VitroLymphocytic leukemiaBiological activitiesAnticancer activityPharmacological activitiesAntifungalPotentAntiviralAnti-tumorCompoundsUptakeDerivativesExhibitLinesCellReviewStructureAntitumor activityMurineAntitumour activityLymphocyticMiceAnticancer ActivitiesBiologicalChemotherapyCytotoxicTitanocene dichlorideLungCellsCell lineInvestigationIsolationChemicalDevelopmentStudiesComponentsCasesBroad
Vitro6
- The compound has been found to show promising in vitro and in vivo activities against certain B-cell malignancies [ 12 ], and has been under preclinical toxicogical development in the National Cancer Institute Experimental Therapeutics (NExT) program. (biomedcentral.com)
- PURPOSE: Our study explored the effect of long noncoding RNA BBOX1-AS1 on colorectal cancer (CRC) radiosensitivity in vivo and in vitro. (bvsalud.org)
- The aim of present study was to investigate in vitro and in vivo whether 20(S)-Rh2 was a P-gp inhibitor and analyze the possible inhibitory mechanisms and potential herb-drug interactions. (indexindex.com)
- Long-term treatment with 20(S)-Rh2 failed to affect intestinal P-gp expression in vitro and in vivo. (indexindex.com)
- Индукция дифференцировки в клетках опухолевых линий in vivo и in vitro. (dissercat.com)
- The evidence for these anticancer effects, in vitro , in vivo , and clinical are summarised, and the putative mechanisms of their action outlined. (ecancer.org)
Lymphocytic leukemia1
Biological activities4
- This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities. (chemfaces.com)
- Besides it provides a valuable snapshot of the chemical structure-activity relationship of compounds, highlighting the presence or absence of some specific atoms and chemical units in the structure of compounds can greatly influence their biological activities. (frontiersin.org)
- Stimulated by the pioneering studies on the cationic porphyrin TMPyP4 and the natural product telomestatin, follow-up studies have developed, rapidly leading to a large diversity of macrocyclic structures with remarkable-quadruplex binding properties and biological activities. (hindawi.com)
- In another review in 2022, Gao and Zhang (2022) reported a total of 196 new metabolites isolated from algae-associated fungi covering from 2016 to 2021, including the chemical diversity and biological activities. (japsonline.com)
Anticancer activity1
- Laetrile has shown little anticancer activity in animal studies and no anticancer activity in human clinical trials. (cancer.gov)
Pharmacological activities1
- Pentacyclic triterpenes have been repeatedly proven to possess a broad spectrum of pharmacological activities. (encyclopedia.pub)
Antifungal2
- Antifungal activity is via inhibition of 1,3-beta-glucan synthase production of BETA-GLUCANS. (lookformedical.com)
- The mechanism of action for this antifungal activity is through the decrease of ergosterol synthesis, required for membrane integrity of fungal cells, via inhibition of the lanosterol 14 alpha-demethylase (14DM) catalyst. (ecancer.org)
Potent2
- Silvestrol represents a natural product scaffold that exhibits potent cytotoxic activity and could be used for the further study of autophagy and its relationship to apoptosis in cancer cells. (biomedcentral.com)
- There is evidence that at the clinically relevant doses, itraconazole has potent anti-angiogenic activity, and that it can inhibit the Hedgehog signalling pathway and may also induce autophagic growth arrest. (ecancer.org)
Antiviral1
- Moreover, compound 5 showed significant antiviral activity against human cytomegalovirus with an IC 50 of 5.2 μg/mL. (mdpi.com)
Anti-tumor3
- Inotodiol shows significant anti-tumor and anti-tumor promoting activities, including human cervical cancer, it inhibits cell proliferation through apoptosis induction by activating caspase-3. (chemfaces.com)
- M.S. Webb, N.L. Boman, D. Masin, D. Yapp, E. Ramsay, P.R. Cullis and M.B. Bally, "A Cationic Liposomal Vincristine Formulation with Improved Vincristine Retention, Extended Circulation Lifetime and Increased Anti-Tumor Activity", Biochim. (ubc.ca)
- 2007). Encapsulation in liposomal nanoparticles enhances the immunostimulatory, adjuvant and anti-tumor activity of subcutaneously administered CpG ODN. (ubc.ca)
Compounds2
- This review report displays the structures of new compounds isolated from algae-derived and sponge-derived fungi and their activities, covering the literature from 2017 to 2021. (japsonline.com)
- Several compounds showed stronger activity than the control. (japsonline.com)
Uptake1
