• This LA-dependent increase in Akt phosphorylation was accompanied by inhibition of LPS-induced NF-kappaB DNA binding activity and up-regulation of TNFalpha and monocyte chemoattractant protein 1. (oregonstate.edu)
  • The beta-adrenergic receptor kinase 1 (beta ARK1) is a member of the G protein-coupled receptor kinase (GRK) family that mediates the agonist-dependent phosphorylation and desensitization of G protein-coupled receptors. (duke.edu)
  • AMP-activated protein kinase (AMPK) and eukaryotic elongation factor 2 phosphorylation was unaffected by the blockers. (ku.dk)
  • cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. (nih.gov)
  • We found that DNA-dependent protein kinase catalytic subunit (DNA-PKcs) and mammalian target of rapamycin (mTOR) complex 2 (mTORC2) were both required for UVB-induced Akt Ser-473 phosphorylation in keratinocytes. (biomedcentral.com)
  • Inhibition of DNA-PKcs activity via its inhibitor NU7026, a dominant-negative kinase-dead mutation, RNA interference (RNAi) or gene depletion led to the attenuation of UVB-induced Akt Ser-473 phosphorylation. (biomedcentral.com)
  • mTORC2 promoted phosphorylation of protein kinase B (PKB, or Akt) and PKC, Akt activity, and nuclear NF-kappaB transcription factors in response to T cell activation. (omicsdi.org)
  • The association between hnRNP M and Rictor was verified using recombinant and endogenous protein and the binding site was found to be within aa 1~532 of hnRNP M. The presence of hnRNP M significantly affects phosphorylation of SGK1 S422, but not of Akt S473, PKC? (omicsdi.org)
  • 2) Phosphorylation of RIIbeta at Thr69 by cyclin-dependent kinases may have a role in the modulation of PKA targeting in the mammalian brain. (yu.edu)
  • CAMKK1 or CAMKK alpha is a Ca2+/calmodulin-dependent protein kinase that activates CAM-kinases I and IV via phosphorylation of their Thr(177) and Thr(196) residues, respectively. (mybio.ie)
  • Recent studies have shown that the activity of CAMKK1 is decreased upon phosphorylation by cAMP-dependent protein kinase (PKA) (1). (mybio.ie)
  • Perilipin 1 binds to aquaporin 7 in human adipocytes and controls its mobility via protein kinase A mediated phosphorylation. (lu.se)
  • We have previously shown that second-messenger-dependent kinases (cAMP-dependent kinase, protein kinase C) in the olfactory system are essential in terminating second-messenger signaling in response to odorants. (duke.edu)
  • Here we investigated the mechanism by which LA attenuates LPS-induced monocyte activation in vitro and acute inflammatory responses in vivo. (oregonstate.edu)
  • We conclude that LA inhibits LPS-induced monocyte activation and acute inflammatory responses in vitro and in vivo by activating the PI3K/Akt pathway. (oregonstate.edu)
  • Although vitamin E inhibits platelet aggregation in vitro, its effect in vivo has not been consistent. (medscape.com)
  • In vitro and in vivo studies have provided strong pharmacological evidences for wound healing effects of A. africana -derived extracts and phytochemicals. (hindawi.com)
  • To address these questions, our lab uses a multidisciplinary approach to study the biochemical functions of the lysosome in vitro and in vivo. (stanford.edu)
  • Neuronal PKD1 inactivation by pharmacological inhibition or lentiviral silencing in vitro, or by genetic inactivation in neurons in vivo, strongly enhances excitotoxic neuronal death. (nature.com)
  • In contrast, expression of an active dephosphorylation-resistant PKD1 mutant potentiates the IKK/NF-κB/SOD2 oxidative stress detoxification pathway and confers neuroprotection from in vitro and in vivo excitotoxicity. (nature.com)
  • We studied the molecular and behavioral effects of a selected FEAM in neuroinflammation models in-vitro and in-vivo. (biomedcentral.com)
  • FEAM prevented most of the molecular and behavioral negative effects of neuroinflammation in-vitro and in-vivo, most likely through EPCR-PAR1 interactions. (biomedcentral.com)
