Voltage gated ion channel kv1 2 potassium channel. Medical search. Frequent questions

Potassium voltage-gated channel subfamily E member 4, originally named MinK-related peptide 3 or MiRP3 when it was discovered, is a protein that in humans is encoded by the KCNE4 gene. (wikipedia.org)
Kv1.1 belongs to the Kv1 subfamily, consisting of eight members (Kv1.1 to Kv1.8). (biomedcentral.com)

KCNE4 is best known for modulating the KCNQ1 Kv α subunit, but it also regulates KCNQ4, Kv1.x, Kv2.1, Kv4.x and BK α subunits in heterologous co-expression experiments and/or in vivo. (wikipedia.org)
KCNE4 often, but not always, acts as an inhibitory subunit to suppress potassium channel function, but this varies depending on the channel subtype. (wikipedia.org)
10. Scott VE, Rettig J, Parcej DN, Keen JN, Findlay JB, Pongs O, and Dolly JO (1994) Primary structure of a β subunit of α-dendrotoxin-sensitive K + channels from bovine brain. (aspetjournals.org)
11. Rettig J, Heinemann SH, Wunder F, Lorra C, Parcej DN, Dolly JO, and Pongs O (1994) Inactivation properties of voltage-gated K + channels altered by presence of β-subunit. (aspetjournals.org)
13. Rhodes KJ, Keilbaugh SA, Barrezueta NX, Lopez KL, and Trimmer JS (1995) Association and colocalization of K + channel α-and β-subunit polypeptides in rat brain. (aspetjournals.org)

12. Kim E, Niethammer M, Rothschild A, Jan YN, and Sheng M (1995) Clustering of Shaker-type K + channels by interaction with a family of membrane-associated guanylate kinases. (aspetjournals.org)
To test this, we are examining whether Nematostella Shaker family Kv channels are resistant to a Shaker-like 2 toxin (Shkl2) present in their own venom. (csumb.edu)
We expressed the Nematostella Shaker channels in Xenopus oocytes to expose them to Shkl2 to assess functional block using two electrode voltage clamp. (csumb.edu)
Results obtained from this experiment suggest resistance in two different Nematostella shaker channels (NvKv1 and NvKv2) to Shkl2 which provides insight into the co-evolution of toxins and their target channels in venomous anthozoans. (csumb.edu)
This gene encodes a voltage-gated delayed potassium channel that is phylogenetically related to the Drosophila Shaker channel. (thermofisher.com)

The KCNE4 gene encodes KCNE4 (originally named MinK-related peptide 3 or MiRP3), a member of the KCNE family of voltage-gated potassium (Kv) channel ancillary or β subunits. (wikipedia.org)
brush resides in a cluster of redundant CNGCs encoding subunits which resemble metazoan voltage-gated potassium (Kv1-Kv4) channels in assembly and gating properties. (elifesciences.org)
The results reveal a mechanism by which quantitative competition between channel subunits for tetramer assembly can impact the phenotype of the mutation carrier. (elifesciences.org)
Therefore, we hypothesized that the truncated Kv1.1 would be expressed and dysregulate other Kv1 subunits in the mceph/mceph mice. (biomedcentral.com)
Interactions between MCEPH and other Kv1 subunits were studied in cell culture, Xenopus oocytes and the brain. (biomedcentral.com)
The channels are hetero- or homotetramers, formed by a great variety of subunits, classified in 12 subfamilies [ 5 ]. (biomedcentral.com)
Kv1.1, Kv1.2 and Kv1.4 are the most abundant Kv1 subunits expressed in the brain [ 6 ]. (biomedcentral.com)
The N-terminus of the channel is associated with beta subunits that can modify the inactivation properties of the channel as well as affect expression levels. (thermofisher.com)

