• Subsequent studies revealed that the dye can be used to monitor lymphocyte proliferation, both in vitro and in vivo, due to the progressive halving of CFSE fluorescence within daughter cells following each cell division. (wikipedia.org)
  • Another novel application of CFSE is its use for the in vitro and in vivo determination of cytotoxic lymphocytes. (wikipedia.org)
  • TSC2 ablation strongly augmented tumor cell sensitivity to CTL attack in vitro and in vivo, suggesting one of its functions is to critically protect tumor cells. (nki.nl)
  • We transfected human and rabbit peripheral blond mononaclear cells (PBMC) with the ACH molecular clone of human T-cell lymphotropic virus type 1 (HTLV-1) to study its in vitro and in vivo properties. (wustl.edu)
  • This clone will facilitate investigations into the role of viral genes on biological properties of HTLV-1 in vitro and in vivo. (wustl.edu)
  • its mode of action and efficacy has been demonstrated in hundreds of in vitro and in vivo studies. (heraldopenaccess.us)
  • In addition to acquiring improved antigen presentation, tumor-APCs had impaired tumorigenicity in vitro and in vivo. (lu.se)
  • Ex vivo analysis of phenotype and TCR usage in relation to CD45 isoform expression on cytomegalovirus-specific CD8+ T lymphocytes. (ox.ac.uk)
  • Experiments using the thy/hu mouse model support export of intrathymically infected CD8 precursors, while recent in vitro data suggest that mature CD8 lymphocytes upregulate CD4 upon activation (generating a CD8bright CD4dim phenotype) and are susceptible to HIV infection. (ox.ac.uk)
  • We hypothesized that CLA modifies peripheral lymphocyte phenotype, regardless of the environment. (iastate.edu)
  • Several studies have clearly demonstrated that distinct cytokine activated signalling and transcription factors regulate the commitment of a naïve T cell along the Th1 or T helper cell type 2 (Th2) phenotype, as well as maintenance of the polarised phenotype. (bmj.com)
  • In conclusion, T lymphocyte signal transduction pathway mapping revealed an enhanced activation of JAK1/STAT3/STAT1 and PKCδ phosphoproteins that may drive the local inflammatory process, characterized by the in vivo expansion of T CD4(+)IL-17A-F(+) and T CD4(+)IL-23R(+) Th17 Teff cells in SF of clinically active joints of PsA patients. (nih.gov)
  • To investigate the relationship between CD8 activation and infection by HIV-1 in vivo, activated subsets of CD8 lymphocytes in peripheral blood mononuclear cells (PBMCs) of HIV-seropositive individuals were investigated for CD4 expression and HIV infection. (ox.ac.uk)
  • Design, synthesis, and biological evaluation of novel aminobisphosphonates possessing an in vivo antitumor activity through a gammadelta-T lymphocytes-mediated activation mechanism. (ox.ac.uk)
  • A small series of aminobisphosphonates (N-BPs) structurally related to zoledronic acid was synthesized with the aim of improving activity toward activation of human gammadelta T cells and in turn their in vivo antitumor activity. (ox.ac.uk)
  • The potent activation of gammadelta T cells, in addition to evidence of the in vivo antitumor activity of 6a, suggests it may be a new potential drug candidate for cancer treatment. (ox.ac.uk)
  • In vivo activation of a T helper 2-driven innate immune response in lung fibrosis induced by multi-walled carbon nanotube s. (cdc.gov)
  • Induction of Th2 cytokines took place in CD4+ T lymphocytes indicating activation of Th2 cells. (cdc.gov)
  • This T-cell-mediated activation of phagocytes depends on interferon gamma (IFN-γ), a major cytokine produced by type 1 T-helper (Th1) cells. (medscape.com)
  • Phagocytic cell activation and inflammation induced by CMI can cause tissue injury, typically called delayed-type hypersensitivity. (medscape.com)
  • The Ag presentation and subsequent T-cell activation via CD3 and T-cell Ag receptor (TCR)(CD3/TCR) complex elicit an influx of macrophages, monocyte, and lymphocytes at the site of Ag exposure. (medscape.com)
  • The focus of Dr. Berg's work is on the signaling proteins and pathways regulating T lymphocyte development, differentiation, activation, and migration, with a strong emphasis on T-cell receptor (TCR) signaling. (cuanschutz.edu)
