Vivo complement c5. Medical search. Frequent questions

In vivo, regulation of complement at the C3 and C5 activation steps is provided by both plasma and membrane proteins. (justia.com)
The plasma protein inhibitors are factor H and C4-binding protein, and the regulatory membrane proteins located on cell surfaces are complement receptors 1 (CR1), decay-accelerating factor (DAF), and membrane cofactor protein (MCP). (justia.com)
These proteins inhibit the C3 and C5 convertases (multi-subunit proteases), by promoting dissociation of the multisubunit complexes and/or by inactivating the complexes through proteolysis (catalyzed by factor I). Several pharmacological agents that regulate or modulate complement activity have been identified by in vitro assay, but most have been shown in vivo to be of low activity or toxic. (justia.com)
Genes that encode the proteins of complement components or their isotypes are distributed throughout different chromosomes, with 19 genes comprising 3 significant complement gene clusters in the human genome. (medscape.com)
The important components of this system are various cell membrane-associated proteins such as complement receptor 1 (CR1), complement receptor 2 (CR2), and decay accelerating factor (DAF). (medscape.com)
The complement system consists of more than 35 soluble and cell-bound proteins, 12 of which are directly involved in the complement pathways. (dadamo.com)
The complement system is a family of plasma proteins that mediates humoral immune surveillance. (ashpublications.org)
Notably, deregulation and abnormality of complement regulatory proteins have also been observed in LN patients [10, 11]. (bso14.org)
10 This distinction is not absolute because genetic defects in complement proteins have been identified in secondary TMA. (jrheum.org)
Enzymes that activate one or more COMPLEMENT PROTEINS in the complement system leading to the formation of the COMPLEMENT MEMBRANE ATTACK COMPLEX, an important response in host defense. (lookformedical.com)
In vivo , palmitoylation of proteins is catalyzed by palmitoyl acyltransferases (PATs or DHHC-PATs) . (yeastevolution.com)
The affected patients' genetic backgrounds revealed significant genetic heterogeneity in several genes involved in complement regulation, including the complement factor H, complement factor H-related proteins, complement factor I, complement factor B, complement component 3, and CD46 genes in the alternative complement pathway. (ekjt.org)

Lectins activate the lectin pathway in a manner similar to the antibody interaction with complement in the classical pathway. (medscape.com)
Activation of the classical pathway (CP) of complement is often associated with autoimmune disorders in which disease pathology is linked to the presence of an autoantibody. (ashpublications.org)
Complement can be triggered by one of three distinct pathways: the classical pathway (CP), alternative pathway (AP), or lectin (LP) pathway. (ashpublications.org)

Complement component C3 plays a central role in activation of all three pathways. (justia.com)
A team of investigators has found that nomacopan, a recombinant biologic derived from blood-feeding ticks, may be an option for the treatment of allergic eye disease due to its ability to down-regulate the LTB4/C5 pathways in experimental allergy conjunctivitis. (ophthalmologytimes.com)
A team of investigators, led by Malihe Eskandarpour, MSc, from Ocular Immunology Group, University College London Institute of Ophthalmology, London, has reported that nomacopan (Akari Therapeutics), a recombinant biologic derived from blood-feeding ticks, may be a potential treatment for allergic eye disease due to its ability to down-regulate the LTB4/C5 pathways in experimental allergy conjunctivitis (EAC). (ophthalmologytimes.com)
Our findings support nomacopan as a potential treatment for allergic eye disease due to its ability to down-regulate LTB4/C5 pathways in EAC. (ophthalmologytimes.com)
The complement cascade consists of 3 separate pathways that converge in a final common pathway. (medscape.com)
Complement pathways and deficiencies. (medscape.com)
Although complement is one of the first lines of defense against infection, hyperactivity of specific pathways has been described in numerous autoimmune and inflammatory disease settings. (ashpublications.org)
A further complicating factor is the cross-talk between complement, neutrophils, and coagulation pathways in the pathophysiology of TMA. (jrheum.org)
Activation of the complement system occurs through the classical (CP), lectin (LP), or alternative (AP) pathways. (jrheum.org)
1986) reported a consanguineous Algerian family in which 2 brothers had early-onset glomerulonephritis with C3 deposits and low levels (less than 10% of normal) of complement factor H . The factor H deficiency was defined by undetectable complement hemolytic activity by the classic (CH50) and alternate (AP50) pathways, and low levels of C3 and factor B (138470). (findzebra.com)
They are enzymes in the various COMPLEMENT ACTIVATION pathways. (lookformedical.com)

