolic syndrome should target not only the cardiometabolic abnormalities, but also the associated liver disorders. (hindawi.com)
  • Notably, NAFLD appears to be an early predictor of metabolic disorders, particularly among normal-weight individuals [ 7 ]. (hindawi.com)
  • Rather, it causes weight gain and cardiovascular disorders. (dibesity.com)
  • In this review we focus on the bene fi cial impact of sleep on glucose metabolism and suggest a possible strategy for therapeutic intervention against sleep-related metabolic disorders. (vdocuments.mx)
  • A 2021 study investigating the mechanisms behind antipsychotic weight gain found that shared genetic pathways between obesity and mental disorders may underlie why treatment is linked to weight gain. (psychcentral.com)
  • These findings suggest that LYPs might be a novel potential therapeutic agent to prevent or treat HFD-induced metabolic disorders by regulating M2 polarization. (bvsalud.org)
  • Risk for obesity and metabolic disorders begins during perspective can inform more effective and sustainable gestation (1). (cdc.gov)
  • Feeding low-protein diets to pregnant rats produces a increased more than in children not exposed to tobacco in broad spectrum of disorders in their offspring (7): hyper- utero. (cdc.gov)
  • Another study found pregnancy has been associated with low birth weight, a that smoking during the 12 months before birth of a child marker of risk for obesity and other metabolic disorders was associated with adolescent overweight (21). (cdc.gov)
  • The possibility that "faulty" circuits could be remodeled by BDNF is an exciting concept for new therapies for obesity and eating disorders. (hyperthermicwellness.com)
  • Over the past two decades, the prevalence of metabolic abnormalities such as type 2 diabetes and metabolic syndrome (MetS) has been increasing worldwide together with the escalating obesity pandemic [ 1 - 3 ]. (hindawi.com)
  • Therefore, NAFLD is expected to become a major burden in Asian countries where the prevalence of obesity is less than that in Western countries [ 10 , 11 ]. (hindawi.com)
  • Prevalence of obesity and severe obesity among adults: United States, 2017-2018. (msdmanuals.com)
  • There are alarming data related to the rising prevalence of obesity and type 2 diabetes mellitus in children of Arab ethnicity. (who.int)
  • However, animal or mainly attributed to the accumulation ing prevalence of uncontrolled weight genetic studies, studies not relevant of intra-abdominal (visceral) fat ( 13 ). (who.int)
  • However, one study identified a population of African children who had a high prevalence of overweight/obesity at the time of arrival, 5 and other data have identified overweight/obesity and associated medical consequences in the newly arriving Iraqi population. (cdc.gov)
  • 10 This trend may reflect the overall rising global prevalence of overweight/obesity and/or the changing socioeconomic status of newly arriving refugees. (cdc.gov)
  • Abdominal obesity, also known as central obesity and truncal obesity, is the human condition of an excessive concentration of visceral fat around the stomach and abdomen to such an extent that it is likely to harm its bearer's health. (wikipedia.org)
  • Visceral and central abdominal fat and waist circumference show a strong association with type 2 diabetes. (wikipedia.org)
  • 2010) examining over 700 adults found evidence to suggest higher volumes of visceral fat, regardless of overall weight, were associated with smaller brain volumes and increased risk of dementia. (wikipedia.org)
  • Abdominal obesity is linked with higher cardiovascular events among South Asian ethnic population. (wikipedia.org)
  • Developing asthma due to abdominal obesity is also a main concern. (wikipedia.org)
  • Obesity causes decreased tidal volumes due to reduced in chest expansion that is caused both by the weight on the chest itself and the effect of abdominal obesity on flattening the diaphragms. (wikipedia.org)
  • MS can be defined by the presence of abdominal obesity and any 2 of the following factors: increased fasting plasma glucose, increased TGs, reduced HDL cholesterol, and hypertension. (biomedcentral.com)
