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  • Pharmacology
  • This volume of the Handbook of Experimental Pharmacology will explore sodium channels from the perspectives of their biophysical behavior, their structure, the drugs and toxins with which they are known to interact, acquired and inherited diseases that affect sodium channels and the techniques with which their biophysical and structural properties are studied. (springer.com)
  • calcium channel
  • In the nervous system, calcium channel blockers have been used successfully to treat absence seizures, and are emerging as potential therapeutic avenues for pathologies such as pain, Parkinson disease, addiction and anxiety. (nih.gov)
  • This Review provides an overview of calcium channels as drug targets for nervous system disorders, and discusses potential challenges and opportunities for the development of new clinically effective calcium channel inhibitors. (nih.gov)
  • A mutation in the low voltage-gated calcium channel CACNA1G alters the physiological properties of the channel, causing spinocerebellar ataxia. (nih.gov)
  • Kv1.3
  • Functional role of Kv1.1 and Kv1.3 channels in the neoplastic progression steps of three cancer cell lines, elucidated by scorpion peptides. (nih.gov)
  • cardiac
  • We directly tested the effects of propranolol on heterologously expressed recombinant human cardiac (Na V 1.5) and brain (Na V 1.1, Na V 1.2, Na V 1.3) sodium channels using whole-cell patch-clamp recording. (frontiersin.org)
  • Our findings establish sodium channels as targets for propranolol and may help explain some beneficial effects of the drug in treating cardiac arrhythmias, and may explain certain adverse central nervous system effects. (frontiersin.org)