Vivo expanded treg cells vivo expansion. Medical search. Frequent questions

effector T cell-mediated antipig cellular responses in vitro (15,16). (buyresearchchemicalss.net)
In this study, we wished to test the hypothesis that ex vivo expanded human Treg were able to protect islet xenografts from rejection mediated by human effector T cells in NOD-SCID IL2r? (buyresearchchemicalss.net)
They may develop due to an impaired function of regulatory T cells (Tregs), which normally suppress self-specific effector immune cells. (uni-stuttgart.de)
Whilst IFN-γ is typically considered to be a pro-inflammatory product of effector T cells, it has been also been demonstrated that IFN-γ −/− mice develop more severe EAE than wild type (WT) controls 5 , highlighting alternate, IFN-γ-dependant negative feedback mechanisms that can constrain EAE disease activity. (nature.com)
STAT1-deficient effector T cells became the target of NK cell-mediated killing, limiting their capacity to induce EAE. (jci.org)
Effector CD4 + T cell subsets have been defined based on their secretion of cytokines, as well as based on transcription factors and cytokines required for their development and maintenance. (jci.org)
It also delivers its function without activating regulatory T cells (Tregs) ( 9 ) and mediating activation-induced cell death of effector cytotoxic T cells ( 10 ). (frontiersin.org)
We have studied the effect of blocking the negative signaling from the inhibitory proteins by means of PD-1/PD-L1 pathway inhibition on effector and regulatory T cells (Treg). (medicalresearch.com)
In contrast, when blood cells from viremic HIV-infected individuals were analyzed, Treg cells expanded efficiently and thus reduced the effector to regulatory T cell ratio that controls HIV. (medicalresearch.com)
As both, effector and regulatory T cells are regulated by this pathway, conditions to achieve a net gain of immune responses should be carefully defined. (medicalresearch.com)
The fourth generation of CAR-T design attempts to deliver cytokines to modulate the tumor microenvironment either by activating host effector T cells or hampering host suppressors and reinforcing memory T cells. (bdbiosciences.com)
Collectively, the BsAb-armed T cell technology represents a simple, time-saving, and highly safe method to generate highly pure cancer-specific effector T cells, thereby providing an affordable T cell immunotherapy to patients. (biomedcentral.com)
However, most effector T cells generated using these established cultivation methods lack cancer specificity [ 8 ]. (biomedcentral.com)
Scientific research has shown that a hostile tumor microenvironment can be significantly regulated by IL-12 through multiple mechanisms, including reactivation of anergic tumor-infiltrated lymphocytes (TILs), inhibition of Treg-mediated suppression of effector T cells, recruitment of NK cells to the tumor site, and inhibition of IL-10 and transforming growth factor-β (TGF-β) secretion by tumor-associated macrophages (TAM). (biomedcentral.com)
To this end, supported by research demonstrating superior antitumor function of naïve derived effector T cells compared to central memory derived effector T cells, I am investigating whether preferential modification of naïve T cells to express CARs will generate a T cell subpopulation with increased efficacy. (stanford.edu)

Second, T cell therapies using Tregs (either polyclonal, antigen-specific, or genetically engineered to express chimeric antigen receptors) to establish active dominant immune tolerance or T cells (engineered to express chimeric antigen receptors) to delete pathogenic immune cells. (frontiersin.org)
In addition, suppressor immune cells such as FOXP3 + regulatory T cells (Tregs) exert dominant immune suppression to control autoreactive T and B cells. (frontiersin.org)
The adoptive transfer of regulatory T-cells (Tregs) is a promising therapeutic approach in transplantation and autoimmunity. (ox.ac.uk)
By comparing their function, phenotype and transcriptomic profile against ex vivo Tregs, we demonstrate that expanded human Tregs switch their metabolism to aerobic glycolysis and show enhanced suppressive function through hypoxia-inducible factor 1-alpha (HIF1A) driven acquisition of CD73 expression. (ox.ac.uk)
In conjunction with CD39, CD73 expression enables expanded Tregs to convert ATP to immunosuppressive adenosine. (ox.ac.uk)
Interleukin 2 (IL-2) and tumor necrosis factor (TNF) have been identified as key players that promote expansion, function and stability of Tregs. (uni-stuttgart.de)
In vivo, both low-dose IL-2 therapy and TNF receptor 2 (TNFR2) agonism were shown to expand Tregs and alleviate autoimmunity. (uni-stuttgart.de)
Prior phenotypic evaluation by CyTOF has identified increases in activated CD8 T cells with activation of Th17 T cells, as well as decreases in Tregs, particularly in patients with toxicity. (nature.com)
Regulatory T cells (Tregs) are a small subpopulation of T cells with potent activities in controlling immune responses. (regimmune.com)
As the nature of T cells, the immunological effects of Tregs are antigen-specific, which gives a unique feature to our Treg-mediated drugs. (regimmune.com)
Our approach for enhancing Treg activity takes advantage of a natural immune pathway using a synthetic small molecule that induces expansion of Tregs. (regimmune.com)
Our lead molecule, RGI-2001, has demonstrated the pharmacological activity in vivo to expand Tregs both in humans and mice. (regimmune.com)
As immune suppressive Tregs play roles in helping tumors to become resistant to immune therapies, Treg suppression is anticipated to enhance efficacy of immune therapies. (regimmune.com)
The transcription factor STAT1 plays a critical role in modulating the differentiation of CD4 + T cells producing IL-17 and GM-CSF, which promote the development of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). The protective role of STAT1 in MS and EAE has been largely attributed to its ability to limit pathogenic Th cells and promote Tregs. (jci.org)
Using mice with selective deletion of STAT1 in T cells (STAT1 CD4-Cre ), we identified a potentially novel mechanism by which STAT1 regulates neuroinflammation independently of Foxp3 + Tregs. (jci.org)
Here we compared T-cell functions including the number of circulating CD3 + T cells, in vitro responses to mitogens, T-cell receptor (TCR) repertoire, TCR excision circles (TREC) levels, and regulatory T cells (Tregs) enumeration in several immunodeficinecy subtypes, clinically presenting with nonreactive residual cells (MHC-II deficiency) or reactive cells. (hindawi.com)
MHC-II deficient patients had slightly reduced T-cell function, normal TRECs, TCR repertoires, and normal Tregs enumeration. (hindawi.com)
While the autoreactive cells displayed significantly reduced Tregs numbers, the alloreactive transplacentally acquired maternal lymphocytes had high functional Tregs. (hindawi.com)
In this context, regulatory T cells (Tregs) hold a key role in balancing immune homeostasis and mediating cutaneous wound healing. (biomedcentral.com)
Regulatory T cells (Tregs) play a pivotal role in this context. (biomedcentral.com)
To this end and within their broad functionality and operationality, Tregs are able to adopt unique features of skin cells and contribute to the skin's role as an immune barrier. (biomedcentral.com)
Our protocol combines intra-bone bone marrow transplantation (IBBMT) with autologous regulatory T cells (Tregs) expanded on donor pig cells to promote tolerance in a pig-to-baboon kidney model. (ixa-ctrms2021.org)
Tregs were obtained by cell sorting recipient baboon PBMCs for CD4+CD25hiCD127- cells. (ixa-ctrms2021.org)
On day 0, 2, 5, and 7 of IBBMT and day 0 of delayed kidney transplantation, performed as a test of tolerance between day 90-110, the ex-vivo expanded Tregs were infused at 40 million/kg/dose. (ixa-ctrms2021.org)
To track the Tregs in vivo, cells were CFSE labeled prior to the final infusion and tracking was performed using flow cytometry and fluorescent microscopy. (ixa-ctrms2021.org)
Expanded Tregs had strong in vitro suppression and expressed FoxP3. (ixa-ctrms2021.org)
After kidney transplantation and adoptive transfer of CFSE labeled Tregs, the ex-vivo expanded Tregs were detectable in the periphery until POD5-8. (ixa-ctrms2021.org)
These cellular components can include cells of the innate immune system, such as myeloid-derived suppressor cells (MDSCs), tumor-associated macrophages (TAMs), and eosinophils, as well as cells of the adaptive immune system, including CD4⁺ T regulatory cells (Tregs) and cytotoxic CD8⁺ T cells. (ubc.ca)
I demonstrated that tumor cells secreted proteins that drove the recruitment and/or expansion of pulmonary TAMs, Tregs, and granulocytic-MDSCs (G-MDSCs), resulting in increased primary lung tumor growth and pulmonary metastasis of mammary carcinoma cells, respectively. (ubc.ca)
BALB/c → C57BL/6 allografts were reconstituted with iPSC-derived MSCs (2 million/transplant/at d0), and allografts were examined for regulatory T cells (Tregs), oxygenation, microvascular blood flow, airway epithelium, and collagen deposition during rejection. (biomedcentral.com)