  • describe how low skeletal muscle mass and abdominal obesity additively increase the risk of incident type 2 diabetes, independently from glycometabolic parameters. (tomwademd.net)
  • Evidence linking depression to metabolic syndrome abnormalities indicates that depression is especially associated with its obesity-related components (for example, abdominal obesity and dyslipidemia). (biomedcentral.com)
  • Using a mouse model of excess corticosterone exposure, we found that the ability of glucocorticoids to increase adiposity, weight gain, hormonal dysregulation, hepatic steatosis, and dyslipidemia was reduced or reversed in mice lacking the cannabinoid CB 1 receptor as well as mice treated with the global CB 1 receptor antagonist AM251. (iasvn.org)
  • In general, lifestyle modifications (eg, smoking cessation, diet, exercise, weight reduction) are initiated before any pharmacologic therapy in the treatment of primary and secondary dyslipidemia, particularly in patients who are asymptomatic. (medscape.com)
  • Recent evidence shows that glucocorticoids possess the ability to increase endocannabinoid signaling, which is known to regulate appetite, energy balance, and metabolic processes through both central and peripheral pathways. (iasvn.org)
  • dose effect of environmentally responsive phytochemicals, respectively, ranging widely over basic metabolic pathways and secondary metabolite biosynthesis. (heraldopenaccess.us)
  • Among microbial metabolites, short-chain fatty acids (SCFA) are modulators of different metabolic pathways. (springer.com)
  • GO and KEGG analysis showed that genes regulated by E2 and/or HFD are mainly responsible for immune response, inflammatory response and metabolic pathways. (scienceopen.com)
  • The Abu-Remaileh Lab is interested in identifying novel pathways that enable cellular and organismal adaptation to metabolic stress and changes in environmental conditions. (stanford.edu)
  • Against this background, several researches have been carried out to identify potential strategies to induce specific changes in the gut microbiota composition towards microbial species with high fermentative activity. (springer.com)
  • 7 - 9 Overweight and obesity are frequently assumed to be associated with assimilation to a U.S. lifestyle (increased availability of high-calorie foods, reduced physical activity), compounded by lack of nutritional education. (cdc.gov)
  • Obesity in Adolescents Obesity is now twice as common among adolescents than it was 30 years ago and is one of the most common reasons for visits to adolescent clinics. (msdmanuals.com)
  • Is metabolic and bariatric surgery a safe and effective therapeutic option for adolescents with severe obesity? (medscape.com)
  • This study was conducted to verify the responses of a multi-professional intervention on anthropometric, body composition, and food profile in adolescents with overweight or obesity. (bvsalud.org)
  • These findings may direct strategies to combat obesity in adolescents and promote positive food consumption changes after nutritional counseling, physical activity, and psychological counseling. (bvsalud.org)
  • There is growing evidence that early development of obesity increases cardiovascular risk later in life, but less is known about whether there are effects of long-term excess body weight on the biological drivers associated with the atherosclerotic pathway, particularly adipokines, inflammatory and endothelial markers. (nature.com)
  • Epidemiological studies show that chronic stress increases the risk of diabetes and metabolic syndrome [ 2 ]. (biomedcentral.com)
  • Researchers discovered that there were not only zero benefits from consuming "diet" foods and drinks containing these artificial sweeteners (known as "non-nutritive sweeteners," since they offer no calories), but they were associated with "increases in weight and waist circumference, and higher incidence of obesity, hypertension, metabolic syndrome, type 2 diabetes and cardiovascular events. (draxe.com)
  • We hypothesize that POPS will yield positive effects compared to Usual Head Start, and that the combined intervention (POPS + IYS) addressing behaviors well-known to be associated with obesity risk, as well as self-regulatory capacity, will be most effective in preventing excessive increases in child adiposity indices (body mass index, skinfold thickness). (biomedcentral.com)