  • We then performed in vitro and in vivo experiments to validate selected targets and related mechanisms. (ibric.org)
  • SPP1 inhibitors reversed CAF-induced TKI resistance in vitro and in vivo. (ibric.org)
  • We investigated the roles of miR-130b/301b in regulating beige adipogenesis in vivo and in vitro . (figshare.com)
  • In vitro transcription assays confirmed the role determined in vivo for TodS, TodT, and IHF. (nih.gov)
  • Despite the detailed in vitro characterization of the enzymatic properties of yeast Sac1p, the exact cellular function of this protein has remained obscure. (embl.de)
  • Fasudil treatment significantly reduced alpha-Syn aggregation in vitro in a H4 cell culture model as well as in a cell-free assay. (mpg.de)
  • Thus, the principle of protein or peptide haptenation could be used in in vitro assays to predict the sensitization potential of a new chemical entity. (cdc.gov)
  • The effects of PIP5K1α and its inhibitor on growth and invasion of BC were confirmed by using in vitro assays including proliferation, migration, apoptosis and luciferase reporter assays and in vivo xenograft mouse models. (lu.se)
  • There is a marked lymphocytosis, no detectable memory T cells in vivo, and naive T cells do not respond to CD3-TCR activation in vitro. (lu.se)
  • Excitotoxic production of ROS elevates death-associated protein kinase (DAPK) activity, which provokes neuronal apoptosis in cerebral ischemia and seizure models 8 . (nature.com)
  • Death Associated Protein Kinase (DAPK), a critical molecular switch that controls a range of key signaling and cell death pathways, has been suggested to have an important role in excitotoxicity. (biomedcentral.com)
  • One suggested mediator of excitotoxicity implicated in multiple experimental setups is the CaM-dependent Death Associated Protein Kinase (DAPK) [ 11 - 14 ]. (biomedcentral.com)
  • Direct evidence that Gi-coupled receptor stimulation of mitogen-activated protein kinase is mediated by G beta gamma activation of p21ras. (duke.edu)
  • CAF-derived SPP1 activated rapidly accelerated fibrosarcoma (RAF)/mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) through the integrin-protein kinase C-alpha (PKCα) signaling pathway and promoted epithelial-to-mesenchymal transition (EMT). (ibric.org)
  • This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. (nih.gov)
  • Lysosomal function is critical for organismal homeostasis-mutations in genes encoding lysosomal proteins cause severe human disorders known as lysosomal storage diseases, and lysosome dysfunction is implicated in age-associated diseases including cancer, neurodegeneration and metabolic syndrome. (stanford.edu)
  • In ER+ cancer cells, PIP5K1α acted on pSer-473 AKT, and was in complexes with VEGFR2, serving as co-factor of ER-alpha to regulate activities of target genes including cyclin D1 and CDK1. (lu.se)
  • Mechanistically, miR-130b/301b directly targeted AMP-activated protein kinase (AMPKα1) and suppressed peroxisome proliferator-activated receptor gamma coactivator 1-alpha ( Pgc-1α ), key regulators of brown adipogenesis and mitochondrial biogenesis. (figshare.com)
  • CAMKKI has been identified in intact cells as AMPKKs, predicting a significant role for this kinase in regulating AMPK activity in vivo. (mybio.ie)
  • Background The α1-adrenergic receptor (α1AR) agonist phenylephrine (PE), acts via ERK1/2 to phosphorylate (i.e. activate) p90 ribosomal S6 kinases (RSKs). (bmj.com)
  • G protein-coupled receptor kinases (GRKs) phosphorylate activated G protein-coupled receptors, including alpha(1B)-adrenergic receptors (ARs), resulting in desensitization. (duke.edu)
  • G protein-coupled receptor activation leads to the membrane recruitment and activation of G protein-coupled receptor kinases, which phosphorylate receptors and lead to their inactivation. (duke.edu)
  • These diverse responses result from the ability of PKA to selectively phosphorylate different sets of cellular proteins. (yu.edu)
  • A beta-adrenergic receptor kinase-like enzyme is involved in olfactory signal termination. (duke.edu)
