• A body fluid model coordinated various flows in a human body with scheduled daily activities and could be used as a drug container to describe formulation-dependent disposition of 5-aminosalicylic acid and enterohepatic circulation of a virtual drug. (bvsalud.org)
  • Probenecid has also been reported to inhibit the renal transport of many other compounds including aminohippuric acid (PAH), aminosalicylic acid (PAS), indomethacin, sodium iodomethamate and related iodinated organic acids, 17-ketosteroids, pantothenic acid, phenolsulfonphthalein (PSP), sulfonamides, and sulfonylureas. (nih.gov)
  • Measurable changes in proximal tubule function, such as decreased clearance of para-aminohippuric acid also occur over a period of years and precede overt kidney failure. (testcatalog.org)
  • Renal blood flow and glomerular filtration rate were measured using infusion clearance of para-aminohippuric acid and a filtration marker, respectively. (biomedcentral.com)
  • It inhibits the tubular reabsorption of urate, thus increasing the urinary excretion of uric acid and decreasing serum urate levels. (nih.gov)
  • It is the simplest amide derivative of benzoic acid. (wikipedia.org)
  • Probenecid is the generic name for 4-[(dipropyl-amino)sulfonyl] benzoic acid. (nih.gov)
  • The chemical name for probenecid is 4-[(dipropylamino) sulfony1] benzoic acid. (nih.gov)
  • Probenecid is uricosuric and renal tubular transport blocking agent.Probenecid is the generic name for 4-[(dipropyl-amino)sulfonyl] benzoic acid. (drugcentral.org)
  • Finally, the adaptive kidney model accurately predicted CLr of para-amino-hippuric acid and memantine, two secreted compounds, in CKD, suggesting successful integration of active secretion into the model, along with passive reabsorption. (bvsalud.org)
  • The excretion of Stavudine can be decreased when combined with Acetylsalicylic acid. (drugbank.com)
  • The acid is a known carcinogen, and its use has been associated with and may cause end-stage renal disease and cancers of the urinary tract that may occur many years after usage has stopped. (unboundmedicine.com)
  • Any of the complex acids that occur as salts in bile, e.g., cholic, glycocholic, and taurocholic acids. (unboundmedicine.com)
  • As shown in Table 1 , thiazide and loop diuretics, which carry as a common chemical characteristic a sulfamoyl group (sulfonamide diuretics), are weak organic acids. (aspetjournals.org)
  • In these cases when alkali is administered, the acid-base balance of the patient should be watched. (nih.gov)
  • The effects of anions on net accumulation of (ρ-aminohippuric acid)(PAH) were studied in rabbit kidney cortical slices. (kyobobook.co.kr)
  • Corticosteroids inhibit formation of arachidonic acid from phospholipids when cell membranes are damaged. (unboundmedicine.com)
  • H 3 BO 3 , a white crystalline acid that in water forms a very weak acid solution poisonous to plants and animals. (unboundmedicine.com)
  • Not recommended in persons with known blood dyscrasias or uric acid kidney stones. (nih.gov)
  • Hypersensitivity to probenecid.Children under years of age.Not recommended in persons with known blood dyscrasias or uric acid kidney stones.Therapy with probenecid should not be started until an acute gouty attack has subsided. (drugcentral.org)
  • C 10 H 18 N 4 O 6 , a compound intermediate in the synthesis of arginine, formed from citrulline and aspartic acid. (unboundmedicine.com)
  • Because the suggestions for drug screening process in antineoplastic remedies need evaluation of individual tumors xenotransplanted into immune-compromised 4-Aminohippuric Acid mice (5), the function from the immune system continues to be neglected (6), producing studies centered on the interplay between disease fighting capability and dying cells required. (treatmentforprostatecancer.info)
  • ABBR: AHA Any of a class of water-soluble acids derived from fruit or milk, having a hydroxyl moiety in the first position in the molecule. (unboundmedicine.com)
  • Glacial (highly purified) acetic acid contains at least 99.5% acetic acid by weight. (unboundmedicine.com)
  • C 20 H 32 O 2 , an omega-6 fatty acid formed by the action of enzymes on phospholipids in cell membranes. (unboundmedicine.com)
  • In the United States, some areas also contain high natural levels of arsenic in rock, which can lead to elevated levels in the soil and drinking water. (testcatalog.org)