• Sirtuins are NAD + -dependent histone deacetylases regulating important metabolic pathways in prokaryotes and eukaryotes and are involved in many biological processes such as cell survival, senescence, proliferation, apoptosis, DNA repair, cell metabolism, and caloric restriction. (biomedcentral.com)
  • Deregulated c-MYC is found in a variety of cancers where it promotes proliferation as well as apoptosis. (ashpublications.org)
  • It promotes cell proliferation and restrains differentiation. (ashpublications.org)
  • MYC induces proliferation, but at the same time it can induce cell death. (ashpublications.org)
  • Targeting NAD depletion in cancer cells has emerged as an attractive therapeutic strategy for cancer treatment, based on the higher reliance of malignant vs. healthy cells on NAD to sustain their aberrant proliferation and altered metabolism. (bvsalud.org)
  • Cancer cells are highly dependent on Nicotinamide phosphoribosyltransferase (NAMPT) activity for proliferation, therefore NAMPT represents an interesting target for the development of anti-cancer drugs. (bvsalud.org)
  • c-Myc (hereafter referred to as Myc) protein plays a fundamental role in cell cycle regulation, proliferation, differentiation, and apoptosis by modulating the expression of a large number of targets [ 1 ]. (oncotarget.com)
  • We found that the expanded cells possessed significantly improved immune effector functions, including proliferation, differentiation, and cancer cell killing, both in vitro and in the humanized mouse model. (nature.com)
  • SOX9 promotes nasopharyngeal carcinoma cell proliferation, migration and invasion through BMP2 and mTOR signaling. (cancerindex.org)
  • Overexpression of SOX9 promoted NPC cell proliferation, migration and invasion. (cancerindex.org)
  • EBVaGC is defined by monoclonal proliferation of carcinoma cells with latent EBV infection, as demonstrated by EBV-encoded small RNA (EBER) in situ hybridization. (spandidos-publications.com)
  • These abnormalities result in significant alterations in gene expression related to cell proliferation, apoptosis, migration and immune signaling pathways. (spandidos-publications.com)
  • Initial control of EBV in healthy persons involves NK cells that can kill virus-infected cells ( 3 , 4 ) and secrete IFN-γ, which inhibits B cell proliferation, and monocytes, which release chemokines in response to virus infection ( 5 ). (frontiersin.org)
  • We are using this virus to study the initiating immortalizing process and switches between resting and proliferating phenotypes to better understand EBV protein - host cell interactions involved in tumorigenesis controlling the switch from cell arrest to proliferation and reprogramming of metabolism. (ki.se)
  • Dichloroacetate (20 mM) did not reduce growth of non-cancerous cells but caused significant decrease in cancer cell proliferation ( P =0.009), which was associated with apoptosis and G 2 phase cell-cycle arrest. (dcaguide.org)
  • We aimed to identify REGγ effects on the proliferation and apoptosis of MCL cells and clarify the underlying mechanisms. (amegroups.org)
  • REGγ inhibited MCL cell proliferation in a mouse tumor xenograft model by promoting apoptosis, increased the expression of the three IκB subunits and inhibited NF-κB signaling. (amegroups.org)
  • The proteasome activator REGγ inhibits mantle cell lymphoma (MCL) cell proliferation by promoting cell apoptosis. (amegroups.org)
  • Cancer cells can be defined by their constant and uncontrolled proliferation. (biomedcentral.com)
  • SFK inhibition also induced muscle differentiation in RMS cells by affecting the NOTCH3 receptor-p38 mitogen-activated protein kinase (MAPK) axis, which regulates the balance between proliferation and differentiation. (oncotarget.com)
  • In addition, hydroxytyrosol is able to regulate the expression of other genes involved in the regulation of tumor cell proliferation, such as extracellular signal-regulated and cyclin-dependent kinases. (blogspot.com)
  • This induces apoptosis and inhibits proliferation in susceptible cancer cells. (blogspot.com)
  • Drs Constantinides Legoux and their colleagues have reported that commensal bacteria exert control of the development of MAIT cells in the thymus (the organ involved in the development and proliferation of T cells) and their subsequent expansion within mucosal tissue. (joessciencescorner.net)
  • Several recent studies point to an even broader range of activity for MAIT cells including: the control of bacterial, fungal and viral infections, a role in autoimmune disease and possible involvement in the immune processes involved in attacking the proliferation of tumor cells. (joessciencescorner.net)
  • Inactivation of tumor suppressor genes, whose products normally provide negative control of cell proliferation, contributes to malignant transformation in various cell types. (medscape.com)
  • In lymphoblastoid cell cultures, Syk tyrosine kinases have been found in LMP2A immunoprecipitates following in vitro kinase reactions followed by Syk antibody reimunnoprecipitation. (wikipedia.org)
  • The underlying mechanism of action of CDBPA in Burkitt`s lymphoma was tested in vitro and its effect on tumor size and survival was tested in a NOD-scid mice model. (longdom.org)
  • CDBPA, possesses strong in vitro and in vivo activity against Ramos cells, representing a potential approach for therapy of Burkitt lymphoma. (longdom.org)
  • Le nanoparticelle sono state caratterizzate in vitro e in vivo durante questo progetto di dottorato. (units.it)
  • Inizialmente sono stati effettuati studi in vitro al fine di valutare l'espressione del CD20 sulla superficie di una linea cellulare di linforma di Burkitt (BJAB), due linee di LLC (MEC1 e EHEB) e cellule purificate da campioni di sangue di pazienti affetti da LLC. (units.it)
  • The availability of nicotinaldehyde in a tumor environment fully blunts the antitumor activity of APO866 in vitro and in vivo. (bvsalud.org)