  • In premenopausal women, ovarian hyperandrogenism likely increases risk by inducing chronic anovulation and progesterone deficiency. (scienceopen.com)
  • These meta-analyses consistently show that depression increases the risk of overall mortality (RR = 1.81) and the development of cardiovascular-related outcomes, such as heart disease (RR = 1.81), diabetes (RR = 1.60), hypertension (RR = 1.42), stroke (RR = 1.34) and obesity (RR = 1.58). (biomedcentral.com)
  • Interestingly, some studies have linked risperidone-induced weight gain with lipolysis and considered that risperidone increases lipid accumulation by altering lipolysis ( 25 ). (frontiersin.org)
  • It has since been observed in many studies that central administration of BDNF induces appetite suppression and weight loss ( 207 , 267 , 269 , 270 ), increases locomotor activity ( 186 ), and resting metabolic rate ( 266 , 268 ). (hyperthermicwellness.com)
  • Simple measures of gestational weight gain provide insufficient detail of the underlying physiological and metabolic adaptations occurring in pregnancy, and should be complemented by measures of body composition, metabolic and endocrine responses. (karger.com)
  • The predominance of central, viscerally deposited fat may alter the immunological, metabolic and endocrine milieu. (benthamscience.com)
  • Today I link to the web page, An Endocrine Society Thematic Issue: Obesity 2023 . (tomwademd.net)
  • In Journal of the Endocrine Society , Enright and coauthors discuss the advent of new weight-loss pharmacotherapies and their potential to move beyond the 5 percent goal. (tomwademd.net)
  • In Endocrine Reviews , Akalestou and others survey mechanisms of weight loss after obesity surgery, which include changed food selection. (tomwademd.net)
  • However, many other factors appear to increase a person's predisposition to obesity, including endocrine disruptors (eg, bisphenol A [BPA]), gut microbiome, sleep/wake cycles, and environmental factors. (msdmanuals.com)
  • Recommendations From the 2023 International Evidence-based Guideline for the Assessment and Management of Polycystic Ovary Syndrome. (medscape.com)
  • Metformin and combined oral contraceptive pills in the management of polycystic ovary syndrome: a systematic review and meta-analysis. (medscape.com)
  • Few obesity prevention programs for low-income preschoolers and their parents have been rigorously tested, and effects are modest. (biomedcentral.com)
  • We are testing a novel obesity prevention program for low-income preschoolers built on the premise that children who are better able to self-regulate in the face of psychosocial stressors may be less likely to eat impulsively in response to stress. (biomedcentral.com)
  • The Growing Healthy study is a randomized controlled trial evaluating two obesity prevention interventions in 600 low-income preschoolers attending Head Start, a federally-funded preschool program for low-income children. (biomedcentral.com)
  • The first intervention ( n = 200), Preschool Obesity Prevention Series (POPS), addresses evidence-based obesity prevention behaviors for preschool-aged children and their parents. (biomedcentral.com)
  • If the project is effective in preventing obesity, results can also provide critical insights into how best to deliver obesity prevention programming to parents and children in a community-based setting like Head Start in order to promote better health among at-risk children. (biomedcentral.com)
  • The goal of the Growing Healthy trial is to test the effectiveness and feasibility of two obesity prevention interventions. (biomedcentral.com)
  • The first intervention is an education curriculum promoting obesity prevention behaviors, and the second intervention places this curriculum in the context of an additional intervention to enhance behavioral self-regulation. (biomedcentral.com)
  • Current studies suggest that manipulation of the gut microbiota could be a promising approach for the prevention and management of metabolic syndrome [ 7 ]. (biomedcentral.com)
  • Here, we have reviewed recent studies concerning the role of the gut microbiota in metabolic syndrome and the effects of probiotic bacterial strains and prebiotics on the prevention or treatment of metabolic syndrome, such as their anti-obesity and anti-inflammatory effects and their ability to improve glycemic control and modulate serum lipids. (biomedcentral.com)
