Vivo antigen presenting cells are dendritic cells. Medical search. Frequent questions

We found that CTL responses against MVA-produced antigens were dominated by cross-priming in vivo , despite the ability of the virus to efficiently infect professional antigen-presenting cells (APC) such as dendritic cells (DC). (uniklinik-duesseldorf.de)
Dendritic cells (DCs) are bone marrow-derived, professional antigen-presenting cells with tolerogenic function. (stanford.edu)
Dendritic cells (DCs) are professional antigen-presenting cells, which are resident or proliferating in organs. (bvsalud.org)
Dendritic cells (DCs) are professional antigen-presenting cells that have multiple subpopulations with different phenotypes and immune functions. (biomedcentral.com)
Dendritic cells (DCs) are professional antigen presenting cells that initiate adaptive immunity by the activation of naïve lymphocytes and induce central and peripheral tolerance by mechanisms that include deletion, anergy and induction of regulatory T lymphocytes. (rotrf.org)
Dendritic cells (DC) are professional antigen-presenting cells (APC) that capture and present processed protein antigens to T cells when they are immature and mature, respectively. (edu.au)

Delivery of biodegradable nanoparticles to antigen-presenting cells (APCs), specifically dendritic cells (DCs), has potential for immunotherapy. (nih.gov)
Finally, an increase in nanoparticle-containing DCs (and other APCs) was seen at 96h vs. 24h, suggesting an infiltration of these cells to lymph nodes. (nih.gov)
Left panel: antigen bound by antibody is taken up via FcR on APCs such as dendritic cells or macrophages. (hindawi.com)
B cells are highly efficient APCs in situations of low antigen concentrations. (hindawi.com)
Likewise, antigen/antibody complexes are bound by the FcR of APCs and processed in a unique fashion dependent on the epitope specificity of the bound antibody. (hindawi.com)
14 As the strongest antigen presenting cell (APCs), DCs play an important role in the immunity of the ocular surface. (bmj.com)
Herein we demonstrate that GC drives type I IFN production and IFN responses in antigen presenting cells (APCs) and has superior potency compared to its corresponding chitosan. (biorxiv.org)
Although it is possible to expand naturally occurring T(regs), an attractive alternative possibility, particularly suited to solid organ and bone marrow transplantation, is the stimulation of total T cell populations with defined allogeneic antigen-presenting cells (APCs) under conditions that lead to the generation or expansion of donor-reactive, adaptive T(regs). (lu.se)
Notably, PDE inhibition also enhanced the enrichment of human Foxp3(+) CD4(+) T cells driven by allogeneic APCs. (lu.se)
Although plasmacytoid dendritic cells (pDCs) express major histocompatibility complex class II (MHCII) molecules, and can capture, process, and present antigens (Ags), direct demonstrations that they function as professional Ag-presenting cells (APCs) in vivo during ongoing immune responses remain lacking. (unige.ch)
pDCs thus function as APCs during the course of EAE and confer a natural protection against autoimmune disease development that is mediated directly by their ability to present of Ags to CD4(+) T cells in vivo. (unige.ch)
Viral vectors encoding TAAs are promising vaccine candidates because they can infect antigen presenting cells (APCs) in vivo they may also signal "danger" to the immune system through pathogen recognition pathways. (ucl.ac.uk)
Dendritic cells (DCs) are the most important antigen-presenting cells (APCs) in the body. (biomedcentral.com)

Alveolar macrophages are also involved in the phagocytosis of apoptotic and necrotic cells. (wikipedia.org)
Thus, blockade of activating FcγR inhibits binding of opsonized antigens, induction of effector functions and secretion of pro-inflammatory cytokines by macrophages, and degranulation of granulocytes. (academie-medecine.fr)
In conditions such as like ITP that is autoantibody-mediated, IVIG Fc fragmentmediated competitive blockade of activating FcγR might inhibit: binding of opsonized antigens, induction of effector functions and secretion of pro-inflammatory cytokines by macrophages, and degranulation of granulocytes [1, 12]. (academie-medecine.fr)
FcRn expressed in endosomal compartment of intestinal epithelium, vascular endothelium and macrophages regulates the serum IgG levels by binding to the pinocytosed antibodies and recirculating them to cell surface without intracellular degradation. (academie-medecine.fr)
We assessed how variation in the amount of GM3, surface-attached PEG and liposomal size affected the binding to, and uptake by, CD169+ macrophages in vitro and in vivo. (uu.nl)
The ligand Is expressed on antigen presenting cells including splenic B cells, dendritic cells, and macrophages. (bioxcell.com)
The function of LPX is to protect from extracellular ribonucleases, mediate the efficient uptake of RNA and its expression of the encoded antigen (by DC population and macrophages) in various lymphoid compartment. (modernloveok.com)
RNA-LPX causes the release of interferon-a by macrophages and plasmacytoid dendritic cells. (modernloveok.com)
Kupffer cells, hepatic stellate cells and sinusoidal endothelium) and infiltrating leukocytes (e.g., monocytes, monocyte-derived macrophages, neutrophils and lymphocytes). (mdpi.com)
Comparative study of the immunoregulatory capacity of in vitro generated tolerogenic dendritic cells, suppressor macrophages, and myeloid-derived suppressor cells. (genescells.ru)
Lipopeptides act as immunomodulators by interacting with pattern recognition receptors (PRRs), such as Toll-like receptors (TLRs), expressed on antigen-presenting cells (macrophages and dendritic cells) to activate immune functions [ 14 ]. (biomedcentral.com)
Histiocytoses encompass a group of diverse proliferative disorders characterized by the accumulation and infiltration of variable numbers of monocytes, macrophages, and dendritic cells in the affected tissues. (medscape.com)
Total cells, macrophages, and eosinophils recovered in BALF lavage were significantly elevated in the OVA + PM/OVA compared to OVA/OVA group. (cdc.gov)

Our results indicated that multiple members of the guinea-pig CD1 family, including members that are homologous to the human CD1b and CD1c proteins, are expressed at the protein level in transfected cells and in specialized antigen-presenting cells such as monocyte-derived dendritic cells. (elsevierpure.com)
Kiertscher SM, Luo J, Dubinett SM, Roth MD. Tumors promote altered maturation and early apoptosis of monocyte-derived dendritic cells. (medscape.com)
Defective migration of monocyte-derived dendritic cells in LAD-1 immunodeficiency. (lu.se)