  • Antiproliferative activity in vitro was evaluated on a panel of solid and haematological cancer cell lines and most of the synthesized compounds showed nanomolar or sub-nanomolar cytotoxic activity in MiaPaCa-2 (pancreatic cancer), ML2 (acute myeloid leukemia), JRKT (acute lymphobalistic leukemia), NMLW (Burkitt lymphoma), RPMI8226 (multiple myeloma) and NB4 (acute myeloid leukemia), with lower IC50 values than those reported for FK866. (bvsalud.org)
  • Finally, the intracellular NAD+ depletion was confirmed in vitro to induced ROS accumulation that cause a time-dependent mitochondrial membrane depolarization, leading to ATP loss and cell death. (bvsalud.org)
  • To apply allogeneic Vγ9Vδ2 T cells in adoptive immunotherapy, the methodology used to obtain adequate cell numbers with optimal effector function in vitro needs to be optimized, and clinical safety and efficacy also need to be proven. (nature.com)
  • AID-Cre(+) GNA13-deficient mice demonstrate disordered GC architecture and dark zone/light zone distribution in vivo, and demonstrate altered migration behavior, decreased levels of filamentous actin, and attenuated RhoA activity in vitro. (duke.edu)
  • Within this analysis, we reveal the efficiency and tolerability from the pan HDACi pracinostat in different in vitro and also in vivo types of AML, and display synergistic benefits at a number of concentrations in conjunction with the JAK2/FLT-3 inhibitor pacritinib in both the in vitro and also in vivo placing. (immune-source.com)
  • Bortezomib has been studied extensively in vitro and in vivo , and anticancer activity has been seen in cell and animal models for several solid tumor types, including prostate cancer. (aacrjournals.org)
  • Cells grown in vitro from neoplastic tissue. (lookformedical.com)
  • In vitro , TRAIL-mediated apoptosis of prostate cancer cell lines can be enhanced by doxorubicin and correlates with the downregulation of the anti-apoptotic protein c-FLIP. (biomedcentral.com)
  • In vitro experiments show that PC3 cells are partially susceptible to Apo2L/TRAIL and that susceptibility is enhanced by doxorubicin. (biomedcentral.com)
  • TRAIL induces apoptosis in a variety of cell lines in vitro and in vivo . (biomedcentral.com)
  • Interestingly, auranofin, a thioredoxin reductase inhibitor, sensitized MLLr BCP-ALL to venetoclax in various in vitro and in vivo models, independently of the p53 pathway functionality. (ox.ac.uk)
  • We particularly study Epstein-Barr Virus (EBV)-infection, which can also be used as a model to study early steps in in vitro transformation, viral genetic switches, non-genetic variation and cancer cell metabolism. (ki.se)
  • The EBV cell line models allow comparison of non-malignant versus malignant phenotypes of human cancer in vitro (lymphoblastoid cell lines, LCL vs Burkitt´s lymphoma cell line, BL). (ki.se)
  • Inhibition of lipogenesis leads to cell death both in vitro and in vivo and does not induce cell death of normal splenocytes. (biomedcentral.com)
  • Using in vitro cell lines derived in from conditional MYC, RAS, and BCR-ABL transgenic murine models and oncogene-driven human cell lines, we determined gene regulation, metabolic profiles, and sensitivity to inhibition of lipogenesis in lymphoid malignancies. (biomedcentral.com)
  • We identify specific cell death responses to TOFA in vitro and in vivo and demonstrate delayed engraftment and progression in vivo in transplanted lymphoma cell lines. (biomedcentral.com)
  • Myc-transformed epithelial cells down-regulate clusterin, which inhibits their growth in vitro and carcinogenesis in vivo. (wikidata.org)
  • Moreover, SI221 decreased in vitro cell migration and invasion and reduced tumor growth in a RMS xenograft model. (oncotarget.com)
  • SV40 is a powerful carcinogen that, in vitro , transforms human mesothelial cells. (sv40.org)
  • We demonstrated that CDBPA significantly reduced cell viability and induced apoptosis via the extrinsic and the intrinsic apoptotic pathways of Burkitts lymphoma cells without causing cell cycle arrest but reduction of the various phases. (longdom.org)
  • Several MYC-induced pathways, such as activation of the p53/ARF pathway, changes in expression, and activity of BCL2 proteins or alterations in death receptor signaling have been linked to apoptosis. (ashpublications.org)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • The authors traced this to bacterial induction of host autophagy pathways upon colonization, which then reduced the capacity for host cells to undergo oxaliplatin-induced apoptosis. (nature.com)
  • It has been reported to reduce growth of these cancer cells mainly by reducing inhibitory phosphorylation of PDH, thereby promoting mitochondrial oxidative phosphorylation and inducing apoptosis through mitochondrial, NFAT-Kv 1.5, and p53 upregulated modulator of apoptosis (PUMA)-mediated pathways. (dcaguide.org)
  • To achieve this, cancer cells must reprogram their metabolic pathways to accumulate intermediates as sources for these building blocks. (biomedcentral.com)
  • Furthermore, whereas dexamethasone induced a G 0 /G 1 cell cycle arrest, PAH had no effect on pro/pre-B cell growth, indicating that growth arrest and apoptosis occur by separable signaling pathways in this early phase of B cell development. (aai.org)
  • The pathways of glutamate and glutamine oxidation by tumor cell mitochondria. (wikidata.org)
  • Analysis of this network shows that it recapitulates known features of the human immune system and can be used uncover novel multi-step immune pathways, examine species-specific differences in immune processes, and predict the response of immune cells to stimuli. (stanford.edu)
  • They have the capacity to control the expression of many downstream genes which can affect several cell regulatory pathways, such as cell growth, differentiation, mobility and apoptosis. (biomedcentral.com)
  • However, the tumour cells have undergone hypermutation, 21 23 a feature of the GC reaction during B-cell activation and differentiation. (bmj.com)
  • Most of these lymphomas represent the malignant counterpart of B-lymphocytes at midstage in the process of differentiation. (lookformedical.com)