The complement system has obtained renewed clinical focus due to increasing number of patients treated with eculizumab, a monoclonal antibody inhibiting cleavage of C5 into C5a and C5b. (ntnu.no)
Furthermore, we confirmed that it was the eculizumab-C5 complexes that were detected in the C5a assay by adding an anti-IgG4 antibody as detection antibody. (ntnu.no)
For example, the half-life extended complement C5-specific antibody, Ultomiris (ravulizumab), has been approved for the treatment of autoimmunity and a half-life extended antibody cocktail (Evusheld) with 'YTE' mutations is used for the prophylaxis of SARS-CoV2. (wikipedia.org)
To date, there are no inhibitors of complement activation used in the clinic, though certain candidates for clinical use exist, specifically, a recombinant form of complement receptor 1 known as soluble complement receptor 1 (sCR1) and a humanized monoclonal anti-C5 antibody (5G1.1-scFv). (justia.com)
8 , 11 - 14 Numerous stimuli can drive the activation of the complement system, including apoptotic debris, pathogens, and antibody-antigen complexes, in addition to ischemia-reperfusion injuries associated with organ transplantation. (jrheum.org)
Introducing a new blocking antibody targeting complement C5, now available for preclinical research! (biolynx.ca)
Complement C5 plays a crucial role in many disease processes, and this new antibody offers the option to mimic blocking of terminal complement pathway. (biolynx.ca)

The drug is a second-generation complement inhibitor with dual activities, ie, it acts on complement component C5 and prevents release of C5a and formation of C5b-9 as well as inhibits leukotriene B4 (LTB4) activity, both of which are part of the immune/inflammatory response. (ophthalmologytimes.com)
Alexion developed and commercializes Soliris ® (eculizumab), the first and only approved complement inhibitor to treat patients with atypical hemolytic uremic syndrome (aHUS), paroxysmal nocturnal hemoglobinuria (PNH), refractory generalized myasthenia gravis (gMG) and neuromyelitis optica spectrum disorder (NMOSD). (ean.org)
Empaveli (pegcetacoplan) is a complement inhibitor used to treat adult patients with paroxysmal nocturnal hemoglobinuria (PNH). (rxlist.com)

The FDA approved indications are paroxysmal nocturnal haemoglobinuria and atypical haemolytic uremic syndrome, but many other diseases are candidates for complement inhibition. (ntnu.no)
Competitive inhibition by anti-C5 antibodies localized the epitope to the C5a moiety of C5. (ntnu.no)
Anti-complement Treatment for Paroxysmal Nocturnal Hemoglobinuria: Time for Proximal Complement Inhibition? (frontiersin.org)
However, novel anti-C5 agents do not improve hematological response to eculizumab, even if some seem associated with a lower risk of breakthrough hemolysis caused by pharmacokinetic reasons (it remains unclear whether more effective inhibition of C5 is possible and clinically beneficial). (frontiersin.org)
At the moment there are three strategies of proximal complement inhibition: anti-C3 agents, anti-factor D agents and anti-factor B agents. (frontiersin.org)
Preliminary data clearly demonstrate that proximal complement inhibition is pharmacologically feasible and apparently safe, and may drastically improve the hematological response to complement inhibition in PNH. (frontiersin.org)
Indeed, we envision a new scenario of therapeutic complement inhibition, where proximal inhibitors (either anti-C3, anti-FD or anti-FB) may prove effective for the treatment of PNH, either in monotherapy or in combination with anti-C5 agents, eventually leading to drastic improvement of hematological response. (frontiersin.org)
As the global leader in complement inhibition, Alexion is leveraging its experience in complement biology to pursue novel molecules and targets in the complement cascade. (ean.org)
In this review we discuss current evidence that complement activation contributes to progression of CKD, how complement could cause renal inflammation and whether complement inhibition would slow progression of renal disease. (wjgnet.com)