CD4+CD25+ regulatory T cells (Treg) that express FoxP3 transcription factor are critically important for the control of autoimmunity and maintenance of allograft tolerance (11,12). (buyresearchchemicalss.net)
We have previously demonstrated that ex vivo expanded human natural Treg were superior to their freshly isolated counterparts at suppressing the xenogenic CD4+ T cell-mediated immune response in vitro, and this suppression by ex vivo expanded human Treg was FoxP3 expression-dependent via an interleukin (IL)-10Cinvolved mechanism (19C21). (buyresearchchemicalss.net)
Description: eBioscience offers a panel of monoclonal antibodies to different epitopes of human Foxp3, providing useful tools for investigating the complete expression pattern of Foxp3 at the protein level, and discerning the precise subsets of Foxp3^+ cells. (thermofisher.com)
Constitutive high expression of Foxp3 mRNA has been shown in CD4+CD25+ regulatory T cells (Treg cells), and ectopic expression of foxp3 in CD4+CD25- cells imparts a Treg phenotype in these cells. (thermofisher.com)
Intracellular staining of human peripheral blood mononuclear cells (PBMCs) with PCH101 antibody using the anti-human Foxp3 Staining Set and protocol reveals approximately 0.5-4% of lymphocytes staining, with the majority of staining occurring in the CD25^bright population. (thermofisher.com)
These cells expand in the periphery, causing tissue infiltration and damage due to breakdown of both central (e.g., autoimmune regulator, AIRE protein dysfunction) and peripheral (FOXP3 + deficiency) tolerance mechanisms [ 3 ]. (hindawi.com)
Previously, we suggested that B cells regulated the number of CD4 + Foxp3 + T regulatory cells (Treg) in the CNS during EAE. (aai.org)

The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation. (wikipedia.org)
Following binding to TL1A, TNFRSF25 signaling increases the sensitivity of T cells to endogenous IL-2 via the IL-2 receptor and enhances T cell proliferation. (wikipedia.org)
Stimulation of TNFRSF25, in the absence of any other exogenous signals, stimulates profound and highly specific proliferation of FoxP3+ regulatory T cells from their 8-10% of all CD4+ T cells to 35-40% of all CD4+ T cells within 5 days. (wikipedia.org)
Upon ligand binding, PD-1 signaling inhibits T-cell activation, leading to reduced proliferation, cytokine production, and T-cell death. (bioxcell.com)
Here we sought to further understand the effects of idelalisib and duvelisib in vitro, and demonstrate that both idelalisib and duvelisib can inhibit T cell proliferation as well as Th1 and Treg differentiation in vitro, while promoting Th2 and Th17 differentiation. (nature.com)
IL-15 is considered superior to IL-2 for cancer immunotherapy due to its strong bioactivity in improving CD8 + T and natural killer (NK) cell survival, proliferation and cytotoxic function ( 8 ). (frontiersin.org)
Furthermore, the proliferation of Th17 cells and Th17‑associated cytokines, including interleukin (IL)17, IL23 and RAR‑related orphan receptor γt, was analyzed by reverse transcription‑quantitative polymerase chain reaction. (spandidos-publications.com)
The anti-CD3 moiety of the BsAb bound to the T cell surface and stimulated the differentiation and proliferation of T cells in PBMCs. (biomedcentral.com)
When we investigated the mechanism whereby B cells induce the proliferation of Treg and EAE recovery, we found that glucocorticoid-induced TNF ligand, but not IL-10, expression by B cells was required. (aai.org)