  • A group of lymphomas exhibiting clonal expansion of malignant T-lymphocytes arrested at varying stages of differentiation as well as malignant infiltration of the skin. (lookformedical.com)
  • IL-2/IL2R also promotes the differentiation of T cells into effector T cells. (ilreceptor.com)
  • Overall, our findings suggest that SFK inhibition, besides reducing RMS cell growth and invasive potential, could also represent a differentiation therapeutic strategy for RMS. (oncotarget.com)
  • These small RNAs have been shown to contribute to the control of cell growth, differentiation and apoptosis, important features related to cancer development and progression. (biomedcentral.com)
  • The majority of mantle-cell lymphomas are associated with a t(11;14) translocation resulting in overexpression of the CYCLIN D1 gene (GENES, BCL-1). (lookformedical.com)
  • These messages are expressed in Epstein-Barr Virus transformed lymphoblastoid cell cultures. (wikipedia.org)
  • Burkitt's Lymphoma (BL) is a rare, aggressive and fast growing human tumor and was the first human tumor to be associated with an Epstein-Barr Virus (EBV) [ 1 ]. (longdom.org)
  • Burkitt lymphoma (BL) can be classified into three forms which differ in geographic distribution and Epstein-Barr virus (EBV) association: endemic (eBL), sporadic (sBL) and HIV-associated BL ( table 1 ). (bmj.com)
  • The connection between microbes and cancer is a long-established paradigm (think Human Papillomavirus and cervical cancer, Epstein-Barr Virus in Burkitt's lymphoma, Hepatitis B and C virus with liver cancer, Helicobacter pylori and gastric cancer). (nature.com)
  • This suggests LMP2A plays an important role in viral latency, as well as in progression of EBV related diseases such as Burkitt's lymphoma, Nasopharyngeal carcinoma, and Hodgkin's lymphoma. (wikipedia.org)
  • Subsequent studies revealed that EBV caused a number of different human malignancies, such as nasopharyngeal carcinoma (NPC), Hodgkin's lymphoma, extranodal NK/T-cell lymphoma, nasal type and lymphoproliferative disorders of immunocompromised hosts ( 2 ). (spandidos-publications.com)
  • The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease. (lookformedical.com)
  • In this review, we aim to summarize the composition of CAR-T cell and its application in the treatment of acute lymphocytic leukemia (ALL), chronic lymphocytic leukemia (CLL), non-Hodgkin's lymphoma (NHL), Hodgkin's lymphoma (HL), multiple myeloma (MM), and acute myeloid leukemia (AML). (hindawi.com)
  • Finally, BNPs ability to treat a new xenograft human/SCID leukemia and Burkitt's lymphoma mouse model was studied. (units.it)
  • Finally, in vivo administration of the new NAMPT inhibitors in a mouse xenograft model of human Burkitt lymphoma delays tumor growth and significantly prolongs mouse survival. (bvsalud.org)
  • Using RNA-seq, we observed that long-term exposure to venetoclax in vivo in a patient-derived xenograft model leads to downregulation of several tumor protein 53 (TP53)-related genes. (ox.ac.uk)
  • NF-κB up-regulates Fas and predisposes to Fas-induced cell death, which is caspase-8 mediated and can be prevented by CFLAR overexpression. (ashpublications.org)
  • We conclude that c-MYC overexpression sensitizes cells to NF-κB-induced apoptosis, and persistent inactivity of NF-κB signaling is a prerequisite for MYC-mediated tumorigenesis. (ashpublications.org)
  • 1 , 3 In Burkitt lymphoma (BL), a highly aggressive non-Hodgkin lymphoma, overexpression of MYC is invariably connected to chromosomal translocations of the MYC proto-oncogene to immunoglobulin loci. (ashpublications.org)
  • In non-Hodgkin lymphomas, although Myc has been described as a defining feature and the driving oncogene for Burkitt lymphoma, Myc overexpression has also been recognized in other aggressive B-cell lymphomas and has been linked to adverse prognosis [ 2 ]. (oncotarget.com)
  • LMP2A is a transmembrane protein that inhibits normal B-cell signal transduction by mimicking an activated B-cell receptor (BCR). (wikipedia.org)
  • Reactivating these miRNAs in Myc-transformed B lymphoma cell lines dramatically inhibits tumorigenesis [ 4 ], indicating that reconstituting lymphoma with these tumor suppressor miRNAs could be therapeutically beneficial in Myc-associated lymphomas. (oncotarget.com)
  • This is the first set of experiments to show that the compound, Delta-tetrahydrocannabinol (THC), inhibits EGF-induced growth and migration in epidermal growth factor receptor (EGFR) expressing non-small cell lung cancer cell lines. (pakalertpress.com)
  • REGγ inhibits MCL cell growth in mice by promoting apoptosis. (amegroups.org)
  • Hydroxyurea selectively inhibits ribonucleoside diphosphate reductase, an enzyme required to convert ribonucleoside diphosphates into deoxyribonucleoside diphosphates, thereby preventing cells from leaving the G1/S phase of the cell cycle. (blogspot.com)
  • However, they have both been shown to induce apoptosis in several different cell types. (listlabs.com)
  • Tumor necrosis factor-related apoptosis-inducing ligand (Apo2L/TRAIL) is a death receptor ligand that can induce apoptosis in a variety of cancer cell lines, including androgen-independent PC3 prostate carcinoma cells. (biomedcentral.com)
  • Experimental approaches include delivery of oncolytic viruses, immunomodulatory molecules, p53 and p21, enzymes that metabolize prodrugs and agents that can induce apoptosis [ 3 ]. (biomedcentral.com)
  • TRAIL is a type II membrane protein that can induce apoptosis by binding to death domain containing receptors DR4 and DR5 [ 4 ]. (biomedcentral.com)
  • B-cell malignancies are a heterogeneous group of clinical conditions including indolent diseases such as Chronic Lymphocytic Leukemia (CLL) and highly aggressive lymphoproliferative disorders such as Burkitt's lymphoma. (units.it)
  • Thus, we propose a novel therapeutic approach for the treatment of CLL and Burkitt's lymphoma in which high-doses of the association of hydroxychloroquine and chlorambucil (HCQ/CLB) or fludarabine were loaded inside biodegradable nanoparticles (BNPs) coated with an anti-CD20 antibody. (units.it)