  • Gestational Period become focal points for obesity prevention or intervention. (cdc.gov)
  • Obesity is linked to in utero exposure to strategies for obesity prevention. (cdc.gov)
  • In the last few decades, hundreds of Chinese herbal medicines in the form of compounds, extracts, single herbs, or formulae have been reported to be effective for the prevention and treatment of hyperlipidemia [ 16 ], especially those high-fat diet (HFD) induced cases. (hindawi.com)
  • With the aim of gaining insights into the latter, this study examined the metabolic profile of young adult male rats that were exposed to chronic unpredictable stress. (biomedcentral.com)
  • After 28 days of chronic unpredictable stress (CUS) the animals submitted to this protocol displayed less weight gain than control animals. (biomedcentral.com)
  • Obesity is a multifactorial disease that is currently developing a threatening tendency towards becoming the main cause of chronic disease in the world. (benthamscience.com)
  • Similarly, a neutral, peripherally restricted CB 1 receptor antagonist (AM6545) was able to attenuate the metabolic phenotype caused by chronic corticosterone, suggesting a peripheral mechanism for these effects. (iasvn.org)
  • Despite professional society guidelines recommending that obesity be treated as a chronic disease by emphasizing the use of lifestyle modification in conjunction with pharmacotherapy, antiobesity medications are uncommonly prescribed in most clinical practices. (tomwademd.net)
  • The ovarian androgen excess may be because of an interaction between obesity-related, chronic hyperinsulinemia with genetic factors predisposing to the development of ovarian hyperandrogenism. (scienceopen.com)
  • Obesity is a chronic, multifactorial, relapsing disorder characterized by excess body weight and defined as a body mass index (BMI) of ≥ 30 kg/m2. (msdmanuals.com)
  • The ABOM stresses obesity be considered a chronic disorder that requires lifelong treatment and follow-up. (msdmanuals.com)
  • 145 ) noted that chronic intraventricular administration of BDNF prevented weight gain. (hyperthermicwellness.com)
  • Furthermore, AA attenuates the predisposition of GLUT10 G128E mice to HFD-triggered eWAT inflammation, adipokine dysregulation, ectopic fatty acid accumulation, metabolic dysregulation and body weight gain, as compared with WT mice. (researchsquare.com)
  • Obesity is frequently associated with WAT inflammation, which contributes to further ectopic fat accumulation and finally T2DM 5 . (researchsquare.com)
  • Patients first should be treated for the metabolic condition that is causing or exacerbating their hyperlipidemia. (medscape.com)
  • CB 1 R signaling is required for GC-mediated metabolic abnormalities. (iasvn.org)
  • VALUE RFVF 10050 ='Chills' 10100 ='Fever' 10120 ='Other symptoms of body temperature' 10121 ='Feeling cold' 10122 ='Feeling hot' 10123 ='Feeling hot and cold' 10150 ='Tiredness, exhaustion' 10200 ='General weakness' 10250 ='General ill feeling' 10300 ='Fainting (syncope)' 10350 ='Symptoms of fluid abnormalities' 10351 ='Edema' 10352 ='Excessive sweating, perspiration' 10353 ='Excessive thirst' 10400 ='Weight gain' 10450 ='Weight loss' 10451 ='Recent weight loss' 10452 ='Underweight' 10460 ='Symptoms of face, not elsewhere class. (cdc.gov)
  • However, the administration of SGA could generate several reported adverse effects, such as weight gain, obesity, metabolic disturbances, and hepatic and renal dysfunctions ( 5 - 7 ). (frontiersin.org)
  • It was observed an improvement in skeletal muscle mass, resting metabolic rate, as well as the consumption of fresh foods/g and processed food/kcal after the intervention period. (bvsalud.org)
  • The first step in the therapeutic strategy against obesity should be the correct diagnosis of its causes and the promotion of lifestyle changes including physical exercise and a healthy diet. (benthamscience.com)
  • While awaiting the release of new drugs, topiramate, alone or combined with phentermine, has been proposed as a novel anti-obesity drug, showing relevant effects not only on weight loss but also on cardiometabolic alterations and biomarkers, even though new studies should clarify the mechanisms of these findings. (benthamscience.com)