  • Recent experimental hypotheses for the persistence of HTLV-I in vivo have led to the development of mathematical models illuminating the balance between proviral latency and activation in the target cell population. (ebi.ac.uk)
  • STING activation induces lymphocyte cell death that is independent of type I IFNs. (bvsalud.org)
  • Mutations in the signalling lymphocyte activation molecule (SLAM)-associated protein SAP, a signalling adaptor molecule, underlie 60% of cases of familial XLP. (lu.se)
  • Using tetrameric complexes of human histocompatibility leukocyte antigen (HLA) class I to identify antigen-specific T cells ex vivo, we observed high frequencies of circulating MelanA-specific, A*0201-restricted cytotoxic T lymphocytes (A2-MelanA tetramer+ CTLs) in seven of nine HLA-A*0201-positive individuals with vitiligo. (ox.ac.uk)
  • In several models of lymphocyte apoptosis, two alterations of mitochondrial function precede advanced DNA fragmentation: (1) a reduction of mitochondrial transmembrane potential (delta psi m) and (2) an increase in mitochondrial generation of superoxide anion. (nih.gov)
  • Our data suggest that apoptosis may and lymphocyte apoptosis in vivo ( 14 ). (cdc.gov)
  • Wild-type tumor cells adapted to CTL attack by shifting their mTOR signaling balance toward increased mTORC2 activity, circumventing apoptosis, and necroptosis. (nki.nl)
  • Another procent of cases is due to defects in in the gene that encodes the X-linked inhibitor-of-apoptosis XIAP (BIRC4) required for the survival and/or differentiation of NKT cells and also a potent regulator of lymphocyte homeostasis in vivo. (lu.se)
  • Lymphocyte monitoring during immunotherapy protocols, such as for example recognition of circulating lymphocytes from entire tumor or bloodstream infiltrating lymphocytes from tissues biopsy, will not supply the whole selection of spatial and dynamic Kaempferol information required. (bioskinrevive.com)
  • We previously published an immune-humanized mouse model in which we transplanted tumor cells and autologous tumor-infiltrating lymphocytes (TILs) from patients in a clinical trial of adoptive T cell transfer (ACT) in Herlev, Denmark - and demonstrated that responses in IL-2 transgenic NOG mice correlated to the responses of the patients in the trial 2 . (taconic.com)
  • Enrichment correlated to NKG2A upregulation on CD8+ tumor-infiltrating T lymphocytes (TIL) but not on CD4+ TILs. (ox.ac.uk)
  • In the context of cancer, appropriately activated DCs can induce anti-tumor immunity by activating innate immune cells and tumor-specific lymphocytes that target cancer cells. (mdpi.com)
  • Here, we use whole-genome CRISPR-Cas9 knockout data to uncover an important role for Tuberous Sclerosis Complex 2 (TSC2) in determining tumor susceptibility to cytotoxic T lymphocyte (CTL) killing in human melanoma cells. (nki.nl)
  • We used the minimal gene regulatory network of type 1 conventional dendritic cells (cDC1) to reprogram cancer cells into professional antigen-presenting cells (tumor-APCs). (lu.se)
  • Human primary tumor cells could also be reprogrammed to increase their capability to present antigen and to activate patient-specific tumor-infiltrating lymphocytes. (lu.se)
  • Looking to the sustained psoriatic arthritis (PsA) joint as a model of local human inflammation, this study was designed to assess the T lymphocyte signal transduction pathways potentially involved in this chronic immune-mediated inflammatory process, as characterized by direct ex vivo analysis of T helper (Th)-17 T effector (Teff) cell phenotypes in synovial fluid (SF) and peripheral blood (PB) of clinically active PsA patients. (nih.gov)
  • Activated peripheral CD8 lymphocytes express CD4 in vivo and are targets for infection by human immunodeficiency virus type 1. (ox.ac.uk)
  • 001). The peripheral CD8+ lymphocyte subpopulation includes four distinct cell subsets: TCRgammadeltaCD8alphaalpha T cells, CD3 --CD8alphaalpha lymphocytes (NK cells) and TCRalphabetaCD8alphabeta T cells, and TCRalphabetaCD4+CD8alphaalpha, and putatively TCRalphabetaCD4 --CD8alphaalpha T cells. (iastate.edu)