Our research is directed to develop new approaches for viral vector design, novel vaccine formulations with improved efficacy and optimized preventive and therapeutic MVA-based immunization strategies (e.g. vaccination protocols for T cell-pillowed immunotherapy). (uniklinik-duesseldorf.de)
Cancer immunotherapy with mRNA-transfected dendritic cells. (nova.edu)
DCs are harvested from cancer patients and manipulated ex vivo in DC-based cancer immunotherapy. (bvsalud.org)
The use of dendritic cells in cancer immunotherapy. (zju.edu.cn)
4Role of RNA-lipoplexes in Cancer Immunotherapy:The systematic delivery of vaccine antigens into dendritic cells is faced with various technical challenges. (modernloveok.com)
As all the polypeptide based antigens can be encoded as RNA, RNA-LPX is an example of a universally applicable vaccine class for DC targeting and synchronized induction of highly potent adaptive plus type-I-IFN-mediated innate immune mechanisms used for cancer immunotherapy. (modernloveok.com)
Cancer vaccines exploiting the in vivo delivery of tumour specific (neo-)antigens to cross-presenting dendritic cells to improve the immunotherapy for melanoma, breast cancer, lymphoma, glioblastoma and virus-driven tumours. (edu.au)
Identify and validate new classes of tumour antigens that can constitute suitable targets for immunotherapy in various types of cancers. (edu.au)
This project will aim to test a cancer immunotherapy approach based on in-vivo dendritic cell reprogramming of tumor cells to reinstate anti-tumor immunity. (lu.se)
2019. Conjugation of a peptide autoantigen to gold nanoparticles for intradermally administered antigen specific immunotherapy . (cardiff.ac.uk)
Advances in understanding the role of dendritic cells (DCs) as the major antigen (Ag)-presenting cell type of the immune system combined with the recent development of methods for the ex vivo expansion of human DCs have opened the possibility for the transfer of tumor Ags to DCs with a view toward tumor immunotherapy. (lookformedical.com)
We conclude that host range-restricted FWPV can be used efficiently to transfer Ag genes to human DCs ex vivo and may have a role in the development of tumor immunotherapy protocols. (lookformedical.com)
Tumor-infiltrating CD8+ T-cells and myeloid cells, harvested after the mice were treated for 2 weeks, were analyzed with flow cytometry to characterize the effect the chemo-immunotherapy regimen had on the tumor microenvironment (TME). (amegroups.org)
The chemo-immunotherapy regimens also increased the number of tumor-infiltrating PD1+CD137+CD8+ T-cells and interferon-gamma-expressing PD1+CD137+CD8+ T-cells, but these increases were not statistically significant. (amegroups.org)
Gemcitabine with GVAX and anti-PD1 with or without anti-CSF-1R also improved the infiltration of effector CD8+ T-cells, and the presence of anti-CSF-1R in the chemo-immunotherapy regimens decreased the infiltration of myeloid cells. (amegroups.org)

Induction of potent CD8 T cell cytotoxicity by specific targeting of antigen to cross-presenting dendritic cells in vivo via murine or human XCR1. (southernbiotech.com)

Vaccines generated by us are being studied in vitro and in vivo in preclinical animal models as well as in collaborative clinical studies. (uniklinik-duesseldorf.de)
Mesenchymal stem cells clearly modulate immune responses, as demonstrated by both in vitro and in vivo studies. (vin.com)
The HK5.3 antibody has been shown to block the binding of ICOSL to ICOS both in vitro and in vivo . (bioxcell.com)
Quantification of centriole abundance in vitro and in vivo identified a linear relationship between surface area and centriole number. (elifesciences.org)
In this project, we will investigate preparation of α-GalCer-incorporated liposomes, in vitro and in vivo mechanisms, and the application in cancer vaccine therapy of α-GalCer-incorporated liposomes. (tmu.edu.tw)
This project will delve into innate immune cell function, establishing in vitro and in vivo systems test innate immune cell function in regeneration. (lu.se)
Inspired from developmental processes, human mesenchymal cell lines can be programmed to form cartilage, bone and bone marrow tissues in vitro and in vivo. (lu.se)

Les IgIV intéragissent avec de nombreux composants du système immunitaire comme les récepteurs Fc, le complément, les cytokines, les lymphocytes T et B, les cellules dendritiques, les granulocytes et les cellules NK, ce qui explique en partie leurs effets anti-inflammatoires. (academie-medecine.fr)
2 The interaction of IVIG with a large number of components of the immune system including Fc receptors, complement molecules, cytokines, B and T lymphocytes, neutrophils and NK cells, may explain at least in part their anti-inflammatory effects. (academie-medecine.fr)
In addition to immature DCs, mesenchymal stem cells were also found to have a positive effect on allotransplantation of solid organs and bone marrow via cytokine expression which decreases the alloreactive effector lymphocytes and increases CD4+/CD25+/FoxP3 Tregs. (stanford.edu)
DCs process the microbial agents or their antigens and migrate to lymphoid tissues to present the antigenic peptide to lymphocytes. (zju.edu.cn)
This leads to activation of antigen-specific lymphocytes. (zju.edu.cn)
DCs are able to activate T lymphocytes (capture, process, present antigen), activate B cells and are associated in the amplification of innate immune response (e.g. activation of natural killer cells). (modernloveok.com)
3Structure of DCs (including antigen presenting to T cells):As shown in figure 1, dendritic cells are often rounded with reinform nuclei and a few or sometimes no dendrites.They can initiate adaptive immune response by presenting Pathogenic antigens to B or T lymphocytes. (modernloveok.com)
Multiple sclerosis (MS) is a neuroinflammatory disease with an autoimmune component that is characterised by activation of self-reactive lymphocytes, which enter the central nervous system (CNS) and cause destruction of myelin producing cells and neurons leading to the formation of inflammatory lesions. (nature.com)
While the autoreactive cells displayed significantly reduced Tregs numbers, the alloreactive transplacentally acquired maternal lymphocytes had high functional Tregs. (hindawi.com)
In some cases, T cells may present, as a result of residual autologous cells or transplacentally acquired maternal lymphocytes [ 1 ]. (hindawi.com)
The origin of the reactive cells in such patients are either thymic release of T-cells that expand at the periphery or transplacentally transfers of maternal T lymphocytes. (hindawi.com)
A distinctive feature of SCID patients, which sometimes can clinically resemble Omenn, [ 6 ] is the presence of alloreactive cells originated from transplacentally maternal T lymphocytes. (hindawi.com)
Evidence for CD4 + T-cell involvement in autoimmune disease pathogenesis and for paracrine calcitriol signaling to CD4 + T lymphocytes is summarized to support the thesis that calcitriol is sunlight's main protective signal transducer in autoimmune disease risk. (frontiersin.org)
Gene-environment interactions, sunlight and vitamin D, and T lymphocytes as autoimmune disease initiators and vitamin D targets are discussed to explain the rationale for reviewing vitamin D mechanisms in T cells. (frontiersin.org)
To induce CD8+ cytotoxic T lymphocytes (CTLs) along with neutralizing antibody and CD4+ T cell help, a live canarypox virus construct expressing gp120, transmembrane gp41, the gag and protease genes, and sequences containing CTL epitopes in nef and pol was given simultaneously with, or followed by, rgp120 SF2. (lookformedical.com)
This review presents analysis of the modern state of transplant tolerance forming problem in recipient organism by using stem/ progenitory cells of bone marrow (BM) and differentiated immunoregulatory (tolerogenic) subsets of blood cells-regulatory B- and T-lymphocytes (Treg), and regulatory dendritic cells (DCreg). (genescells.ru)
CD1 molecules are cell-surface glycoproteins with strong structural similarities to major histocompatibility complex (MHC) class I molecules, and studies in humans and mice have demonstrated that CD1 proteins perform the unique role of presenting lipid antigens to T lymphocytes. (elsevierpure.com)
Le pourcentage de CD44 dans les lymphocytes T périphériques était significativement plus élevé chez les patients que chez les témoins, comme détecté par la cytométrie en flux. (who.int)