  • The specific mechanisms by which GCs modulate these processes remain largely unknown, but GCs increase production of endocannabinoids-potent central and peripheral regulators of appetite, energy balance, and metabolism. (iasvn.org)
  • Li and colleagues identify mechanisms that may account for the weight-loss-inducing effects of berberine. (tomwademd.net)
  • However, the effect of large yellow tea polysaccharides (LYPs) against obesity-associated metabolic syndrome and their underlying mechanisms remain unclear and must be extensively investigated. (bvsalud.org)
  • The pharmacological targets and molecular mechanisms related to risperidone-induced lipogenesis (RIL) remain to be elucidated. (frontiersin.org)
  • Risperidone upregulates fatty acid synthase (FASN) and sterol regulatory element-binding protein 1 (SREBP1) expression in hepatocyte cultures and mouse liver by targeting the hepatic SREBP-1c/FASN couple, which is also one of the mechanisms by which risperidone induces weight gain ( 24 ). (frontiersin.org)
  • As the underlying cellular mechanisms remain incompletely understood pharmacotherapies for chemotherapy-induced neuropathy are limited. (gp120-inhibitors.com)
  • The heterogeneity of the depression concept seems to play a differentiating role: metabolic syndrome and inflammation up-regulations appear more specific to the atypical depression subtype, whereas hypercortisolemia appears more specific for melancholic depression. (biomedcentral.com)
  • We have previously showed that genetic polymorphisms in glucose transporter 10 (GLUT10) gene are associated with a T2DM intermediate phenotype in non-diabetic population, and GLUT10 G128E mice (carrying human orthologous GLUT10 G128E variant) are highly sensitive to HFD-induced metabolic dysregulation. (researchsquare.com)
  • In addition to their marginal effects, many genetic factors are thought to alter susceptibility by environmental factors, such as high-fat diet (HFD), accelerating the development of T2DM 3 . (researchsquare.com)
  • Such complex interactions between various genetic risk factor combinations and specific diet or lifestyle characteristics make clinical studies on the effects of AA on T2DM difficult to design. (researchsquare.com)
  • In this study, we examined AA effects on metabolism in wild-type (WT) mice and GLUT10 G128E mice fed with a normal diet (CD) or HFD, as we previously showed that GLUT10 G128E mice are highly sensitive to HFD-induced T2DM 9 . (researchsquare.com)
  • Usually, gestational diabetes is treated and maintained through monitoring your glucose on a daily basis and by changing your diet and taking blood control supplements to help manage your blood glucose levels and keep it within a normal range. (loweringbloodsugar.com)
  • Obesity results from a combination of factors that occur exhibit low birth weight and glucose intolerance -- a mul- at different stages during a person's lifetime. (cdc.gov)
  • We support the concept that elevated glucose and fatty acids synergize in causing toxicity in islets and other organs, a process that may be instrumental in the pleiotropic defects associated with the metabolic syndrome and type 1 and type 2 diabetes. (diabetesjournals.org)
  • We investigated the impacts of AA on high-fat diet (HFD)-induced metabolic dysregulation in wild type (WT) and GLUT10 G128E mice. (researchsquare.com)
  • Here we show that AA has greater metabolic impacts on HFD-fed GLUT10 G128E mice than HFD-fed WT mice. (researchsquare.com)
  • AA plays an important role in improving WAT development and HFD-induced metabolic dysregulation in GLUT10 G128E mice. (researchsquare.com)
  • Graphs show that CORT-treated CB 1 R −/− mice have reduced ( A ) weight, ( B ) adiposity, and ( C ) adipocyte size. (iasvn.org)
  • CB 1 R −/− mice are also protected against the CORT-induced increase in ( G ) liver weight, ( H ) plasma cholesterol, ( I ) alanine aminotransferase (ALT), ( J ) triglycerides, and ( K ) hepatic triglycerides. (iasvn.org)
  • These mice experienced significant improvements in body weight, colon length and disease symptoms. (buypeptidesonlineusa.com)