  • Lack of homing receptors on the surface of autoreactive CTLs could be a mechanism to control peripheral tolerance in vivo. (ox.ac.uk)
  • Thus CFSE represents an extremely valuable fluorescent dye for immunological studies, allowing lymphocyte proliferation, migration and positioning to be simultaneously monitored. (wikipedia.org)
  • By the use of fluorescent antibodies against different lymphocyte cell surface markers it is also possible to follow the proliferation behaviour of different lymphocyte subsets. (wikipedia.org)
  • Furthermore, the use of CFSE has extended beyond the immune system, with the dye being used to monitor the proliferation of many other cell types such as smooth muscle cells, fibroblasts, hematopoietic stem cells and even bacteria. (wikipedia.org)
  • The proliferation and trafficking of T lymphocytes in immune responses are necessary events in determining inflammatory responses. (bioskinrevive.com)
  • in this type of research the effect of LSD is studied after the substance has been ingested by or injected into animals or humans. (druglibrary.net)
  • An in vivo assessment of in vitro sensitized human lymphocytes using athymic, "nude" mice. (jax.org)
  • IL-17 KO mice did display attenuated delayed-type hypersensitivity (DTH) against bovine serum albumin and bacille Calmette-Guérin (BCG). (medscape.com)
  • The lack of any hydrogel-derived immunoreaction was demonstrated in vivo by mice subcutaneous implantation. (nature.com)
  • in vivo in the spleen and lymph nodes of crazy type mice, with specificity confirmed through in vivo obstructing and depletion studies. (bioskinrevive.com)
  • Our laboratory uses transgenic and knockout mice to study the molecular mechanisms responsible for the normal control of T-lymphocyte reactivity and the changes that occur when T-lymphocytes become either aggressive against self antigens or inappropriately reactive against substances (allergens) normally present in the environment. (nyu.edu)
  • Currently, we are examining the development of experimental autoimmune encephalomyelitis (EAE), an animal model for multiple sclerosis, in transgenic mice bearing antimyelin basic protein (MBP) T-lymphocytes. (nyu.edu)
  • Mice harboring large numbers of anti-MBP T-lymphocytes in addition to other lymphocytes seldom develop EAE spontaneously. (nyu.edu)
  • However, when these mice are crossed with RAG-l KO mice, thereby producing only anti-MBP T-lymphocytes, they all develop spontaneous EAE. (nyu.edu)
  • The sharp contrast in susceptibility to EAE between the two types of anti-MBP transgenic mice, one carrying regulatory lymphocytes and the other not, enables us to pursue identifying and characterizating those cells. (nyu.edu)
  • In vivo, humanized mice had been used to judge the result of nivolumab on osteosarcoma. (nanoker-society.org)
  • Nivolumab inhibited osteosarcoma metastasis in humanized mice by raising Compact disc4+ and Compact disc8+ lymphocytes as well as the cytolytic activity of Compact disc8 lymphocytes in the lung but didn't affect principal osteosarcoma growth. (nanoker-society.org)
  • Using STING knock-in mice, we found that lymphocytes from the HAQ , AQ , and Q293 mice are resistant to STING-mediated cell death ex vivo , establishing a critical role of STING residue 293 in cell death. (bvsalud.org)
  • Combined, these findings provide evidence that antigenic stimulation of CD8 lymphocytes in vivo induces CD4 expression that renders them susceptible to HIV infection and destruction. (ox.ac.uk)
  • Finally, we observed that the A2-MelanA tetramer+ CTLs isolated from vitiligo patients expressed high levels of the skin homing receptor, cutaneous lymphocyte-associated antigen, which was absent from the CTLs seen in the single A*0201-positive normal control. (ox.ac.uk)
  • They may play a specialized role in the cutaneous homing of LYMPHOCYTES. (lookformedical.com)
  • These observations may be important for the understanding and for the direct ex vivo quantitation of HIV-triggered lymphocyte destruction. (nih.gov)