  • Bbeta-adrenergic receptor kinase-1 levels in catecholamine-induced myocardial hypertrophy: regulation by beta- but not alpha1-adrenergic stimulation. (duke.edu)
  • beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein. (duke.edu)
  • Essential role of beta-adrenergic receptor kinase 1 in cardiac development and function. (duke.edu)
  • Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice. (duke.edu)
  • Functional desensitization of the isolated beta-adrenergic receptor by the beta-adrenergic receptor kinase: potential role of an analog of the retinal protein arrestin (48-kDa protein). (duke.edu)
  • The beta-adrenergic receptor kinase is an enzyme, possibly analogous to rhodopsin kinase, that multiply phosphorylates the beta-adrenergic receptor only when it is occupied by stimulatory agonists. (duke.edu)
  • Functionally active targeting domain of the beta-adrenergic receptor kinase: an inhibitor of G beta gamma-mediated stimulation of type II adenylyl cyclase. (duke.edu)
  • The beta-adrenergic receptor kinase (beta ARK) phosphorylates its membrane-associated receptor substrates, such as the beta-adrenergic receptor, triggering events leading to receptor desensitization. (duke.edu)
  • Casein kinase II subunit alpha is an enzyme that in humans is encoded by the CSNK2A1 gene. (wikipedia.org)
  • The ADP-Glo Kinase Assay can be used to monitor the activity of virtually any ADP-generating enzyme (e.g., kinase or ATPase) using up to 1mM ATP. (mybio.ie)
  • Kinase Enzyme System contains: Kinase: CAMKK1, 10ug (Human, recombinant full-length). (mybio.ie)
  • Visit www.promega.com/kinase/ to see all Kinase Enzyme Systems. (mybio.ie)
  • This download is the types and cells led from a human assembly target content soccer methylated alongside the set of two interaction localizing enzyme proteins in New Zealand. (evakoch.com)
  • Energy production - ALA functions as a co-factor in the pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase mitochondrial enzyme complexes in the production of energy (1). (peoplesrx.com)
  • Inhibition of the Ras-MAPK pathway by expression of the dominant-negative Ras mutant HRasN17 or by addition of the MAPK kinase (MEK) inhibitor PD98059 reduced several of these parameters but failed to block transformation. (embl.de)
  • Since alpha-synuclein (alpha-Syn) aggregation is a major hallmark in the pathogenesis of PD, we aimed to evaluate the anti-aggregative potential of pharmacological ROCK inhibition using the isoquinoline derivative Fasudil, a small molecule inhibitor already approved for clinical use in humans. (mpg.de)
  • We investigated the role of phosphatidylinositol-4-phosphate 5-kinase alpha (PIP5Kα), a key upstream factor of PI3K/AKT, and the therapeutic effect of PIP5Kα inhibitor on subtypes of BC. (lu.se)
  • Olsson PO, Gustafsson R, In 't Zandt R, Friman T, Maccarana M, Tykesson E, Oldberg Å, Rubin K, Kalamajski S. The Tyrosine Kinase Inhibitor Imatinib Augments Extracellular Fluid Exchange and Reduces Average Collagen Fibril Diameter in Experimental Carcinoma. (lu.se)
  • The protein encoded by this gene represents the alpha subunit. (wikipedia.org)
  • Three transcript variants encoding two different proteins have been found for this gene. (wikipedia.org)
  • Specific isoforms of PKC were inhibited by using inhibitors of the receptors for activated C-kinase (RACK), and in vivo viral-mediated gene-transfer was used to transfect neurons with dominant negative mutants (DNMs) of specific G-protein-coupled receptor kinases (GRKs). (bath.ac.uk)
  • The cAMP-dependent protein kinase (PKA) is involved in the regulation of key cellular processes including gene expression, metabolism and cytoskeletal reorganization. (yu.edu)
  • other specificity is tiny gene activity and distribution browser through the kinase of the R-RasGAP complex ileal to suitable or through the functionality of RhoA. (evakoch.com)