  • First of all, a Burkitt's lymphoma cell line (BJAB), two CLL cell lines (MEC1 and EHEB) and cells purified from patients' blood samples were used to confirm CD20 expression and to assess BNPs binding and internalization. (units.it)
  • Drugs-loaded BNPs were able to improve HCQ/CLB efficacy in vivo allowing the cure of treated all Burkitt's lymphoma-bearing mice and 3 out of 7 leukemia-bearing animals. (units.it)
  • EBV was the first virus to be associated with human malignancy, which was discovered from a Burkitt's lymphoma cell line in 1964 ( 1 ). (spandidos-publications.com)
  • A regimen consisting of cyclophosphamide, vincristine, doxorubicin and dexamethasone, administered on a hyperfractionated schedule, used to treat adult L3 acute lymphoblastic leukemia (ALL3 or Burkitt's-type) and adult small non-cleaved cell (Burkitt's) lymphoma. (blogspot.com)
  • EBV, the virus that causes Burkitt's lymphoma found predominantly in Africa, is the same virus that causes mononucleosis in individuals in the West. (joessciencescorner.net)
  • BL cells and normal fibroblasts were exposed to CDBPA for cytotoxicity screening by XTT assay, followed by cell cycle arrest, determination of apoptosis using Flow Cytometry and by annexin V/FITC/PI assay. (longdom.org)
  • SI221, which showed to be mainly effective against the SFK member YES, significantly reduced cell viability and induced apoptosis, without affecting non-tumor cells, such as primary human skin fibroblasts and differentiated C2C12 cells. (oncotarget.com)
  • Recently, a study showed that FOXO4/p53 was interfered by an engineered peptide, which caused targeted apoptosis of the senescent fibroblasts [ 11 ]. (hindawi.com)
  • The NF-κB pathway is extinguished in murine lymphoma cells, and extrinsic stimuli typically inducing NF-κB activity fail to activate this pathway. (ashpublications.org)
  • Using cell lines derived from conditional MYC, RAS, and BCR-ABL transgenic murine models, we demonstrate shared responses to inhibition of lipogenesis by the acetyl-coA carboxylase inhibitor 5-(tetradecloxy)-2-furic acid (TOFA), and other lipogenesis inhibitors. (biomedcentral.com)
  • Then, BNPs therapeutic effect was evaluated by MTT test, AnnV/PI assay and western blot to put in evidence apoptosis induction and autophagy inhibition. (units.it)
  • v] Their research was published in the Journal of the National Cancer Institute Advance Access on December 25th of 2007 in a paper entitled Inhibition of Cancer Cell Invasion by Cannabinoids via Increased Expression of Tissue Inhibitor of Matrix Metalloproteinases-1. (pakalertpress.com)
  • Combination of doxorubicin with Apo2L/TRAIL resulted in more apoptotic cell death and tumor growth inhibition than Apo2L/TRAIL alone. (biomedcentral.com)
  • Combination of doxorubicin and Apo2L/TRAIL is more effective in growth inhibition of PC3 xenografts in vivo than either agent alone and could present a novel treatment strategy against hormone-refractory prostate cancer. (biomedcentral.com)
  • Pyruvate dehydrogenase kinase inhibition attenuates glycolysis and facilitates mitochondrial oxidative phosphorylation, leading to reduced growth of colorectal cancer cells but not of non-cancerous cells. (dcaguide.org)
  • Therefore, we treated 4T1 cells with DMF, a NF-κB inhibitor, in order to determine whether suppression of the NF-κB p65 subunit would LBH589 mouse result in the inhibition of RANKL-mediated EMT. (pdgfreceptor.com)
  • Nicotinaldehyde supplementation replenishes the intracellular NAD level in leukemia cells treated with NAMPT inhibitor APO866 and prevents APO866-induced oxidative stress, mitochondrial dysfunction and ATP depletion. (bvsalud.org)
  • The apoptosis inhibitor c-FLIP is structurally similar to caspase-8 but lacks the cysteine residue essential for catalytic activity. (biomedcentral.com)
  • Representative colorectal cancer and non-cancerous cell lines were treated with dichloroacetate (DCA), an inhibitor of pyruvate dehydrogenase kinase. (dcaguide.org)
  • Here, we assessed the effect of a recently developed selective SFK inhibitor (a pyrazolo[3,4- d ]pyrimidine derivative, called SI221) on RMS cell lines. (oncotarget.com)
  • Novo SM, Wedge SR, Stark LA. Ex vivo treatment of patient biopsies as a novel method to assess colorectal tumour response to the MEK1/2 inhibitor, Selumetinib . (ncl.ac.uk)
  • The p16INK4A protein is a cell-cycle inhibitor that acts by inhibiting activated cyclin D:CDK4/6 complexes, which play a crucial role in the control of the cell cycle by phosphorylating Rb protein. (medscape.com)
  • Gene expression experiments indicated that CARD9, BNIP3(L), TNFRSF-1B, and TNFRSF-25 genes are highly expressed in Ramos BL cells following treatment with CDBPA. (longdom.org)
  • A gene expression profile analysis has been performed and the results indicated that CBPDA is significantly increased the expression of five genes: CARD9, BNIP, TNFRSF-1B, TNFRSF25 and TNF-alpha, that have an important role in induction of apoptosis. (longdom.org)
  • The protein encoded by this gene, together with spectrin and actin, constitute the red cell membrane cytoskeletal network. (cancerindex.org)
  • It has been known for many years that the fundamental transforming event in BL is the translocation of the MYC gene, and the events that bring about this translocation and those that allow cells to survive with the constitutive expression of MYC have been the subject of intense investigation. (bmj.com)
  • The prognosis for B-cell precursor acute lymphoblastic leukemia patients with Mixed-Lineage Leukemia (MLL) gene rearrangements (MLLr BCP-ALL) is still extremely poor. (ox.ac.uk)
  • My lab is interested in what controls the initiation of antibody gene rearrangement during B cell development. (umassmed.edu)
  • 1 V(D)J recombination and the activity of genes of interest (using GFP as a reporter of gene expression) can be detected as intracellular fluorescence and are measured simultaneously in the same cell population, at the single cell level. (umassmed.edu)