  • CMI manifests as delayed type cellular immune responses as typically seen in Mantaux test. (medscape.com)
  • Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). (thermofisher.com)
  • Although most normal immune responses against pathogens require the action of T-lymphocytes, their improper control lies at the heart of two types of disease: autoimmunity and allergy. (nyu.edu)
  • However, perhaps the most important CFSE investigations have been those demonstrating that many of the effector functions of lymphocytes, such as cytokine production by T lymphocytes, and antibody class switching by B cells, are division dependent. (wikipedia.org)
  • 8- 10 Similarly, the transcriptional mechanisms that underlie the distinct Th1-type cytokine repertoire in CD remain unknown. (bmj.com)
  • Immunity against CMV comprises a large population of CD8+ T lymphocytes with heterogeneous potential, a spectrum in which CD45 isoform expression may play a central role. (ox.ac.uk)
  • The basic and common immunologic defect in common variable immunodeficiency is a failure of B-lymphocyte differentiation into plasma cells that produce the various immunoglobulin (Ig) isotypes. (medscape.com)
  • Tissues, including the placenta, are comprised of diverse cell types with distinguishable developmental or functional origin that form a complex niche 1 . (nature.com)
  • A comprehensive assessment of cellular heterogeneity is traditionally performed by immunophenotyping which can be biased and relies on a small set of pre-selected markers, limiting the cell types that can be inspected 13 . (nature.com)
  • Detailed protocols are now available that can be used to label lymphocytes (and other cell types) with a high degree of reliability and precision. (wikipedia.org)
  • Infection with virulent infl u- target cell type for the viral replication. (cdc.gov)
  • We previously demonstrated in an autopsy case that alveo- middle lung fi elds and a masslike infi ltration at the right lar epithelial cells are the major target cell type of this virus middle lung fi eld. (cdc.gov)
  • To determine whether these mechanisms operate in vivo and to assess their relative importance in the generation of circulating HIV-infected CD8 lymphocytes, we quantified HIV long terminal repeat (LTR) DNA in CD8+ CD4- and CD8bright CD4dim lymphocytes isolated from HIV-infected individuals by fluorescence-activated cell sorting. (ox.ac.uk)
  • Subsequently, a murine model of HSC transplantation shown successful in vivo detection of T cell repopulation at 2, 4, and 8 weeks post-HSC transplant using the 89Zr-radiolabeled anti-CD4 and -CD8 cDbs. (bioskinrevive.com)
  • Mouse monoclonal to CD22.K22 reacts with CD22, a 140 kDa B-cell specific molecule, expressed in the cytoplasm of all B lymphocytes and on the cell surface of only mature B cells. (bioskinrevive.com)
  • Direct cell labeling is suffering from restrictions of radionuclide half-life, probe dilution Kaempferol because of cell department, and potential dangerous effects because of the radiosensitivity of lymphocytes. (bioskinrevive.com)
  • In coeliac disease (CD) mucosa, the histological lesion is associated with marked infiltration of T helper cell type 1 (Th1) cells. (bmj.com)
  • T-bet and STAT-4, two Th1 promoting transcription factors, and STAT-6 and GATA-3, transcription factors which govern T helper cell type 2 (Th2) cell polarisation, were examined in duodenal biopsies by western blotting. (bmj.com)
  • There is now little doubt that in coeliac disease (CD) the histological lesion is associated with a predominant T helper cell type 1 (Th1) cell response. (bmj.com)
  • Autofluorescence imaging permits label-free cell type identification in live airway tissue and reveals the dynamic formation of airway secretory cell associated antigen passages. (elifesciences.org)
  • Evidence for CD4 + T-cell involvement in autoimmune disease pathogenesis and for paracrine calcitriol signaling to CD4 + T lymphocytes is summarized to support the thesis that calcitriol is sunlight's main protective signal transducer in autoimmune disease risk. (frontiersin.org)
