Vivo erythrocytes. Medical search. Frequent questions

A study was not selected as the substance was negative in an in vitro Ames test and in an in vivo mammalian erythrocyte micronucleus test. (europa.eu)

The in vivo micronucleus assay of MRD-89-582 in mice was negative. (europa.eu)
Micronucleus frequency in erythrocytes of mice after long-term exposure to radiofrequency radiation med. (emf-portal.org)

Evidence suggests that both species may also infect endothelial cells in vivo. (usda.gov)

To better understand Plasmodium biology, researchers can whether proceed to in vitro studies or use in vivo models. (wjgnet.com)
In vitro experiments are also generally more rapid and less expensive to conduct than in vivo studies, thus in vitro studies are more likely than in vivo studies to be available for assessment of dietary supplement safety. (nationalacademies.org)

Genetic toxicology studies were conducted in Salmonella typhimurium, cultured Chinese hamster ovary cells, mouse bone marrow erythrocytes, and mouse peripheral blood erythrocytes. (nih.gov)
MRD-89-582 was examined for its potential to induce chromosomal damage in bone marrow erythrocytes in mice dosed by oral gavage at concentrations of 5.0,2.5, and 1.25 g/kg. (europa.eu)

Erythrocyte aggregation is the reversible clumping of red blood cells (RBCs) under low shear forces or at stasis. (wikipedia.org)

Rouleaux formation also determines Erythrocyte sedimentation rate which is a non-specific indicator of the presence of disease. (wikipedia.org)
Erythrocyte sedimentation rate closely reflects the extent of aggregation, therefore can be used as a measure of aggregation. (wikipedia.org)

Genetic toxicology studies were conducted in Salmonella typhimurium and Escherichia coli , Drosophila melanogaster , and mouse peripheral blood erythrocytes. (nih.gov)

Exposure to AZT was toxic to the bone marrow, resulting in significant changes in the peripheral blood (decreased hematocrit values, erythrocyte counts, and hemoglobin concentrations, and increased mean cell volume and mean cell hemoglobin) and bone marrow (erythroid hypoplasia) characteristic of a dose- and time-dependent, minimal to moderate, poorly regenerative macrocytic anemia. (nih.gov)
2000). The high polyunsaturated fatty acid content of the erythrocyte membrane and the continuous exposure to high concentrations of oxygen and iron in heamoglobin are factors that make erythrocytes very sensitive to oxidative injury (Bernabucci et al . (scialert.net)
To study genotoxicity of long-term exposure to radiofrequency electromagnetic fields by measuring of micronuclei formation in erythrocytes . (emf-portal.org)
The exposure dose as measured by determination of Hb-adduct concentrations is integrated over the average life span of human erythrocytes, which is approximately 120 days. (who.int)

In parallel, the development of animal models opened new opportunities to study parasite biology in vivo . (wjgnet.com)
Plasmodium falciparum in G6PD normal and G6PD-deficient erythrocytes : the parasite cycle and adaptive phenomena / by Esien Archibong Usanga. (who.int)

The ex vivo infection model closely reflects the situation in vivo and can be used to study the infection and replication mechanisms of PRV, as well as the antiviral immune responses of salmonid erythrocytes. (biomedcentral.com)

[ 1 , 20 ] Excess protoporphyrin is formed during maturation of erythroid cells in the bone marrow and present at the highest levels in reticulocytes and young erythrocytes. (medscape.com)

In addition, the erythrocytes generated an antiviral immune gene activation after PRV infection, with significant up-regulation of IFN-α, RIG-I, Mx and PKR transcripts. (biomedcentral.com)
The research showed that an increase in the expression of the c-MYC gene led to an enhancement of the replication ability of erythrocyte progenitor cells. (sciencedaily.com)
It was also found that the expression of the BCL-XL gene was higher during the maturation process of erythrocyte progenitor cells than during their replication process. (sciencedaily.com)
As the c-MYC gene and BCL-XL gene are present within erythrocyte progenitor cells, methods that make use of them actually mimic the body's own system and can therefore be thought of as safer with a view to future clinical application than the previously developed systems for large-scale erythrocyte production using oncogene-derived from Human papillomavirus that are not normally expressed in the human body. (sciencedaily.com)
Additionally, we've made progress in hepatocyte-targeted in vivo gene silencing by modifying the siRNAs. (genengnews.com)