  • For example, the TP53 gene, located on chromosome 17, encodes a 53-kd nuclear protein that functions as a cell cycle checkpoint. (medscape.com)
  • The TP53 gene is also capable of stimulating apoptosis of cells containing damaged DNA. (medscape.com)
  • 1 BL tumour cells usually express IgM, 13 - 15 B-cell markers such as CD19, CD20 and CD22 and markers of germinal centre (GC) centroblasts such as CD10, BCL6 4 and the human germinal centre-associated lymphoma (HGAL) protein. (bmj.com)
  • 17 - 22 The cell surface phenotype of BL tumour cells reflects a GC origin but the site of tumour growth is frequently the jaw or ovary, neither of which normally contain GCs. (bmj.com)
  • The glycolytic phenotype offers growth advantages to cancer cells by resisting apoptosis, and facilitating tumour spread and metastasis (Yeluri et al, 2009). (dcaguide.org)
  • HPV is present in the tumour cells. (sv40.org)
  • Using down stream inhibitors of Ras signaling components, they demonstrated activation of PI3K/Akt pathway is involved in LMP2A mediated B cell survival and resistance to apoptosis Caldwell et al. (wikipedia.org)
  • 1998) demonstrated the ability of LMP2A to provide survival signals to B-cells in vivo where expression of an LMP2A transgene in mice disrupts with normal B-cell development. (wikipedia.org)
  • Among these 132 patients, 8 liver cancer patients and 10 lung cancer patients who received ≥5 cell infusions showed greatly prolonged survival, which preliminarily verified the efficacy of allogeneic Vγ9Vδ2 T-cell therapy. (nature.com)
  • TIME possesses distinct populations of myeloid cells and lymphocytes to influence the immune escape of cancer, the response to immunotherapy, and the survival of patients. (biomedcentral.com)
  • Studies with bortezomib (VELCADE, formerly known as PS-341) and other proteasome inhibitors indicate that cancer cells are especially dependent on the proteasome for survival, and several mechanisms used by prostate cancer cells require proteasome function. (aacrjournals.org)
  • Prediction of improved survival in patients with pancreatic cancer via IL-21 enhanced detection of mesothelin epitope-reactive T-cell responses. (ki.se)
  • Increased levels of iron concentration in blood are associated with blood loss, increased destruction of red blood cells (e.g. hemorrhage) or decreased blood cell survival, acute hepatitis, certain sideroachrestic anemias, ingestion of iron-rich diets, defects in iron storage (e.g. pernicious anemia). (biotrend.com)
  • The importance of antiCD20 antibody in the homing of BNPs was confirmed by in vivo Time-Domain Optical Imaging performed in localized B-cell malignancy-bearing mice. (units.it)
  • nonetheless, further in vivo scientific studies making use of tumor-bearing mice are going to be expected to totally examine its feasibility and/or limitations. (pkainhibitors.com)
  • We also found that GNA13-deficient mice have increased numbers of GC B cells that display impaired caspase-mediated cell death and increased frequency of somatic hypermutation in the immunoglobulin VH locus. (duke.edu)
  • Heterologous expression of CDD-L in E. coli was sufficient to confer gemcitabine deactivation activity, and co-injection of CDD-L expressing E. coli with colon cancer cells into mice lead to enhanced gemcitabine resistance in vivo . (nature.com)
  • For in vivo studies, PC3 prostate carcinoma cells were grown subcutaneously in athymic nude mice and tumor growth was measured following treatment with doxorubicin and/or Apo2L/TRAIL. (biomedcentral.com)
  • The uniformity of the numbers of terminal repeats (TRs) among EBV positive carcinoma cells reflects the clonal origin of a tumor and suggests that EBV is a causative virus for gastric carcinoma ( 6 ). (spandidos-publications.com)
  • A large clonal or oligoclonal expansion of CD8 cells is observed during infectious mononucleosis ( 6 ). (frontiersin.org)
  • The PAH-induced death signaling pathway resembles the signaling cascade activated during clonal deletion and modeled by B cell receptor cross-linking or by dexamethasone exposure of immature surface Ig + B cells in that apoptosis is mediated by NF-κB down-regulation. (aai.org)
  • As in clonal deletion models, and as predicted by the down-regulation of NF-κB, PAH-induced death of pro/pre-B cells was at least partially dependent on c-Myc down-regulation. (aai.org)
  • Finally, in contrast to clonal deletion, PAH-induced pro/pre-B cell death was not dependent on p27 Kip1 or p21 WAF1 up-regulation but did coincide with p53 induction. (aai.org)
  • These results distinguish the PAH-induced apoptosis pathway from that activated during clonal deletion and indicate that signaling cascades leading to growth arrest and/or apoptosis in pro/pre-B cells differ from those active at later B cell developmental stages. (aai.org)
  • This clonal deletion has been modeled by cross-linking surface Ig (sIg) 3 in immature B cell lines such as WEHI-231 ( 1 , 2 , 3 , 4 ). (aai.org)
  • B-cell malignancies treatments take advantage of dose-intensive chemotherapeutic regimens and immunotherapy via monoclonal antibodies. (units.it)
  • All these data together put the basis for the potential use of BNPs in the treatment of B-cell malignancies. (units.it)
  • Persistent infection with H. pylori induces atrophic gastritis and intestinal metaplasia, and subsequently leads to gastric malignancies including gastric carcinoma and extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma). (spandidos-publications.com)
  • Although the initiating oncogenic lesion may vary, tumor cells in lymphoid malignancies often share similar environments and potentially similar metabolic profiles. (biomedcentral.com)
  • We examined cells from mouse models of MYC-, RAS-, and BCR-ABL-driven lymphoid malignancies and find a convergence on de novo lipogenesis. (biomedcentral.com)
  • In a panel of human cell lines, we demonstrate sensitivity to TOFA treatment as a metabolic liability due to the general convergence on de novo lipogenesis in lymphoid malignancies driven by MYC, RAS, or BCR-ABL. (biomedcentral.com)