abstract = "Dendritic cells (DC) play an important role as antigen-presenting cells in T cell stimulation. (uni-luebeck.de)

Dendritic cells (DCs) are specialized antigen presenting cells that instruct T cell responses through sensing environmental and inflammatory danger signals. (frontiersin.org)
Maintaining the homeostasis of the multiple functionally distinct conventional dendritic cells (cDC) subsets that exist in vivo is crucial for regulating immune responses, with changes in numbers sufficient to break immune tolerance. (frontiersin.org)
As a consequence, cDC2 dependent CD4 + T cell proliferation and T follicular helper cell responses are increased. (frontiersin.org)
Collectively, our data demonstrate that PTPN22 controls cDC2 homeostasis, which in turn ensures appropriate cDC2-dependent T cell responses under antigenic challenge. (frontiersin.org)
Functionally, cDC1 cross-present exogenous antigens to activate CD8 + T cells and can promote IL-12 dependent Th1 responses ( 1 , 5 - 7 ). (frontiersin.org)
Under polarizing inflammatory conditions, cDC2 induce Th2 responses in the lung ( 9 , 10 ), drive Th17 responses through IL-23 secretion ( 11 - 17 ), and initiate SIRPα dependent induction of T follicular helper cells (T FH ) and germinal center (GC) formation ( 18 ). (frontiersin.org)
Reciprocal roles of T-cell help for B cells during adaptive immune responses and B-cell help in CD4+ T-cell activation are being increasingly recognized. (hindawi.com)
In particular, we are aiming to characterize the molecular and cellular mechanisms which control and shape the quality and quantity of antigen-specific CD8+ and CD4+ T cell responses during viral infections or vector-based vaccination. (uniklinik-duesseldorf.de)
Therefore, one focus of our work is the identification of key mechanisms essential for the efficient generation (priming) and expansion (recall) of anti-viral or vaccine-induced T cell responses. (uniklinik-duesseldorf.de)
5. Arnaboldi PM, Roth-Walter F, Mayer L. Suppression of Th1 and Th17, but not Th2, responses in a CD8 + T cell mediated model of oral tolerance. (southernbiotech.com)
Most notably, some gut helminths can also downregulate T cell responses to inflammatory stimuli including asthmatic and allergic reactions through stimulation and expansion of Foxp3+ regulatory T cells. (cam.ac.uk)
The ability of DCs to regulate alloantigen-specific T cell responses and to promote tolerance has aligned them ideally for a role in vascularized composite allotransplantation (VCA). (stanford.edu)
Here we use the conditional in vivo ablation of CD11c high DC to investigate the role of these cells in T-independent type 2 immune responses. (uni-luebeck.de)
Our results suggest that support for plasma cell formation in T cell-independent immune responses can be provided by non-DC such as stromal cells, or is independent of external signals. (uni-luebeck.de)
Dendritic cells (DCs) are the most potent antigen-presenting cells and are the key initiator of tumor-specific immune responses. (asiaimmune.com)
As a proof of concept, we prepared GM3-targeted liposomes containing a long synthetic ovalbumin peptide and tested the capacity of these liposomes to induce CD8+ and CD4+ T-cell responses compared to control liposomes or soluble peptide. (uu.nl)
Upon ICOSL binding, ICOS signaling co-stimulates T and B cell responses. (bioxcell.com)
Lentiviral vector-based dendritic cell vaccines induce protective T cell responses against viral infection and cancer in animal models. (jci.org)
Dendritic cells are pivotal antigen-presenting cells for generating adaptive T-cell responses. (psu.edu)
Here, we show that dendritic cells belonging to either the myeloid-related or lymphoid-related subset are permissive for infection by mouse polyomavirus and, when loaded with a peptide corresponding to the immunodominant anti-polyomavirus CD8 + T-cell epitope or infected by polyomavirus, are each capable of driving expansion of primary polyomavirus-specific CD8 + T-cell responses in vivo. (psu.edu)
We demonstrate that mice exhibiting a selective abrogation of MHCII expression by pDCs develop exacerbated experimental autoimmune encephalomyelitis (EAE) as a consequence of enhanced priming of encephalitogenic CD4(+) T cell responses in secondary lymphoid tissues. (unige.ch)
The aim of this project was to assess their ability to deliver antigens to dendritic cells in vivo and to stimulate effective T cell responses. (ucl.ac.uk)
The findings of this thesis are that: Directly injected lentivectors can stimulate CD4+ (and CD8+) T cell responses to their encoded antigen if it is targeted into the endocytic pathway. (ucl.ac.uk)
They act as a surveillance system to detect foreign antigens and shape immunogenic or tolerogenic responses [ 1 ]. (biomedcentral.com)
Here we compared T-cell functions including the number of circulating CD3 + T cells, in vitro responses to mitogens, T-cell receptor (TCR) repertoire, TCR excision circles (TREC) levels, and regulatory T cells (Tregs) enumeration in several immunodeficinecy subtypes, clinically presenting with nonreactive residual cells (MHC-II deficiency) or reactive cells. (hindawi.com)
By exploiting the most advanced technologies (nanoparticle-based vaccines, neo-antigens identification and validation, etc.), suitable preclinical models, and investigation of anti-tumour immune responses in cancer patients, we are developing innovative strategies potentially able to improve current approaches. (edu.au)
Tumour neo-antigen-specific immune responses in oesophageal cancer long-term survivors: proof-of-concept for improved personalised therapeutic strategies. (edu.au)
Project aiming at characterizing the role of neo-antigen immune responses in mouse and human breast cancer. (edu.au)
Project aiming at characterising tumour neo-antigen-specific immune responses in oesophageal adenocarcinoma patients with long-term survival. (edu.au)
Cross-presentation initiates immune responses against tumors and viral infections by presenting extracellular antigen on MHC I to activate CD8 + T cell-mediated cytotoxicity. (elsevierpure.com)
iNKT cells have emerged as important contributors to the regulation of immune responses, T cell activation, and anti-tumor activity. (tmu.edu.tw)
Thus, α-GalCer-incorporated liposome is capable of improving the delivery of antigen to antigen-presenting-cell and inducing effective immune responses via various routes. (tmu.edu.tw)