This invention relates to activation of the complement cascade in the body. (justia.com)
Deficiencies in the complement cascade can lead to overwhelming infection and sepsis. (medscape.com)
New studies point to the complex interplay between the complement cascade and adaptive immune response, and complement is also being studied in association with ischemic injury as a target of therapy. (medscape.com)
Activation of the complement cascade, with the formation of the effector MAC unit, results in cytotoxic and cytolytic reactions. (dadamo.com)
The main functions of the complement cascade and its role in the acute inflammatory reaction are summarized in Table 1. (dadamo.com)
Complement activation results in an enzymatic cascade leading to the production of opsonins and anaphylatoxins responsible for clearing pathogens and initiating inflammation. (ashpublications.org)
2006) summarized features of MPGN relevant to the complement cascade. (findzebra.com)
More than 80% of patients with MPGN II are positive for serum C3 nephritic factor (C3NeF), an autoantibody directed against C3bBb, the convertase of the alternative pathway of the complement cascade. (findzebra.com)
This complex is arranged in nine subunits (six disulfide-linked dimers of A and B, and three disulfide-linked homodimers of C). C1q has binding sites for antibodies (the heavy chain of IMMUNOGLOBULIN G or IMMUNOGLOBULIN M). The interaction of C1q and immunoglobulin activates the two proenzymes COMPLEMENT C1R and COMPLEMENT C1S, thus initiating the cascade of COMPLEMENT ACTIVATION via the CLASSICAL COMPLEMENT PATHWAY. (lookformedical.com)

A North African study of molecular basis of complement factor I deficiency in atypical hemolytic and uremic syndrome patients suggested that the Ile357Met mutation may be a founding effect. (medscape.com)
The role of complement dysregulation on vascular endothelial cells has been well established in atypical hemolytic uremic syndrome (aHUS), a thrombotic microangiopathy (TMA) characterized by microangiopathic hemolytic anemia, thrombocytopenia, and target organ injury. (jrheum.org)
7 - 9 A TMA is called "primary" when a genetic or acquired defect in a complement protein is identified (as in atypical hemolytic uremic syndrome [aHUS]) or "secondary" when occurring in the context of another disease process or factor such as infection, autoimmune disease, malignancy, or drugs. (jrheum.org)
Many recent studies on atypical hemolytic uremic syndrome have described genetic abnormalities related to excessive activation of the alternative complement pathway. (ekjt.org)

Compounds comprising peptides and peptidomimetics capable of binding the C3 protein and inhibiting complement activation are disclosed. (justia.com)
In particular, this invention provides peptides and peptidomimetics capable of binding the C3 protein and inhibiting complement activation. (justia.com)
It is therefore possible that inhibiting complement activation would reduce inflammation, lead to reduced fibrosis and preservation of renal function. (wjgnet.com)

4 , 13 Complement plays a crucial role in host defense against foreign bodies by promoting phagocyte-mediated clearance of cell debris through activation of an inflammatory response, opsonization of pathogens, and lysis of susceptible bacteria and cells. (jrheum.org)

Laboratory features usually include decreased serum levels of factor H , complement component C3 (120700), and a decrease in other alternative pathway components, indicating activation of the alternative complement pathway. (findzebra.com)
A glycoprotein that is central in both the classical and the alternative pathway of COMPLEMENT ACTIVATION. (lookformedical.com)

Revisiting the role of factor H in age-related macular degeneration: Insights from complement-mediated renal disease and rare genetic variants. (ncl.ac.uk)
Welch (2002) discussed the role of complement in renal disease. (findzebra.com)

IVERIC bio, through its collaborative sponsored research agreement with UMass Medical School, is evaluating several ABCA4 minigene constructs in both in vitro and in vivo experiments. (ivericbio.com)
In summary, our studies give first proof that AT-RvD1 and its metabolically steady analogue, p-RvD1, play a critical part in blocking acute inflammatory responses induced by IgG immune complexes each in vitro and in vivo inside the lungs. (estrogen-receptor.com)

Many novel terminal complement inhibitors are now in clinical development: they all target C5 (as eculizumab), potentially paralleling the efficacy and safety profile of eculizumab. (frontiersin.org)

In combination with experimental peritonitis, heat sterilized PD fluid compared to filter sterilized, inhibited the CINC-1 release and the recruitment of neutrophils to the peritoneal cavity without affecting the intraperitoneal complement activation.The results of the present thesis indicate that addition of LMWH to the PD fluid improves ultrafiltration, probably by blocking C5a activity. (gu.se)
Heat sterilized PD fluids also inhibit the recruitment of neutrophils to the peritoneal cavity by a mechanism independent of complement activation but probably depending on cytokine CINC-1 release during peritonitis. (gu.se)