- Cancer cells also enhance glucose-uptake to fuel these enhanced metabolic activities [ 2 ]. (degruyter.com)
Derivatives1
- Arglabin and its derivatives are biologically active and demonstrate promising antitumor activity and cytoxocity against varying tumor cell lines. (wikipedia.org)
Exhibit1
- Guaianolides are known to exhibit significant biological activity. (wikipedia.org)
Lines1
- The in vivo antitumoral/antileukemic activity was evaluated using the following panel of tumor lines: P-388 leukemia, sarcoma (S-37), Ehrlich ascitic tumor (EAT), Lewis lung carcinoma (LLC), MB-F10 melanoma and ADC-755 mammary adenocarcinoma. (greenmedinfo.com)
Cell1
- Clinical trials have shown that patients with prostate, lung, and basal cell carcinoma have benefited from treatment with itraconazole, and there are additional reports of activity in leukaemia, ovarian, breast, and pancreatic cancers. (ecancer.org)
Review1
- This review also describes the chemical structure of 232 NPs presenting anti-CRC activity with the being majority of quinones, lactones, alkaloids, peptides, and glycosides. (frontiersin.org)
Structure1
- The affinity and spectrum of biological activity is associated with the diverse triterpene skeleton structure and connected substituents. (encyclopedia.pub)
Antitumor activity3
- Arglabin and its derivatives are biologically active and demonstrate promising antitumor activity and cytoxocity against varying tumor cell lines. (wikipedia.org)
- 35. A controlled release system of titanocene dichloride by electrospun fiber and its antitumor activity in vitro. (nih.gov)
- Evaluation of the in vivo antitumor activity and in vitro cytotoxic properties of auranofin, a coordinated gold compound, in murine tumor models. (nih.gov)
Murine1
Antitumour activity2
- 31. Biological and pharmacological characterisation of three models of human ovarian carcinoma established in nude mice: use of the CA125 tumour marker to predict antitumour activity. (nih.gov)
- However, in contrast to the well characterized platinum-based anticancer drugs, the active species responsible for antitumour activity in vivo has not been identified and the mechanism whereby irreparable DNA damage and/or structural modification of DNA or other cellular targets occurs is poorly understood. (eurekaselect.com)
Lymphocytic1
- The coordinated gold compound, 2,3,4,6-tetra-O-acetyl-1-thio-beta-D-glucopyranosato-S-triethylphosphine-gold (auranofin) was found to be effective in increasing the life span of C57BL x DBA/2 F1 mice inoculated with the lymphocytic leukemia P388. (nih.gov)
Mice3
- In vivo administration of PDX-101 increased median survival in mice carrying P388 leukemia cells from 9 to 16 days. (medscape.com)
- As many consider P388 an "artificial" model (an "in vivo test tube"), further studies were performed with A2780 human xenografts in mice. (medscape.com)
- The metallocene dihalides are a relatively new class of small, hydrophobic organometallic anticancer agents that exhibit antitumour properties against numerous cell lines including leukemias P388 and L1210, colon 38 and Lewis lung carcinomas, B16 melanoma, solid and fluid Ehrlich ascites tumours and several human colon and lung carcinomas transplanted into athymic mice. (eurekaselect.com)
Anticancer Activities1
- Quinoxaline-1, 4-dioxide derivatives have been claimed to have interesting anticancer activities. (japsonline.com)
Biological6
- Guaianolides are known to exhibit significant biological activity. (wikipedia.org)
- The patterns of histone acetylation were followed in the tumors and in the blood, thus providing a useful biomarker of in vivo biological activity. (medscape.com)
- Soft corals (Cnidaria, Anthozoa, Octocorallia) are an important source of chemically diverse metabolites with a broad spectrum of biological activities. (nature.com)
- The importance of studying marine invertebrates lies in their extraordinary ability to produce a broad variety of chemical compounds with unique chemical structures that in most cases have been correlated with significant biological activities, which has led to the successful development of commercial drugs. (nature.com)
- PMID- 214395 TI - Chemical modification of peptide antibiotics : Part VII--Biological activity of derivatives of polymyxin B. PMID- 214396 TI - Temporal relations in phosphohydrolases of mouse testes. (nih.gov)
- The biological activity of cis isomers was much higher than that of trans isomers. (go.jp)
Chemotherapy1