Distinct subsets of DCs exist in vivo , broadly divided into conventional (cDC) and plasmacytoid (pDC) subsets. (frontiersin.org)
These cells have a plasmacytoid dendritic cell phenotype, a distinct response to TLR ligation and present antigen to T cells far less efficiently on comparison to conventional CD11c(hi) dendritic cells. (cam.ac.uk)
My research is now focusing on manipulating plasmacytoid dendritic cell populations in vivo and determining the cause for the changes in the CDllc(lo) and Foxp3+ T cell populations following infection. (cam.ac.uk)
Lymphoid lineage DCs primarily differentiate into plasmacytoid DCs and occupy approximately 0.5% of peripheral blood mononuclear cells (PBMCs) in humans [ 2 ], but the cell population percentage is unclear in horses. (biomedcentral.com)
Plasmacytoid dendritic cells (pDCs) are the professional producers of IFN-I in response to many viruses, including all of the herpesviruses tested. (mdpi.com)

Deposited immune complexes can activate complement and effector cells. (hindawi.com)
These anaphylatoxins promote release of proinflammatory cytokines and serve as chemoattractants for effector cells. (hindawi.com)
Moreover they induce the upregulation of activating FcR on effector cells. (hindawi.com)
Binding of the Fc portion of the antibodies to FcR leads to activation of effector cells and further release of proinflammatory cytokines and proteolytic enzymes, mediators of antibody-dependent cell-mediated cytotoxicity (ADCC). (hindawi.com)
Without further manipulation or selection, the resultant population delayed skin allograft rejection mediated by polyclonal CD4(+) effectors or donor-reactive CD8(+) T cell receptor transgenic T cells and inhibited both effector cell proliferation and T cell priming for interferon-γ production. (lu.se)
The objective of these vaccines is to induce tumour-specific effector T cells which can reduce the mass of tumour and that can lead to immunological memory to control tumour relapse. (modernloveok.com)
Whilst IFN-γ is typically considered to be a pro-inflammatory product of effector T cells, it has been also been demonstrated that IFN-γ −/− mice develop more severe EAE than wild type (WT) controls 5 , highlighting alternate, IFN-γ-dependant negative feedback mechanisms that can constrain EAE disease activity. (nature.com)
Animal modeling and human mechanistic data are summarized to support the view that vitamin D probably influences thymic negative selection, effector Th1 and Th17 pathogenesis and responsiveness to extrinsic cell death signals, FoxP3 + CD4 + T-regulatory cell and CD4 + T-regulatory cell type 1 (Tr1) cell functions, and a Th1-Tr1 switch. (frontiersin.org)
This combination regimen also increased the infiltration of CD8+ T-cells that expressed both PD1 and CD137, and these T-cells were shown to express high levels of interferon-gamma, a marker of cytotoxic effector CD8+ T-cells. (amegroups.org)
and iii) directly activated DCs induce effector memory CD4 T cells upon a secondary challenge, while indirectly activated DCs preferentially induce central memory CD4 T cells. (edu.au)

However, knowledge about the biological properties of target antigens or modalities of antigen delivery to efficiently induce or expand MVA-vaccine-mediated immunity in vivo is still sparse. (uniklinik-duesseldorf.de)

They are highly adaptive and can release many secretions, to interact with other cells and molecules using several surface receptors. (wikipedia.org)
Autoantibodies can bind to basic structural molecules and interfere with the synthesis of structural elements and facilitate the uptake of antigen. (hindawi.com)
After processing, antigen is presented on MHC molecules. (hindawi.com)
To assess the effects of BDE on pulmonary antigen presenting cells (APC), expression of CD80, CD86, CD40 and MHCII class molecules on lung dendritic cells (DC) was evaluated. (cdc.gov)
For example, MSC are poor antigen presenting cells and do not express MHC class II or co-stimulatory molecules and only low levels of MHC class I molecules. (vin.com)
Recent insights indicate that these therapies additionally augment tumor immunity by targeting immunosuppressive cell subsets in the TME, inducing immunogenic cell death (ICD), or blocking inhibitory molecules. (asiaimmune.com)
MHC-II molecules drive the development, activation, and homeostasis of CD4 + T-helper cells. (hindawi.com)
Moreover, while the mainstay of the diagnosis of MHC-II deficiency is the absence of constitutive and inducible expression of MHC-II molecules on all cell types, other tests for T-cell function are less informative in such patients. (hindawi.com)
Alpha-galactosylceramide (α-GalCer) is a glycolipid that can be loaded into MHC-class-I-related CD1d molecules by dendritic cells and has been shown to stimulate invariant natural killer T (iNKT) cells. (tmu.edu.tw)
In contrast, while indirect activation of DC elicits a similar expression level of MHCII and co-stimulator molecules, these cells have impaired cytokine production. (edu.au)
CD117 by immunohistochemical methods sion molecules, involved in cell-cell and in order to clarify the role of the infiltrating cell matrix interactions and thought to take inflammatory cells in the pathomechanisms part in cell motility [ 2,3 ]. (who.int)

Cancer vaccine effectiveness could be enhanced by targeting vaccine antigens to antigen-presenting cells, thereby increasing T-cell activation. (uu.nl)

5Conclusion:The review above demonstrates the role of dendritic cells in both innate (engulfment of pathogens) and adaptive (activation of B and T cells) immune response. (modernloveok.com)

The role of B cells in autoimmune diseases involves different cellular functions, including the well-established secretion of autoantibodies, autoantigen presentation and ensuing reciprocal interactions with T cells, secretion of inflammatory cytokines, and the generation of ectopic germinal centers. (hindawi.com)
Independent of antibody secretion B cells secrete proinflammatory cytokines, support the formation of ectopic GCs, and serve as antigen presenting cells. (hindawi.com)
However, the limitations were found in clinical application that (1) iNKT cells failed to produce cytokines and proliferate when additional doses of α-GalCer were given by systemic route and (2) poor hydrophilicity of α-GalCer. (tmu.edu.tw)
Cytokines, antigen-specific antibodies and subtype antibodies of serum and nasal wash fluid will be analyzed in order to investigate the enhancement of the Th1/Th2 immune-modulatory pathway. (tmu.edu.tw)
The integration of pathogen-associated molecular patterns (PAMPs) from microorganisms with their surface receptors in the immune cells, induces the production of several cytokines and chemokines that presents either a pro- and/or anti-inflammatory role by stimulating the secretion of a great variety of antibody subtypes and the activation of mechanisms of controlling the disease, such as the regulatory T cells. (bvsalud.org)