  • Hematological malignancies, which include lymphoid, myeloid, histiocytic, and mast cell neoplasms, are a heterogeneous group of diseases of diverse incidence, pathogenesis and prognosis (Kornblau et al . (bbrc.in)
  • T cell immune protection plays a pivotal role in the treatment of patients with hematological malignancies. (hindawi.com)
  • However, T cell exhaustion might lead to the possibility of immune escape of hematological malignancies. (hindawi.com)
  • Adoptive cell therapy (ACT) with chimeric antigen receptor T (CAR-T) cells can restore the activity of exhausted T cell through reprogramming and is widely used in the treatment of relapsed/refractory (r/r) hematological malignancies. (hindawi.com)
  • However, CAR-T cells can also produce some adverse events after treatment of hematological malignancies, such as cytokine release syndrome (CRS), neurotoxicity, and on-target/off-tumor toxicity, which may cause systemic immune stress inflammation, destruction of the blood-brain barrier, and even normal tissue damage. (hindawi.com)
  • Traditionally, the treatment of hematological malignancies is administrated by chemotherapy, radiotherapy, and stem cell transplantation. (hindawi.com)
  • It is noted that T cell has great potential for immunotherapy of hematological malignancies. (hindawi.com)
  • In addition, the isolation and storage of umbilical cord blood hematopoietic stem cells have been used to rebuild the immune system for the treatment of hematological malignancies and might be promising for the dynamic equilibrium expansion of functional T cells [ 12 ]. (hindawi.com)
  • The latter event leads to ATP loss and mitochondrial depolarization with induction of apoptosis and necrosis. (bvsalud.org)
  • Myc, HDCA3, and PRC2 form a repressive complex tethered to miR-29a/b1 and miR-29b2/c promoter regulatory elements to epigenetically repress transcription of these miRNAs in Myc-expressing lymphoma cells and that subsequent miR-29 down-regulation results in induction of oncogenic proteins (CDK6 and IGF-1R) and Myc-driven lymphomagenesis. (oncotarget.com)
  • Potent, p53-independent induction of NOXA sensitizes MLL-rearranged B-cell acute lymphoblastic leukemia cells to venetoclax. (ox.ac.uk)
  • Synergistic activity of these drugs resulted from auranofin-mediated upregulation of NOXA pro-apoptotic protein and potent induction of apoptotic cell death. (ox.ac.uk)
  • CaCO-2 cell uptake assay and human liver microsome studies proved that ARV is a substrate of CYP3A4 but not of P-gp effluX pump. (nadph-oxidasesignaling.com)
  • Do DTT or IGEPAL/NP-40 in cell lysis buffer will have any influence on the assay? (biotrend.com)
  • Assay: Iron in human prostate cancer cell lysates. (biotrend.com)
  • B-cells from LMP2A transgenic E line undergo immunoglobulin light chain rearrangements, but not heavy chain rearrangement. (wikipedia.org)
  • Most CD8 cells are directed to lytic antigens initially, and these cells rapidly undergo apoptosis ( 7 ). (frontiersin.org)
  • Our aim was to determine if switching metabolism from glycolysis towards mitochondrial respiration would reduce growth preferentially in colorectal cancer cells over normal cells, and to examine the underlying mechanisms. (dcaguide.org)
  • Dichloroacetate reduced lactate levels in growth media and induced dephosphorylation of E1 α subunit of pyruvate dehydrogenase complex in all cell lines, but the intrinsic mitochondrial membrane potential was reduced in only cancer cells ( P =0.04). (dcaguide.org)
  • Here we investigated the role of NF-κB in mouse and human c-MYC-transformed lymphomas. (ashpublications.org)
  • 3 Increased amounts of MYC protein are found in many types of human cancer because control mechanisms keeping MYC in check are inactivated during malignant transformation of cells. (ashpublications.org)
  • Here, we report the identification of nicotinaldehyde as a novel precursor that can be used for NAD biosynthesis by human leukemia cells. (bvsalud.org)
  • γδ T cells, specifically the Vγ9Vδ2 subset, which is the dominate subset among γδ T cells in human peripheral blood, recognize target cells in a human leukocyte antigen (HLA)-independent manner. (nature.com)
  • Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells. (wikidata.org)
  • OR14I1 is a receptor for the human cytomegalovirus pentameric complex and defines viral epithelial cell tropism. (umassmed.edu)
  • However, from the beginning of puberty after thymus degeneration, human cytomegalovirus (HCMV) persists due to the chronic activation of cytomegalovirus in humans causing repeated activation of T cells, which is considered the driving factor of human immune aging [ 9 ]. (hindawi.com)
  • Various biological processes including immunoreaction of infection, tumor prevention, and human aging could cause telomere damage, tumor-related stress responses, and T regulatory (Treg) cells activation, which even trigger T cell senescence showing the distinctive phenotypic and functional alternation [ 9 , 10 ]. (hindawi.com)
  • Another important class of tumor suppressor genes involved in cell cycle control and in the generation of human cancers is the cyclin-dependent kinase (CDK) inhibitors. (medscape.com)
  • The expression patterns, function and regulation of microRNAs in normal and neoplastic human cells are largely unknown but emerging data and their frequent location at fragile sites, common break-points or regions of amplification or loss of heterozygosity reveal that they may play significant roles in human carcinogenesis. (biomedcentral.com)
  • Activation of p21 or p16 therefore causes cell cycle arrest. (medscape.com)
  • The p19ARF protein, which is encoded by the same locus as p16, also leads to cell cycle arrest by inhibiting the ability of MDM2 to inactivate TP53. (medscape.com)
  • To do so, MYC controls transcription of multiple genes involved in cell growth and metabolism, vasculogenesis, cell adhesion, and genomic stability. (ashpublications.org)