However, human natural Treg comprise only 5C10% of peripheral blood CD4+ T cells (17), and large-scale ex vivo expansion would be required for any future clinical application (18). (buyresearchchemicalss.net)
Peripheral blood mononuclear cell isolation and expansion of human Treg. (buyresearchchemicalss.net)
Human peripheral blood mononuclear cells (PBMC) were obtained from healthy donors using density gradient centrifugation over Ficoll-Paque (Amersham Biosciences, Uppsala, Sweden). (buyresearchchemicalss.net)
We further demonstrate directly using intracellular flow cytometry that autoimmune toxicity in patients is associated with higher absolute numbers of CD4 and CD8 T cells with Th17 differentiation in peripheral blood prior to therapy, and that gastrointestinal tissues from patients with active autoimmune complications of PI3Kδ inhibitors show infiltration with Th17 + T cells. (nature.com)
Peripheral blood cellular immunological changes were assessed by flow cytometry and transcript levels of BAFF , interferon (IFN)-induced and plasma cell-expressed genes were quantified by NanoString. (biomedcentral.com)
In this study, we examined peripheral blood T and B cell populations and their activation in asymptomatic ANA + individuals together with patients with undifferentiated connective tissue disease (UCTD) and early SARD to determine whether the cellular immune characteristics found in SARD are distinct from those seen in asymptomatic ANA + individuals, most of whom will not progress to SARD. (biomedcentral.com)
Flow cytometry was used to investigate the percentage of Th17 and Th1 cells in peripheral blood mononuclear cells. (spandidos-publications.com)
The results revealed that the prevalence of Th17 cells in patients with LSCC was elevated in their primary tumors, as well as in peripheral blood, compared with that in healthy controls. (spandidos-publications.com)
The present study revealed that patients with LSCC have elevated levels of Th17 cells in their primary tumors and peripheral blood compared with those in healthy controls. (spandidos-publications.com)
In this study, we developed a non-genetic engineering technology for rapidly manufacturing a large amount of cancer-specific T cells by utilizing a unique anti-cancer/anti-CD3 bispecific antibody (BsAb) to directly culture human peripheral blood mononuclear cells (PBMCs). (biomedcentral.com)

In interaction with other non-immune cells, such immune cell subsets ensure the functionality and integrity of the skin layers [ 1 ]. (biomedcentral.com)
A number of the immunologic abnormalities seen in SARD, including changes in peripheral B (switched memory) and T (iNKT, T regulatory, activated memory T follicular helper) subsets and B cell activation, were also seen in asymptomatic ANA + subjects and those with UCTD. (biomedcentral.com)
kodzsiki kojiki was especially gated - please your expansion subsets! (deadbatteries.com)
I identified several potentially suppressive myeloid cell subsets, including TAMs and arginase-1ʰⁱ monocytic-MDSCs (M-MDSCs) that expand during CD8⁺ T cell-mediated tumor regression and subsequent recurrence, which may play a role in tumor regrowth. (ubc.ca)

Ultimately, we propose that IL2-EHD2-sc-mTNFR2 is a dual-acting cytokine that efficiently promotes Treg expansion and might have a superior therapeutic window than conventional IL-2-based drugs. (uni-stuttgart.de)
In addition to their efficient lipid-lowering effects, statins exhibit independent so called pleiotropic effects potentially affecting several immune response properties including immune cell activation, migration, cytokine generation, immune metabolism, and survival. (archivesofmedicalscience.com)
These experimental cytokine-producing CAR-Ts, called T cells redirected for universal cytokine killing (TRUCKs), can deliver a variety of cytokines, such as IL-12, IL-15, IL-18 or IL-21. (bdbiosciences.com)
It has been confirmed that naïve (uncommitted) CD4 + T cells can be induced to different specific lineages according to the local cytokine, including towards T helper (Th)1, Th2, Th17 and T regulatory (Treg) cells ( 7 ). (spandidos-publications.com)
cytokine levels cause a decline in cell numbers. (123dok.net)
A more cytokine online Technisches Freihandzeichnen: Lehr of the mutations and money patients that have the Treg people will build other if warcorrespondent umbilical designations please to ensure published. (michael-noeres.de)
Notably, the BsAb-armed T cells did not cause obvious cytokine release syndrome or tissue toxicity in SCID mice bearing human tumors. (biomedcentral.com)
IL-12 is a heterodimeric inflammatory cytokine produced by activated antigen-presenting cells (APCs), neutrophils, and macrophages. (biomedcentral.com)
IL-4 is an immunosuppressive cytokine in the tumor microenvironment that can promote fibrogenesis, support tumor growth and protect malignant cells from immune destruction. (biomedcentral.com)
To protect CAR-PSCA T cells from the inhibitory effects of IL4, Somala Mohammed transgenically expressed a custom inverted cytokine receptor (ICR) in which the IL-4 receptor ectodomain was fused to the IL-7 receptor endodomain, switching the inhibitory effects to promoting effects to ultimately result in potent and sustained anti-tumor effects [ 10 ]. (biomedcentral.com)
Specifically, we argue that the hypercoagulable and hyperinflammatory state of severe COVID-19 is a consequence of the expanded tropism of SARS-CoV-2, which allows it to infect vascular endothelial cells, and that cytokine storm physiology contributes to a lesser degree. (ersjournals.com)

simple and effective strategy Uridine 5′-monophosphate for generating autologous Treg and highlighted Uridine 5′-monophosphate a potential adoptive Treg cell therapy to suppress antigraft T-cell responses and reduce the requirement for immunosuppression in islet xenotransplantation. (buyresearchchemicalss.net)
In some cases, T cells may present, as a result of residual autologous cells or transplacentally acquired maternal lymphocytes [ 1 ]. (hindawi.com)
Residual autologous T cells are usually emerging from partial thymic maturation impairment such as in the case of Major histocompatibility complex class II (MHC-II) deficiency. (hindawi.com)
Solid tumors, autoimmune diseases, graft versus host disease (GvHD), genetic diseases and neurodegenerative diseases are investigated using many types of autologous and allogeneic cells with rapidly evolving cell engineering and editing approaches. (bdbiosciences.com)

To achieve this, clinically applicable strategies for immunomodulation need to be developed to suppress the T cell-mediated xenoimmune response (7C10). (buyresearchchemicalss.net)
We develop drugs that either enhance or suppress Treg activities to treat various disease conditions. (regimmune.com)
Treg enhancing drugs can maintain tolerance to antigens and suppress immune responses, therefore they are useful in treating transplantation rejection, autoimmune diseases, and allergy. (regimmune.com)
For example, our Treg enhancing drug to prevent transplantation rejection will not suppress immune responses to pathogens, and our Treg suppressing drug to fight against cancers will not induce autoimmune diseases. (regimmune.com)
In large patient populations, we have shown a CD56 bright natural killer (NK) population to strongly associate with a lack of cGvHD and we hypothesize that these cells function to suppress cGvHD. (haematologica.org)
We also found that viable NK reg cells may be isolated by sorting on CD56 + and CD16 - NK cells, and this population can suppress allogeneic CD4 + T cells, but not T reg cells or CD8+ T cells through a non-cytolytic, cell-cell contact dependent mechanism. (haematologica.org)
Because Treg suppress autoimmune responses, we asked whether B cells control autoimmunity by maintenance of Treg numbers. (aai.org)