  • Animal modeling and human mechanistic data are summarized to support the view that vitamin D probably influences thymic negative selection, effector Th1 and Th17 pathogenesis and responsiveness to extrinsic cell death signals, FoxP3 + CD4 + T-regulatory cell and CD4 + T-regulatory cell type 1 (Tr1) cell functions, and a Th1-Tr1 switch. (frontiersin.org)
  • Subsequent studies revealed that EBV caused a number of different human malignancies, such as nasopharyngeal carcinoma (NPC), Hodgkin's lymphoma, extranodal NK/T-cell lymphoma, nasal type and lymphoproliferative disorders of immunocompromised hosts ( 2 ). (spandidos-publications.com)
  • Although α-particles induced more intrachanges, their association with complex exchanges, which are likely to be unstable and nontransmissible through cell division, will limit their applicability as a marker of past in vivo exposure. (radioprotection.org)
  • July 20, 2021 -- Cellular reprogramming of ex vivo cells may offer improvements on first-generation adoptive cell therapies, which have experienced limited clinical success due to complex manufacturing, potential patient rejection, and availability of clinical cell types. (scienceboard.net)
  • Cellular reprogramming involves remodeling gene expression to generate a desired cell lineage or type. (scienceboard.net)
  • They leverage transcriptomic and epigenetic data to systematically identify key regulatory switches, such as the optimal combination of transcription factors or growth factors, required to directly differentiate any source cell type to any target cell type , as well as maintain cell identity . (scienceboard.net)
  • This circumvents the need for any intermediary steps and reduces the time required to produce a cell type for therapeutic use. (scienceboard.net)
  • Coupled with well-established in vitro culture and expansion protocols for T lymphocytes, CAR enabled the antigen-directed cytotoxicity of T cells to be harnessed, expanding the scope of cell therapy. (scienceboard.net)
  • First-generation ex vivo cell therapies, such as autologous anti-CD19 CAR T cells, demonstrated the clinical value and curative potential of enhancing the therapeutic qualities of immune and other patient-derived cell types. (scienceboard.net)
  • Cell-free synthesis of equine herpesvirus type 3 nucleocapsid polypeptides. (microbiologyresearch.org)
  • A monocyte chemoattractant protein that has activity towards a broad variety of immune cell types. (lookformedical.com)
  • The in vivo significance and mechanism of STING-mediated cell death is unclear. (bvsalud.org)
  • The term pemphigus refers to a group of autoimmune blistering diseases of the skin and mucous membranes characterized histologically by intraepidermal blister and immunopathologically by the finding of in vivo bound and circulating immunoglobulin G (IgG) antibody directed against the cell surface of keratinocytes. (medscape.com)
  • Isolated A2-MelanA tetramer+ CTLs were able to lyse A*0201-matched melanoma cells in vitro and their frequency ex vivo correlated with extent of disease. (ox.ac.uk)
  • Frequencies of activated CD8 lymphocytes were higher in HIV-infected study subjects than in seronegative controls, and they frequently coexpressed CD4 (mean frequencies on CD69(+), CD71(+), and HLA class II(+) cells of 23, 37, and 8%, respectively, compared with 1 to 2% for nonactivated CD8 lymphocytes). (ox.ac.uk)
  • For high LET irradiation, such as that from internally deposited α-emitting radionuclides, the relationship between chromosome aberration frequencies in blood lymphocytes and dose is more difficult to establish. (radioprotection.org)
  • Therefore, the quantification of chromosome biomarkers of α-irradiation must take into account the distribution and transmissibility of the different aberration types if it is to provide information that is relevant to the interpretation of in vivo frequencies. (radioprotection.org)
  • Lymphocytes in their first in vitro division following exposure to 213Bi α-particles were analysed by sFISH and genomic aberration frequencies derived. (radioprotection.org)