  • Diet-induced obesity in C57BL/6 mice triggers common features of human metabolic syndrome (MetS). (scienceopen.com)
  • Therefore, we first used a genetically predisposed mouse model to investigate whether AA effects on metabolism might be influenced by particular genetic and diet. (researchsquare.com)
  • central regulators of metabolism and adipogenesis). (iasvn.org)
  • Together, these data indicate that glucocorticoids recruit peripheral endocannabinoid signaling to promote metabolic dysregulation, with hepatic endocannabinoid signaling being especially important for changes in lipid metabolism. (iasvn.org)
  • Alterations in endogenous hormone metabolism may provide the main links between endometrial cancer risk, and excess body weight and physical inactivity. (scienceopen.com)
  • Additionally, a 2020 study involving rats tested the effects of ginger water on weight loss and the metabolism of certain nutrients. (medicalnewstoday.com)
  • Consistent beneficial results for intestinal barrier function, immune system and metabolism were reported in animals may encourage long-term randomized clinical trials in people with obesity and cardiometabolic risk. (biomedcentral.com)
  • As protein can also manage your hormones that can elevate appetite so a low protein diet can cause weight gain easily. (dibesity.com)
  • Obesity, endogenous hormones, and endometrial cancer risk: a synthetic review. (scienceopen.com)
  • Studies indicate that obesity is associated with decreased testosterone, increased aromatase activity and secretion alterations of LH and FSH hormones. (militarymuscle.co)
  • Their offspring tend to have higher birth weights and more body fat, and carry an increased risk of obesity later in life. (karger.com)
  • 11 Several factors have been identified that increase the risk of obesity among refugees, including length of stay in the host country 12 - 14 , level of acculturation to U.S. lifestyles 15 - 17 , existing cultural beliefs and values 18 , and poor quality of housing. (cdc.gov)
  • Since NAFLD is closely associated with obesity, diabetes, and MetS, it is unknown whether the relationship between NAFLD and all-cause mortality and cardiovascular death, if any, is independent of cardiometabolic risk factors (Figure 1 ) such as MetS and type 2 diabetes. (hindawi.com)
  • Liver monocyte chemoattractant protein 1 (a proinflammatory protein associated with metabolic syndrome) gene expression was also significantly elevated in peri-SCN area dopaminergic lesioned rats. (biomedcentral.com)
  • 11), altered liver structure and function (12), altered naire data from 8,765 children aged 5 to 7 years, smoking gene expression (13), and possibly type 2 diabetes mel- after pregnancy was not associated with childhood obesity litus (10). (cdc.gov)
  • Depression has been shown to subsequently increase the risk of, for example, cardiovascular, stroke, diabetes and obesity morbidity. (biomedcentral.com)
  • Gaps exist in our information about diabetes and obesity in Arabpopulations in relation to ethnic-specific cut-off points for diagnosis and treatment of diabetes. (who.int)
  • Causes of obesity are multifactorial and include genetic predisposition and behavioral, metabolic, and hormonal influences. (msdmanuals.com)
  • According to the National Alliance on Mental Illness (NAMI) , second-generation antipsychotics have been the most closely associated with antipsychotic weight gain. (psychcentral.com)
  • Patients with triglyceride concentrations greater than 1000 mg/dL should receive diet and drug therapy and be closely monitored to prevent pancreatitis. (medscape.com)
  • Read our special collection of journal articles, published in 2022-2023, focused on obesity! (tomwademd.net)
  • Paclitaxel triggers anti-mitotic actions by impeding the cell cycle in the late Everolimus mTOR inhibitor stages of mitosis, backing microtubule formation, and eventually inducing apoptosis. (gp120-inhibitors.com)
  • Part of the difficulty with weight loss and maintenance by lowcalorie diets is that the body responds to CER through a series of compensatory changes in biological and behavioral determinants of body composition. (researchgate.net)
  • The improved metabolic syndrome of LYPs might be associated with the modulation of macrophage polarization. (bvsalud.org)