The presence or increased concentrations of acute phase proteins, particularly fibrinogen, results in enhanced erythrocyte aggregation. (wikipedia.org)
Another consideration is that i n vitro procedures may be less informative if performed with substrate concentrations that are not comparable with those reached in vivo or if the substrate is not metabolized similarly in vitro and in vivo . (nationalacademies.org)

Although these erythrocytes consisted mostly of fetal-type hemoglobin, they were confirmed to have oxygen-carrying capacity and to have circulatory capacity following transfusion into mice. (sciencedaily.com)

Erythrocyte aggregation is a physiological phenomenon that takes places in normal blood under low-flow conditions or at stasis. (wikipedia.org)
Erythrocyte aggregation is determined by both suspending phase (blood plasma) and cellular properties. (wikipedia.org)
Surface properties of erythrocytes, such as surface charge density strongly influence the extent and time course of aggregation. (wikipedia.org)
Erythrocyte aggregation is the main determinant of blood viscosity at low shear rate. (wikipedia.org)
Influence of erythrocyte aggregation on in vivo blood flow is still a controversial issue. (wikipedia.org)
Erythrocyte aggregation also affects hemodynamic mechanisms in microcirculation and vascular control mechanisms. (wikipedia.org)
Erythrocyte aggregation can also be quantitated by monitoring optical properties of blood during the time course of aggregation process. (wikipedia.org)
The hemorheological parameters, erythrocyte aggregation and deformability are determined in jaundice patients and are compared with that of healthy subjects. (iospress.com)

Erythrocytes may be coated with blood group antibodies with or without reacting complement or sometimes apparently with complement alone. (bmj.com)
Direct antiglobulin test is used to demonstrate in vivo coating of red blood cells with IgG antibodies and complement (C3d). (medscape.com)
Red blood cell coating by immunoglobulins or complement in vivo causes positive DAT. (medscape.com)

The erythrocyte deformability is determined by measurement of passage time (reciprocal of deformability) of erythrocyte suspension in phosphate buffered saline at hematocrit 6% through cellulose … membranes. (iospress.com)

Osterman-Golkar 1976) proposed the use of hemoglobin (Hb) as a dosimeter for alkylation in vivo. (cdc.gov)

Some of these patients of hemolytic disease of the newborn and drug-related hemolytic anemias become sensitized (antibodies against the erythrocytes are formed and bind to the their surface but do not cause hemolysis), but these patients do not exhibit symptoms of disease. (medscape.com)

Lipid peroxidation, hemolysis and thiol contents were studied in intact goat erythrocytes exposed to phenylhydrazine. (scirp.org)
An increase in lipid peroxidation, hemolysis and thiol content was observed after phenylhydrazine treatment of erythrocyte. (scirp.org)
Extracellular Ca2+ potentiates the phenylhydrazine-induced lipid peroxidation and hemoly- sis of erythrocytes significantly. (scirp.org)
No effect of Ca2+ on control lipid peroxidation, hemolysis and thiol contents of erythrocytes was observed. (scirp.org)
Chowdhury, T.D., Das, N., Chattopadhyay, A. and Datta, A.G. (1999) Effect of oxidative stress and erythropoietin on cytoskeletal protein and lipid organization in human erythrocytes. (scirp.org)
Hence, as with the erythrocyte lipid raft protein stomatin, podocin is present in high-order oligomers and may serve a scaffolding function. (jci.org)

By transducing two genes (c-MYC and BCL-XL) into iPS cells and ES cells, a research team has succeeded in producing erythrocyte progenitor cells with almost unlimited ability to replicate in vitro, which they then differentiated successfully into mature erythrocytes. (sciencedaily.com)

