This fact, coupled with general societal pressure to reduce animal use, has resulted in calls for tiered and integrative testing strategies using high-throughput in silico, in vitro, and other alternative models to screen and assess ENMs along their chemical life cycle. (cdc.gov)
To date, much progress has been made in improving in silico, in vitro, and ex vivo model systems with increased complexity and with promising predictivity of tissue-level responses. (cdc.gov)
Moreover, because hypoxia increases the expression of P-glycoprotein in vitro, we examined whether in vivo acute moderate hypoxia modulates the expression of several membrane transporters in the liver. (aspetjournals.org)
Precision-Cut Lung Slices1
To simulate lung distension, we optimized both an ex vivo model with precision cut lung slices and an in vivo model of fetal tracheal occlusion. (lu.se)
Hepatic7
Rho-kinase (ROCK) activation in hepatic stellate cells (HSC) is a key mechanism promoting liver fibrosis and portal hypertension (PTH). (ibecbarcelona.eu)
Portosystemic encephalopathy (PSE) or hepatic encephalopathy (HE) is a neuropsychiatric syndrome associated with hepatocellular failure or portal-systemic venous shunting. (medscape.com)
Type C: Hepatic encephalopathy associated with cirrhosis and portal hypertension or portal-systemic shunts. (medscape.com)
however, shunting may result from other causes, including portal vein thrombosis or compression, congenital hepatic fibrosis, iatrogenic shunt placement, and congenital shunt formation. (medscape.com)
The aim of this study was to assess whether acute moderate hypoxia modulates the expression of CYP2B4, 2C5, and 2C16 in vivo, and to determine whether the changes in hepatic P450 are conveyed by serum mediators. (aspetjournals.org)
The present study aimed to explore whether acute moderate hypoxia down-regulates CYP2B4, 2C5, and 2C16 in vivo, the rabbit's orthologs of human CYP2B6, 2C9 and 2C19, respectively, because of their relative importance in the biotransformation of drugs, and to identify ex vivo the serum mediators implicated in the in vivo down-regulation of these hepatic isoforms. (aspetjournals.org)
Rats7
Ex vivo analysis of baseline function revealed reduced left ventricular pressure development (LVDP) and contractility in hyperbilirubinaemic rats. (edu.au)
Rabbits and rats were exposed to a fractional concentration of oxygen of 8% for 48 h to generate a stable arterial partial pressure of O 2 of 34 ± 1 mm Hg. (aspetjournals.org)
In vivo, in rats, hypoxia increased the mRNA and protein expression of P-glycoprotein but did not affect the mRNA of breast cancer resistance protein and organic anion-transporting polypeptide 2. (aspetjournals.org)
Treatment with Abana (3 g/kg/day, p.o) for 3 weeks, reduced the blood pressure of unilaterally nephrectomized DOCAsalt-treated hypertensive rats. (ijp-online.com)
Similar reduction in blood pressure was also observed in the CdCl2 (1 mg/kg/day, i.p. for two weeks) treated hypertensive rats. (ijp-online.com)
However, Abana (3 g/kg/day, p.o) administered to normotensive female albino rats for 3 weeks did not alter the mean blood pressure and the pressor response to adrenaline and noradrenaline (1 and 2 'g/kg). (ijp-online.com)
The vascular reactivity to noradrenaline in isolated aortic strip and portal vein was also reduced by the chronic administration of Abana in the hypertensive rats. (ijp-online.com)
Vascular7
In a new study published in the Journal of Biochemistry , a research team led by experts from the University of Tsukuba investigated the activity of APJ, a membrane receptor that is commonly expressed in cardiovascular tissue, such as blood vessels and the heart, and found that APJ was closely associated with hypertension (increased blood pressure) through effects on vascular smooth muscle cells in laboratory mice. (sortiwa.com)
Although prior experiments indicated that APJ might be related to hypotension (lower blood pressure), those experiments did not use vascular smooth muscle cells, which are the primary cells that express APJ. (sortiwa.com)
Transgenic mice that overexpressed APJ in vascular smooth muscle cells showed transient and intense elevation of blood pressure due to APJ activation through apelin injection," says Akiyoshi Fukamizu, corresponding author on the study. (sortiwa.com)
The results of this study may help to understand the mechanisms that control blood pressure and support the development of therapies for conditions such as vascular stenosis and vasospasm. (sortiwa.com)
The purpose of the present study as to evaluate the effect of changes in intravascular pressure and the inflammatory mediator bradykinin on rat mesenteric arterial and venous vascular permeability. (bvsalud.org)
Vascular permeability to dextran was determined at 100, 200 and 300 % of physiological pressures. (bvsalud.org)
vascular permeability was present at all measurements for both vessels and its magnitude directly proportional to the intravascular pressure. (bvsalud.org)
Vein2
A surgical procedure was developed to deliver mammary tumor cells to the murine liver via portal vein injection. (jove.com)
Visual demonstration of this method is critical, as the portal vein injection requires precise manipulations that rely on direct anatomical surveillance. (jove.com)
Arterial3
Featured Abstract(top 5%), In vivo Intravascular MR Imaging: Transvenous Technique for Arterial Wall Imaging. (stanford.edu)
Studies conducted in vivo more than two decades ago suggested that the postcapillary venules were more important than the arterial vessels in the process of edema formation. (bvsalud.org)
Reduces blood loss: In total hip arthroplasty (THA), studies have demonstrated that both spinal and epidural anesthesia tend to have approximately a 30% reduction in intraoperative blood loss compared with general anesthesia , owing to lower arterial and venous pressures. (medscape.com)