Here we demonstrate that stimulation of mouse CD4(+) T cells by immature allogeneic dendritic cells combined with pharmacological inhibition of phosphodiesterase 3 (PDE) resulted in a functional enrichment of Foxp3(+) T cells. (lu.se)
While injection of mature DCs rapidly increases T-cell activity in humans and promotes transplant rejection, the injection of immature DCs acts as an immunosuppressant and inhibits T-cell activity. (stanford.edu)
Increased survival and decreased tumor size due to intratumoral injection of ethanol followed by administration of immature dendritic cells. (zju.edu.cn)
In this approach, a patient's monocytes are obtained by leukapheresis and then differentiated ex vivo to immature DCs. (jci.org)
More recent studies suggested that DCs derived from tissues without "danger" signal stimulation should be regarded as immature DCs, based on their major role in antigen uptake and endocytosis of antigens [ 11 , 14 ]. (biomedcentral.com)

Mechanistically, PTPN22 mediates cDC2 homeostasis in a cell intrinsic manner by restricting cDC2 proliferation. (frontiersin.org)
These cells inhibited T cell proliferation in a standard in vitro mixed lymphocyte assay and, moreover, attenuated the development of vasculopathy mediated by autologous peripheral blood mononuclear cells in a functionally relevant humanized mouse transplant model. (lu.se)
Among their other immunological properties, MSC inhibit lymphocyte proliferation and cytokine production, suppress dendritic cell function and alter DC cytokine production, and decrease IFN-g production by NK cells. (vin.com)

2015). "ICOS coreceptor signaling inactivates the transcription factor FOXO1 to promote Tfh cell differentiation" Immunity 42(2): 239-251. (bioxcell.com)
The differentiation of Tfh cells is a multi-step process that depends upon the co-receptor ICOS and the activation of phosphoinositide-3 kinase leading to the expression of key Tfh cell genes. (bioxcell.com)
FOXO1 regulated Tfh cell differentiation through a broad program of gene expression exemplified by its negative regulation of Bcl6. (bioxcell.com)
Final differentiation to germinal center Tfh cells (GC-Tfh) was instead FOXO1 dependent as the Foxo1(-/-) GC-Tfh cell population was substantially reduced. (bioxcell.com)
In contrast, patients with reactive T cells exhibited poor T-cell differentiation and activity. (hindawi.com)
For example, Omenn syndrome, a typical case of impaired T-cell differentiation with abnormal self-reactive cells, is invariably characterized by autoimmune features such as generalized scaly exudative erythroderma, enlarged lymphoid tissues, and peripheral expansion of oligoclonal T-cells, in addition to increased susceptibility for severe infections [ 3 , 4 ]. (hindawi.com)
Second, we will analyze the effects of SFA on murine DC differentiation, maturation and cytokine production under normal and dynamic conditions in vivo . (rotrf.org)
However, a major unresolved question is how each cell regulates the precise number of its motile cilia during differentiation. (elifesciences.org)
In addition, CD1 proteins, especially guinea-pig CD1b3, were expressed on a large number of B cells in the guinea-pig, and CD1 expression appeared to be regulated by B-cell maturation or differentiation. (elsevierpure.com)

I am interested in the mechanisms underlying this Foxp3+ regulatory T cell expansion in vivo and have focused on whether antigen presenting cells such as dendritic cells are re-programmed to a tolerogenic, regulatory T cell inducing, phenotype following infection. (cam.ac.uk)
Protocols, based on the using of Treg and DCreg, do note gain the impression of reliable, although at the application of their cells the tolerogenic effect can be obtain. (genescells.ru)

Loading DCs ex vivo with tumor antigens can stimulate potent antitumor immunity in tumor-bearing mice. (nova.edu)
Introduction: DCs are antigen presenting cells that control immunity and tolerance. (modernloveok.com)
It is likely that L-DCs play an important role in antigen uptake and processing of respiratory pathogens and are major contributors to respiratory tract immunity and may be ideal tools for future in vitro or ex vivo studies. (biomedcentral.com)
Until today the activity of such substances had to be tested in animal models because of complex interactions between endothelial cells, coagulation and innate immunity. (forschung3r.ch)

Recent years have brought increased interest in the potential for adult stem cells to help in the treatment of many diseases through both their regenerative properties as well as their apparent ability to alter the environment in injured and diseased tissues. (vin.com)
Adult stem cells can be obtained from many differentiated tissues including but not limited to bone marrow, bone, fat, and muscle. (vin.com)
DCs are located in the surface barrier and function by recognizing pathogens in tissues within the body by examining the major histocompatibility complex (MHC) of body cells. (modernloveok.com)

Injected lentiviral vector preferentially transduced splenic dendritic cells and resulted in long-term expression. (jci.org)

After identifying the pathogen the DCs undergo maturation which culminates with cytokine production and efficient antigen presentation. (modernloveok.com)
The maturation and cytokine production of dendritic cells will also be investigated after cultured with α-GalCer-incorporated liposomes in vitro. (tmu.edu.tw)

Interestingly, we found plasma blasts to express CD11c and to be diphtheria toxin-sensitive in CD11c-diphtheria toxin receptor-transgenic mice, providing a unique tool for future analysis of in vivo aspects of plasma cell biology. (uni-luebeck.de)
Experience in dendritic cell biology and antigen presentation mechanisms is a merit, T cell biology is also attractive. (lu.se)
Improved understanding of the pathology of histiocytic disorders requires knowledge of the origins, biology, and physiology of the cells involved. (medscape.com)

Both secreted autoantibodies and BCR on B cells can modulate the processing and presentation of antigen and thereby affect the nature of presented T-cell determinants. (hindawi.com)
This also includes to broaden our knowledge and understanding of virus-host interactions on the molecular level for instance with components of the antigen processing and presentation machinery. (uniklinik-duesseldorf.de)
Many approaches are used to enhance antigen presentation process of DCs and capture cancer cells. (bvsalud.org)
Endogenous synthesis of antigen results in efficient proteolytic peptide processing and presentation of peptide antigen on MHC class I proteins. (jci.org)
For immune defense, the respiratory tract contains DCs that function as a robust antigen presentation system. (biomedcentral.com)
In vitro studies in dendritic cells (DCs) established SNARE protein SEC22B as a specific regulator of cross-presentation. (elsevierpure.com)
However, the in vivo contribution of SEC22B to cross-presentation has not been tested. (elsevierpure.com)
Although in vitro small hairpin RNA (shRNA)-mediated Sec22b silencing in bone-marrow-derived dendritic cells (BMDCs) reduced cross-presentation, treatment of SEC22B-deficient BMDCs with the same shRNA produced a similar defect, suggesting the Sec22b shRNA modulates cross-presentation through off-target effects. (elsevierpure.com)

c) Effect of antibodies and antigen-specific B cells on antigen uptake. (hindawi.com)
This FcR-mediated antigen uptake is more efficient than antigen uptake by pinocytosis. (hindawi.com)
BCR-mediated antigen uptake can influence antigen processing and the nature of MHC-displayed T-cell determinants. (hindawi.com)
Concurrent with this observation, L-MCs possessed significantly more antigen-uptake capacity compared to their counterparts from blood. (biomedcentral.com)

