Vitro-in vivoMurineUptakeDefect modelTumorsMiceEfficacyQuantitativeTumorRabbitsStudyToxicologicalExposureInhalationTransgenicHydrogelsDeveloped a novelToxicityExperimentsMagneticComputationalExperimentalPreclinical modelStudiesToxicologyTherapeuticDrosophilaBiologyMethodsCellularFeasibilityMammalianHumanRabbitZebrafishHumansEpithelialDataReductionPracticePhysiologicalResultsParticlesInteractionsMouse ModelDevelopmentTailDescribeCells
Vitro-in vivo2
- While we have applied this approach in the specific context of COVID-19, this in vitro-in vivo translational methodology is also broadly applicable to repurposing drugs for diseases of the lower respiratory tract. (medrxiv.org)
- Eurofins Discovery의 Pharmacology Discovery Services는 BSL-2 (Biosafety Level 2) 시설에서 새로운 Microbial의 발견 및 개발을 위한 in vitro/in vivo service를 지원합니다. (chayon.co.kr)
Murine2
- Human tissue-engineered colon forms from postnatal progenitor cells: an in vivo murine model. (ca.gov)
- DNA strand breaks and TDP-43 mislocation are absent in the murine hSOD1 G93A model of amyotrophic lateral sclerosis in vivo and in vitro " has been published in PLOS ONE . (neurodegenerationresearch.eu)
Uptake1
Defect model1
- For this purpose, an ex vivo defect model with osteochondral grafts is used, in which a defect is generated in these bone-cartilage cylinders and the hydrogels are cultivated in 3D-printed and injected form over several weeks. (donau-uni.ac.at)
Tumors2
Mice4
- These data demonstrate that CAR-induced cytokine release syndrome can be modeled in mice that express target Ag in an appropriate distribution. (kcl.ac.uk)
- In vivo, 4T1 cells were implanted into the mammary fat pad of BALB/c mice. (bmj.com)
- Furthermore, MDM2-ALT1-expressing p53 null mice represent a novel mouse model of fusion-negative RMS. (bvsalud.org)
- For instance, mice are able to reconstitute most lymphomas in monkeys and humans woodchuck hepatitis virus induces major components of the human provides strong support for a direct hepatocellular carcinoma (HCC) haematolymphoid system including oncogenic role of EBV in vivo. (who.int)
Efficacy4
- Here, we optimized NM injuries in ex vivo human corneas and assessed DEX efficacy. (aspetjournals.org)
- This slow development is in part due to the cost of materials and the animal models used for screening the efficacy and safety of those delivery approaches. (oregonstate.edu)
- The aim of this study is to develop an in vivo study to corroborate its efficacy. (ugr.es)
- Here we present proof-of-concept (POC) in vivo data showing efficacy of intratumorally administered PH-109 in an orthotopic 4T1 model of metastatic mammary cancer. (bmj.com)
Quantitative2
- Given that most studies to date rely on in vitro or observational clinical data, our aim was to develop a novel, quantitative animal model enabling further investigation of the biofilm hypothesis in vivo. (northwestern.edu)
- We have established and validated a highly quantitative, reproducible in vivo biofilm model, while providing evidence that the biofilm phenotype specifically contributes to profound cutaneous wound healing impairment. (northwestern.edu)
Tumor4
- Tumor cells can be cultured by our staff in preparation for in vivo studies. (stanford.edu)
- For this purpose, two tumor induction models have been developed. (ugr.es)
- In orthotopic xenograft model, it has been shown that EE reduces tumor size without hematological toxicity. (ugr.es)
- In vivo experiments demonstrate that these nanocapsules can target to tumor sites through fluorescence/magnetic resonance imaging and offer remarkable therapeutic results. (nature.com)
Rabbits1
Study13
- In this paper, we review the different protocols available to study human Plasmodium species either by using stem cell or alternative animal models. (wjgnet.com)
- In parallel, the development of animal models opened new opportunities to study parasite biology in vivo . (wjgnet.com)
- We created an in vivo air sampling model to study airborne transmission of tuberculosis from patients coinfected with human immunodeficiency virus (HIV) and to evaluate environmental control measures. (nih.gov)
- An in vivo arteriovenous malformation model in swine: preliminary feasibility and natural history study. (ajnr.org)
- In addition, we used difference maps between input and output of the trained model generator to study the translated characteristics of in vivo data. (lu.se)
