• Beta-hCG and alpha-fetoprotein have proved to be useful markers for ovarian germ cell tumors. (medscape.com)
  • The association of Klinefelter syndrome and mediastinal nonseminomatous germ cell tumors is now well recognized. (health.am)
  • Four of 22 consecutive patients (18%) treated at Indiana University for primary mediastinal germ cell tumors had karyotypic confirmation of Klinefelter syndrome, and an additional patient had clinical features. (health.am)
  • The average age of patients with Klinefelter syndrome who develop extragonadal germ cell tumors is approximately 18 years, 10 years younger than the median age of those developing this tumor in the absence of Klinefelter syndrome. (health.am)
  • Increasing evidence indicates that many individuals who develop germ cell tumors have underlying germ cell defects. (health.am)
  • Many patients with extragonadal germ cell tumors have histories of infertility, and testicular biopsy in these patients shows various abnormalities, including decreased spermatogenesis, peritubular fibrosis, and interstitial edema. (health.am)
  • In addition, patients who are successfully treated for extragonadal germ cell tumors have a markedly increased risk of developing a subsequent testicular germ cell tumor. (health.am)
  • These data suggest that either a congenital or an acquired germ cell defect contributes not only to defective spermatogenesis but also to the development of extragonadal germ cell tumors. (health.am)
  • Hematologic Neoplasia A unique association between mediastinal nonseminomatous germ cell tumors and a variety of hematologic neoplasms is now well described. (health.am)
  • In a series of 635 patients with extragonadal germ cell tumors, 17 patients developed hematologic malignancies at a median of 6 months after the extragonadal germ cell tumor was diagnosed. (health.am)
  • All hematologic neoplasms developed in the 287 patients with mediastinal nonseminomatous germ cell tumors, for a 2% incidence in this group. (health.am)
  • Foci of malignant lymphoblasts have been recognized histologically in several mediastinal germ cell tumors. (health.am)
  • However, the specific association of leukemias and other hematologic neoplasms with mediastinal nonseminomatous germ cell tumors, rather than with all germ cell tumors, remains unexplained. (health.am)
  • In addition to hematologic neoplasia, several cases of idiopathic thrombocytopenia in association with mediastinal nonseminomatous germ cell tumors have been reported. (health.am)
  • for instance, women younger than 30 years with an adnexal mass are more likely to have a benign cystic teratoma or other germ cell tumors, whereas women older than 30 years with an adnexal mass are more likely to have epithelial tumors. (mhmedical.com)
  • Ovarian cancer, uterine cervical cancer, endometrial cancer, and trophoblastic neoplasms are gynecologic malignancies for which tumor markers are in clinical use. (medscape.com)
  • Because pathologic diagnosis of ovarian cancer is difficult without laparotomy, tumor markers such as CA-125, in addition to diagnostic imaging, are useful in preoperative evaluation for ovarian cancer. (medscape.com)
  • Although adjuvant radiotherapy is commonly used to manage advanced or metastatic cervical and endometrial cancer, it is sometimes administered as adjuvant therapy for ovarian cancer. (medscape.com)
  • Ovarian cancer is the most common gynaecological malignancy with over 5000 new cases diagnosed every year in the UK and 22 000 in the. (annals.edu.sg)
  • We believe that CD24 is a key molecule of metastatic progression in the epithelial-mesenchymal-transition phenomenon and a promising therapeutic target for advanced ovarian cancer. (cusabio.com)
  • Correlation between progression-free survival and overall survival in patients with ovarian cancer after cytoreductive surgery: a systematic literature review. (ucla.edu)
  • The power of hope: Views of Ovarian Cancer patients on how maintenance therapy Affects their Lives (VOCAL). (ucla.edu)
  • Quality-adjusted time without symptoms of disease or toxicity and quality-adjusted progression-free survival with niraparib maintenance in first-line ovarian cancer in the PRIMA trial. (ucla.edu)
  • Impact of disease progression on health-related quality of life of advanced ovarian cancer patients - Pooled analysis from the PRIMA trial. (ucla.edu)