Through these mechanisms B cells are involved both in autoimmune diseases that are traditionally viewed as antibody mediated and also in autoimmune diseases that are commonly classified as T cell mediated. (hindawi.com)
This new understanding of the role of B cells opened up novel therapeutic options for the treatment of autoimmune diseases. (hindawi.com)
Traditionally, autoimmune disorders were classified as T cell mediated or autoantibody mediated. (hindawi.com)
The observation that most autoantibodies in traditionally autoantibody-mediated diseases are of the IgG isotype and carry somatic mutations strongly suggests T-cell help in the autoimmune B-cell response. (hindawi.com)
Likewise B cells function as crucial antigen presenting cells in autoimmune diseases that are traditionally viewed as T cell mediated. (hindawi.com)
however, it needs to be emphasized that most autoimmune diseases are driven by a dysfunction in the immune network consisting of B cells, T cells, and other immune cells. (hindawi.com)
These interactions promote the selective expansion of myelin-Ag-specific natural regulatory T cells that dampen the autoimmune T cell response. (unige.ch)
While all cells are functionally deficient, resulting in high susceptibility to infections, only some of these cells are causing autoimmune symptoms. (hindawi.com)
SCID patients presenting with circulating T cells show different patterns of T-cell activity and regulatory T cells enumeration that dictates the immunodeficient and autoimmune manifestations. (hindawi.com)
In contrast, patients with self-reactive cells have significant autoimmune features in addition to their clinical and molecular immunodeficient state. (hindawi.com)
These cells expand in the periphery, causing tissue infiltration and damage due to breakdown of both central (e.g., autoimmune regulator, AIRE protein dysfunction) and peripheral (FOXP3 + deficiency) tolerance mechanisms [ 3 ]. (hindawi.com)
Finally, unanswered questions relating to vitamin D mechanisms in CD4 + T cells are highlighted to promote further research that may lead to a deeper understanding of autoimmune disease molecular etiology. (frontiersin.org)
Taken together, these results provide further evidence for substantial similarities between the guinea-pig and human CD1 systems, thus supporting the possibility that the guinea-pig may offer significant advantages as an animal model for the study of the in vivo role of CD1 proteins in infectious and autoimmune diseases. (elsevierpure.com)
Pemphigus vulgaris (PV) is a life-threate- disorders and to shed a light on the role of ning blistering skin disease in which pa- mast cells in autoimmune diseases [ 7 ]. (who.int)

The size of the plasma pool ensures the vast diversity of IgG repertoire in IVIG that interacts with a large number of self-antigens, in addition to pathogens and external antigens [2]. (academie-medecine.fr)

Major histocompatibility complex (MHC) Class I and II on DCs in normal steady conditions process and present antigens including cancer antigens. (bvsalud.org)

Vaccination by direct injection of lentiviral vector was more effective in sterile alpha motif and HD-domain containing protein 1-knockout (SAMHD1-knockout) mice, suggesting that lentiviral vectors containing Vpx, a lentiviral protein that increases the efficiency of dendritic cell transduction by inducing the degradation of SAMHD1, would be an effective strategy for the treatment of chronic disease in humans. (jci.org)
Several features of lentiviral vectors have made them advantageous for the expression of therapeutic proteins in vivo. (jci.org)
These properties have made lentiviral vectors advantageous for use in dendritic cell (DC) vaccines. (jci.org)
This thesis is concerned with the development of vaccines based on lentiviral vectors (lentivectors) such vectors are readily used for gene therapy because they can stable modify non-dividing cells. (ucl.ac.uk)

The striking observation from two phase I clinical trials, in patients with prostate cancer immunized with prostate-specific antigen mRNA-transfected DCs and patients with renal cancer immunized with autologous tumor RNA-transfected DCs, was that the majority of patients exhibited a vaccine-induced T-cell response. (nova.edu)
Initially, conventional cancer therapies, such as chemotherapy and radiotherapy, were thought to specifically target cancerous cells. (asiaimmune.com)
In addition, different combinations with DCs therapy such as combination with the monoclonal antibody, cytokine-induced killer cells, adjuvants, chemotherapy (DCs-based chemoimmunotherapy), and nanoparticles were listed and explored for their effectiveness against cancer, and mainly against colorectal cancer. (bvsalud.org)
In addition, the optimum nanosuspension was characterized for its nanoparticle sensitivity against colorectal cancer cells using MTT assay in comparison to the untreated, naringenin, and blank groups. (bvsalud.org)
Dendritic cells making progress with cancer vaccination. (zju.edu.cn)
6 Therefore, high quantities of antigen are presented to DCs by cancer vaccines in order to break the tolerance. (modernloveok.com)
5Function of DCs and the strategies used to fight cancer (including contribution of Ralph Steinman):In 1973, Zanvil Cohn and Ralph Steinman identified a rare cell type in the murine spleen which was identical to a phagocytic cell with dendrites like protrusions and they named them dendritic cells (DCs). (modernloveok.com)
Also highlighting the work of Ralph Steinman and his colleagues which contributes towards finding new strategies involving dendritic cells to fight cancer. (modernloveok.com)
Cancer vaccines were initially comprised of tumour associated antigens (TAAs), but since these were poorly immunogenic, they were replaced with dendritic cell (DC) vaccines loaded with TAAs (adopted because DC prime naive T cells). (ucl.ac.uk)
Documented knowledge in tumor immunology, with practical experience in in-vivo evaluation of cancer immunotherapies using mouse syngeneic mouse models. (lu.se)
Transcriptomic profiling of T-cell populations in non-muscle invasive and muscle invasive bladder cancer. (lu.se)

B cells have antibody-dependent and antibody-independent pathogenic functions. (hindawi.com)
The HK5.3 monoclonal antibody reacts with mouse ICOSL (inducible T cell co-stimulator ligand) also known as CD275, B7RP-1, and B7-H2. (bioxcell.com)