- This study compares in vitro and in vivo models of lipid digestion from almond particles within a complex food matrix (muffins) investigating whether the cell-wall barrier regulates the bioaccessibility of nutrients within this matrix. (nuthealth.org)
- We additionally highlight the alternative models that reduce the use of mammals as model organisms, which have been gaining importance in the study of fungal host-microbe interactions. (uu.nl)
- The insect renal (Malpighian) tubule has long been a model system for the study of fluid secretion and its neurohormonal control, as well as studies on ion transport mechanisms. (bordeaux-neurocampus.fr)
- This study assessed the combination of the endothelin receptor antagonist macitentan and the phosphodiesterase-5 inhibitor vardenafil in a human ex vivo model.MethodsStudy patients did not suffer from PAH. (uni-regensburg.de)
- In this study, we have evaluated safety of T4 immunotherapy in vivo using a SCID beige mouse model. (kcl.ac.uk)
- A study of the current masticatory system requires the recording of impressions for the fabrication of study models (see image below). (medscape.com)
- Preoperative study models. (medscape.com)
- Moreover, The use of animals as surrogate rine host, can provide a platform for animal models for tumour viruses in hosts for the study of human tu- in vivo infection. (who.int)
Toxicological2
- however, toxicological results are seldom concordant between in vivo and in vitro models. (cdc.gov)
- As coculture gene expression better correlated with in vivo gene expression, we suggest that cellular cocultures may offer enhanced in vitro models for nanoparticle risk assessment and the reduction of in vivo toxicological testing. (cdc.gov)
Exposure4
- Physiology-based (pharmaco)kinetic PB(P)K modelling has become a promising tool to predict plasma and/or tissue exposure to xenobiotics based on in vitro disposition data. (norecopa.no)
- Significance Statement NM exposure-induced injuries were optimized in an ex vivo human cornea culture model and studies were carried out at 24 h post 100 nmoles NM exposure. (aspetjournals.org)
- Consistent with this disappointing performance in the clinic, translational modeling for ivermectin predicts insufficient exposure in the lungs under the clinically-approved oral regimen [ 13 ]. (medrxiv.org)
- When reduced to only those genes involved in inflammation and fibrosis, known outcomes of in vivo MWCNT exposure, there were more disease-related concordant genes expressed in coculture than monoculture. (cdc.gov)
Inhalation1
- Our proposed solution to the problem of ineffective drug repurposing for COVID-19 antivirals is two-fold: to broaden the therapeutic window by reformulating therapeutics for the pulmonary route, and to select drug repurposing candidates based on their model-predicted therapeutic index for inhalation. (medrxiv.org)
Transgenic1
- Transgenic mouse models pro- fection. (who.int)
Hydrogels1
- This in vivo stroke model confirmed that self-assembling silk fibroin hydrogels provide a favourable microenvironment as a future support matrix in the stroke cavity. (strath.ac.uk)
Developed a novel1
Toxicity2
- Inclusion of the partition coefficients and metabolic clearance data from the day before in the PBPK model in Berkeley Madonna, evaluation of the model performance and use of the model for QIVIVE of toxicity data. (norecopa.no)
- Participants discussed the ways in which small fish are being used as models to screen toxicants and understand mechanisms of toxicity. (oregonstate.edu)
Experiments1
- Single cell experiments [ 11 ] could provide iterative validation of models with experimental results. (lu.se)
Magnetic1
- In vivo magnetic resonance spectroscopy (MRS) is a specialized technique associated with magnetic resonance imaging (MRI). (wikipedia.org)
Computational2
- The Nottingham Physiology Simulator (NPS), a validated computational model of cardiopulmonary physiology [ 2 ], was used to validate the ability of VR to reflect ventilatory efficiency ex vivo . (biomedcentral.com)
- Computational techniques, including predictive algorithms and mathematical models that describe a selected process (e.g., skin permeation) by means of analytical or numerical methods. (cdc.gov)
Experimental3
- Dramatic advances in materials science and cell biology have led to the development of new and increasingly complex experimental platforms for disease modelling. (sivb.org)
- Methods: In this work, we propose to use deep learning to model the authentic intra-muscular skeletal muscle contraction pattern using domain-to-domain translation between in silico (simulated) and in vivo (experimental) image sequences of skeletal muscle contraction dynamics. (lu.se)