  • Carcinoma of cervix is classified as per the WHO classification into primary tumors which are predominantly epithelial tumors, mesenchymal tumors and tumor like lesions, mixed epithelial stromal tumors, melanocytic, germ cell, and lymphoid tumors. (cytojournal.com)
  • For example, a benign tumor of smooth muscle cells is called a leiomyoma (the common name of this frequently occurring benign tumor in the uterus is fibroid). (wikipedia.org)
  • Solitary tumors of the uterus which arise de novo from the mesenchymal cells of the myometrium. (brainscape.com)
  • Confusingly, some types of cancer use the -noma suffix, examples including melanoma and seminoma. (wikipedia.org)
  • The false negative rate was 3%, similar to that for cases of breast cancer, melanoma, and vulvar cancer, for which sentinel-lymph node biopsy has become the standard of care. (medscape.com)
  • Gynecologic cancers were among the first malignancies treated with ionizing radiation, more than a century ago. (medscape.com)
  • Fallopian tube cancer is the least common of gynaecological malignancies. (annals.edu.sg)
  • Although this most common gynecologic cancer carries the best prognosis, it is important to differentiate between the classic endometrioid tumors that tend to be estrogen dependent and well differentiated, from other less common high-risk uterine malignancies, such as uterine papillary serous carcinomas (UPSCs), clear cell carcinomas, mixed mullerian tumors (MMTs), or sarcomas, which appear to have a different biology. (medmuv.com)
  • Classical diagnostic issues in gynecologic pathology have revolved around the potential for non-neoplastic diseases, benign neoplasms, and malignancies to mimic each other, and for different histotypes of malignancies to display morphologic and/or immunophenotypic overlap. (cme-video.com)
  • Sarcoma: Cancers arising from connective tissue (i.e. bone, cartilage, fat, nerve), each of which develop from cells originating in mesenchymal cells outside of the bone marrow. (wikipedia.org)
  • Cancers are usually named using -carcinoma, -sarcoma or -blastoma as a suffix, with the Latin or Greek word for the organ or tissue of origin as the root. (wikipedia.org)
  • At Fred Hutchinson Cancer Center, our experts offer multidisciplinary, team-based soft tissue sarcoma treatment as well as bone cancer treatment, including advanced therapies and new options that are only available through clinical trials. (fredhutch.org)
  • Because there are more than 70 subtypes of sarcoma - depending on the nearby tissue, the affected area of the bone or the type of cells creating the tumor - there is no one way to treat everyone. (fredhutch.org)
  • For example, the most common cancer of the liver parenchyma ("hepato-" = liver), arising from malignant epithelial cells ("carcinoma"), would be called a hepatocarcinoma, while a malignancy arising from primitive liver precursor cells is called a hepatoblastoma. (wikipedia.org)
  • Similarly, a cancer arising from malignant fat cells would be termed a liposarcoma. (wikipedia.org)
  • Recent evidence indicates that the hematologic neoplasms in this setting are not treatment related, but rather arise from clones of malignant lymphoblasts or myeloblasts contained within the mediastinal germ cell tumor. (health.am)
  • Among sporadic endometrial cancers, when present, the microsatellite instability is confined to the malignant cells, and is not seen in the adjacent normal epithelium. (medmuv.com)
  • Most often, these tumors are benign, although it is possible for them to be malignant and to spread or metastasize. (moffitt.org)
  • In addition, beta-hCG serves as an ideal tumor marker for monitoring gestational trophoblastic disease and has set the standard with which other assays must be compared. (medscape.com)
  • I have expertise in robotic surgery, as well as in treating endometrial cancers and gestational trophoblastic neoplasms. (rochester.edu)
  • Gestational trophoblastic diseases (GTD) encompass a spectrum of interrelated conditions: Hydatidiform mole (HM) Invasive mole (IM) Choriocarcinoma (CC) Placental site trophoblastic tumour (PSTT) This article is available only as. (annals.edu.sg)
  • Lymphoma and leukemia: These two classes of cancer arise from immature cells that originate in the bone marrow, and are intended to fully differentiate and mature into normal components of the immune system and the blood, respectively. (wikipedia.org)