Complement is implicated in several disease states, including various autoimmune diseases, and has been found to contribute to other clinical conditions such as adult respiratory syndrome, heart attack, rejection following xenotransplantation and burn injuries. (justia.com)
Some new clinical entities are linked with partial complement defects. (medscape.com)
This article outlines some of the disease states associated with complement deficiencies and their clinical implications. (medscape.com)
1-3 In such indications, therapeutic intervention by preventing complement activation may have clinical utility. (ashpublications.org)

Cases of complement deficiency have helped defined the role of complement in host defense. (medscape.com)

These two latter pathogenic mechanisms are the target of novel strategies of anti-complement treatments, which can be split into terminal and proximal complement inhibitors. (frontiersin.org)
Indeed, proximal inhibitors are designed to interfere with early phases of complement activation, eventually preventing C3-mediated extravascular hemolysis in addition to intravascular hemolysis. (frontiersin.org)
Advancements in the understanding of the etiopathogenesis of aHUS paved the way for the successful development of anticomplement therapies (complement C5 inhibitors), which have revolutionized the treatment of aHUS. (jrheum.org)

The complement system is the first line of immunological defense against foreign pathogens. (justia.com)
Although the complement system is part of the body's innate, relatively nonspecific defense against pathogens, its role is hardly primitive or easily understood. (medscape.com)
The complement system helps clear pathogens from an organism. (dadamo.com)

at the same time, the inflammation promoted by complement activation can result in cellular damage when not kept in check. (medscape.com)
The complement system is a potent mechanism for initiating and amplifying inflammation. (dadamo.com)
In particular, it has yet to be elucidated whether MSCT influences the function of the complement system in LN. LN is usually a type I interferon-driven autoimmune disease manifested with chronic inflammation [25]. (bso14.org)
Complement activation occurs in progressive chronic kidney disease and may contribute to the chronic inflammation that is characteristically found in the kidney. (wjgnet.com)

In the case of the CP, activation is driven by immune complexes containing complement-fixing antibodies. (ashpublications.org)
But that's not all - Hycult also has new antibodies to target complement C7 and clusterin, two molecules associated with the formation of the TCC/MAC-complex. (biolynx.ca)

CR1 on erythrocytes may bind circulating immune complexes (that had activated complement) and transport them to the liver where the immune complexes are partially degraded and thus become more soluble. (dadamo.com)
The C5 nonadherent phage were then incubated with immobilized rC5a in the presence of soluble C5. (absoluteantibody.com)
Bound phage were eluted and subjected to two additional cycles of subtraction with immobilized C5 and selection with immobilized rC5a in the presence of soluble C5. (absoluteantibody.com)

This review aims to provide an assessment of the nature and extent of complement involvement in TMA associated with autoimmune diseases such as systemic lupus erythematosus, antiphospholipid syndrome, and scleroderma renal crisis. (jrheum.org)
10 This review aims to provide an assessment of the nature and extent of complement involvement in the underlying pathophysiology of TMA associated with autoimmune diseases that will help to stratify patients for targeted therapy. (jrheum.org)

C3 can be cleaved into COMPLEMENT C3A and COMPLEMENT C3B, spontaneously at low level or by C3 CONVERTASE at high level. (lookformedical.com)
The larger fragment C3b binds with C3 convertase to form C5 convertase. (lookformedical.com)

The complement system is a tightly regulated, cascading protein network representing a key component linking the innate and humoral immune systems. (jrheum.org)
The complement system is a tightly regulated, cascading protein network that performs multiple roles in homeostasis and disease prevention and is a key component of both the innate and the humoral immune systems. (jrheum.org)
1987) studied a family in which 3 female sibs had undetectable levels of factor H and C3 nephritic factor, low levels of factor B, C3, and C5 (see 120500), and normal levels of C4-binding protein (120830), factor I (217030), and classic pathway factors. (findzebra.com)

Inappropriate activation of complement may lead to host cell damage. (justia.com)
activation of complement. (workflowdigital.com)

After the administration of QFPD treatment in LPS-induced ALI mice, the therapeutic effect was evaluated through the H&E staining of lung tissues and the level of inflammatory factors in vivo . (xiahepublishing.com)