This can be done either by culturing ex vivo DCs that are obtained from a patient with adjuvant (that leads to DC maturation) and the specific tumour antigens and then the injection of these cells back into the patient or by inducing of DCs to take up specific tumour antigens in vivo. (modernloveok.com)
Residual autologous T cells are usually emerging from partial thymic maturation impairment such as in the case of Major histocompatibility complex class II (MHC-II) deficiency. (hindawi.com)
Maturation of dendritic cells leads to up-regulation of cellular FLICE-inhibitory protein and concomitant down-regulation of death ligand-mediated apoptosis. (medscape.com)

Front Cell Infect Microbiol. (southernbiotech.com)
FWPV was found to infect and express a lacZ marker gene in a number of mammalian cell lines of fibroblastic, epithelial, and hemopoietic lineage origins. (lookformedical.com)
LacZ recombinant FWPV (rFWPV) was found subsequently to infect human DCs that had been cultured ex vivo from peripheral blood monocytes. (lookformedical.com)

We hypothesized that the toxicity of biodiesel exhaust (BDE) is dependent at least on three major mechanisms: direct reactivity of BDE PM electrophiles towards critical biomolecules, induction of robust inflammatory response associated with the nano-sized components of BD PM, and triggering of oxidative stress via depletion of essential antioxidants and activation of oxidative burst in inflammatory cells. (cdc.gov)
Ultimately, my interest is in understanding the immunological mechanisms underlying helminth persistence, to determine whether these conditions can be replicated to drive tolerance in vivo. (cam.ac.uk)
This study aimed to determine the mechanisms by which MIS416-induced IFN-γ reduces disease severity in EAE and investigate the IFN-γ-dependent effects on disease-inducing auto-reactive CD4 T cells as well as the peripheral and CNS resident myeloid cells that are directly targeted by MIS416. (nature.com)
Research on vitamin D regulation of thymocyte selection, Th1 and Th17 cells, T-cell programed cell death, and T-regulatory (Treg) cells is summarized and integrated into model mechanisms. (frontiersin.org)
It was given supposition that at using BM cells the forming of steady transplant tolerance state is a result of successive entering of central (thymical induction of temporary mixed chimer-ism) and peripheral tolerance mechanisms. (genescells.ru)
Induced Regulatory T cells: Mechanisms of Conversion and Suppressive Potential. (genescells.ru)
Thus, more basic research is needed on the chemical reactions involved in the antigen formation and the immunological mechanisms. (cdc.gov)

DCs are very effective antigen presenting cells and have a vital role in coordinating of both innate and adaptive immune response. (modernloveok.com)
We know that innate immune cells are required for blastema progenitor cell formation, but are lacking an understanding of the immune cell processes and functions that are required for inducing and maintaining these progenitors cells. (lu.se)

In comparison, cDC2s are potent activators of CD4 + T cells ( 8 ). (frontiersin.org)
In vivo , GC induced a potent response of type I IFN and upregulated genes associated with STING signaling within the tumor microenvironment (TME). (biorxiv.org)
Bone marrow-derived dendritic cells (DCs) are the most potent antigen-presenting cells capable of activating naïve T cells. (nova.edu)

Injection of a lentiviral vector encoding an MHC class I-restricted T cell epitope of lymphocytic choriomeningitis virus (LCMV) and CD40 ligand induced an antigen-specific cytolytic CD8 + T lymphocyte response that protected the mice from infection. (jci.org)
A novel CD18 genomic deletion in a patient with severe leucocyte adhesion deficiency: a possible CD2/lymphocyte function-associated antigen-1 functional association in humans. (lu.se)

Alternatively, the DCs are transduced with a viral vector that expresses the antigen. (jci.org)
Therefore, a clearer understanding capsid expression was analyzed by immunofluorescent assay of WNV is necessary in order to identify new strategies to treat in HeLa, 293-T, RD, or SH-SY5Y cells by using anti-His tag or prevent this viral infection (3). (cdc.gov)
In a multivariable model, typical bacterial CAP was associated with pleural effusion (OR 7.3, 95% CI 4.7-11.2) and white blood cell 15 000/mL (OR 3.2, 95% CI 2.2-4.9), and absence of wheeze (OR 0.5, 95% CI 0.3-0.8) or viral detection (OR 0.2, 95% CI 0.1-0.4). (cdc.gov)

A truncated C-terminal fragment of Mycobacterium tuberculosis HSP70 enhances cell-mediated immune response and longevity of the total IgG to influenza A virus M2e protein in mice. (southernbiotech.com)
We show that CD11c high DC are dispensable for the initiation and maintenance of a primary immune response against the T-independent type 2 antigen (4-hydroxy-3-nirophenyl)acetyl-Ficoll. (uni-luebeck.de)
Figure 1 shows a dendritic cell presenting a foreign antigen to a Cytotoxic T cell which than leads to a specific immune response. (modernloveok.com)
Clinical trials for many indications, such as using dendritic cell-derived exosomes to facilitate immune response to cancers, are now underway. (bioquicknews.com)
There are two hallmark phenotypes of allergic asthma: (1) inflammatory, due to a T helper cell type 2 (Th2)-mediated immune response resulting in elevated inflammatory cells in the airways, and (2) airway hyper-reactivity, during which volume and flow of inhaled air decreases as a consequence of airway constriction. (cdc.gov)

Antigen gene transfer to cultured human dendritic cells using recombinant avipoxvirus vectors. (lookformedical.com)

The DCs are then pulsed with synthetic peptide or cell lysate and matured with cytokine or TLR agonists. (jci.org)

The bi-stable switch would enable T cells to integrate signals from pathogens, hormones, cell-cell interactions, and soluble mediators and respond in a biologically appropriate manner. (frontiersin.org)

2015). "IL-6 and ICOS Antagonize Bim and Promote Regulatory T Cell Accrual with Age" J Immunol 195(3): 944-952. (bioxcell.com)

Langerhans cell histiocytosis (LCH) can be localized and manifest as pain or may even be asymptomatic, as is the case in isolated bone lesions. (medscape.com)
Normal histiocytes originate from pluripotent stem cells, which can be found in bone marrow. (medscape.com)
Epidermal Langerhans cells are derived from cells originating in bone marrow. (medscape.com)

We conclude with a discussion of novel therapies aimed at the selective targeting of pathogenic B cells. (hindawi.com)
These data establish a method for the ex vivo generation of graft-reactive, functional mouse and human T(regs) that uses a clinically approved agent, making pharmacological PDE inhibition a potential strategy for T(reg)-based therapies. (lu.se)
Despite the promising findings, the efficacy of cell-based therapies varies greatly across studies, partly due to different methods of cell isolation and purification techniques, source, route and timing of administration, and combination immunosuppressive therapy. (stanford.edu)
Dendritic cell-based therapies in the bench and the bed sides. (zju.edu.cn)