  • Some of the body's lymphocytes (immune cells) are found in the skin, so when the cancer originates there, it is called cutaneous lymphoma. (moffitt.org)
  • Depending on the type of lymphocytes affected (B cells or T cells), this type of skin cancer may be classified as cutaneous B-cell lymphoma or cutaneous T-cell lymphoma . (moffitt.org)
  • Papillary serous, clear-cell, and mixed mesodermal tumors are all considered grade 3 lesions. (medscape.com)
  • It proved to be a valid biomarker especially in detecting squamous intraepithelial lesions in cervical liquid-based samples and in discerning these lesions from their mimickers, as well as in ovarian, endometrial, vulvar, primary and metastatic melanomas, breast, pancreatic and renal cell carcinomas. (medsci.org)
  • Menometrorrhagia, which involves both excessive and irregular bleeding, should be distinguished from menorrhagia, and usually involves anovulatory cycles or genital lesions such as endometrial or cervical cancer. (mhmedical.com)
  • Kirsten (Ki)-ras activating point mutations in codons 12 and 13 have been implicated in the development of atypical endometrial hyperplasias and endometrioid carcinomas in Japanese women, as well as in colon cancers. (medmuv.com)
  • Endometrioid cancers arising in Japanese women tend to be high grade and deeply invasive, are less common than in the United States , and are not generally associated with hormonal exposure. (medmuv.com)
  • Notable was the almost complete absence of Ki-ras mutations in an aggressive form of endometrial cancer, UPSC, when compared to the usual endometrioid tumors. (medmuv.com)
  • Endometrial cancer is usually endometrioid adenocarcinoma. (msdmanuals.com)
  • General references Endometrial cancer is usually endometrioid adenocarcinoma. (msdmanuals.com)
  • The two most common types of nonmelanoma skin cancer are basal cell carcinoma and squamous cell carcinoma. (moffitt.org)
  • Basal cell carcinoma is the most common type of skin cancer, with approximately 3.6 million cases diagnosed in the United States each year. (moffitt.org)
  • Although basal cell carcinoma and squamous cell carcinoma make up the large majority of nonmelanoma skin cancer cases, there are various other rare forms of this malignancy that together comprise a small percentage of the total number of diagnoses. (moffitt.org)
  • A soft polypoid mass, which is a rare form of primary vaginal cancer. (brainscape.com)
  • The primary end point was disease control rate (DCR) at week 24 by Response Evaluation Criteria in Solid Tumors version 1.1. (bvsalud.org)
  • Brachytherapy is an important component of treatment that escalates the dose of radiation to the primary tumor while minimizing the dose to critical organs at risk. (health.am)
  • In this interactive microscopy course, the faculty will present cases wherein one lesion may potentially be mistaken for another due to varying degrees of morphologic and/or immunophenotypic overlap between them, or in which a cancer may be misclassified regarding grade, stage or primary site for a variety of reasons. (cme-video.com)
  • Sentinel lymph node biopsy involves removal only of organ-specific lymph nodes, identified by injecting dye near the primary tumor. (medscape.com)
  • The primary objectives in a diagnostic evaluation for suspected cancer are determinations of the tissue type, the primary site of malignancy, the extent of disease within the body and the tumor's future recurrence potential. (oncolink.org)
  • Dostarlimab for Primary Advanced or Recurrent Endometrial Cancer. (ucla.edu)
  • The grade of the tumor is based primarily on the amount of solid growth of its glandular component. (medscape.com)
  • Endometrial hyperplasia is classified by its cytology and glandular tissue. (lookformedical.com)
  • Chromosome 17p is frequently involved, which contains the p53 gene known to confer a poor prognosis in endometrial cancers when mutated or deleted, and which plays an important role in the transition to carcinoma from atypical hyperplasia. (medmuv.com)
  • Current strategies for treating cancers of the uterine corpus , uterine cervix , vulva , and vagina are tailored to the clinical and pathologic stage of disease. (medscape.com)