- The results show that there were large differences between the spatial features of in silico and in vivo data, and that a model could be trained to generate authentic spatio-temporal features similar to those obtained from in vivo experimental data. (lu.se)
Preclinical model2
- In a preclinical model of mouse xenografted with human renal cancer, we analysed the bio-distribution of a single dose (160 μg/kg) intravenously injected of poly-ethylene glycol (PEG)ylated gold nanoshells (~150 nm), in blood, normal and tumoral tissues. (springer.com)
- P11-4) on periodontal regeneration in a preclinical model. (whiterose.ac.uk)
Studies6
- To better understand Plasmodium biology, researchers can whether proceed to in vitro studies or use in vivo models. (wjgnet.com)
- CONCLUSIONS A simple technique for creating an arteriovenous malformation model in swine is now possible and is promising for future studies. (ajnr.org)
- Complementing our animal model studies, DEX was shown to mitigate vesicant-induced toxicities in ex vivo human corneas. (aspetjournals.org)
- In this mini review, we present different models that have been implemented in fungal infections studies with greater attention to Malassezia spp. (uu.nl)
- Ethics Approval Animal studies were performed at Pharma Models LLC, Marlborough, MA 01752, under standard protocol approved by their IACUC. (bmj.com)
- Multi-walled carbon nanotube -induced gene expression in vitro: concordance with in vivo studies. (cdc.gov)
Toxicology2
- Advancing toxicology research using in vivo high throughput toxicology with small fish models. (oregonstate.edu)
- The Collaborative Workshop on Aquatic Models and 21st Century Toxicology was held at North Carolina State University on May 5-6, 2014, in Raleigh, North Carolina, USA. (oregonstate.edu)
Therapeutic2
- Preclinical In Vivo Modeling of Cytokine Release Syndrome Induced by ErbB-Retargeted Human T Cells: Identifying a Window of Therapeutic Opportunity? (kcl.ac.uk)
- This, combined with these data in a clinically relevant orthotopic mouse model of metastatic breast cancer, could support accelerated clinical investigation of PH-109 as an anticancer therapeutic. (bmj.com)
Drosophila3
- Examples of alternative models are Caenorhabditis elegans, Drosophila melanogaster, Tenebrio molitor, and Galleria mellonella. (uu.nl)
- Drosophila melanogaster, however, is an outstanding model organism for molecular genetics. (bordeaux-neurocampus.fr)
- The development of this first physiological assay for a Drosophila epithelium, allowing combined approaches of integrative physiology and functional genomics, has now provided biologists with an entirely new model system, the Drosophila Malpighian tubule, which is utilized in multiple fields as diverse as kidney disease research and development of new modes of pest insect control. (bordeaux-neurocampus.fr)
Biology1
- Our model highlights the importance of bacterial biofilms in chronic wound pathogenesis, providing an in vivo platform for further inquiry into the basic biology of bacterial biofilm-host interaction and high-throughput testing of antibiofilm therapeutics. (northwestern.edu)
Methods1
- However, appropriate image-based simulation models, which would assist the continued development of these new imaging methods are missing. (lu.se)
Cellular1
- not unique for the embryonic system but are shared by other ogenesis regulation must consider different scales of multi-cellular modeling areas. (lu.se)
Feasibility1
Mammalian1
- This is due to the fact that these systems have been shown to have reliable results, which correlate with those obtained from mammalian models. (uu.nl)
Human4
- In addition to the new in vitro systems, in recent years there were also significant advances in the development of new animal models that allows studying the entire cell cycle of human malaria. (wjgnet.com)
- In preparation for human uterus transplantation trials, most teams use the sheep as a model system for research and team training, since the vasculature and the uterus is of similar size as in the human. (nih.gov)
- Animal models for human tumour mental animals is not easy to answer does induce adult T-cell leukaemia/ viruses that make use of animal virus- for these agents, because cancer bi- lymphoma (ATLL), albeit in monkeys es are scarce. (who.int)