Hypertension4
Inflammation and oxidative stress play a key role in the pathophysiology of advanced chronic liver disease (ACLD) and portal hypertension (PH). (mdpi.com)
Similarly, despite an improvement in blood pressure management, largely due to pharmacological interventions, hypertension remains a silent killer. (kcl.ac.uk)
Measurements2
During the PDM mandate, I will work on the first work package of my FWO-project with the aim to determine the influence of different surface mechanical properties on muscle-tendon interactions of the triceps surae during running using in-vivo measurements techniques and musculoskeletal modelling and by creating different surface configurations. (researchportal.be)
Maternal BMI at booking, standardised blood pressure measurements and birth weight centile were also recorded. (gla.ac.uk)
Societal pressure1
At the same time - also due to societal pressure and political ambitions - companies search for alternatives for animal experimentation. (uu.nl)
Reduces1
Specific delivery of ROCK-inhibitor Y-27632 (Y27) to HSC targeting mannose-6-phosphate-receptors reduces portal pressure and fibrogenesis. (ibecbarcelona.eu)
Model3
The fibrosis in portal tract and perilobular regions are highlighted by green and blue arrows, respectively, in the NASH model ( left ). (wuxibiology.com)
Virtual thermal and Virtueel thermisch en biomechanisch hoofdmodel om lokaal (dis)comfort te kwantificeren (vir-head) head model to quantify local (dis)comfort (vir-head). (researchportal.be)
In conclusion, our ex vivo model quantifies substrate compartmental distribution and transport across hepatocyte membranes and provides an additional understanding of substrate distribution in the liver. (aspetjournals.org)
Blood pressure3
Many epidemio logical studies have found increases in blood pressure to be associated with increases in PbB. (cdc.gov)
Animal data demonstrate that oral exposure to lead increases blood pressure. (cdc.gov)
Taking N-acetyl cysteine by IV also seems to help prevent nitroglycerin tolerance, but it might increase the risk for headaches and low blood pressure. (medlineplus.gov)
Models1
52 How to use Ex vivo models in teaching Therapeutic Endoscopic Ultrasound (T-EUS). (medcorea.com)
Systemic2
This complex condition results in the flow of portal blood containing putative toxins produced in the gut to the systemic circulation and, ultimately, the brain via extrahepatic shunts (collateral flow). (medscape.com)
However, we are increasingly learning that biological systemic responses and toxicities (e.g., adaptive immune, cardiovascular, and neurological responses) can occur systemically to the original portal of entry. (cdc.gov)
Fluid1
Accurate fluid pressure in the fetal lung is critical for its development, especially at the beginning of the saccular stage when alveolar epithelial type 1 (AT1) and type 2 (AT2) cells differentiate from the epithelial progenitors. (lu.se)
Exposure1
Human exposure may occur via inhalation due to the high vapor pressure of iodomethane. (cdc.gov)
Contrast1
Though I have the true download peer pressure (issues that contains that contrast, and the turn white medium it received to put them, what I needed is that the various treatise of analytical acetylides suggests unequivocally hard to tilt an blogging birth. (dbmass.com)
Lower1
deep download peer pressure (issues that concern transfusion Skills as a heat for the Lower effective Staerklé. (dbmass.com)
Injection1
Inhalation Toxicology Downloaded from informahealthcare.com by CDC Information Center on 07/06/12 stored as a liquid under pressure, but volatilizes rapidly fol- to agricultural soil is expected to occur over a time period lowing injection into soil. (cdc.gov)
Experiments1
Its synthesized experiments use you well in download peer pressure to the Expository Golden Age. (dbmass.com)
Type1
download peer pressure (issues that concern of Polyhedron, une specialisation, Current metal, Many type! (dbmass.com)
Increase1
In vivo, the increase in CYP3A6 by hypoxia is associated with the increased expression and nuclear translocation of hypoxia-inducible factor-1 (HIF-1), activator protein 1 (AP-1), and constitutive androstane receptor ( Fradette and du Souich, 2003 ). (aspetjournals.org)
Effect1
Additionally, duration of ventricular ejection increased progressively, indicating a negative inotropic effect of bilirubin in vivo. (edu.au)
Activity1
I determined ex vivo lipolytic activity (basal, isoprotenerol stimulated and insulin suppression of lipolysis) and adipokine production in response to lipopolysaccharide (LPS) stimulation from these biopsies. (gla.ac.uk)
Features1
Vivo X Fold+ features a foldable design, the outer display is a 6.53 inch E5 OLED panel that has a Full HD+ resolution, 120Hz refresh rate, HDR10+ support, 100 percent DCI P3 color gamut, and 21:9 aspect ratio. (alezay.com)
Development1
Recent development of longer lasting CGRP agonists may therefore offer a practical solution to investigating CGRP further in cardiovascular disease in vivo. (kcl.ac.uk)
Weeks1
The structure of the retina and optic nerve was in vivo evaluated using optical coherence tomography (OCT) every two weeks and functionally using dark- and light-adapted electroretinography at 0-12-24 weeks. (uab.cat)
Main1
main Palaeolithic Thames download peer pressure (issues that pools at Globe Pit, Little Thurrock, and their presented Acid-Base surprise. (dbmass.com)
Views1
OPPO views smartphone as a key device portal to connect users, but it is not necessarily the only one. (strategyanalytics.com)
Critical1
The critical download peer pressure (issues that concern you) Oedipus Rex required existed by Sophocles and socially coexpressed in 429 BC. (dbmass.com)
HEALTH1
Health (as of 2021 at epa.ohio.gov/Portals/28/documents/labcert/Combined-Lab-List. (osu.edu)