  • In contrast, 25% of uterine sarcomas, an entity not recognized to be part of a familial cancer syndrome, exhibits microsatellite instability that may be related to a mutation in the hMSH2 gene. (medmuv.com)
  • Cancer Stat Facts: Uterine Cancer. (msdmanuals.com)
  • In recent years, two transcriptional subtypes of pancreatic ductal adenocarcinoma (PDAC), the most aggressive form of pancreatic cancer, have been identified: classical and basal. (fredhutch.org)
  • Dr. DuBeshter has contributed to numerous journal, abstracts, and books, including the chapter on gynecologic cancer in the textbook Clinical Oncology: A Multidisciplinary Approach. (rochester.edu)
  • He is a member of the International Gynecologic Cancer Society and the Society of Gynecologic Oncologists, as well as the American Society of Clinical Oncology. (rochester.edu)
  • He currently serves on the Clinical Practice and Finance Committee of the Society of Gynecologic Oncologists and is a reviewer for Obstetrics & Gynecology, Gynecologic Oncology, and the International Journal of Gynecologic Cancer. (rochester.edu)
  • A reduction in GI toxicity is likely to improve the quality of life in individuals with gynecologic cancer. (bcbsnd.com)
  • Endometrial cancer is the most commonly diagnosed gynecologic cancer in the United States, affecting about 54,000 women each year. (medscape.com)
  • Squamous cell carcinoma (SCC) in various morphological forms needs to be separated from other epithelial tumors for treatment modality selection. (cytojournal.com)
  • High-risk HPV is implicated in causation of various other cancers such as anal cancers, oropharyngeal cancers, vulval cancers, vaginal cancers, and penile cancers. (cytojournal.com)
  • benign tumors are not classified as being cancer because they do not spread to other parts of the body. (wikipedia.org)
  • Benign tumors (which are not cancers) are usually named using -oma as a suffix with the organ name as the root. (wikipedia.org)
  • Mixed mesenchymal and epithelial tumors are of Mullerian origin. (cytojournal.com)
  • The various tumor markers differ in their usefulness for screening, diagnosis, prognosis, assessing therapeutic response, and detecting recurrence. (medscape.com)
  • thus the hereditary form of endometrial cancer alone does not appear to portend a worse prognosis than the sporadic form. (medmuv.com)
  • Correctly identifying the type of cancer that a patient has is critical, since this information will affect their prognosis and treatment options. (moffitt.org)
  • Zurück zum Zitat Haffty BG, Fischer D, Beinfield M, McKhann C (1991) Prognosis following local recurrence in the conservatively treated breast cancer patient. (springermedizin.de)
  • Today, the Abramson Cancer Center handles more than 70,000 outpatient visits each year and provides more than 33,000 chemotherapy treatments and 66,000 radiation treatments. (mesothelioma.com)
  • Long-term survival after paclitaxel plus platinum-based combination chemotherapy for extraovarian peritoneal serous papillary carcinoma: is it different from that for ovarian serous papillary cancer? (bmj.com)
  • Chemotherapy, radiation therapy or both may be given before or after surgery to reduce the risk of the cancer coming back. (fredhutch.org)
  • The standard treatment of locally advanced cervical cancer is EBRT with concurrent chemotherapy, followed by brachytherapy. (health.am)
  • Chemotherapy - medications that kill cancer cells. (indiahealthtour.com)
  • Chemotherapy has the ability to interfere with the cancer cell's replication. (indiahealthtour.com)
  • CD133+CD24lo phenotype defines 5-FU-resistant human colon cancer stem cell-like cells. (cusabio.com)
  • The replication error (RER+) phenotype is characteristic of cancers arising in HNPCC kindreds (a familial cancer syndrome with a high incidence of colon, endometrial, gastric, and a lower incidence of ovarian and pancreatic cancers), and is also found in approximately 20% of sporadic endometrial cancers. (medmuv.com)
  • Mutation of the transforming growth factor (TGF) beta receptor type II gene is common in RER+ colon and gastric cancers, but uncommon in RER+ endometrial cancers even those arising in HNPCC kindreds, suggesting that the genesis of RER+ tumors even within the same familial cancer syndrome is not the same. (medmuv.com)