However, the real-time examination of altered RBC-brain endothelial interactions in vivo, and their relationship with clearance of stalled RBC, microglial responses, and CMH development, has not been reported. (biomedcentral.com)
Our in vivo and ex vivo findings show the stalling and clearance of oxidatively stressed RBC in cerebral capillaries, highlighting the significance of microglial responses and altered RBC-brain endothelial interactions in CMH development. (biomedcentral.com)
Rosetting Responses of Plasmodium-infected Erythrocytes to Antimalarials. (tropmedres.ac)

In malaria, rosetting is a phenomenon involving the cytoadherence of uninfected erythrocytes to infected erythrocytes (IRBC) harboring the late erythrocytic stage of Plasmodium spp. (tropmedres.ac)
The history and development of the WHO standard in vivo and in vitro test systems for the sensitivity of Plasmodium falciparum and other human Plasmodia to antimalarial drugs / by David Payne. (who.int)

These findings indicate that these genes are important for the maturation of erythrocytes. (sciencedaily.com)

The present study was conducted to investigate the in vitro dose-dependent effect of curcumin on PMRS activity of erythrocytes and validated through in vivo studies on Wistar rats. (hindawi.com)
The weight of evidence from in vitro and in vivo mutagenic studies indicates that kerosine and jet fuels are likely not mutagens. (europa.eu)

In this study we developed an ex vivo cultivation system for PRV in Atlantic salmon erythrocytes. (biomedcentral.com)
This study demonstrates that PRV replicates in Atlantic salmon erythrocytes ex vivo. (biomedcentral.com)
The study of PRV infection in erythrocytes will be important to understand the pathogenesis of PRV infection and its implications on Atlantic salmon health. (biomedcentral.com)
The present study investigates the effect of curcumin on PMRS activity of erythrocytes isolated from Wistar rats in vitro and in vivo and validated through an in silico docking simulation study using Molegro Virtual Docker (MVD). (hindawi.com)
Hence, the present study was designed to examine the effect of T. chebula on erythrocyte oxidation products level, antioxidant status, membrane ATPases and glycoproteins in aged rats compared with young rats. (scialert.net)
This study investigated the rosetting response of P. falciparum and P. vivax clinical isolates to ex vivo antimalarial treatments. (tropmedres.ac)
The study of genotoxic effects was made through the test of modifications in the frequency of micronuclei and the cytotoxic effects by modifications in the relationship between polychromatic erythrocytes and normochromic erythrocytes. (bvsalud.org)

That podocin interacts with CD2AP and nephrin in vivo is shown by coimmunoprecipitation of these proteins from glomerular extracts. (jci.org)

Drug carriers are used in drug-delivery systems such as the controlled-release technology to prolong in vivo drug actions, decrease drug metabolism, and reduce drug toxicity. (bvsalud.org)

The increased levels of oxidants and decreased levels of enzymatic, nonenzymatic antioxidants, glycoproteins and ATPases were observed in erythrocytes of aged rats. (scialert.net)
These results indicate that the administration of T. chebula acts as a free radical scavenger with potential antioxidant effects in erythrocytes of aged rats. (scialert.net)

Ca2+ does not influence much the thiol content of phenylhydrazine treated erythrocytes. (scirp.org)

availability of large amounts (erythrocytes in whole blood), availability of methods for chemical identification (specific and sensitive), and the well-defined life span due to absence of DNA repair (Ogawa et al. (who.int)

Erythrocytes aggregate in a special way, forming rouleaux. (wikipedia.org)
During the differentiation process from hematopoietic progenitor cells, chromosomes in the cell nucleus aggregate and the cell becomes a mature erythrocyte by subsequently losing this nucleus (enucleation). (sciencedaily.com)

however, when they arise in vivo , they do indicate that a putative mutagen/carcinogen has reached the critical cellular target for direct genotoxicity. (who.int)