KCNE4 strongly inhibits Kv1.1 and Kv1.3 channels when co-expressed in HEK cells and in Xenopus laevis oocytes, while leaving Kv1.2 and Kv1.4 currents unaffected. (wikipedia.org)
The Kv1.3 channel has become a therapeutic target for the treatment of various diseases. (mdpi.com)
In this work, we developed an efficient system for the production of three potent Kv1.3 channel blockers from different scorpion venoms: Vm24, AnTx, and Ts6. (mdpi.com)
Voltage-gated potassium channel KV1.3 inhibitors have been shown to be effective in preventing T-cell proliferation and activation by affecting intracellular Ca2+ homeostasis. (bvsalud.org)

The delayed rectifier-type (IK)channels (Kv1.5, Kv2.1, and Kv2.2) are expressed on all neuronal somata and proximal dendrites and are also found in a wide variety of non-neuronal cells types including pancreatic islets, alveolar cells and cardiac myocytes (Hwang et al. (antibodiesinc.com)

KCNE4 slows activation and inactivation of Kv4.2 channels, and induces overshoot upon recovery from inactivation. (wikipedia.org)
Scorpion α-toxins (α-NaTx) inhibiting the inactivation of voltage-gated sodium channels (Nav ) are a well-studied family of small proteins. (bvsalud.org)
Herein we used a natural source of new peptide compounds active on ion channels and screened for drugs capable to inhibit channel inactivation as a way to compensate for decreased channel function. (bvsalud.org)

Cyclic nucleotide-gated channel (CNGC) family members mediate Ca 2+ influx from cellular stores in plants (Charpentier et al. (elifesciences.org)

These oscillations are driven primarily by voltage-gated sodium channels and are distinct from resonant properties derived from other active membrane properties. (jneurosci.org)
Nav1.1 is an important pharmacological target as this voltage-gated sodium channel is involved in neurological and cardiac syndromes. (bvsalud.org)
Voltage-gated sodium channels (Navs) play an essential role in neurotransmission, and their dysfunction is often a cause of various neurological disorders. (bvsalud.org)

Predicted to enable delayed rectifier potassium channel activity. (mcw.edu)
8. Paulmichl M, Nasmith P, Hellmiss R, Reed K, Boyle WA, Nerbonne JM, Peralta EG, and Clapham DE (1991) Cloning and expression of a rat cardiac delayed rectifier potassium channel. (aspetjournals.org)
1 channels to the delayed rectifier current in freshly dispersed smooth muscle cells from rabbit urethra. (antibodiesinc.com)

Treatment with potassium channel blockers have been shown to block apoptosis in various cell types [ 11 ]. (biomedcentral.com)

Predicted to be involved in potassium ion transmembrane transport. (mcw.edu)

Several onconeural antibodies were described by the group at Memorial Sloan Kettering 2 and were subsequently named according to the initials of the patients (Hu, Yo, Ri, etc.) in whom they were discovered. (touchneurology.com)
This group of diseases behaves like the target-specific antibodies-the effect of autoantibodies on potassium channels was described by Hart et al. (touchneurology.com)

The responsible mutation was recently revealed to be an eleven base pair deletion, leading to a frame shift, in the gene encoding the potassium channel Kv1.1. (biomedcentral.com)
Western blot analysis of KV1.1 (KCNA1) in Lane 1: rat brain tissue lysate (40 µg), Lane 2: rat testis tissue lysate (40 µg), Lane 3: rat cardiac muscle tissue lysate (40 µg), Lane 4: HeLa whole cell lysate (40 µg), Lane 5: U87 whole cell lysate (40 µg), Lane 6: SHG whole cell lysate (40 µg), Lane 7: NEURO whole cell lysate (40 µg). (thermofisher.com)
A synthetic peptide corresponding to a sequence at the C-terminus of human Kv1.1 potassium channel (465-481aa IAHYRQVNIRTANCTTA). (thermofisher.com)

TASK-1 channels are sensitive to a wide array of physiological and pharmacological mediators that affect their activity such as unsaturated fatty acids, extracellular pH, hypoxia, anaesthetics and intracellular signalling pathways. (ersjournals.com)
Their activity is gated by a range of stimuli, including voltage and a variety of physiological and pharmacological mediators. (ersjournals.com)