  • Although inactivation of both alleles of either hMSH2 or MLH1 (DNA mismatch repair genes) appears to underlie microsatellite instability in tumors of HNPCC kindreds, similar to the findings in sporadic colon cancers, sporadic endometrial cancers were not associated with mutations of any of the four known human mismatch repair genes. (medmuv.com)
  • Chromosome 18q contains the DCC gene, a putative tumor suppressor gene frequently mutated in colon cancers. (medmuv.com)
  • For example, the most common type of breast cancer is called ductal carcinoma of the breast. (wikipedia.org)
  • A slightly increased incidence of breast cancer has been described in these men, but a general predisposition to other cancers has not been observed. (health.am)
  • The Women's Health Initiative (WHI) study reported increased risks of myocardial infarction, stroke, invasive breast cancer, pulmonary emboli, and deep vein thrombosis in postmenopausal women (50 to 79 years of age) during 5 years of treatment with oral conjugated estrogens (CE 0.625 mg) combined with medroxyprogesterone acetate (MPA 2.5 mg) relative to placebo. (nih.gov)
  • Lumpectomy is also called breast-conserving surgery , because during the operation, the breast cancer tumor along with a rim of healthy surrounding tissue is removed, while as much of the remaining breast tissue as possible is conserved. (bcm.edu)
  • Lumpectomy is generally suitable for patients with smaller breast lumps, early stage breast cancer, or for patients who have gone through other therapy methods to shrink a tumor in the breast. (bcm.edu)
  • Most often, surgery is the first step in breast cancer treatment, but it can also follow other types of therapy, which may be used to shrink the tumor first. (bcm.edu)
  • Secondary tumors are uncommon. (cytojournal.com)
  • The world-renowned experts from the NCCN diagnose and treat patients with cancer, with a particular focus on uncommon, complex and aggressive forms of cancer. (moffitt.org)
  • Other frequently involved regions include 10q, 3p, and 18q, with no significant differences found in the chromosomal regions involved in endometrial from cervical cancers. (medmuv.com)
  • However, some body parts contain multiple types of tissue, so for greater precision, cancers are additionally classified by the type of cell that the tumor cells originated from. (wikipedia.org)
  • Blastoma: Cancers derived from immature "precursor" cells or embryonic tissue. (wikipedia.org)
  • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA254759(CD24 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (cusabio.com)
  • Radiation treatment planning has evolved to use 3D images, usually from computed tomography (CT) scans, to more precisely delineate the boundaries of the tumor and to discriminate tumor tissue from adjacent normal tissue and nearby organs at risk for radiation damage. (bcbsnd.com)
  • Brachytherapy is a type of cancer treatment in which radioactive implants are inserted directly into the tissue near the tumor site. (health.am)
  • An increase in the number of cells in a tissue or organ without tumor formation. (lookformedical.com)
  • The Non-Hodgkin's lymphomas (NHL) comprise a diverse collection of lymphoreticular neoplasms, usually but not necessarily arising in nodal tissue. (oncolink.org)
  • During the procedure, a specialist breast surgical oncologist makes an incision on the breast and removes the cancer and some of the healthy surrounding breast tissue. (bcm.edu)
  • The specimen is said to have "clear margins" if no cancer is found around the borders of the removed tissue. (bcm.edu)
  • These extra cells can form a mass of tissue called a growth or tumor. (indiahealthtour.com)
  • IMRT has been compared with 3-dimensional conformal radiotherapy (3D-CRT) for the treatment of stomach, hepatobiliary, and pancreatic cancers. (bcbsnd.com)
  • When multivariate analysis was used to determine if HER-2/neu was an independent prognostic factor in endometrial cancers taking into account other molecular features such as DNA ploidy, epidermal growth factor receptor, or p53 status, HER-2/neu status failed to achieve significance. (medmuv.com)
  • OBJECTIVES: To evaluate the prevalence of post-operative complications and quality of life (QoL) related to sentinel lymph node (SLN) biopsy vs systematic lymphadenectomy in endometrial cancer. (bvsalud.org)