  • This review summarizes and integrates research on vitamin D and CD4 + T-lymphocyte biology to develop new mechanistic insights into the molecular etiology of autoimmune disease. (frontiersin.org)
  • Evidence linking sunlight, vitamin D, and the risk of multiple sclerosis and type 1 diabetes is summarized to develop the thesis that vitamin D is the environmental factor that most strongly influences autoimmune disease development. (frontiersin.org)
  • Gene-environment interactions, sunlight and vitamin D, and T lymphocytes as autoimmune disease initiators and vitamin D targets are discussed to explain the rationale for reviewing vitamin D mechanisms in T cells. (frontiersin.org)
  • There have been multiple reports of co-occurrence of lichen sclerosus with autoimmune disease, including vitiligo, Hashimoto's thyroiditis, and type 1 diabetes ( 14 ). (iiarjournals.org)
  • Finally, using primary lung stem cells or lymphocytes from different donors, we study the effects of radon on patients, who are treated in radon spas or baths to alleviate rheumatic diseases. (gsi.de)
  • The effect of gliadin and IFN-γ on expression of T-bet was examined in an ex vivo culture of biopsies taken from normal and treated CD patients. (bmj.com)
  • Lamina propria T lymphocytes (T-LPL) isolated from the intestine of patients with active CD released interferon (IFN)-γ in response to gluten stimulation, and neutralisation of endogenous IFN-γ prevented the gliadin mediated morphological changes in an ex vivo organ culture of treated CD biopsies. (bmj.com)
  • In contrast, no A2-MelanA tetramer+ CTL could be identified ex vivo in all four A*0201-negative vitiligo patients or five of six A*0201-positive asymptomatic controls. (ox.ac.uk)
  • Earlier studies suggested a primary B-lymphocyte defect as a cause of common variable immunodeficiency in a small group of patients. (medscape.com)
  • These functionalities recover following antibody-mediated blockade in vitro and ex vivo. (ox.ac.uk)
  • Activated CD8 lymphocytes were identified by expression of CD69, CD71, and the human leukocyte antigen (HLA) class II, the beta-chain of CD8, and the RO isoform of CD45. (ox.ac.uk)
  • In some individuals, expansions of antigen-specific CD8+ T lymphocytes bearing specific TCR Vbeta chains were restricted to cells of particular CD45 isoforms. (ox.ac.uk)
  • The specific targeting of responding CD8 lymphocytes may provide a functional explanation for the previously observed impairment of cytotoxic T-lymphocyte (CTL) function disproportionate to their numerical decline in AIDS and for the deletion of specific clones of CTLs responding to HIV antigens. (ox.ac.uk)
  • There is also evidence for the induction of CD4 expression and susceptibility to infection by HIV-1 of CD8 lymphocytes activated in vitro. (ox.ac.uk)
  • Human immunodeficiency virus (HIV)-infected CD8 lymphocytes have been reported in vivo, but the mechanism of infection remains unclear. (ox.ac.uk)
  • consider LS a lymphocyte-mediated chronic inflammatory disease of the skin with an increasing evidence for an underlying autoimmune mechanism ( 12 , 13 ). (iiarjournals.org)
  • There is increasing evidence that CD8 lymphocytes may represent targets for infection by human immunodeficiency virus type 1 (HIV-1) in vivo whose destruction may contribute to the loss of immune function underlying AIDS. (ox.ac.uk)
  • Infection of epithelial cells and lymphocytes play an important role. (cdc.gov)
  • High levels of human immunodeficiency virus infection of CD8 lymphocytes expressing CD4 in vivo. (ox.ac.uk)
  • Thus, HIV-infected CD8 lymphocytes commonly circulate in HIV-infected individuals and are generated through infection of activated CD8 lymphocytes rather than through export of intrathymically infected precursors. (ox.ac.uk)
  • The high level of infection of CD8bright CD4dim lymphocytes could have a direct role in the decline in CD8 lymphocyte function that accompanies HIV disease progression. (ox.ac.uk)
  • Human T-lymphotropic virus type I (HTLV-I) causes chronic infection for which there is no cure or neutralising vaccine. (ebi.ac.uk)
