• This is because they are formed by entrapment of odontoblast processes between ameloblasts prior to and during amelogenesis. (wikipedia.org)
  • Taken together, our findings indicate that autophagy plays a crucial role in ameloblast differentiation and that its failure results in amelogenesis imperfecta through ectopic NRF2 activation. (bvsalud.org)
  • Enamel formation occurs through the process of amelogenesis, during which ameloblasts form and secrete the extracellular matrix which eventually matures into the outer hydroxyapatite layer of the tooth crown. (nih.gov)
  • In genetic conditions such as amelogenesis imperfecta (AI), in which certain enamel proteins are mutated, teeth are weak and often require repeated and increasingly extensive restorations to regain partial function. (nih.gov)
  • Collectively, our data highlight the importance of TMEM2 in adhesion to HA-rich extracellular matrix, cell-to-cell adhesion, ameloblast differentiation, and enamel matrix mineralization. (bvsalud.org)
  • In this study, we demonstrate Tmem2 messenger RNA expression in inner enamel epithelium and presecretory, secretory, and mature ameloblasts. (bvsalud.org)
  • Tmem2 knock-in reporter mice reveal TMEM2 protein localization at the apical and basal ends of secretory ameloblasts. (bvsalud.org)
  • Irregular actin filament assembly was also observed at the apical and basal ends of secretory ameloblasts. (bvsalud.org)
  • With the increase in enamel matrix deposition, immunostaining on the secretory pole of ameloblasts also increased. (bvsalud.org)
  • Dentine and predentine are deposited between the ameloblast layer, which is differentiated from the inner dental epithelium, and the odontoblasts. (nature.com)
  • The ameloblasts deposit a thin layer of an enamel-like matrix called enameloid on the surface of the dentine, and thus a new tooth is formed. (nature.com)
  • The teeth of male and, to a lesser degree, female rats had areas of microscopic dentine dysplasia and degeneration of ameloblasts. (nih.gov)
  • Whilst being weaker, dentine is a living a tissue and reacts by laying down more and more tubes, shrinking the nerve away from the harmful caries. (jamiethedentist.com)
  • Scanning electron microscopy of enamel from Tmem2-CKO mice revealed an irregular enamel prism structure, while the microhardness and density of enamel were significantly reduced, indicating impaired ameloblast differentiation and enamel matrix mineralization. (bvsalud.org)
  • At the molecular level, ameloblast differentiation was compromised through ectopic accumulation and activation of NRF2, a specific substrate of autophagy. (bvsalud.org)
  • These efforts may include establishing cells in the ameloblast lineage that retain their properties in culture or 3-dimensional co-cultures of various cell types that incorporate multiple biological signals necessary for the differentiation, growth, and function of ameloblast cells. (nih.gov)
  • Results: : The intensity varied among the layers from intense to weak in basal / peripheral ameloblast- like cells and parabasal layers respectively and negative staining was seen only in superficial layer of KCOT but not in Ameloblastoma-central stellate reticulum-like cells in qualitative assessment. (journalcra.com)
  • Quantitatively the basal layer/ peripheral ameloblast- like cells of both tumours had similar over expression while parabasal and central/superficial cells showed considerable differences. (journalcra.com)
  • Our study indicates similar over-expression of bcl-2 in both the odontogenic lesions specifically basal layer / peripheral ameloblast- like cells which may represent tumorigenesis by escaping apoptosis. (journalcra.com)
  • Your teeth become weak, causing them to become vulnerable to cavities , chipping, and even breaking. (zwivel.com)
  • Histological evaluation indicated weak adhesion between cells and the basement membrane in Tmem2-CKO mice. (bvsalud.org)
  • In addition, abnormal HA accumulation in the ameloblast layer and weak claudin 1 immunoreactivity in Tmem2-CKO mice indicate impaired tight junction gate function. (bvsalud.org)
  • This developmental condition is caused by the lack of mineralisation of enamel during its maturation phase, due to interruption to the function of ameloblasts. (web.app)
  • During this insufficiency, your enamel becomes thin and weak. (zwivel.com)