Therapeutic agonists of TNFRSF25 can be used to stimulate Treg expansion, which can reduce inflammation in experimental models of asthma, allogeneic solid organ transplantation and ocular keratitis. (wikipedia.org)
However, because large cell numbers are needed to achieve a therapeutic effect, in vitro expansion is required. (ox.ac.uk)
We conclude that for maximum therapeutic benefit, Treg expansion protocols should be optimised for CD39/CD73 co-expression. (ox.ac.uk)
Hematopoietic stem cell transplantation (HSCT) is an important therapeutic option for patients with non-malignant diseases as well as high-risk and refractory hematopoietic malignancies. (haematologica.org)
This ability of MSCs to adopt a different phenotype in response to sensing an inflammatory environment is not captured in assays that are commonly used to characterize these cells, but it is crucial for understanding their therapeutic potential in immune-mediated disorders. (pdffox.com)
The present study investigated the expression of T helper (Th)17 cytokines in patients with laryngeal squamous cell carcinoma (LSCC) and their clinical significance in providing new therapeutic insights. (spandidos-publications.com)
In conclusion, Th17 cells have a substantial impact on the carcinogenesis of LSCCs, and could serve as a potential therapeutic target to modulate the anti‑tumor response in these carcinomas. (spandidos-publications.com)
In July 2018, Samantha Bradshaw, ebook of the television from the Oxford Internet Institute( OII) at Oxford University, found that ' The knowledge of cells where However characterized therapeutic towns dictionary is is Thus burned, from 28 to 48 users as. (pferdepension-finkhaus.de)
Benefiting from the remarkable therapeutic outcome of chimeric antigen receptor (CAR) T cell treatment of refractory/relapsed B cell malignancy, CAR T cells are transitioning from the lab to the cancer ward. (biomedcentral.com)
Despite initial therapeutic outcomes, conventional stem cells face key limitations. (biomedcentral.com)

mice and that IL-10 was an important mediator in this suppression in vivo. (buyresearchchemicalss.net)
We aimed to isolate and define the characteristics of regulatory NK (NK reg ) cells associated with suppression of cGvHD. (haematologica.org)
Moreover, this is the first paper to clearly establish that a CD56 bright CD3 - CD16 - perforin- NK reg population associates with a lack of cGvHD and has several unique characteristics, including the suppression of helper T-cell function in vitro. (haematologica.org)
With further investigation we may decipher the mechanism of NK reg suppression and operationalize expansion of NK reg cells associated with cGvHD suppression. (haematologica.org)
Various immune-suppressive cell populations appear to associate with suppression of cGvHD, including T reg cells, B reg cells, M2 macrophages, dendritic cells, and CD56 bright natural killer (NK) cells. (haematologica.org)

My work involving the depletion of PTPα in TNBC reveals PTPα as a regulator of ECM degradation and invasion in vitro and in vivo. (ubc.ca)

Death receptor 3 (DR3), also known as tumor necrosis factor receptor superfamily member 25 (TNFRSF25), is a cell surface receptor of the tumor necrosis factor receptor superfamily which mediates apoptotic signalling and differentiation. (wikipedia.org)
TNFRSF25 is activated by a monogamous ligand, known as TL1A (TNFSF15), which is rapidly upregulated in antigen presenting cells and some endothelial cells following Toll-Like Receptor or Fc receptor activation. (wikipedia.org)
This receptor has been shown to signal both through the TRADD adaptor molecule to stimulate NF-kappa B activity or through the FADD adaptor molecule to stimulate caspase activation and regulate cell apoptosis. (wikipedia.org)
Specifically, activation of TNFRSF25 is dependent upon previous engagement of the T cell receptor. (wikipedia.org)
Because the activation of the receptor is T cell receptor dependent, the activity of TNFRSF25 in vivo is specific to those T cells that are encountering cognate antigen. (wikipedia.org)
PD-1 is a 50-55 kDa cell surface receptor encoded by the Pdcd1 gene that belongs to the CD28 family of the Ig superfamily. (bioxcell.com)
Engineered chimeric antigen receptor (CAR) T cell therapies (CAR-T) are now commercially available to treat certain leukemias and lymphomas. (bdbiosciences.com)
CAR-T cells, which incorporate an antibody-derived extracellular receptor and T cell derived intracellular signaling domains, have shown convincing outcomes in certain types of leukemia and lymphoma, including commercial licensure of CD19 CAR-Ts for the treatment of relapsed/ refractory large B cell lymphoma and acute lymphoblastic leukemia. (bdbiosciences.com)
Cancer immunotherapy by chimeric antigen receptor-modified T (CAR-T) cells has shown exhilarative clinical efficacy for hematological malignancies. (ijbs.com)
As chimeric antigen receptor (CAR) T cells have displayed an unprecedented efficacy in the treatment of CD19-positive malignances, it is believed that this cell therapy will be a milestone in the history of mankind's conquering of cancer. (biomedcentral.com)
Here, I investigate the role of one intrinsic factor (receptor-type protein tyrosine phosphatase alpha) and one extrinsic factor (ionizing radiation) in facilitating cancer cell invasion. (ubc.ca)
Receptor-type protein tyrosine phosphatase alpha (PTPα is a widely expressed transmembrane-bound protein that has been implicated in integrin signaling, focal adhesion formation, and normal cell migration. (ubc.ca)
This phase I trial studies the best dose and side effects of CD19/CD22 chimeric antigen receptor (CAR) T cells when given together with chemotherapy, and to see how well they work in treating children or young adults with CD19 positive B acute lymphoblastic leukemia that has come back or does not respond to treatment. (stanford.edu)
A CAR is a genetically-engineered receptor made so that immune cells (T cells) can attack cancer cells by recognizing and responding to the CD19/CD22 proteins. (stanford.edu)

A mononuclear lymphoplasmacytic and polymorphonuclear cell infiltrate is observed in the mucosa. (medscape.com)

Interleukin (IL)17-producing Th17 cells, which are different from Th1 and Th2 cells, have been described as serving critical roles in inflammation and autoimmune diseases, as well as in cancer development ( 8 - 11 ). (spandidos-publications.com)
English got initially to Interleukin-6-induced cell and hUCB-MSC. (deadbatteries.com)
We also explore the potential aetiologies of the lymphopenia associated with severe COVID-19: the virus' expanded tropism, elevated serum cytokines (particularly interleukin-6 and tumour necrosis factor-α), and excessive lymphocyte recruitment to the lungs. (ersjournals.com)

Therapeutically expanded human regulatory T-cells are super-suppressive due to HIF1A induced expression of CD73. (ox.ac.uk)
This latter are suppressive white blood cells also subject to the same inhibitory pathway regulation. (medicalresearch.com)
In Chapter 2, I examined how proteins secreted by cancer cells can promote a tumor-permissive microenvironment through the recruitment of suppressive innate and adaptive immune cells to the lungs. (ubc.ca)
Targeting tumor-secreted proteins, or the suppressive immune cells that are expanded in response to said proteins, led to a decrease in primary and metastatic pulmonary disease. (ubc.ca)

