CamptothecinWaterTopoisomerase I InhibitorsDNA Topoisomerases, Type IWater SupplyAntineoplastic Agents, PhytogenicFresh WaterBody WaterTopotecanTopoisomerase InhibitorsWater PurificationWater PollutionCamptothecaDNA DamageWater Pollutants, ChemicalMolecular StructureAntineoplastic AgentsWater PollutantsEnzyme InhibitorsTopoisomerase II InhibitorsTeniposideOrganosilicon CompoundsStructure-Activity RelationshipDrug Screening Assays, AntitumorTumor Cells, CulturedRubiaceaeApoptosisOrganic Chemistry PhenomenaAphidicolinCell Line, TumorDNAMagnetic Resonance SpectroscopyKB CellsMolecular Sequence DataKineticsWater DeprivationEtoposideDNA Topoisomerases, Type IICell SurvivalDose-Response Relationship, DrugDrug ResistanceDNA, SuperhelicalWater MovementsAmsacrineEllipticinesWater SofteningLeukemia L1210Cell LineInhibitory Concentration 50Intercalating AgentsBase SequenceDNA ReplicationDrinkingChromatography, High Pressure LiquidDNA CleavageMutationModels, MolecularLactonesLeukemia P388DNA RepairCell CycleTime FactorsBinding SitesDrug Resistance, NeoplasmChemistry, OrganicIridoid GlucosidesNaphthoquinonesPlasmidsAmino Acid SequenceStereoisomerismProdrugsSubstrate SpecificityDiterpenesProtein BindingAlkaloidsNeoplasmsCricetinaeDNA, NeoplasmEstersIndicators and ReagentsSolubilitySecondary MetabolismAquaporinsTumor Suppressor Protein p53CatalysisDrug StabilityHeLa CellsMolecular ConformationDrug SynergismTemperatureMass SpectrometryPoly(ADP-ribose) PolymerasesCell DivisionHL-60 CellsDrug CarriersModels, BiologicalDNA-Binding ProteinsCells, CulturedHT29 CellsHematoporphyrin Derivative