- that is histopathological y very simi- T cel s, B cel s, natural kil er cel s, LMP1 of EBV can transform ro- lar to that caused by hepatitis B vi- macrophages, and dendritic cells, dent fibroblasts and is expressed rus (HBV) in humans, but it does so and this humanized mouse model in most of the human cancers as- through a different mechanism. (who.int)
Rabbit1
- Previously, we showed that SM-/NM-induced injuries ( in vivo and ex vivo rabbit corneas) are reversed upon dexamethasone (DEX) treatment, an FDA approved, steroidal anti-inflammatory drug. (aspetjournals.org)
Zebrafish1
- Small freshwater fish models, especially zebrafish, offer advantages over traditional rodent models, including low maintenance and husbandry costs, high fecundity, genetic diversity, physiology similar to that of traditional biomedical models, and reduced animal welfare concerns. (oregonstate.edu)
Humans1
- These beneficial biological properties have been extensively studied in humans and animal models, both in vitro and in vivo . (hindawi.com)
Epithelial1
- The mechanisms involved in viral interference have been evaluated in differentiated airway epithelial cells and in animal models susceptible to the respiratory viruses of interest. (cdc.gov)
Data2
- While physiological parameters that characterize the target population have been largely implemented in several PB(P)K platforms, further consensus building is needed with respect to the quality requirements of in vitro data used for a successful bottom-up modelling approach. (norecopa.no)
- Effects of 3E-7M and 1E-6M macitentan and effects of all doses of ACT-132577 were not further enhanced by 1E-6M vardenafil.ConclusionsThese data suggest that vasodilator effects of macitentan and vardenafil combined may surpass monotherapy in vivo if drug doses are adjusted properly. (uni-regensburg.de)
Reduction1
- Using the Azoxymethane/Dextran Sulfate Sodium model, a reduction of dysplastic polyps has been demonstrated, showing its preventive power. (ugr.es)
Practice1
- A prerequisite for the use of these biocompatible nanoparticles in oncology daily practice is to check in vivo their tolerance in the long-term and on the organs that are the most sensitive to efficient anticancer drugs, particularly the liver, bone marrow, kidney, heart and lung [ 7 , 8 ]. (springer.com)
Physiological1
- Results: This work provides a model to generate authentic intra-muscular skeletal muscle contraction dynamics that could be used to gain further and much needed physiological and pathological insights and assess and overcome limitations within the newly developed research field of neuromuscular imaging. (lu.se)
Results1
- In vivo digestion of these muffins by an ileostomy volunteer (0-10 h) gave similar results with 96.5% and 56.5% lipid digested, respectively. (nuthealth.org)
Particles1
- Muffins containing small (AF) or large (AP) particles of almond were digested in triplicate using an in vitro dynamic gastric model (DGM, 1 h) followed by a static duodenal digestion (8 h). (nuthealth.org)
Interactions1
- In Vitro or In Vivo Models, the Next Frontier for Unraveling Interactions between Malassezia spp. (uu.nl)
Mouse Model1
- Scholars@Duke publication: Targeting Dormant Ovarian Cancer Cells In Vitro and in an In Vivo Mouse Model of Platinum Resistance. (duke.edu)
Development3
- The recent development of stem cell research and the possibility of generating cells that can be stably and permanently modified in their genome open a broad horizon in the world of in vitro modeling. (wjgnet.com)
- Workshop participants agreed that the lack of standardized protocols is an impediment to broader acceptance of these models, whereas development of standardized protocols, validation, and subsequent regulatory acceptance would facilitate greater usage. (oregonstate.edu)
- Welcome to The IN VIVO Blog, home of daily commentary on recent developments in biopharmaceutical business development, R&D, financing, marketing, and policy. (blogspot.com)
Tail1
- It acquires cross-sectional images from head to tail, with high resolution, in vivo and in real time. (lu.se)
Describe1
Cells2
- CTGF-inhibition has shown promise in decreasing metastatic dissemination and sensitizing to cancer cells to chemotherapy in preclinical models. (bmj.com)
- genic models are inadequate for number of activated CD8-positive T LMP1 was strongly expressed in the understanding the cancer etiology in cells increased considerably in the lymphoma tissues but was hardly the context of natural viral infection. (who.int)