The results suggest that oxidative damage of erythrocyte caused by phenyl hydrazine could be prevented by calcium channel antagonist, diltiazem, which may act as antioxidant also. (scirp.org)

PRV was successfully passaged to naïve erythrocytes using lysates of blood cells from infected salmon. (biomedcentral.com)

In the evaluation of compounds of the plant species Zanthoxylum chiloperone (Rutaceae), it was shown that isolated compounds of the extract had leishmanicidal, trypanocidal and antifungal in vivo activities. (bvsalud.org)

Supernatants from the first passage successfully transmitted virus to naïve erythrocytes. (biomedcentral.com)

[ 11 , 17 ] Like EPP, XLP is caused by bone marrow heme synthetic dysfunction, but most often results in a greater ratio of accumulated erythrocyte zinc-protoporphyrin to metal-free protoporphyrin than is typical for EPP. (medscape.com)
Defective CLPX leads to increased ALAS post-translational stability, which results in excess accumulation of erythrocyte protoporphyrin. (medscape.com)

The effect of Alcide®, a new antimicrobial drug, on rat blood glutathione and erythrocyte osmotic fragility, in vitro. (cdc.gov)

Alkylating agents, either direct-acting or generated in vivo, form an important class of environmental mutagens and carcinogens. (cdc.gov)

Erythrocytes, which have the function of transporting oxygen within the body, have no nucleus and are therefore not capable of self-replication. (sciencedaily.com)

Preliminary In Vitro and In Vivo Evaluation of Antidiabetic Activity of Ducrosia anethifolia Boiss. (hindawi.com)
The in vivo activity was investigated by measuring some oxidative stress markers. (hindawi.com)

At peak infection phase more than 50% PRV positive erythrocytes were detected in individual fish. (biomedcentral.com)

Going forward, this technology is expected to contribute to a more reliable transfusion system by offering a new option that allows a stable supply of erythrocytes to be produced without depending on the availability of donor blood. (sciencedaily.com)
Hopes for the creation of a more stable transfusion system have centered on the establishment of a technology for large-scale erythrocyte production ex vivo, using for instance iPS cells or ES cells. (sciencedaily.com)

This may occur in vivo in such conditions as autoimmune acquired haemolytic anaemia, haemolytic disease of the newborn, or after transfusions of incompatible blood. (bmj.com)

Curcumin also increased the GSH level in erythrocytes and plasma while simultaneously decreasing the oxidant potential (PFEOP) of plasma. (hindawi.com)

According to rough calculations, the amount of culture medium needed to produce enough erythrocytes for a normal transfusion pack (containing one trillion units) is 1,000 -- 2,000 liters when using direct differentiation from undifferentiated iPS cells, whereas 50-100 liters is sufficient with the newly developed method. (sciencedaily.com)

Erythrocytes have been used as a biological probe in exploring the aging process (Bernabucci et al . (scialert.net)

Anatomy12

Organisms13

Diseases11

Chemicals and Drugs66

Analytical, Diagnostic and Therapeutic Techniques and Equipment17

Phenomena and Processes35

Information Science2

Health Care1

Mammalian1

Micronucleus2

Endothelial Cells1

Vitro studies2

Bone marrow erythrocytes2

RBCs1

Sedimentation rate2

Mouse peripheral blood erythrocytes1

Exposure4

Parasite2

Closely reflects1

Reticulocytes1

Gene5

Concentrations2

Mice1

Aggregation8

Complement3

Deformability1

Hemoglobin1

Antibodies1

Lipid6

Mature erythrocytes1

Responses3

Plasmodium2

Findings1

Studies2

Study7

Proteins1

Decrease1

Rats2

Influence1

Identification1

Aggregate2

Cellular1

Antioxidant1

Blood cells1

Species1

Successfully1

Results2

Effect1

Important1

Oxygen1

Activity2

Positive1

Technology2

Disease1

Level1

Normal1

Process1