Induced PD-L1 expression is common in many tumors including squamous cell carcinoma, colon adenocarcinoma, and breast adenocarcinoma. (bioxcell.com)
High avidity T cells (Tet hi ), if present, were only found in progressing PD-1 refractory tumors. (bmj.com)
Despite the progresses made in treating hematological malignancies, challenges still remain for use of CAR-T cell therapy to treat solid tumors. (ijbs.com)
In this landscape, most studies have primarily focused on improving CAR-T cells and overcoming the unfavorable effects of tumor microenvironment on solid tumors. (ijbs.com)
To further understand the current status and trend for developing CAR-T cell based therapies for various solid tumors, this review emphasizes on CAR-T techniques, current obstacles, and strategies for application, as well as necessary companion diagnostics for treatment of solid tumors with CAR-T cells. (ijbs.com)
However, due to intricacies of solid tumors and their locations in the human body, treatment of solid tumors with CAR-T cells is facing multiple obstacles, such as the hostile tumor microenvironment, on-tumor/off-tumor toxicities, and undesired antigen specificity [ 2 ]. (ijbs.com)
Encouragingly and optimistically, in this landscape, more than forty clinical trials in treatment of solid tumors by CAR-T cells have been registered in China alone (Table 1 ) [ 6 ]. (ijbs.com)
Therefore, in this review, we focus on current CAR-T techniques , obstacles, strategies for overcoming these obstacles, as well as necessary companion diagnostics in treatment of solid tumors with CAR-T cells. (ijbs.com)
However, there are some issues that restrict CAR T cells from reaching their optimal anti-tumor capacity, especially in the treatment of solid tumors. (biomedcentral.com)
To obtain better efficacy in the treatment of leukemia and solid tumors, we need to continuously upgrade CAR T cell technology by incorporating novel functional elements into CAR T cells to overcome these restrictions. (biomedcentral.com)
Interestingly, they found that the co-expression of IL-12 may contribute to TIA-1 expression in tumors after MUC1 CAR T cell treatment. (biomedcentral.com)
[ 1 ] Patients with chronic atrophic gastritis develop low gastric acid output and hypergastrinemia, which may lead to enterochromaffin-like (ECL) cell hyperplasia and carcinoid tumors. (medscape.com)

Mice lacking PI3Kγ show increased CD8 T cell activation and cytotoxicity due to transcriptional activation of NFκB and inhibition of C/EBPβ in macrophages within the microenvironment [ 9 ]. (nature.com)
Specifically, the timely orchestration of pro- and anti-inflammatory responses, based on the activation and inhibition of various cell types, such as tissue-resident cells and different types of immune cells, can significantly impact wound repair [ 7 ]. (biomedcentral.com)
Intraperitoneal administration of IL-15cx results in a moderate inhibition of breast cancer growth that is associated with an increase in the frequency of cytotoxic CD8 T cells and the improvement of their function. (frontiersin.org)
Therefore, they modified CD19-targeted CAR T cells to constitutively secrete IL-12, and the results showed that this treatment was able to safely eradicate established disease in the absence of prior conditioning and to acquire intrinsic resistance to Treg-mediated inhibition. (biomedcentral.com)

This thesis work aims to examine the diverse phenotype and function of myeloid cells in primary and metastatic disease, ultimately contributing to an improved understanding of the interplay between the innate and adaptive immune system in the solid tumor microenvironment. (ubc.ca)

The origin of the reactive cells in such patients are either thymic release of T-cells that expand at the periphery or transplacentally transfers of maternal T lymphocytes. (hindawi.com)
B cell deficiency achieved either genetically (μMT) or by depletion with anti-CD20 resulted in a significant reduction in the number of peripheral but not thymic Treg. (aai.org)

PD-1 is transiently expressed on CD4 and CD8 thymocytes as well as activated T and B lymphocytes and myeloid cells. (bioxcell.com)
Additionally, Pdcd1 mRNA is expressed in developing B lymphocytes during the pro-B-cell stage. (bioxcell.com)
Les IgIV intéragissent avec de nombreux composants du système immunitaire comme les récepteurs Fc, le complément, les cytokines, les lymphocytes T et B, les cellules dendritiques, les granulocytes et les cellules NK, ce qui explique en partie leurs effets anti-inflammatoires. (academie-medecine.fr)
2 The interaction of IVIG with a large number of components of the immune system including Fc receptors, complement molecules, cytokines, B and T lymphocytes, neutrophils and NK cells, may explain at least in part their anti-inflammatory effects. (academie-medecine.fr)
Multiple sclerosis (MS) is a neuroinflammatory disease with an autoimmune component that is characterised by activation of self-reactive lymphocytes, which enter the central nervous system (CNS) and cause destruction of myelin producing cells and neurons leading to the formation of inflammatory lesions. (nature.com)
A distinctive feature of SCID patients, which sometimes can clinically resemble Omenn, [ 6 ] is the presence of alloreactive cells originated from transplacentally maternal T lymphocytes. (hindawi.com)
Cutaneous T-cell lymphoma (CTCL) (see the image below) is a heterogeneous group of lymphoproliferative disorders characterized by localization of neoplastic T lymphocytes to the skin, with no evidence of extracutaneous disease at the time of diagnosis. (medscape.com)

To this end, multiple tissue-resident cells and recruited immune cells cooperate to efficiently repair the injured tissue. (biomedcentral.com)
Such as inhibitory cytokines, immune checkpoint molecules, hypoxia and other adverse factors hindering CAR T cell from efficiently expanding and killing tumor cells. (biomedcentral.com)

PI3Kδ inhibitors are approved for the therapy of B cell malignancies, but their clinical use has been limited by unpredictable autoimmune toxicity, despite promising efficacy and evidence that toxicity is associated with improved clinical outcomes. (nature.com)
Insights into future directions and challenges for the appropriate development of biomarkers to evaluate both product bioactivity and treatment efficacy of T cell therapy trials. (biomedcentral.com)
The goal of this study was to examine the activity of IL-15/IL-15Rα complex (IL-15cx) to CD8 + T cells and evaluate its potential efficacy in murine breast cancer models. (frontiersin.org)
The antitumor efficacy was studied in mouse mammary carcinoma models (Her2/neu transgenic and 4T1-luc mammary cancers) treated with systemic recombinant protein with/without the depletion of myeloid-derived suppressor cells or intra-tumoral gene electrotransfer (GET). (frontiersin.org)
Beside the focuses on the aspects of treatment, companion diagnostics are increasingly recognized as playing important roles in patient screening, treatment regimen, efficacy evaluation, and real-time monitoring of CAR-T cell therapies. (ijbs.com)
Cytotoxins (perforin and granzyme) and cytokines (TNF-α and IFN-γ) were dramatically released from the BsAb-armed T cells after engaging cancer cells, resulting in a remarkable anti-cancer efficacy. (biomedcentral.com)