The complement system is part of the innate immune system. (medscape.com)
The actions of the complement system affect both innate immunity and acquired immunity. (dadamo.com)
The complement system is an integral part of the innate immune system but also augments adaptive immune responses. (wjgnet.com)
Now, we know that complement system, protecting the host through innate immune system, could trigger harmful endothelial pathogenesis. (biomedcentral.com)

Accumulating evidence suggests that a large percentage of the patients diagnosed with secondary TMA exhibit genetic abnormalities associated with complement dysregulation. (ekjt.org)

In addition to playing an important role in host defense against infection, the complement system is a mediator in both the pathogenesis and prevention of immune complex diseases, such as systemic lupus erythematosus (SLE). (medscape.com)

These data demonstrate that MSCs inhibit the activation of pathogenic C5 via Neridronate up-regulation of FH, which Neridronate improves our understanding of the immunomodulatory mechanisms of MSCs in CD246 the treatment of lupus nephritis. (bso14.org)

Complement factor H deficiency (CFHD) can manifest as several different phenotypes, including asymptomatic, recurrent bacterial infections, and renal failure. (findzebra.com)
See also complement factor I deficiency (610984), which shows phenotypic overlap with this disorder. (findzebra.com)

Furthermore, the complement-related pathway was enriched through the network pharmacology and transcriptome analysis of the gene expression. (xiahepublishing.com)

Anaphylatoxins are proteolytic products of the serine proteases of the complement system: C3a, C4a and C5a. (dadamo.com)

The complement system plays an important part in defense against pyogenic organisms. (medscape.com)
These findings underscore the duality of the complement system. (medscape.com)
Knowledge about the complement system is expanding. (medscape.com)
An intricate system regulates complement activity. (medscape.com)
The complement system influence the activity of numerous cells, tissues and physiological mechanism of the body. (dadamo.com)
Few data are available regarding the effects of MSCT around the complement system [24]. (bso14.org)
Therefore, a clearer understanding of the role of the complement system in TMA associated with other conditions will help to identify patients who would benefit from these therapies. (jrheum.org)

Anemia occurs as a result of autoantibody-mediated CP activation on the surface of the erythrocyte, leading to the deposition of complement opsonins that drive extravascular hemolysis in the liver. (ashpublications.org)

[ 2 ] , whereas C5 to C9 may have enhanced susceptibility to meningococcal disease. (medscape.com)

We collected 40 individual CAD patient samples and showed that TNT003 prevented cold agglutinin-mediated deposition of complement opsonins that promote phagocytosis of RBCs. (ashpublications.org)

Towner R, Smith N. In vivo and in situ detection of macromolecular free radicals using immuno-spin trapping and molecular MRI. (omrf.org)
Low molecular weight heparin (LMWH) and C5 blockade improved ultrafiltration. (gu.se)

In 1 family, of Polish origin, a teenaged male had vasculitis, thrombocytopenia, proteinuria, and depressed levels of serum factor H and complement component C3. (findzebra.com)
A panel of mAbs against the activated complement component C5a was obtained from a filamentous phage M13-Fab display library generated from mice immunized with human rC5a. (absoluteantibody.com)
To isolate Fabs specific for neoepitopes expressed on C5a but not on the native complement component C5, the library was rescreened in a competitive manner. (absoluteantibody.com)

[ 4 ] A registry of complement deficiencies has been established as a means to promote joint projects on treatment and prevention of diseases associated with defective complement function. (medscape.com)
Yet, a great deal of complexity exists around the role of complement in TMA associated with other diseases. (jrheum.org)
Complement activation is known to occur in many diverse renal diseases, including glomerulonephritis, thrombotic microangiopathies and transplant rejection. (wjgnet.com)

Complement activation is an early step in the acute reaction to PD and probably mediates the downstream events that lead to the recruitment of inflammatory cells to the peritoneal cavity. (gu.se)

By size exclusion chromatography of patient serum obtained before and after infusion of eculizumab, we document that the neoepitope was exposed in the fractions containing the eculizumab-C5 complexes, being positive in this actual C5a assay and negative in others. (ntnu.no)
This cellular mechanism provides an explanation for the prolonged in vivo half-lives of IgG and serum albumin and transport of these ligands across cellular barriers. (wikipedia.org)

Comply with the most current Advisory Committee on Immunization Practices (ACIP) recommendations for vaccinations against encapsulated bacteria in patients with altered immunocompetence associated with complement deficiencies. (rxlist.com)