  • Dopamine receptors modulate T lymphocytes via inhibition of cAMP-CREB signaling pathway. (nel.edu)
  • Huang Y, Chen C, Wang T, Qiu Y, Peng Y. Dopamine receptors modulate T lymphocytes via inhibition of cAMP-CREB signaling pathway. (nel.edu)
  • A CC-type chemokine with specificity for CCR10 RECEPTORS. (lookformedical.com)
  • A CC-type chemokine that is found at high levels in the THYMUS and has specificity for CCR4 RECEPTORS. (lookformedical.com)
  • A CC-type chemokine that is specific for CCR3 RECEPTORS. (lookformedical.com)
  • Dr. Aturk's research is focused on immune checkpoint inhibitor-induced type 1 diabetes. (cuanschutz.edu)
  • One of the permanent endocrine side effects is type 1 diabetes. (cuanschutz.edu)
  • A goal of Dr. Akturk's lab is to identify risk factors to develop diabetes and develop screening algorithms to prevent morbidity and mortality related to diabetic ketoacidosis and understand PD-1 pathway in possible prevention of the development of childhood onset type 1 diabetes. (cuanschutz.edu)
  • Dr. Alonso's primary academic interest is redesigning the system in which care is provided to children and adolescents with type 1 diabetes. (cuanschutz.edu)
  • He also works with model-based control, e.g., like the artificial pancreas project, but in the context of type-2 diabetes, cystic fibrosis related diabetes, and within the intensive care unit unrelated to diabetes. (cuanschutz.edu)
  • The global burden has risen with the near tripling in the last half-century of multiple sclerosis (MS) ( 2 , 3 ), type 1 diabetes (T1D) ( 4 ), and other autoimmune diseases. (frontiersin.org)
  • Autophagy plays beneficial effect on diabetic encephalopathy in type 2 diabetes: studies in vivo and in vitro. (nel.edu)
  • Jing Y, Zhang L, Gao L, Qi C, Lv D, Song Y, Yin J, Wang D. Autophagy plays beneficial effect on diabetic encephalopathy in type 2 diabetes: studies in vivo and in vitro. (nel.edu)
  • CFSE was originally developed as a fluorescent dye that could be used to stably label lymphocytes and track their migration within animals for many months. (wikipedia.org)
  • Here we show that two fluorochromes allow for the identification of analogous mitochondrial perturbations in circulating T lymphocytes from human immunodeficiency virus (HIV)-1+ donors. (nih.gov)
  • The cells studied were in most cases human white blood cells (lymphocytes). (druglibrary.net)
  • The other family members include herpes simplex virus type 1 (HSV-1 or HHV-1) and herpes simplex virus type 2 (HSV-2 or HHV-2), varicella zoster virus (VZV), human herpes virus (HHV)-6, HHV-7, and HHV-8. (medscape.com)
  • DTH responses in the skin have been used to assess CMI in vivo. (medscape.com)
  • We are also interested to test other types of immunotherapies and combination therapies in this model. (taconic.com)
  • We also focus on a transgenic mouse model for asthma to determine in vivo the factors controlling the synthesis of important interleukins involved in the asthmatic process such as IL-4 and IL-5 and the increased production of immunoglobulin E. (nyu.edu)
  • their combination with stem cells is among the best alternatives for their continuous generation in vivo . (heraldopenaccess.us)
  • This review highlights recent advances in vitamin D and T-lymphocyte biology in an effort to harness vitamin D's potential to reduce the impact of autoimmune diseases. (frontiersin.org)
  • Furthermore, PD-1 blockade could control osteosarcoma pulmonary metastasis in vivo effectively. (nanoker-society.org)
  • Dose-response relationships for different radiation types (neutrons, radon, alpha particles, HZE-particles, X-rays) over a wide range of LETs/energies (in vitro studies). (gsi.de)
  • In the in vivo studies, the blood samples were drawn from subjects who had been exposed to either 'street acid' (illicit material allegedly containing LSD) or pharmaceutically pure LSD. (druglibrary.net)
  • In gastric carcinoma cells, EBV is not integrated into the host genome but maintained as a type of plasmid called an episome. (spandidos-publications.com)
  • [ 10 ] Each type of pemphigus has distinct clinical and immunopathologic features. (medscape.com)