Sometimes of the 2019 early dozens in India, Facebook is appended 103 cells, authors and Agencies on Facebook and Instagram themes getting from Pakistan. (michael-noeres.de)

The focus of this review is to highlight the role of statins in modulating the function and differentiation of various blood cells. (archivesofmedicalscience.com)
TGF-β, IL-6, and IL-23 promote the differentiation of Th17 cells. (jci.org)
In contrast, patients with reactive T cells exhibited poor T-cell differentiation and activity. (hindawi.com)
For example, Omenn syndrome, a typical case of impaired T-cell differentiation with abnormal self-reactive cells, is invariably characterized by autoimmune features such as generalized scaly exudative erythroderma, enlarged lymphoid tissues, and peripheral expansion of oligoclonal T-cells, in addition to increased susceptibility for severe infections [ 3 , 4 ]. (hindawi.com)
Cluster of differentiation (CD) 4 + T cells are essential organizers of cell-mediated immunity, participating in each stage of the immune response. (spandidos-publications.com)

Elimination of NK cells restored EAE susceptibility in STAT1 CD4-Cre mice. (jci.org)
Preclinical studies have shown that resveratrol induces immunomodulatory effects, including the upregulation of NKG2D receptors on natural killer cells (NK) that it promotes the NKG2D-dependent killing of tumor cells [ 13 , 14 ] and the induction of regulatory T cells (Treg) in the colonic tissues of mice exposed to colonic inflammatory stress [ 15 ]. (hindawi.com)
The introduction of β-cell autoantigens via the gut through Lactococcus lactis ( L. lactis ) has been demonstrated to be a promising approach for diabetes reversal in NOD mice. (silverchair.com)
Adoptive transfer of WT B cells into μMT mice restored both Treg numbers and recovery from EAE. (aai.org)
We showed that after EAE induction by immunization with the myelin basic protein (MBP) peptide Ac1-11, B10.PL mice deficient in peripheral B cells (μMT) failed to undergo spontaneous recovery and exhibited chronic disease ( 1 , 2 ). (aai.org)

Resveratrol was safe and well tolerated and was associated with significant increases in the numbers of circulating γδ T cells and regulatory T cells and resulted in small, yet significant, decreases in the plasma levels of the proinflammatory cytokines TNF- α and MCP-1 and a significant increase in the plasma antioxidant activity compared with the corresponding antioxidant baseline activity and with that in four control individuals. (hindawi.com)
It was further demonstrated that Th17 cells could be induced and expanded in the tumor microenvironment through cytokines produced by the tumor cells. (spandidos-publications.com)
Many strategies and approaches have been tried to overcome these obstacles, including arming CAR-T cells with knock-out of PD-1 expression or secretion of cytokines/chemokines and using CAR-T cells in combination with other treatments [ 3 - 5 ]. (ijbs.com)

Third, IL-2 therapies aiming at expanding immunosuppressive regulatory T cells in vivo . (frontiersin.org)
Taken together, our data point to Treg cells as an important component in the outcome of PD-1/PD-L1 pathway inhibitor therapies and suggest a net gain in anti-HIV immune responses only when the HIV loads are well controlled during the administration of these novel compounds. (medicalresearch.com)
Our ex-vivo study with blood cells from HIV-infected individuals at different disease stages and viral loads suggests that such therapies should be administered only when HIV is completely controlled i.e. by antiretroviral drugs. (medicalresearch.com)
Investigational cell therapies are addressing a wide range of hematological malignancies. (bdbiosciences.com)
Cell-mediated immunotherapy is emerging as an alternative in single and combination therapies to rescue rejecting transplants. (biomedcentral.com)

Patient PBMCs are collected by leukapheresis followed by enrichment approaches to isolate T cells while removing other cells such as B cells, monocytes, neutrophils, dendritic cells and contaminating tumor cells. (bdbiosciences.com)

Autoimmune diseases are caused by uncontrolled endogenous immune responses against healthy cells. (uni-stuttgart.de)
Treg suppressing drugs can enhance immune responses, therefore they are useful in fighting against cancers by enhancing anti-tumor immune responses. (regimmune.com)
Experimental autoimmune encephalomyelitis (EAE), which serves as an animal model of MS, is also induced by the activation of myelin reactive CD4 + T cells and their subsequent migration in the CNS, where they mediate inflammatory responses, resulting in demyelination and neurodegeneration. (jci.org)
Conclusions Targeting subdominant T cell responses with lower avidity against pMHC affinity neoepitopes showed potential for improving PD-1 immunotherapy. (bmj.com)
B cells are important for the regulation of autoimmune responses. (aai.org)
B cells functionally contribute to both innate and adaptive immune responses by contributing to Ag presentation and through Ab production. (aai.org)

In addition, human Treg have been shown to be capable of suppressing CD4+CD25? (buyresearchchemicalss.net)
The resulting CD4+CD25+CD127lo cells with 98% purity were expanded as described previously (19). (buyresearchchemicalss.net)
If you have on a simple ebook the unsung, like at expansion, you can evaluate an footage control on your V to replace CD25 it is Finally randomized with catalog. (pferdepension-finkhaus.de)

FcRn expressed in endosomal compartment of intestinal epithelium, vascular endothelium and macrophages regulates the serum IgG levels by binding to the pinocytosed antibodies and recirculating them to cell surface without intracellular degradation. (academie-medecine.fr)
CAR comprises an extracellular, cancer-specific antibody fused with the intracellular signaling activation domains of CD3 and co-activation ligands, such as CD28 or 4-1BB [ 17 , 18 ], which provide engineered T cells with an MHC‐independent mechanism through which to kill cancer cells directly. (biomedcentral.com)

At rest, and for individuals without underlying autoimmunity, the majority of T cells that regularly encounter cognate antigen are FoxP3+ regulatory T cells. (wikipedia.org)
Therefore, our study suggests that the STAT1 pathway can be manipulated to limit autoreactive T cells during autoimmunity directed against the CNS. (jci.org)
Atrophy of the gastric mucosa is the endpoint of chronic processes, such as chronic gastritis associated with Helicobacter pylori infection, other unidentified environmental factors, and autoimmunity directed against gastric glandular cells. (medscape.com)
Our results demonstrate that B cells play a major role in immune tolerance required for the prevention of autoimmunity by maintenance of Treg via their expression of glucocorticoid-induced TNFR ligand. (aai.org)
The first evidence for the existence of regulatory B cells in autoimmunity was obtained using the mouse model of multiple sclerosis (MS), experimental autoimmune encephalomyelitis (EAE). (aai.org)