It has been postulated that eculizumab does not inhibit C5a formation in vivo, in contrast to what would be expected since it blocks C5 cleavage. (ntnu.no)
In the present study, we identified expression of a neoepitope which was exposed on C5 after binding to eculizumab in vivo. (ntnu.no)
These data are important for interpretation of complement analyses in patients treated with eculizumab. (ntnu.no)

The second group of receptors reacts with small complement fragments (C4a, C3a, C5a) as well as with C1q, Ba, Bb and factor H. Stimulation of these receptors results in various biological effects (chemotaxis, secretion of vasoactive amines, mediators of the inflammatory and anaphylactic reaction etc. (dadamo.com)

Complement-mediated tissue injury has also been found to result from bioincompatibility situations such as those encountered in patients undergoing dialysis or cardiopulmonary bypass. (justia.com)
Deficiencies in complement predispose patients to infection via 2 mechanisms: (1) ineffective opsonization and (2) defects in lytic activity (defects in MAC). (medscape.com)
In this study, over-activated C5 was found in lupus patients and mice, and we exhibited that MSCT attenuated glomerulonephritis in lupus mice via inhibiting the extensive activation of C5. (bso14.org)

Different fragments, released from individual components during complement activation, operate by a non-cytolytic mechanism through specific receptors present on various cell types. (dadamo.com)
C5 blockade seems to improve ultrafiltration by a mechanism that involves a reduction in glucose transport, possibly by reducing C5 induced vasodilation. (gu.se)

Engineering of albumin-FcRn interactions has also generated albumin variants with increased in vivo half-lives. (wikipedia.org)

Materials and Methods: We used in vitro, in vivo, and archival human HNSCC tissue analysis to evaluate the effects of CSC on cancer stem-like cell formation. (umn.edu)

describes the use of a phage-displayed combinatorial random peptide library to identify a 27-residue peptide that binds to C3 and inhibits complement activation. (justia.com)

MSCs produced Factor H (FH) upon IFN- stimulation in vitro and, importantly, MSCT up-regulated the amount of circulating FH in vivo. (bso14.org)

Similarly, mice deficient in C5 and C5aR have been protected from IgG immune complex-induced alveolitis (26, 47). (estrogen-receptor.com)

These effects may involve either the whole complement, or only individual components or fragments. (dadamo.com)
This is mediated through fragments of complement components. (dadamo.com)
The quantitative real-time PCR and apoptotic analysis further confirmed that QFPD inhibited ALI through the classical complement pathway as no additive changes were observed when its key components were silenced plus QFPD treatment. (xiahepublishing.com)

Activation of C3 by complement pathway C3 convertases and its subsequent attachment to target surface leads to assembly of the membrane attack complex and ultimately to damage or lysis of the target cells. (justia.com)
Complement-mediated tissue injuries are directly mediated by the membrane attack complex, and indirectly by the generation of C3a and C5a. (justia.com)
By inhibiting cold agglutinin-mediated complement deposition on the cellular membrane, TNT003 prevents RBCs from being phagocytosed. (ashpublications.org)
Complement activation generates membrane attack complex (MAC). (biomedcentral.com)

Anatomy3

Organisms3

Diseases5

Chemicals and Drugs61

Analytical, Diagnostic and Therapeutic Techniques and Equipment4

Phenomena and Processes9

Information Science3

Proteins12

Classical pathway3

Pathways11

Antibody7

Inhibitor3

Inhibition9

Cascade9

Hemolytic4

Inhibiting complement activation3

Plays a crucial role1

Alternative pathway2

Renal disease2

Vitro and in vivo2

Terminal complement1

Neutrophils2

Clinical4

Defined the role of complement1

Inhibitors3

Pathogens3

Inflammation4

Antibodies2

Soluble3

Associated with autoimmune diseases2

Convertase2

Protein3

Activation of complement2

Therapeutic1

Innate4

Dysregulation1

Role in host defense1

Regulation1

Deficiency2

Pharmacology1

Proteases1

System7

Extravascular hemolysis1

Susceptibility to meningococcal1

Phagocytosis1

Molecular2

Component3

Diseases3

Acute1

Serum2

Bacteria1

Eculizumab3

Biological1

Patients3

Mechanism2

Variants1

Materials and Met1

Binds1

Factor1

Mice1

Components3

Membrane4