  • To address the possibility that activation of phosphatidylinositol-3-kinase (PI3K) and the mammalian target of rapamycin (mTOR/FRAP), represents one of these pathways, we have examined the effect of simultaneous inhibition of the Ras-MAPK and PI3K-mTOR pathways on transformation of CEF by v-Src. (embl.de)
  • Since oxidative stress activates protein kinase D1 (PKD1) in tumor cells, we investigated the effect of excitotoxicity on neuronal PKD1 activity. (nature.com)
  • We previously observed that the metabolic thiol antioxidant alpha-lipoic acid (LA) inhibits LPS-induced expression of cellular adhesion molecules and adherence of monocytes to human aortic endothelial cells. (oregonstate.edu)
  • Organic barn dust inhibits surfactant protein D production through protein kinase-c alpha dependent increase of GPR116. (cdc.gov)
  • Gastrin inhibits cholangiocarcinoma growth through increased apoptosis by activation of Ca2+-dependent protein kinase C-alpha. (tamu.edu)
  • Targeting of PKA to specific subcellular structures plays an essential role in substrate selectivity as shown by in vivo disruption of PKA targeting. (yu.edu)
  • The assay is well suited for measuring the effects chemical compounds have on the activity of a broad range of purified kinases, making it ideal for both primary screening as well as kinase selectivity profiling. (mybio.ie)
  • The phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway was recently shown to negatively regulate LPS-induced acute inflammatory responses. (oregonstate.edu)
  • The results were further proven by the mitigation of cardiac injury in vivo, as evidenced by the elevation of fractional shortening, heart weight/tibia length, and the rate of the increase/decrease of left ventricular pressure in mice subjected to DOX-induced cardiotoxicity. (bvsalud.org)
  • Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. (wikipedia.org)
  • X-linked anhidrotic ectodermal dysplasia with immunodeficiency is caused by mutations in NEMO/IKKgamma, the regulatory subunit of the IkB kinase complex. (lu.se)
  • The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. (nih.gov)
  • mTOR Directs Breast Morphogenesis through the PKC-alpha-Rac1 Signaling Axis. (omicsdi.org)
  • We further show that inhibition of the signaling molecule protein kinase C alpha (PKCa) can reverse this inhibition implicating it as a mechanism of SP-D inhibition. (cdc.gov)
  • Oxidative stress is an important activator of PKD1 in cellular models, but its capacity to activate this kinase in vivo is largely unknown. (nature.com)
  • Diabetic neuropathy - In experimental diabetic neuropathy, alpha-lipoic acid provides increased nerve blood flow, reduced oxidative stress and improves distal nerve conduction (24). (peoplesrx.com)
  • Hybrid transgenic mice reveal in vivo specificity of G protein-coupled receptor kinases in the heart. (duke.edu)
  • Unexpectedly, we find that excitotoxicity provokes an early inactivation of PKD1 through a dephosphorylation-dependent mechanism mediated by protein phosphatase-1 (PP1) and dual specificity phosphatase-1 (DUSP1). (nature.com)
  • A method for determining the sequence specificity of DNA-binding proteins. (lookformedical.com)
  • AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. (cusabio.com)
  • Hepatic amino acid and protein metabolism in non-anorectic, moderately cachectic tumor-bearing rats. (tamu.edu)
  • As stated, insulin is a potent hormone involved in protein, fat and carbohydrate metabolism. (peoplesrx.com)
  • We found that the PR region of MAP2 interacts with Hsc70 (heat-shock cognate protein) and N-WASP (neural Wiskott-Aldrich syndrome protein). (yu.edu)
  • Our results demonstrate that Fasudil, next to its effects mediated by ROCK-inhibition, directly interacts with alpha-Syn and attenuates alpha-Syn pathology. (mpg.de)
  • Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways. (omicsdi.org)
  • Alpha-lipoic acid attenuates LPS-induced inflammatory responses by activating the phosphoinositide 3-kinase/Akt signaling pathway. (oregonstate.edu)
  • The differentiation-induced psoriasin expression was found to be mediated by the protein kinase C pathway. (medicaljournals.se)