Co-expression with KChIP2 produces intermediate gating kinetics in complexes with Kv4.2 and KCNE4. (wikipedia.org)

Channel activators are actively sought to try to compensate for haploinsufficiency in several of these pathologies. (bvsalud.org)

Andreasen M, Hablitz JJ (1993) Local anesthetics block transient outward potassium currents in rat neocortical neurons. (yale.edu)
Christie JM, Westbrook GL (2003) Regulation of backpropagating action potentials in mitral cell lateral dendrites by A-type potassium currents. (yale.edu)
The voltage dependence of hEag currents is not determined solely by membrane-spanning domains. (epfl.ch)

Few selective inhibitors of this channel are known in the literature. (bvsalud.org)
In this work, we report the discovery of a new series of aryl and acylsulfonamides as state-dependent inhibitors of Nav1.3 channels. (bvsalud.org)

The majority of studies of KCNE4 function, structure-function relationships and effects of pathological gene sequence variants within KCNE4 have utilized the widely reported 170 residue version of the protein encoded by exon 2 of the human KCNE4 gene. (wikipedia.org)
1. McKinnon D (1989) Isolation of a cDNA clone coding for a putative second potassium channel indicates the existence of a gene family. (aspetjournals.org)
9. Grissmer S, Dethlefs B, Wasmuth JJ, Goldin AL, Gutman GA, Cahalan MD, and Chandy KG (1990) Expression and chromosomal localization of a lymphocyte K + channel gene. (aspetjournals.org)

A direct link between potassium channel dysfunction and apoptosis is that reduced intracellular potassium levels appear to promote critical events early in the suicide program. (biomedcentral.com)
A sustained increase in the intracellular Ca²⁺ concentration induces proteolytic cleavage of EAG2 channel. (epfl.ch)
Roles of surface residues of intracellular domains of heag potassium channels. (epfl.ch)

2. Kamb A, Weir M, Rudy B, Varmus H, and Kenyon C (1989) Identification of genes from pattern formation, tyrosine kinase, and potassium channel families by DNA amplification. (aspetjournals.org)
5. Chandy KG, Williams CB, Spencer RH, Aguilar BA, Ghanshani S, Tempel BL, and Gutman GA (1990) A family of three mouse potassium channel genes with intronless coding regions. (aspetjournals.org)

KCNE4 inhibits BK activity by positive-shifting the voltage dependence of BK activation and accelerating BK protein degradation. (wikipedia.org)
In the rat heart, KCNE4 protein co-localizes with Kv4.2, a channel that KCNE4 also functionally regulates. (wikipedia.org)
Further experiments found that the channel formed by the mutated CNGC protein is leaky and allows calcium ions to enter the cell in the absence of any cue from the environment. (elifesciences.org)
These findings provide important insights into the function of CNGCs and reveal how a small change in a channel protein can have far reaching effects on an organism. (elifesciences.org)
The C-terminus of the channel is complexed to a PDZ domain protein that is responsible for channel targeting. (thermofisher.com)

Somatodendritic ion channel expression in substantia nigra pars compacta dopaminergic neurons across postnatal development. (antibodiesinc.com)
Antic S, Zecevic D (1995) Optical signals from neurons with internally applied voltage-sensitive dyes. (yale.edu)
Colbert CM, Pan E (2002) Ion channel properties underlying axonal action potential initiation in pyramidal neurons. (yale.edu)
K+ channel regulation of signal propagation in dendrites of hippocampal pyramidal neurons. (modeldb.science)
Differential localization of rat Eag1 and Eag2 K+ channels in hippocampal neurons. (epfl.ch)

These proteins act as channels and allow ions to move across cell membranes. (elifesciences.org)
All patients were negative for the VGKC-complex-associated proteins LGI1, CASPR2 and contactin-2. (bmj.com)

ABSTRACT: The opening and closing of voltage-gated ion channels are regulated by voltage sensors. (chemaxon.com)