- The broad spectrum of antitumor effects, [ 24 ] the potential synergy with chemotherapy, and the encouraging in vivo data, concluded Dr. Carey, are fueling the further development of subtype-specific inhibitors, in the hope to achieve selective clinical applications for cancer patients. (medscape.com)
Cytotoxic1
- on the other hand, a metabolomic analysis of PSYCHE data obtained under the same parameters revealed that when a decoupled experiment is performed, it was possible to establish a statistically valid correlation between the chemical composition of soft corals and their cytotoxic activity against the PC3 cancer cell line, where the asperdiol and plexaurolone markers were putatively identified and related to the cytotoxic activity presented by extracts of Plexaurella sp. (nature.com)
Titanocene dichloride1
- New structure activity studies including the design of hydrolytically stable metallocenes and the preparation of highly water soluble amino acid analogues have not led to improved anticancer activity of titanocene dichloride 1. (eurekaselect.com)
Lung1
- Overexpression of the multidrug resistance proteins P-glycoprotein (Pgp), multidrug resistance protein (MRP-1), breast cancer resistance protein (BCRP), and lung resistance protein (LRP) is associated with treatment failure in acute myeloid leukemia (AML) and other malignancies. (aacrjournals.org)
Cells5
- Biochemical assays with cell lysates showed that this compound is able to inhibit the enzymatic activity of HDACs with an IC50 (inhibitory concentration, 50) of about 40 nM in HeLa cells. (medscape.com)
- Acetylation patterns of histone 3 and 4 are being determined in peripheral blood mononuclear cells to evaluate in vivo bioactivity of PDX-101 and correlate it with dose responses. (medscape.com)
- Different molecules appear to have differential activity in different target cells, thus raising the possibility to develop subtype-specific HDAC inhibitors, increase efficacy, and reduce toxicity associated with a broad HDAC inhibition. (medscape.com)
- Leukemia, a malignant transformation of hematopoietic cells, is one of the most prevalent types of cancer, especially in children and, globally, it was ranked 10th for cancer incidence and nineth for cancer deaths. (japsonline.com)
- Leukemia is a malignant transformation of hematopoietic cells which produces an abnormal leukemic clone of cells suppressing the production of normal blood cellular components ( Duhrsen and Hossfeld, 1996 ). (japsonline.com)
Cell line1
- Because the efflux transporter P-glycoprotein (P-gp) is involved in the absorption, distribution, and excretion of many drugs and often participates in drug-drug interactions, we studied the effect of a crude kava extract and the main kavalactones kavain, dihydrokavain, methysticin, dihydromethysticin, yangonin, and desmethoxyyangonin on the P-gp-mediated efflux of calcein-acetoxymethylester in the P-gp-overexpressing cell line P388/dx and the corresponding cell line P388. (nih.gov)
Investigation1
- The modern scientific research with the investigation of anticancer activity of N. sativa is comparatively recent affair (for the last 2-3 decades). (naturestudysociety.org)
Isolation1
- We report on the isolation, identification, synthesis and structure-activity relationships of allelopathic substances, which are designated as C inhibitors, from E. citriodora Hook. (go.jp)
Chemical2
- The vastly different chemical and hydrolytic stability of each of the metallocenes points to a unique mechanism of action of each metallocene in vivo. (eurekaselect.com)
- Causes of leukemia are diverse and they could be familial, infectious, physical, or chemical depending on the cell type and the individual variations from one patient to another ( Pui, 1995 ). (japsonline.com)
Development1
- Obesity, smoking, and exposure to electromagnetic fields and ionizing radiation have been reported to be risk factors for the development of leukemia. (japsonline.com)
Studies1
- Antitumour Metallocenes: Structure-Activity Studies and Interactions with Biomolecules. (eurekaselect.com)
Components1
- Although the anti-cancer activity of N. sativa components was recognized thousands of years ago but proper scientific research with this important traditional medicine is a history of last 2-3 decades. (naturestudysociety.org)
Cases1
- around 60,300 new cases of leukemia were expected to be diagnosed in the US in 2018. (japsonline.com)
Broad2
- An imidazole derivative with a broad spectrum of antimycotic activity. (lookformedical.com)
- Cyclosporin A modulates Pgp, MRP-1, BCRP, and LRP, and this broad-spectrum activity may contribute to its clinical efficacy. (aacrjournals.org)