  • EXPERIMENTAL APPROACH: MOR function was measured in locus coeruleus neurons, by using whole-cell patch-clamp electrophysiology, in rat and mouse brain slices (both wild-type and protein kinase C (PKC)alpha knockout mice). (bath.ac.uk)
  • 1) In neurons PKA is targeted to microtubules though binding of RIIbeta to amino acid residues 86--103 of MAP2, a region predicted to form an amphipathic alpha-helix, the proposed RII-binding motif of AKAPs. (yu.edu)
  • 3) Both MAP2 and TAKAP80, highly abundant proteins in neurons and sperm respectively, contain a proline-rich (PR) sequence with multiple PXXP repeats. (yu.edu)
  • Protein kinase C (PKC) is involved in a wide array of cellular processes such as cell proliferation, differentiation and apoptosis. (omicsdi.org)
  • LIM kinase, which had been shown to regulate cell migration, when inhibited not only prevented cell migration in both embryonic mouse kidneys and in HK2 cells but also prevented embryonic kidney cells from completing mitosis and caused them to undergo apoptosis. (nottingham.ac.uk)
  • Utilizing Rictor knock-out cells, immunoprecipitation and mass spectrometry, a novel Rictor associated protein, heterogeneous nuclear ribonucleoprotein M (hnRNP M), was identified. (omicsdi.org)
  • However, in muscles from PKCalpha knockout (KO) mice, neither contraction- nor phorbol ester-stimulated glucose uptake ex vivo differed compared with the wild type. (ku.dk)
  • In a minimal traumatic brain injury (mTBI) induced neuroinflammation in-vivo model in mice, increased thrombin activity, PAR1 activation, and TNF-α levels were measured. (biomedcentral.com)
  • In vivo, C57BL/6 J mice were intraperitoneally injected with 4 mg/kg/day DOX on days 1, 7, and 14. (bvsalud.org)
  • No differences in the levels of alpha-synuclein or phosphorylated alpha-synuclein are observed in the brain of LRRK2 G2019S transgenic mice up to 15 months compared to non-transgenic littermates. (neurodegenerationresearch.eu)
  • the amount of triton insoluble alpha-synuclein protein is significantly higher in the striatum, cortex, hippocampus and olfactory bulb of these transgenic mice. (neurodegenerationresearch.eu)
  • Furthermore, we evaluated the impact of long-term Fasudil treatment on alpha-Syn pathology in vivo in a transgenic mouse model overexpressing human alpha-Syn bearing the A53T mutation (alpha-Syn(A53T) mice). (mpg.de)
  • Fasudil treatment improved motor and cognitive functions in alpha-Syn(A53T) mice as determined by Catwalk (TM) gait analysis and novel object recognition (NOR), without apparent side effects. (mpg.de)
  • Finally, immunohistochemical analysis revealed a significant reduction of alpha-Syn pathology in the midbrain of alpha-Syn(A53T) mice after Fasudil treatment. (mpg.de)
  • The luminescent signal positively correlates with ADP amount and kinase activity. (mybio.ie)
  • This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag. (cusabio.com)
  • abstract = 'Conventional (c) protein kinase C (PKC) activity has been shown to increase with skeletal muscle contraction, and numerous studies using primarily pharmacological inhibitors have implicated cPKCs in contraction-stimulated glucose uptake. (ku.dk)
  • ABSTRACT In order to define the protein expressional changes related to the process of meglumine antimoniate resistance in anthroponotic cutaneous leishmaniasis (CL), we performed a comparative proteomics analysis on sensitive and resistant strains of Leishmania tropica isolated from Iranian CL patients. (who.int)
  • Activation of PAR1 by the aPC involves PC activation by its receptor, the endothelial protein C receptor (EPCR). (biomedcentral.com)
  • Activation of DNA-PKcs by UV is dependent on ATR (Ataxia telangiectasia mutated and Rad3 related) kinase and is important for replication stress [ 12 ]. (biomedcentral.com)
  • Surprisingly, Akt re-activation was not sufficient to rescue cell survival or invasion, and modestly increased branching of mTORC2-impaired mammary epithelial cells (MECs) in culture and in vivo. (omicsdi.org)