Related T cell approaches such as engineered T cell receptors also show promise. (bdbiosciences.com)
The prevalence of Th17 cells and their receptors in patients with LSCC was studied using immunohistochemical analysis via tissue microarray technology. (spandidos-publications.com)
The binding of specific T cell receptors (TCR) to major histocompatibility complex (MHC)/antigen complexes on cancer cells induces the TCR/CD3-mediated signal transduction pathway and stimulates the release of specific toxins (perforin and granzyme) for cancer elimination [ 6 , 7 ]. (biomedcentral.com)
The urgent need for novel treatments inspired me to pursue a research project in adoptive immunotherapy, genetically modifying Tcells to express artificial T cell receptors, termed chimeric antigen receptors (CARs), that target AML specific antigens. (stanford.edu)

If islet transplantation is to be made widely available and the current restricted selection criteria expanded, an alternate and renewable source of -cells is required. (buyresearchchemicalss.net)
Islet tissue from pigs has been accepted as a potential source of -cells for transplantation (5,6). (buyresearchchemicalss.net)
Chronic graft- versus -host disease (cGvHD) is a major cause of morbidity after hematopoietic stem cell transplantation (HSCT). (haematologica.org)
Our Heritage discussed in California in 1966, K-Swiss is a ebook the unsung flexible TV cell, restored for transplantation wall and passage production. (pferdepension-finkhaus.de)

Loss of tissue is then repaired in a complex process that involves tissue-resident immune, stromal, and epithelial cells, as well as infiltrating immune cells [ 2 ]. (biomedcentral.com)
Multiple organisms (brown) are observed adhering to gastric surface epithelial cells. (medscape.com)
Significant damage associated with the release of bacterial and inflammatory toxic products is inflicted on the gastric epithelial cells, resulting in increasing cell loss or gastric atrophy over time. (medscape.com)

Considering these facts, it could be concluded that pro-inflammatory Th17 cells may have extensive effects on LSCC pathogenesis and anti-tumor response. (spandidos-publications.com)
In addition, the LSCC microenvironment was identified as a strong Th17-cell inducer. (spandidos-publications.com)
ebook the unsung hero of CD4+ CellsUnlike Th1 and Th2 cells, which are oriented to puncture historically decreased, Th17 and Treg indicate treated data, hardly sharing that they are well as was( Figure 1). (pferdepension-finkhaus.de)
Treg was ebook the unsung to register to Th17 and Tfh. (pferdepension-finkhaus.de)

In Chapter 4, I profiled the dynamic myeloid compartment following antigen specific CD8⁺ T cell-mediated tumor regression and recurrence. (ubc.ca)

We also consider important differences between COVID-19 and influenza, mainly the protean clinical presentation and associated lymphopenia of COVID-19, the contrasting role of interferon-γ in mediating the host immune response to these viruses, and the tropism for vascular endothelial cells of SARS-CoV-2, commenting on the potential limitations of influenza as a model for COVID-19. (ersjournals.com)

In contrast, patients with self-reactive cells have significant autoimmune features in addition to their clinical and molecular immunodeficient state. (hindawi.com)
In addition to their stem/progenitor properties, mesenchymal stromal cells (MSCs) possess broad immunoregulatory properties that are being investigated for potential clinical application in treating immune-based disorders. (pdffox.com)
Building off experience in hematopoietic stem cell transplant and exploiting advances in genetic engineering, genome editing, immunology, immunotherapy, stem cell biology, understanding disease mechanisms and cell therapy manufacturing, considerable progress has been made with hundreds of clinical trials underway. (bdbiosciences.com)
The technique has also shown preliminarily promising outcomes in B cell acute lymphoblastic leukemia (B-ALL), B cell non-Hodgkin's lymphoma (B-NHL), chronic lymphocytic leukemia (CLL), Hodgkin's lymphoma and multiple myeloma in clinical trials targeting CD19, CD20, CD22, CD30 and B-cell maturation antigen (BCMA), with many more under investigation. (bdbiosciences.com)
T cell-targeted immunomodulators such as monoclonal antibodies against PD-1 or CTLA4 may be used in combination with CAR-T cells in clinical trials. (bdbiosciences.com)
Cancer-specific adoptive T cell therapy has achieved successful milestones in multiple clinical treatments. (biomedcentral.com)
Stem cell-based immunotherapy has been recognized as a crucial immunoregulatory regimen in various preclinical and clinical studies. (biomedcentral.com)
Of clinical significance is the finding that anti-CD20 depletion of B cells accelerated spontaneous EAE and colitis. (aai.org)
In parallel to my clinical training, I constructed an AML specific CAR and demonstrated its ability to redirect T cell function mediating eradication of AML cells. (stanford.edu)
Also, the term "primary cutaneous CD4 + small/medium T-cell lymphoma" was changed to "primary cutaneous CD4 + small/medium T-cell lymphoproliferative disorder" because of its indolent clinical behavior and uncertain malignant potential. (medscape.com)

Introduction Mesenchymal stromal cells (MSCs) are adult, fibroblast-like multipotent cells characterized by the ability to differentiate into tissues of mesodermal origin, such as adipocytes, chondroblasts, and osteoblasts (Friedenstein et al. (pdffox.com)

Background CD8 + T cells are a highly diverse population of cells with distinct phenotypic functions that can influence immunotherapy outcomes. (bmj.com)
Further insights on the roles of CD8 + specificities and TCR avidity of naturally arising tumor-specific T cells, where both high and low avidity T cells recognizing the same peptide-major histocompatibility complex (pMHC) coexist in the same tumor, are crucial for understanding T cell exhaustion and resistance to PD-1 immunotherapy. (bmj.com)
Immunotherapy with CAR-T cells has achieved tremendous successes in treatment of hematological malignancies. (ijbs.com)

An early increase of local cytotoxic cells correlates with GET treatment and an increase of long-term memory T cells results from animals with complete tumor regression. (frontiersin.org)
I demonstrated that using glucose restriction of CD8⁺ T cells in vitro led to improved tumor regression in vivo. (ubc.ca)

In this study, I hypothesized that PTPα promotes invadopodia-mediated triple-negative breast cancer (TNBC) cell invasion. (ubc.ca)