  • Within this context, the prebiotic effect of dietary fibres might be a feasible strategy to prevent T2D, through the modulation of metabolic response. (springer.com)
  • It is possible that associations of GWG with outcomes do not result from GWG itself, but rather to underlying factors that influence both weight gain and the outcomes (e.g., maternal diet composition or physical activity level). (nationalacademies.org)
  • Mongraw-Chaffin and coauthors find a strong graded association of body mass index and diabetes with self-reported COVID-19 that suggests obesity and diabetes might play a role in risk for symptomatic SARS-CoV-2 infection, beyond their co-occurrence with socioeconomic factors. (tomwademd.net)
  • In our overall synthesis, we conclude that development of ovarian hyperandrogenism may be a central mechanism relating nutritional lifestyle factors to endometrial cancer risk. (scienceopen.com)
  • It may also decrease risk factors of metabolic syndrome, a cluster of conditions that raise the risk of heart disease, stroke, and diabetes. (medicalnewstoday.com)
  • Testosterone levels naturally decline with age , but certain lifestyle factors, such as diet and exercise, can also impact hormone levels. (militarymuscle.co)
  • With both factors acting to modulate many aspects of metabolic and neural functioning - including central nervous system function. (militarymuscle.co)
  • Final y, the PEER REVIEWED cumulative effects of multiple factors contribute to eating behavior and obesity (3). (cdc.gov)
  • A developmen- sity from a developmental perspective combines social tal perspective recognizes the cumulative effects of factors context and biological influences with individual behav- that contribute to eating behavior and obesity, including ior (4,5). (cdc.gov)
  • Although a person is at risk for During gestation, risk factors for obesity include maternal obesity throughout his life, we focus on specific develop- diet, overweight, and smoking. (cdc.gov)
  • Type 2 diabetes is considered to be in most cases a polygenic disease with a strong involvement of environmental factors, such as diet and exercise ( 1 ). (diabetesjournals.org)
  • Risperidone-induced weight gain is associated with a number of factors, including gene polymorphisms ( 12 - 14 ), exercise ( 15 - 17 ), peripheral molecules ( 18 ), and hyperphagia caused by regulating the expression of melanocortin-4 receptor (MC4R), neuropeptide Y (NPY), and agouti-related peptide (AgRP) ( 19 - 21 ). (frontiersin.org)
  • There is a large potential population health gain if multiple risk factors are jointly controlled. (who.int)
  • An ILSI Europe workshop reviewed the key contributors leading to adverse outcomes in pregnancy and childhood, including gestational weight gain and nutrition. (karger.com)
  • The primary outcomes of this study were changes in blood pressure and weight, and the secondary outcomes were changes in body composition, glycosylated hemoglobin A1c (HbA1c), and blood lipids. (researchgate.net)
  • Of course, a few smaller cohort studies did find weight loss to be a benefit - but, as is the norm for aspartame research, those were sponsored by industries benefiting from positive outcomes. (draxe.com)
  • No matter what is the cause of this weight gain, if it is unintentional then it surely needs to be assessed and treated immediately in order to prevent any extreme outcomes. (dibesity.com)
  • Ultimately, obesity results from a long-standing imbalance between energy intake and energy expenditure, including energy utilization for basic metabolic processes and energy expenditure from physical activity. (msdmanuals.com)
  • Enhancing behavioral self-regulation skills in low-income children may be a unique and important intervention approach to prevent childhood obesity. (biomedcentral.com)
  • For diet-driven alterations of gut microbial composition particularly the type and proportion of complex indigestible carbohydrates that reach the colon turn out to be of great importance ( 18 , 19 , 21 - 24 ). (frontiersin.org)
  • Obesity was firstly described in 2000 as a cardiometabolic disease, even before Metabolic Syndrome, type 2 diabetes mellitus and coronary disease were considered as such. (benthamscience.com)