  • These are referred to as mucosal-associated invariant T (MAIT) cells and that these MAIT cells recognize and react to metabolites that are that are a byproduct of microbial metabolism. (joessciencescorner.net)
  • Heme-dependent er stress apoptosis: A mechanism for the selective toxicity of the dihydroartemisinin, nsc735847, in colorectal cancer cells. (biotrend.com)
  • One method is to target senescent T cells which have selective apoptosis function. (hindawi.com)
  • In addition, my lab studies the process of developmental committment to the B cell lineages, using 7-color flow cytometry on a state-of-the-art 3 laser FACS. (umassmed.edu)
  • This results in BCR-negative cells being able to exit the bone marrow and survive in peripheral lymphoid organs. (wikipedia.org)
  • This indicates that LMP2A signaling bypasses the requirement for immunoglobulin recombination and allows immunoglobulin M-negative type cells to bypass apoptosis, allowing them to colonize peripheral lymphoid organs. (wikipedia.org)
  • A group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes. (lookformedical.com)
  • Lymphoid cells concerned with humoral immunity. (lookformedical.com)
  • Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. (lookformedical.com)
  • Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. (lookformedical.com)
  • Extranodal lymphoma of lymphoid tissue associated with mucosa that is in contact with exogenous antigens. (lookformedical.com)
  • Many of the sites of these lymphomas, such as the stomach, salivary gland, and thyroid, are normally devoid of lymphoid tissue. (lookformedical.com)
  • B-cell lymphoid tumors that occur in association with AIDS. (lookformedical.com)
  • Remedy with alisertib up-controlled outrageous style p53 in Granta-519 MCL cells specifying G0/G1 arrest consequent to G2/M checkpoint activation. (immune-source.com)
  • Cell phone routine analyses suggest M-VCR-R is considered the most powerful mix in triggering reduction in G0/G1, G2/M arrest, overriding the spindle checkpoint resulting in elevated apoptosis currently-reliant manner (Figure 3B). (immune-source.com)
  • The most striking G 2 arrest was evident in well-differentiated HT29 cells, in which DCA caused an eight-fold increase in cells in G 2 phase after 48 h. (dcaguide.org)
  • Treatment of WEHI-231 cells with Ig-specific antisera leads to growth arrest in the late G 1 phase of cell cycle concomitant with NF-κB inactivation, NF-κB-mediated c-Myc down-regulation, p27 Kip1 up-regulation, and apoptosis ( 1 , 2 , 5 , 6 ). (aai.org)
  • A second, potentially overlapping pathway, leading to anti-Ig-induced, immature B cell growth arrest and death, involves p53-dependent up-regulation of p21 WAF1 ( 8 ). (aai.org)
  • In those cell types, the receptor concentration and binding is modulated by factors such as tumor necrosis factor (TNF), interleukins, and fatty acid content of the membranes. (listlabs.com)
  • One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). (lookformedical.com)
  • One agent that has received considerable attention as a novel apoptosis-inducing agent is tumor necrosis factor-related apoptosis inducing ligand (TRAIL/Apo2L). (biomedcentral.com)
  • Two motifs that are centered on Y74 and Y85 are spaced 7 residues apart to form an immunoreceptor tyrosine-based activation motif (ITAM) commonly found in Fc receptors and signal molecules of B-cell and T-cell receptors. (wikipedia.org)
  • The effects of Shiga toxin 1 and Shiga toxin 2 have been shown to vary with cell type because Gb3 receptors are present in certain tissues, particularly sensory neurons and renal cells. (listlabs.com)
  • Apoptosis is initiated by binding to receptors DR4/DR5 (TRAIL-R1, 2), which is followed by assembly of the death inducing signaling complex and activation of caspase-8. (biomedcentral.com)
  • In the present study, up-regulation of SOX9 was observed in both NPC tissues and different NPC cells. (cancerindex.org)
  • TP53 activates the expression of genes involved in apoptosis, cell cycle regulation (p21), and MDM2. (medscape.com)
  • Cell Reports 2017, 21 (5), 1386-1398. (ncl.ac.uk)
  • Recently, it has been reported by many workers that the potential functions of exosomes contributed to various aspects of hematological tumorigenesis, particularly with a focus on the exosome-mediated tumor progression, metastasis, drug resistance and immune escape by altering the function of receiver cells via diverse exosomal cargoes including proteins, DNA, messenger RNAs (mRNAs), and microRNAs) (Whiteside and Boyiadzis, (2017). (bbrc.in)
  • CDBPA exerted a strong apoptotic cell death. (longdom.org)
  • Androgens are necessary for normal prostate cell growth (1) , and in animal models, androgen ablation causes cell atrophy and death of prostate epithelial cells (2) . (aacrjournals.org)
  • Likewise, in the early stages of prostate cancer, the growth of cancerous prostatic epithelial cells is often androgen dependent (3) . (aacrjournals.org)
  • i.e ., radiation or chemotherapy) provide temporary palliation, but eventually prostate cancer cells become resistant to chemotherapy and radiation, with ensuing failure to control tumor growth. (aacrjournals.org)
  • This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth. (lookformedical.com)
  • Thus, microbes can promote gemcitabine resistance and this may compromise chemotherapy efficacy in vivo . (nature.com)
  • Administration of oxygen under hyperbaric conditions enhances the delivery of oxygen to hypoxic tumor cells, thereby increasing their sensitivity to radiation and chemotherapy. (blogspot.com)
  • Therefore, it is likely that Myc hyperactivity contributes to widespread repression of miRNA expression and that Myc-driven miRNA repression underlies the molecular mechanisms related to lymphoma aggressive transformation. (oncotarget.com)
  • Prior to now the cellular mechanisms underlying this effect were unclear and the relevance of the findings to the behavior of tumor cells in vivo remains to be determined. (pakalertpress.com)