2007). Here, we report the unusual genetic behavior of a quantitative gain-of-function CNGC mutation ( brush ) in Lotus japonicus resulting in a leaky tetrameric channel. (elifesciences.org)
Multistate structural modeling and voltage-clamp analysis of epilepsy/autism mutation Kv10.2-R327H demonstrate the role of this residue in stabilizing the channel closed state. (epfl.ch)

Eag1, Eag2, and SK3 potassium channel expression in the rat hippocampus after global transient brain ischemia. (epfl.ch)

KCNE4 has no known effect on KCNQ2, KCNQ3 or KCNQ5 channels, but augments activity of KCNQ4 in HEK cells, mesenteric artery and Xenopus laevis oocytes. (wikipedia.org)
The heterologous expression system of the Xenopus oocyte was used to assess the effects of test compounds on hMCT4, whereupon isobutyrate derivatives, fibrates, and bindarit (2-[(1-benzyl-1H-indazol-3-yl)methoxy]-2-methylpropanoic acid) were demonstrated to exhibit selective inhibitory effects against this transporter. (chemaxon.com)

Central to this surveillance system is the movement of calcium ions into and out of cells. (elifesciences.org)
Calcium ions are normally kept at very low levels inside of cells and subtle changes in these levels relay information about the external environment. (elifesciences.org)
In the case of plant roots, changes in the concentration of calcium ions herald essential information about soil conditions and the presence of microorganisms, and in turn trigger appropriate responses. (elifesciences.org)
Calcium ion signals are essential for peas, beans and other members of the legume family to form close relationships (known as symbioses) with soil bacteria called rhizobia. (elifesciences.org)
The leaky entry of calcium ions likely confuses the plant's surveillance system, which disturbs the normal development of the root. (elifesciences.org)

KCNE4 strongly inhibits the KCNQ1 potassium channel, which is known to play important roles in human cardiac myocyte repolarization, and in multiple epithelial cell types. (wikipedia.org)

They span the membrane of cells, allowing the selective permeation of K + ions from one side of the membrane to the other, usually from the inside of the cell to the outside. (ersjournals.com)

The classic syndromes are antigen-target-oriented syndromes such as myasthenia gravis (MG), Lambert-Eaton myasthenic syndrome (LEMS), and ion channel-mediated diseases. (touchneurology.com)

TWIK-related acid-sensitive potassium channel 1 (TASK-1 encoded by KCNK3) belongs to the family of two-pore domain potassium channels. (ersjournals.com)
Divalent cations slow activation of EAG family K+ channels through direct binding to S4. (epfl.ch)

Potassium (K + ) channels constitute the largest group of ion channels in the human genome. (ersjournals.com)
Three-dimensional structure of human Kv10.2 ion channel studied by single particle electron microscopy and molecular modeling]. (epfl.ch)
Statistical epistasis and functional brain imaging support a role of voltage-gated potassium channels in human memory. (epfl.ch)
Differential expression of potassium ion channels in human renal cell carcinoma. (epfl.ch)
Neural differentiation of human mesenchymal stem cells: Evidence for expression of neural markers and eag K+ channel types. (epfl.ch)

Recent studies show that modulation of TASK-1 channels, either directly or indirectly by targeting their regulatory mechanisms, has the potential to control pulmonary arterial tone in humans. (ersjournals.com)

Mutations in K + channel sequences can lead to a variety of clinical disorders exemplifying their physiological importance [ 3 ]. (ersjournals.com)

We demonstrate that subthreshold oscillations mediated by voltage-gated Na + channels play a key role in conferring graded differences in firing properties. (jneurosci.org)

They regulate the excitability of cells and contribute to their resting membrane potential [ 1 , 2 ]. (ersjournals.com)
Voltage-gated K+ channels are important determinants of neuronal membrane excitability (Pongs, 1999). (antibodiesinc.com)
For example, Nematostella has all types of voltage-gated K+ channels (Kvs) found in higher animals, demonstrating that these critical regulators of neuronal excitability evolved prior to the divergence of cnidarians and bilaterians roughly 600 million years ago. (csumb.edu)