Mechanisms of peripheral tolerance include inactivation of autoantigen-recognizing T and B cells by the induction of apoptosis, anergy or conversion into immunosuppressive regulatory cells. (frontiersin.org)
Further refinements of the immune induction and Treg expansion protocols to promote more durable mixed chimerism and tolerance are ongoing. (ixa-ctrms2021.org)

The depletion of myeloid-derived suppressor cells (MDSCs) has no impact on mouse breast cancer growth. (frontiersin.org)

Regulatory T Cell Isolation Kit (Miltenyi Uridine 5′-monophosphate Biotec, Bergisch Gladbach, Germany). (buyresearchchemicalss.net)

2 cGvHD is a multisystemic disorder that occurs due to foreign donor immune cells attacking the recipient's tissues. (haematologica.org)
1999). First identified and isolated from the bone marrow (BM), MSCs can now be expanded from a variety of other tissues including adipose tissue (AT), umbilical cord blood (UCB), skin, tendon, muscle, and dental pulp (Im et al. (pdffox.com)

This raises the possibility that Treg may be used therapeutically at the time of xenotransplantation to reduce the requirement of systemic immunosuppression (15,16). (buyresearchchemicalss.net)

My studies suggest that PTPα is an intrinsic regulator of TNBC cell invasion. (ubc.ca)
Individuals with autoimmune gastritis may develop pernicious anemia because of extensive loss of parietal cell mass and anti-intrinsic factor antibodies. (medscape.com)

Newborn pigs from local farms were used for the isolation of neonatal porcine islet cell clusters (NICC). (buyresearchchemicalss.net)

Loss of immune tolerance to autoantigens associated with a specific organ results in the activation of organ-specific T and B cells that in turn cause organ-specific inflammation and the development of autoimmune diseases such as multiple sclerosis (MS) ( 5 ), rheumatoid arthritis (RA) ( 6 ), psoriasis ( 7 ), and type 1 diabetes (T1D) ( 8 ). (frontiersin.org)
Production of IL-10 by regulatory B cells has been shown to modulate the severity EAE and other autoimmune diseases. (aai.org)

Resveratrol is the most extensively studied stilbene, and preclinical studies have revealed that this compound has several biological effects including, antioxidant, anti-inflammatory, and cytotoxic effects against human cancer cell lines derived from various tumor types [ 1 , 3 , 4 ]. (hindawi.com)
I found that eosinophils were directly cytotoxic towards mammary carcinoma cells, likely through degranulation, and that eosinophils decreased pulmonary metastatic growth of breast cancer cells. (ubc.ca)

T cell therapy represents an emerging and promising modality for the treatment of both infectious disease and cancer. (biomedcentral.com)
In the context of cell therapy trials, the definition of biomarkers can be extended to include a description of parameters of the cell product that are important for product bioactivity. (biomedcentral.com)
This review will focus on biomarker studies as they relate to T cell therapy trials, and more specifically: i. (biomedcentral.com)
An overview and description of categories and classes of biomarkers that are specifically relevant to T cell therapy trials, and ii. (biomedcentral.com)
In response to this challenge, the International Society for Cellular Therapy formulated minimal criteria for defining MSCs in order to create a broader consensus for more uniform characterization of these cells (Dominici et al. (pdffox.com)
Tremendous advances have been made in cell therapy in the past decade. (bdbiosciences.com)
A common theme in cell therapy is the need to characterize and understand cell phenotypes and heterogeneity at every step of the process. (bdbiosciences.com)
kodzsiki kojiki of Art therapy and the cells. (deadbatteries.com)

In vitro cytotoxicity assays and in vivo adoptive transfer experiments were performed to determine the cytotoxicity of high and low avidity populations. (bmj.com)
Future interventions may consider expanding low avidity populations via vaccination or adoptive transfer. (bmj.com)
The aim of this thesis work is to interrogate the pro- and anti- tumorigenic roles myeloid cells play in primary and metastatic disease, and how these myeloid populations interact with cells of the adaptive immune system to influence anti-tumor immunity. (ubc.ca)

95% of all laryngeal malignancies are squamous cell carcinomas (SCCs) ( 2 ). (spandidos-publications.com)

Two baboons received IBBMT from hCD47/hCD55 transgenic GalT-KO pigs after conditioning with irradiation and B and T cell depletion using Rituximab and rATG, respectively. (ixa-ctrms2021.org)

Tetramer staining was performed to determine the frequency and avidity of CD8 + T cells targeting the tumor-specific epitope GSW11 and confirmed with tetramer competition assays. (bmj.com)

However, the commercial production of cancer-specific T cells is often hampered by laborious cell culture procedures, the concern of retrovirus-based gene transfection, or insufficient T cell purity. (biomedcentral.com)
With this technology, a large amount of cancer-specific BsAb-armed T cells can be rapidly generated with a purity of over 90% in 7 days. (biomedcentral.com)

The CAR-T cell manufacturing platform is based on the ex vivo genetic engineering of a patient's T cells to express CAR, followed by the reinfusion of the T cells into the patient. (biomedcentral.com)

Severe combined immunodeficiency (SCID) is typically characterized by significantly low number and/or defective function of T and B cells. (hindawi.com)
Moreover, while the mainstay of the diagnosis of MHC-II deficiency is the absence of constitutive and inducible expression of MHC-II molecules on all cell types, other tests for T-cell function are less informative in such patients. (hindawi.com)
This function of the cutaneous system is mediated by a myriad of highly specialized immune cells. (biomedcentral.com)

Anatomy40

Organisms12

Diseases21

Chemicals and Drugs93

Analytical, Diagnostic and Therapeutic Techniques and Equipment48

Phenomena and Processes48

Disciplines and Occupations1

Information Science3

Named Groups1

Health Care1

Effector15

Tregs30

FOXP37

Proliferation9

Peripheral blood10

Subsets4

Cytokine11

Autologous4

Suppress7

Therapeutic10

Suppression5

Vitro and in vivo1

Receptor14

Mononuclear1

Interleukin3

Suppressive4

Tumors12

Inhibition4

Phenotype1

Thymic2

Lymphocytes7

Efficiently2

Efficacy6

20191

Differentiation5

Mice5

Cytokines3

Therapies5

Dendritic Cells1

Responses6

CD253

Intracellular2

Autoimmunity5

Receptors4

Transplantation4

Epithelial cells3

Th174

Antigen-specific1

Endothelial cells1

Clinical10

Stromal cells1

Immunotherapy3

Tumor regression2

Promotes1

Induction2

Myeloid-derived suppressor cells1

Regulatory T ce1

Tissues2

Therapeutically1

Intrinsic2

Isolation1

Autoimmune diseases2

Cytotoxic2

Therapy8

Populations3

Malignancies1

Depletion1

Assays1

Purity2

Patient's1

Function3