  • Several mechanisms have been proposed to account for the development of androgen independence in prostate cancer cells (4) . (aacrjournals.org)
  • 18 Such advantages enable γδ T cells to rapidly respond against malignant transformation and pathogenic stress. (nature.com)
  • Cancer is not a chaotic malignant cell mass, but a delicate "hostile" organ, where many other cells are recruited and domesticated to become "accomplices", thereby protecting themselves from recognition and attack by the immune system [ 1 ]. (biomedcentral.com)
  • Among the components of TME, distinct populations of innate and adaptive immune cells consist of tumor immune microenvironment (TIME). (biomedcentral.com)
  • TIME primarily consists of myeloid cells, lymphocytes and some other innate immune cells. (biomedcentral.com)
  • and the innate immune cells contain natural killer (NK) cells and dendritic cells (DCs) (Fig. 1 ). (biomedcentral.com)
  • Substantial cells are divided into immune cells and non-immune cells. (biomedcentral.com)
  • The infiltrating immune cells in the TME constitute the main body of TIME. (biomedcentral.com)
  • Both the innate immune response (especially NK cells) and the acquired immune response (virus-specific CD4 and CD8 cells) have a critical role in clearing the infection ( 2 ). (frontiersin.org)
  • Polycyclic aromatic hydrocarbons (PAH) are common environmental pollutants that suppress the immune system in part by inducing pro/pre-B cell apoptosis. (aai.org)
  • Novel understanding in the interaction between immune system and cancer cells of the patient holds great promise for immunotherapy development [ 4 - 6 ]. (hindawi.com)
  • The most active T cell endogenous inhibitory pathway is the immunoglobulin superfamily such as CD28/cytotoxic T lymphocyte antigen-4 (CTLA-4): B7-1/B7-2 receptor/ligand grouping, which plays a central role in coordinating immune responses [ 7 , 8 ]. (hindawi.com)
  • ARA55, ARA54, ARA70, BRCA1, and heat-shock proteins) may allow cells to become independent of androgens (intrinsic activation). (aacrjournals.org)
  • Like Rb protein, many of the proteins encoded by tumor suppressor genes act at specific points in the cell cycle. (medscape.com)
  • The c-MYC (MYC) transcription factor has been implicated in the control of many aspects of tumor cell biology. (ashpublications.org)
  • If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely. (lookformedical.com)
  • This influence had not been noticed in U-2932 DLBCL cells exactly where p53 is mutated (Number 1) implicating a differential reaction to alisertib. (immune-source.com)
  • However, androgen-independent cells are eventually selected during androgen ablation therapy (4) , and progression to an androgen-independent state remains the primary cause of mortality in these patients within an average of 1.5 years. (aacrjournals.org)
  • The CDK4-cyclinD complex normally phosphorylates the retinoblastoma protein (Rb protein), leading to release of the E2F transcription factor and cell cycle progression. (medscape.com)
  • There is a low background incidence of BL worldwide (sBL), which is rarely associated with EBV and accounts for 1-2% of adult lymphoma in Western Europe and America, but eBL is associated with (EBV) in over 95% of cases and is predominant in the equatorial belt of Africa and other parts of the world where malaria is hyperendemic. (bmj.com)
  • A form of undifferentiated malignant LYMPHOMA usually found in central Africa, but also reported in other parts of the world. (lookformedical.com)
  • Therefore, we developed a novel formula to improve the expansion of peripheral γδ T cells from healthy donors. (nature.com)
  • A group of malignant lymphomas thought to derive from peripheral T-lymphocytes in lymph nodes and other nonlymphoid sites. (lookformedical.com)
  • A recent study showed that patients with CAEBV or infectious mononucleosis have a decrease in the TCR-beta repertoire and expanded T cell clones in their peripheral blood compared with healthy carriers of EBV ( 14 ). (frontiersin.org)
  • nontargeting shRNA-transduced cells had been used as controls.As depicted in Figure 4A, MET knockdown xenografts showed slower development in addition to a substantially decreased volume at examine termination as compared with control tumors. (pkainhibitors.com)
  • Because of this, the pH gradient current amongst the extracellular microenvironment plus the cell cytosol is expanded in some solid tumors relative towards the pH gradient in usual tissues. (pkainhibitors.com)
  • However, when SN-38G is excreted into the gastrointestinal system, commensals that encode beta-glucuronidases convert SN-38G back to SN-38, leading to accumulation of active drug and targeting of gut epithelial cells. (nature.com)
  • Burkitt lymphoma (BL) is an aggressive B-cell malignancy with endemic, sporadic and immunodeficiency-associated variants. (bmj.com)
  • Mantle cell lymphoma (MCL) is an aggressive B-cell non-Hodgkin lymphoma (NHL). (amegroups.org)
  • Apoptosis assays by circulation cytometry ensure elevated exercise of M-VCR opposed to M or VCR (Shape 3A). (immune-source.com)
  • Migration was analyzed by Boyden chamber assays using Falcon cell culture inserts. (pdgfreceptor.com)
  • Most importantly, ARV showed promising cytotoXicity, anti-migration and apoptotic activity against vemurafenib-resistant melanoma cells. (nadph-oxidasesignaling.com)
  • of EMT markers, cell migration, and invasion. (pdgfreceptor.com)
  • DMF inhibited the upregulation of EMT markers, cell migration, and invasion in 4T1 cells (Figure 4B-4C). (pdgfreceptor.com)
  • Vγ9Vδ2 T cells recognize pyrophosphates secreted by many microbes or overproduced by malignant cells in the context of butyrophilin 3A1 molecules. (nature.com)
  • TME consists of cell component, the extracellular matrix (ECM) and abundant soluble signaling molecules. (biomedcentral.com)
  • What makes MAIT cells distinct is the fact that in their activity they do not recognize the major histocompatibility complex (MHC) molecules like classic T cells. (joessciencescorner.net)