3. Stuhmer W, Ruppersberg JP, Schroter KH, Sakmann B, Stocker M, Giese KP, Perschke A, Baumann A, and Pongs O (1989) Molecular basis of functional diversity of voltage-gated potassium channels in mammalian brain. (aspetjournals.org)
Molecular basis of potassium channels in pancreatic duct epithelial cells. (epfl.ch)
Molecular regions responsible for differences in activation between heag channels. (epfl.ch)

The punctate localization of rat Eag1 K+ channels is conferred by the proximal post-CNBHD region. (epfl.ch)
Differential localization of rat Eag1 and Eag2 potassium channels in the retina. (epfl.ch)

Voltage-gated potassium channels (Kv) represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. (wikipedia.org)

The functional channel is a homotetramer. (thermofisher.com)

In rat mesenteric artery, KCNE4 augments KCNQ4 channel activity to regulate arterial tone. (wikipedia.org)
Eight compounds had an IC50 value of less than 1 µM against the Nav1.3 channel inactivated state, with one compound displaying an IC50 value of 20 nM, whereas activity against the inactivated state of the Nav1.5 channel and Nav1.7 channel was approximately 20-fold weaker. (bvsalud.org)

This review summarises our current state of knowledge of the functional role of TASK-1 channels in the pulmonary circulation in health and disease, with special emphasis on current advancements in the field. (ersjournals.com)

It is also well known that anthozoans such as Nematostella contain diverse voltage gated potassium channel (Kv) toxins in venoms that they use to paralyze prey or defend themselves in their natural habitats. (csumb.edu)

Djurisic M, Antic S, Chen WR, Zecevic D (2004) Voltage imaging from dendrites of mitral cells: EPSP attenuation and spike trigger zones. (yale.edu)

EAG2 potassium channel with evolutionarily conserved function as a brain tumor target. (epfl.ch)

KCNE4 has also been found to regulate the large-conductance Ca2+-activated potassium channel, BK. (wikipedia.org)

4. Yokoyama S, Imoto K, Kawamura T, Higashida H, Iwabe N, Miyata T, and Numa S (1989) Potassium channels from NG108-15 neuroblastoma-glioma hybrid cells: primary structure and functional expression from cDNAs. (aspetjournals.org)
7. Roberds SL and Tamkun MM (1991) Cloning and tissue-specific expression of five voltage-gated potassium channel cDNAs expressed in rat heart. (aspetjournals.org)
Moreover, differences in K+ channel expression patterns and densities contribute to the variations in action potential waveforms and repetitive firing patterns evident in different neuronal cell types. (antibodiesinc.com)

Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics. (epfl.ch)

Predicted to be part of voltage-gated potassium channel complex. (mcw.edu)

An intermediate-conductance Ca2+-activated K+ channel is important for secretion in pancreatic duct cells. (epfl.ch)

Anatomy28

Organisms16

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Chemicals and Drugs150

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Phenomena and Processes40

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Technology, Industry, Agriculture1

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Subfamily2

Subunit5

Shaker5

Subunits8

Kv1.34

Kv2.11

Inactivation3

Cyclic1

Sodium3

Rectifier3

Blockers1

Transmembrane1

Antibodies2

Kv1.13

Pharmacological2

Kinetics1

Activators1

Currents3

Inhibitors2

Gene3

Intracellular3

Genes2

Protein5

Neurons5

Proteins2

ABSTRACT1

Mutation2

Transient1

Xenopus2

Calcium5

Cardiac1

Selective1

Syndromes1

Family2

Human5

Regulatory1

Mutations1

Properties1

Excitability3

Molecular3

Localization2

Structural1

Functional channel1

Activity2

Role1

Diverse1

Dendrites1

Brain1

Found1

Expression3

Cell1

Complex1

Important1