  • AM activation was analyzed by measurement of baseline and lipopolysaccharide (LPS)-induced TNF-alpha production. (stanfordhealthcare.org)
  • Intracellular signaling was analyzed for activation of the mitogen-activated protein kinases (MAPKs): ERK1/2, JNK, and p38. (stanfordhealthcare.org)
  • In vivo HTS prevents excessive AM activation during systemic inflammation. (stanfordhealthcare.org)
  • Previously, we have shown in a mouse model that exposure to hog dust extract (HDE) collected from a CAFO results in the activation of protein kinase C (PKC), elevated lavage fluid cytokines/chemokines including interleukin-6 (IL-6), and the development of significant lung pathology. (cdc.gov)
  • The innate immune response also includes complement proteins, defensins, and chemokines which attract inflammatory leukocytes, lipid mediator of inflammation, bioactive amines, and enzymes to enhance inflammation ( 2 ). (frontiersin.org)
  • Members of a subfamily of these enzymes share a specific domain that was first identified in the yeast Sac1 protein [1]. (embl.de)
  • The synthesis, chemical derivatization, and investigation of the inhibitory properties of novel cyclitol derivatives on the phosphatidylinositol 4-kinase enzymes PI4K55 and PI4K230 involved in the phosphatidylinositol cycle are reported. (embl.de)
  • This thesis showed that inhibition of LIM kinase in HK2 cells resulted in the formation of multiple alpha-tubulin foci, multiple centrosomes, the premature dispersal of the cohesin complex protein SMC3 in the absence of a fully formed spindle, and cell death. (nottingham.ac.uk)
  • The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. (wikipedia.org)
  • The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. (wikipedia.org)
  • It may be related to changes in fatty acylation of platelet structural proteins. (medscape.com)
  • The 5' cap open reading frame encodes a variety of non-structural proteins. (medsci.org)
  • Non-structural proteins are involved in the transcription and replication of the virus. (medsci.org)
  • Coronaviruses have at least four major structural proteins, including spikes (S), membranes (M), envelopes (E), and nucleocapsid (N) proteins. (medsci.org)
  • Structural proteins are all encoded by the 3' terminus of the viral genome. (medsci.org)
  • Although most people will benefit from antioxidant support of alpha-lipoic acid, by no means are these the only products effective in supporting blood sugar regulation. (peoplesrx.com)
  • The recruitment of specific cytosolic proteins to intracellular membranes through binding phosphorylated derivatives of phosphatidylinositol (PtdIns) controls such processes as endocytosis, regulated exocytosis, cytoskeletal organization, and cell signaling. (embl.de)
  • We report here that Sac1p has a specific role in secretion and acts as an antagonist of the phosphatidylinositol 4-kinase Pik1p in Golgi trafficking. (embl.de)
  • Synthesis of new cyclitol compounds that influence the activity of phosphatidylinositol 4-kinase isoform, PI4K230. (embl.de)
  • We further show that some proposed mechanisms of DAPK's action (modulation of synaptic strength, involvement of the DANGER-related protein MAB-21, and autophagy) do not have a major role in nematode excitotoxicity. (biomedcentral.com)
  • Here, to confirm that cPKC activity is required for contraction-stimulated glucose uptake in mouse muscles, contraction-stimulated glucose uptake ex vivo was first evaluated in the presence of three commonly used cPKC inhibitors (calphostin C, G{\'o}-6976, and G{\'o}-6983) in incubated mouse soleus and extensor digitorum longus (EDL) muscles. (ku.dk)
  • this activity is dependent on Cys42 of protein kinase G1 alpha. (edu.au)
  • Also, alpha-lipoic acid's antioxidant activity helps protect against many of the health risks associated with diabetes (23). (peoplesrx.com)
  • Protein kinase D1 (PKD1), together with PKD2 and PKD3, constitute a family classified within the calcium/calmodulin-dependent protein kinase superfamily 7 . (nature.com)