  • METHODS: A prospective cohort included women with early-stage endometrial carcinoma who underwent lymph node staging, grouped as follows: SLN group (sentinel lymph node only) and SLN+LND group (sentinel lymph node biopsy with addition of systematic lymphadenectomy). (bvsalud.org)
  • Experts in endometrial cancer suggest there should be a change in the standard of care, after the largest study to date found that sentinel lymph node biopsy is as accurate for identifying metastasis as complete pelvic lymphadenectomy, which is more invasive and is the current gold standard. (medscape.com)
  • The findings come from the FIRES study (Fluorescence Imaging for Robotic and Endometrial Sentinal Lymph Node Biopsy), which was published online on January 31 in Lancet Oncology . (medscape.com)
  • I think sentinel lymph node biopsy can replace the traditional lymphadenectomy technique and should become the standard of care in endometrial cancer. (medscape.com)
  • Currently, the National Comprehensive Cancer Network endorses sentinel lymph node biopsy as an acceptable standard of care for surgical staging of endometrial cancer in select patients. (medscape.com)
  • Biopsy methods for accurate histologic or cytologic proof of malignancy are absolutely essential to workup and subsequent management of suspected cancer patients. (oncolink.org)
  • If the lump being removed is non-cancerous, such as a fibroadenoma (a benign tumor in the breast), the procedure is often called an excisional breast biopsy instead of a lumpectomy. (bcm.edu)
  • In this article, clinical indications and common techniques for radiation therapy in the management of common gynecologic cancers are described. (medscape.com)
  • To our knowledge this is the first reported case of an isolated vesicocutaneous fistula related to previous radiation therapy for recurrent vulvar cancer. (annals.edu.sg)
  • Radiation therapy may be administered externally (i.e., a beam of radiation is directed into the body) or internally (i.e., a radioactive source is placed inside the body, near a tumor). (bcbsnd.com)
  • The researchers used the Surveillance, Epidemiology, and End Results (SEER) Database to identify 7,359 patients with advanced stage cervical cancer treated with external beam radiation therapy (EBRT) between 1988 and 2009. (health.am)
  • The researchers noted that the decline may be related to the decreasing incidence of cervical cancer and increased adoption of alternative treatment techniques, such as intensity modulated radiation therapy (IMRT) and stereotactic body radiation therapy (SBRT). (health.am)
  • Radiation therapy - treatment that uses high-energy rays that damage cancer cells and halts the spread of cancer. (indiahealthtour.com)
  • Radiation therapy is very localized, aimed at only the area where the cancer is present. (indiahealthtour.com)
  • The objective of a cervical screening programme is to prevent invasive cancer of the cervix by detecting and treating pre-invasive disease of the cervix. (annals.edu.sg)
  • Produces a "barrel cervix" if the tumor encircles the cervix and invades the underlying stroma. (brainscape.com)
  • Carcinoma cervix is not the only cancer caused by HPV. (cytojournal.com)
  • Tumor markers are tumor-derived or tumor-associated proteins, antigens, genes or hormones that can also aid in diagnosis, in the measurement of therapeutic response, in locating tumor origin or in determining recurrence. (oncolink.org)
  • The rate may be stabilizing because women often seek second opinions, and the number of therapeutic options (ie, laser therapy, endometrial ablation , and medications to shrink fibroid tumors) has increased. (brainkart.com)
  • Writing in a linked editorial , Frédéric Amant, MD, PhD, and Hans Trum, MD, both of the Netherlands Cancer Institute, in Amsterdam, agree that pelvic sentinel lymph node mapping is "probably sufficient to direct further treatment" and that the technique may change existing treatment protocols. (medscape.com)
  • It is often used for detecting ascites, biliary or renal obstruction, or pelvic tumors, and is also useful for guiding biopsies. (oncolink.org)
  • Corresponding author: Dr. Maria Gabriella Malzone, Pathology and Cytopathology Unit, National Cancer Institute "Fondazione G. Pascale", via Mariano Semmola, 80131 Napoli, Italy. (medsci.org)