  • metabolic syndrome, type 2 diabetes, cardiovascular lesions and malignancies. (benthamscience.com)
  • Type 1 diabetes mellitus is a metabolic disease resulting from the destruction of insulinproducing β cells in the pancreas, that leads to hyperglycemia [1,2,20]. (researchgate.net)
  • Type 2 diabetes is becoming more common due to the growing number of older Americans, increasing obesity, and failure to exercise. (adam.com)
  • Type 2 diabetes can be improved, and in some cases even reversed, by lifestyle changes, such as adopting a healthy diet, becoming more active, and losing excess weight. (adam.com)
  • G6P availability directly modulates the activity of 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1), an ER-bound enzyme playing a key role in the development of the metabolic syndrome (MS). (biomedcentral.com)
  • Dr. Aturk's research is focused on immune checkpoint inhibitor-induced type 1 diabetes. (cuanschutz.edu)
  • They say there is no cure for type 2 diabetes but I was able to reverse the diagnosed pre diabetes and I was taken off my medication by staying away from sweets and sugary drinks, following a program consisting of a protein based, nutrient dense diet with moderate exercise. (loweringbloodsugar.com)
  • The chemotherapeutic agent used, dosing schedule, type of cancer, and presence of additional medical complications make a difference to the occurrence and severity of chemotherapy-induced neuropathy. (gp120-inhibitors.com)
  • These effects may partly be related to the heightened risk of gestational diabetes, occurring in at least 16% of all pregnancies irrespective of current body weight. (karger.com)
  • Future research should take into account the different causes of obesity and its adverse health conditions, which in turn have drastic effects on the microbiome balance. (frontiersin.org)
  • Finally, our own experience with topiramate is described, focusing on its effects upon weight loss and inflammatory markers. (benthamscience.com)
  • Proponents of diet drinks claim that no adverse effects have been proven and that aspartame-laced products contribute to weight loss. (draxe.com)
  • But along with symptom relief can come unexpected side effects-like weight gain. (psychcentral.com)
  • Clozapine has also been recognized as a prescription with more pronounced metabolic side effects-including weight gain- compared to other antipsychotic drugs. (psychcentral.com)
  • While antipsychotics are often associated with weight gain, you can experience other side effects that may impact your appetite and weight. (psychcentral.com)
  • Large yellow tea, a traditional functional beverage in China, has been shown to possess anti-obesity effects. (bvsalud.org)
  • A 2019 review of clinical trials looked into the effects of ginger shots on weight. (medicalnewstoday.com)
  • Because of its anorexigenic effects, many treated children maintain or lose weight. (medscape.com)
  • glucocorticoids, protein restrictions, and maternal diet and obesity. (cdc.gov)
  • A relatively constant percentage of synthetic glucocorticoids is bound to plasma proteins, and, because this percentage is concentration independent, the rate of metabolic clearance remains constant for synthetic glucocorticoids, regardless of dose. (medscape.com)
  • The emphasis of the report Nutrition During Pregnancy (IOM, 1990) was on the short-term consequences of gestational weight gain (GWG). (nationalacademies.org)
  • Recordings of maternal dietary intake and nutrient status are often limited and potential correlations with gestational weight gain have been poorly studied. (karger.com)
  • A number of potential implications for clinical practice are derived from the cardiometabolic state underlying obesity and its comorbidities. (benthamscience.com)
  • Obesity has become a global health crisis affecting over 1.5 billion people, resulting in metabolic and cardiovascular comorbidities as well as hypogonadic conditions characterized by decreased testosterone production or enhanced aromatase degradation of testosterone. (militarymuscle.co)
  • BACKGROUND: The role of obesity related genes (ORGs) in the immune checkpoint inhibitors (ICIs) treatment of prostate adenocarcinoma (PRAD) has not yet been proved by research. (bvsalud.org)