Moreover, stable mature protein was preferred to pre-processed antigen or antigen fragments as the substrate for cross-priming. (uniklinik-duesseldorf.de)
More were stained with toluidine blue, and photographed with importantly, direct in vivo expression of WNV-Cp protein in Ektachrome 160T film (Eastman Kodak Co., Rochester, NY). (cdc.gov)

Conversely, complement receptor-mediated pathogen ingestion occurs without observable membrane extensions (particles just sink into the cell) and does not generally results in an inflammatory mediator response. (wikipedia.org)
Chronic persistence of the adult worm infection can be modified by use of a synthetic TGF -beta type 1 receptor inhibitor in vivo. (cam.ac.uk)
These regulatory T cell changes could be inhibited with excess antigen or the retinoic acid receptor antagonist LE540 and are enhanced with recombinant TGF -beta. (cam.ac.uk)

Rosa et al, Science Immunology 2022 ) and has shown recently that the same combination of factors can reprogram tumor cells into antigen presenting cells (Zimmermannova et al, In revision). (lu.se)

T follicular helper (Tfh) cells are essential in the induction of high-affinity, class-switched antibodies. (bioxcell.com)

We aimed to determine the significance of detecting expression of some antigens that might be pivotal to the process, namely CD44 and CD117, in patients with active pemphigus vulgaris. (who.int)

The morphology and densities of conjunctival epithelial cells, goblet cells (GCs), dendritic cells (DCs) and the positive rate of conjunctival microcysts were analysed. (bmj.com)
Results The morphology and the densities of both conjunctival epithelial cells and GCs showed no significant age-related differences. (bmj.com)
4,6,7 It has been proposed that some of these MSC may actually differentiate into functional renal tubular epithelial cells, though this theory remains controversial. (vin.com)

Regulatory T cells (Tregs), a subset of CD4(+) T cells, dramatically accumulate with age in humans and mice and contribute to age-related immune suppression. (bioxcell.com)

After EAE induction, pDCs are recruited to lymph nodes and establish MHCII-dependent myelin-Ag-specific contacts with CD4(+) T cells. (unige.ch)
Induction of CD8+ cytotoxic T cells is considered one of the important correlates for the protective efficacy of candidate human immunodeficiency virus type 1 (HIV-1) vaccines. (lookformedical.com)

For the last year, mice will be immunized and the activities of cytotoxic T cells and NK cells will be illustrated. (tmu.edu.tw)

Contrary to the paradigm, SEC22B-deficient DCs efficiently cross-present both in vivo and in vitro. (elsevierpure.com)
The recombinant viruses obtained were unstable, although the foreign genes were expressed efficiently in the mammalian cells infected with the viruses. (lookformedical.com)

Finally, MIS416-mediated protection was shown to correlate with IFN-γ-dependant expansion of PDL-1-expressing peripheral myeloid cells, a subset of which was found to be selectively recruited to the brain. (nature.com)
Together, these findings provide insight into regulatory myeloid cell activities amplified by MIS416-mediated NOD-2 and TLR-9 signalling and highlight the potential importance of these cells in accessing the brain where they may act locally and contribute to the control of neuroinflammation. (nature.com)

Identification of a novel cell type in the peripheral lymphoid organs of mice. (zju.edu.cn)
HK5.3 treatment of mice has been reported to lead to a loss of regulatory T cells. (bioxcell.com)
Next, we analyzed the gene expression profile of Tregs, naive T cells, and memory T cells in aged mice. (bioxcell.com)
ICOS contributed to Treg maintenance in aged mice, because in vivo Ab blockade of ICOSL led to a loss of eTregs, and this loss was rescued in Bim-deficient mice. (bioxcell.com)
The injection of chronically infected mice with a lentiviral vector encoding LCMV MHC class I and II T cell epitopes and a soluble programmed cell death 1 microbody rapidly cleared the virus. (jci.org)
During the second year, mice will be immunized with α-GalCer-incorporated liposome vaccine via intravenous or intranasal routes and T cell activities will be analyzed. (tmu.edu.tw)

Regulatory T cells (T(regs)) manipulated ex vivo have potential as cellular therapeutics in autoimmunity and transplantation. (lu.se)

Signals via the adaptor MyD88 in B cells and DCs make distinct and synergistic contributions to immune activation and tissue damage in lupus. (southernbiotech.com)
CD11c(lo) cells polarise naive T cells to distinct T cells lineages, encouraging the expansion of antigen-specific Foxp3 T cells and polarisation away from Th17 cells. (cam.ac.uk)
1Mononuclear phagocytic cells are distinct ancestor of DCs which specialise in antigen presenting. (modernloveok.com)
Multiple sclerosis and T1D have distinct target organs, genetic risk factors, onset ages, and female to male ratios, but target organ-specific T cells as initiators unite these diseases. (frontiersin.org)

I have found that chronic helminth infection is associated with the expansion of CD11c(lo) dendritic cells in the draining lymph nodes of the gut. (cam.ac.uk)
For example, tumor exosomes are thought to participate in metastasis of tumor cells, seeding tumor-draining lymph nodes prior to tumor cell migration, and increasing their motility. (bioquicknews.com)

Project aiming at exploiting our Clec9A-targeting vaccination platform to enhance co-stimulation and in vivo persistence of CAR-T cells with dual specificity. (edu.au)
In this project, α-GalCer was incorporated into the lipid bilayer of the liposome, while the galactose molecular was expressed on the surface of the liposome to form a targeting liposome antigen-carrier with immunemodulatory effect. (tmu.edu.tw)

Anatomy41

Organisms9

Diseases9

Chemicals and Drugs131

Analytical, Diagnostic and Therapeutic Techniques and Equipment25

Phenomena and Processes41

Disciplines and Occupations1

Information Science3

Health Care2

Professional antigen-prese6

APCs13

Macrophages13

Monocyte-derived dendritic cells3

Immunotherapy15

Cross-presenting dend1

Vitro and in vivo7

Lymphocytes18

Abstract1

Responses32

Plasmacytoid5

Effector10

Induce1

Molecules11

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Role of dendritic cells1

Cytokines5

Immature5

Proliferation3

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Tolerogenic2

Immunity4

Tissues3

Splenic1

Cytokine production2

Biology3

Presentation8

Uptake4

Autoimmune14

Self-antigens1

Present antigens1

Lentiviral vectors4

Cancer11

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Maturation3

Infect3

Mechanisms7

Innate2

Potent3

Lymphocyte2

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Immune response5

Vectors1

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Pathogens1

Immunol1

Bone3

Therapies4

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Immunology1

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Humans1

Induction2

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Distinct4

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Targeting2