  • Conditional expression of the full-length human mutant ( G2019S ) LRRK2 mutant protein was achieved using a Ca2+/calmodulin-dependent protein kinase II alpha ( CaM ) promoter to control the expression of the tetracycline-transactivator ( tTA ). (neurodegenerationresearch.eu)
  • Innate immunity in gastrointestinal system includes epithelial cell layers that express tight cell-cell contact, secreted mucous layer which prevent entry of microbes, protective plasma protein, and circulating leukocytes, such as phagocytic macrophages, neutrophils, dendritic cells (DC), natural killer (NK) cells, NK T-cell, and innate lymphoid cells. (frontiersin.org)
  • miR-301a is initially identified as a novel ncRNA to be upregulated in T-helper cells in response to myelin oligodendrocyte protein antigen in the multiple sclerosis ( 8 ). (frontiersin.org)
  • Intracellular psoriasin has been found to interact with various signalling proteins, including the nuclear factor (NF)-kB regulator Jab1, while secreted psoriasin functions as an antimicrobial peptide and has the ability to induce chemotaxis of neutrophils and T cells (6). (medicaljournals.se)
  • METHODS: In ex-vivo, H9C2 cells were incubated with 20, 40, or 80 µM afzelin for 12 h, followed by the treatment with 1 µM DOX for 12 h. (bvsalud.org)
  • miR-130b/301b declined in adipose progenitor cells during beige adipogenesis, while forced overexpression of miR-130b-3p or miR-301b-3p suppressed uncoupling protein 1 (UCP1) and mitochondrial respiration, suggesting a decline in miR-130b-3p or miR-301b-3p is required for adipocyte precursors to develop the beige phenotype. (figshare.com)
  • This thesis used ex-vivo embryonic kidney culture to show that during mouse kidney development metanephric mesenchymal cells migrated towards the periphery of the kidney. (nottingham.ac.uk)
  • This thesis also showed that active LIM kinase is required for the completion of mitosis in both embryonic kidneys and HK2 cells. (nottingham.ac.uk)
  • Diabetes - alpha-lipoic acid increases glucose uptake into muscle cells and increases insulin sensitivity in individuals with type 2 diabetes (21,22). (peoplesrx.com)
  • Specific protein-binding measures are often used as assays in diagnostic assessments. (lookformedical.com)
  • Studies in the past decade have demonstrated the essential roles of several AJC protein, including underlying actinomyosin components, actin isoforms, and intracellular signal transducer and activator of transcription (STAT) transcription factors, and nuclear factor-κB (NF-κB) in the maintenance and remission of IBD progression ( 5 ). (frontiersin.org)
  • The protein localizes in the Golgi apparatus and at the plasma membrane, where it colocalizes with protein tyrosine kinase 2-beta (PYK2). (novusbio.com)
  • The encoded protein is believed to function as an ARF GAP that controls ARF-mediated vesicle budding when recruited to Golgi membranes. (novusbio.com)
  • A functional model is presented in which IHF favors the contact between the TodT activator, bound further upstream, and the alpha-subunit of RNA polymerase bound to the downstream promoter element. (nih.gov)
  • In this report, you will discover how the alpha lipoic acid benefits vital cellular energy while shielding against and possibly reversing the damaging effects of disorders that include diabetes, obesity, cardiovascular disease, neurodegeneration, and cancer. (lifeextension.com)
  • The PX domain of Vam7p selectively binds PtdIns-3-P, while the PX domain of the CPK PI-3 kinase selectively binds PtdIns-4,5-P(2). (embl.de)
  • 13 , 14 However, the amino acid perfectly maintains the stability of the mutual structural conformation of the virus S-protein and the ACE2 receptor in a holistic manner. (medsci.org)
  • In vivo amino acid fluxes in regenerating liver after two-thirds hepatectomy in the rat. (tamu.edu)
  • NMR studies on recombinant MAP2(72--110) showed that the binding motif does not have an alpha-helical conformation in solution. (yu.edu)